Safety evaluation of the food enzyme asparaginase from the genetically modified Aspergillus niger strain ASP Article Swipe
Claude Lambré
,
José Manuel Barat Baviera
,
Claudia Bolognesi
,
Pier Sandro Cocconcelli
,
Riccardo Crebelli
,
David Michael Gott
,
Konrad Grob
,
Evgenia Lampi
,
Marcel Mengelers
,
Alicja Mortensen
,
Gilles Rivière
,
Inger‐Lise Steffensen
,
Christina Tlustos
,
Henk Van Loveren
,
Laurence Vernis
,
Holger Zorn
,
Lieve Herman
,
Jaime Aguilera
,
Magdalena Andryszkiewicz
,
Daniele Cavanna
,
Cristina Fernández‐Fraguas
,
Yi Liu
,
Sandra Rainieri
,
Yrjö Roos
,
Andrew Chesson
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.2903/j.efsa.2024.8874
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.2903/j.efsa.2024.8874
The food enzyme asparaginase (l‐asparagine amidohydrolase; EC 3.5.1.1) is produced with the genetically modified Aspergillus niger strain ASP by DSM Food Specialties B.V. The genetic modifications do not give rise to safety concerns. The food enzyme was considered free from viable cells of the production organism and its DNA. The food enzyme is intended to be used in the prevention of acrylamide formation in foods and in the processing of yeast and yeast products. Dietary exposure to the food enzyme‐total organic solids (TOS) was estimated to be up to 0.792 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level at the highest dose tested of 1038 mg TOS/kg bw per day, which when compared with the estimated dietary exposure, resulted in a margin of exposure of at least 1311. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and no match was found. The Panel considered that the risk of allergic reactions upon dietary exposure cannot be excluded, but the likelihood is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2903/j.efsa.2024.8874
- OA Status
- diamond
- Cited By
- 1
- References
- 27
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4400658815
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4400658815Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.2903/j.efsa.2024.8874Digital Object Identifier
- Title
-
Safety evaluation of the food enzyme asparaginase from the genetically modified Aspergillus niger strain ASPWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-07-01Full publication date if available
- Authors
-
Claude Lambré, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger‐Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Lieve Herman, Jaime Aguilera, Magdalena Andryszkiewicz, Daniele Cavanna, Cristina Fernández‐Fraguas, Yi Liu, Sandra Rainieri, Yrjö Roos, Andrew ChessonList of authors in order
- Landing page
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https://doi.org/10.2903/j.efsa.2024.8874Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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diamondOpen access status per OpenAlex
- OA URL
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https://doi.org/10.2903/j.efsa.2024.8874Direct OA link when available
- Concepts
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Food science, Genotoxicity, Aspergillus niger, Food safety, Enzyme, Toxicity, Biology, Acrylamide, Genetically modified organism, Toxicology, Biotechnology, Chemistry, Biochemistry, Copolymer, Gene, Organic chemistry, PolymerTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
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27Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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