Safety, Efficacy, and Outcomes of N-Butyl Cyanoacrylate Glue Injection through the Endoscopic or Radiologic Route for Variceal Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis Article Swipe
Olivier Chevallier
,
Kévin Guillen
,
Pierre‐Olivier Comby
,
Thomas Mouillot
,
Nicolas Falvo
,
Marc Bardou
,
Marco Midulla
,
Serge Aho
,
Romaric Loffroy
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/jcm10112298
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/jcm10112298
We performed a systematic review and meta-analysis of published studies to assess the efficacy, safety, and outcomes of N-butyl cyanoacrylate (NBCA) injection for the treatment of variceal gastrointestinal bleeding (GIB). The MEDLINE/PubMed, EMBASE, and SCOPUS databases were searched for English-language studies published from January 1980 to December 2019 and including patients who had injection of NBCA for variceal GIB. Two independent reviewers extracted and evaluated the data from eligible studies. Exclusion criteria were sample size < 5, article reporting the use of NBCA with other embolic agents, no extractable data, and duplicate reports. NBCA was injected during endoscopy in 42 studies and through a direct percutaneous approach for stomal varices in 1 study. The study’s endpoints were: Technical success, 30-day rebleeding, and 30-day overall and major complications. The estimated overall rates were computed with 95% confidence intervals, based on each study rate, weighted by the number of patients involved in each study. In total, 43 studies with 3484 patients were included. The technical success rate was 94.1% (95% CI: 91.6–96.1%), the 30-day rebleeding rate was 24.2% (18.9–29.9%), and 30-day overall and major complications occurred in 15.9% (11.2–21.3%) and 5.3% (3.3–7.8%) of patients, respectively. For treating variceal GIB, NBCA injection is a safe and effective method that demonstrates high technical success rate and very low major complication rate.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm10112298
- https://www.mdpi.com/2077-0383/10/11/2298/pdf?version=1621995068
- OA Status
- gold
- Cited By
- 22
- References
- 92
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3165078361
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3165078361Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/jcm10112298Digital Object Identifier
- Title
-
Safety, Efficacy, and Outcomes of N-Butyl Cyanoacrylate Glue Injection through the Endoscopic or Radiologic Route for Variceal Gastrointestinal Bleeding: A Systematic Review and Meta-AnalysisWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-05-25Full publication date if available
- Authors
-
Olivier Chevallier, Kévin Guillen, Pierre‐Olivier Comby, Thomas Mouillot, Nicolas Falvo, Marc Bardou, Marco Midulla, Serge Aho, Romaric LoffroyList of authors in order
- Landing page
-
https://doi.org/10.3390/jcm10112298Publisher landing page
- PDF URL
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https://www.mdpi.com/2077-0383/10/11/2298/pdf?version=1621995068Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2077-0383/10/11/2298/pdf?version=1621995068Direct OA link when available
- Concepts
-
Medicine, Cyanoacrylate, Meta-analysis, Percutaneous, Surgery, Confidence interval, Gastrointestinal bleeding, Varices, Complication, GLUE, MEDLINE, Internal medicine, Chemistry, Organic chemistry, Layer (electronics), Materials science, Adhesive, Composite material, Political science, Law, CirrhosisTop concepts (fields/topics) attached by OpenAlex
- Cited by
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22Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 7, 2023: 2, 2022: 7, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
92Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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