Safety evaluation of an extension of use of the food enzyme glucan 1,4‐α‐glucosidase from the non‐genetically modified Rhizopus arrhizus strain AE‐G Article Swipe
Claude Lambré
,
José Manuel Barat Baviera
,
Claudia Bolognesi
,
Pier Sandro Cocconcelli
,
Riccardo Crebelli
,
David Michael Gott
,
Konrad Grob
,
Evgenia Lampi
,
Marcel Mengelers
,
Alicja Mortensen
,
Gilles Rivière
,
Inger‐Lise Steffensen
,
Pavel Tlustoš
,
Henk Van Loveren
,
Laurence Vernis
,
Holger Zorn
,
Daniele Cavanna
,
Yi Liu
,
Giulio di Piazza
,
Andrew Chesson
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.2903/j.efsa.2024.8773
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.2903/j.efsa.2024.8773
The food enzyme glucan 1,4-α-glucosidase (4-α-d-glucan glucohydrolase; EC 3.2.1.3) is produced with the non-genetically modified Rhizopus arrhizus strain AE-G by Amano Enzyme Inc. A safety evaluation of this food enzyme was made previously, in which EFSA concluded that this food enzyme did not give rise to safety concerns when used in one food manufacturing process. Subsequently, the applicant requested to extend its use to nine additional processes and revised the use levels. In this assessment, EFSA updated the safety evaluation of this food enzyme for uses in a total of 10 food manufacturing processes. As the food enzyme-total organic solids (TOS) is removed from the final foods in two food manufacturing processes, the dietary exposure to the food enzyme-TOS was estimated only for the remaining eight processes. Dietary exposure was up to 0.424 mg TOS/kg body weight (bw) per day in European populations. When combined with the no observed adverse effect level previously reported (1868 mg TOS/kg bw per day, the highest dose tested), the Panel derived a margin of exposure of at least 4406. Based on the data provided for the previous evaluation and the margin of exposure revised in the present evaluation, the Panel concluded that this food enzyme does not give rise to safety concerns under the revised intended conditions of use.
Related Topics
Concepts
Rhizopus arrhizus
Strain (injury)
Glucan
Enzyme
Food science
Biology
Chemistry
Microbiology
Biochemistry
Lipase
Anatomy
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2903/j.efsa.2024.8773
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.2903/j.efsa.2024.8773
- OA Status
- diamond
- References
- 6
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4396737382
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4396737382Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.2903/j.efsa.2024.8773Digital Object Identifier
- Title
-
Safety evaluation of an extension of use of the food enzyme glucan 1,4‐α‐glucosidase from the non‐genetically modified Rhizopus arrhizus strain AE‐GWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-05-01Full publication date if available
- Authors
-
Claude Lambré, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger‐Lise Steffensen, Pavel Tlustoš, Henk Van Loveren, Laurence Vernis, Holger Zorn, Daniele Cavanna, Yi Liu, Giulio di Piazza, Andrew ChessonList of authors in order
- Landing page
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https://doi.org/10.2903/j.efsa.2024.8773Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.2903/j.efsa.2024.8773Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.2903/j.efsa.2024.8773Direct OA link when available
- Concepts
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Rhizopus arrhizus, Strain (injury), Glucan, Enzyme, Food science, Biology, Chemistry, Microbiology, Biochemistry, Lipase, AnatomyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
6Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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