Safety of endovascular therapy in ischemic stroke patients ⩾90 years: A cohort study from the EVA-TRISP collaboration Article Swipe
Jasmine Jost
,
Lukas Enz
,
Martina Goeldlin
,
Philipp Baumgartner
,
Davide Strambo
,
Nabila Wali
,
Nicolas Martinez‐Majander
,
Georg Kägi
,
Laura Vandelli
,
Christoph Riegler
,
Danna Krupka
,
Matteo Paolucci
,
Mauro Magoni
,
Giovanni Bianco
,
Hamza Jubran
,
D Jovanović
,
Tomas Klail
,
Laura P. Westphal
,
Alexander Salerno
,
Leon A. Rinkel
,
Laura Mannismäki
,
Tolga Dittrich
,
Livio Picchetto
,
Regina von Rennenberg
,
Miguel Serôdio
,
Stefano Forlivesi
,
Dikran Mardighian
,
Carlo W. Cereda
,
Ronen R. Leker
,
Višnja Padjen
,
Mira Katan
,
Marios‐Nikos Psychogios
,
Urs Fischer
,
Tomas Dobrocky
,
Mirjam R. Heldner
,
Patrik Michel
,
Paul J. Nederkoorn
,
Sami Curtze
,
Gian Marco De Marchis
,
Guido Bigliardi
,
Christian H. Nolte
,
João Pedro Marto
,
Andrea Zini
,
Alessandro Pezzini
,
Susanne Wegener
,
Marcel Arnold
,
Stefan T. Engelter
,
Henrik Gensicke
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1177/23969873251360607
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1177/23969873251360607
Introduction: Data on safety of endovascular therapy (EVT) in the very elderly are scarce. Using data from a large prospective EVT registry, we aimed at providing better evidence for EVT decision-making in patients aged 90 years and older. Patients and methods: In this multicentre observational study from the EVA-TRISP collaboration outcomes were compared between patients aged ⩾90 years with those aged <90 years using multivariate logistic regression analysis and reporting odds ratios and 95% confidence intervals. Outcomes were occurrence of poor functional outcome in survivors (modified Rankin Scale (mRS) 3–5 if pre-stroke mRS 0–2 and mRS higher than pre-stroke mRS if pre-stroke mRS 3–5), mortality at 3 months after stroke, unsuccessful recanalization (mTICI 0–2a) and symptomatic intracranial hemorrhage (sICH, defined by ECASS-II-/III-criteria). Results: Of 13,306 eligible patients, 892 were ⩾90 years old (6.7%). The very elderly had a higher median National Institutes of Health Stroke Scale (NIHSS) on admission (16 vs 14) and were more likely to have a pre-stroke mRS of 3–5 (38.0% vs 8.7%). The odds of poor functional outcome (OR adjusted 2.35 (95%-CI 1.87–2.97); 61.6% vs 38.7%), death (OR adjusted 3.04 (95%-CI 2.60–3.55); 53.9% vs 21.3%) and unsuccessful recanalization (OR adjusted 1.34 (95%-CI 1.14–1.57); 32.4% vs 27.2%) were higher in patients aged ⩾90 years. The odds of sICH did not differ (OR adjusted 0.92 (95%-CI 0.66–1.28); 5.1% vs 5.0%). Discussion and conclusion: EVT-treated stroke patients ⩾90 years had higher odds of poor functional outcome, mortality and unsuccessful recanalization than younger patients. However, the probability of sICH after EVT was not increased. The decision in favor of or against EVT in the very elderly should not be based on age alone.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/23969873251360607
- OA Status
- hybrid
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413114034
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4413114034Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1177/23969873251360607Digital Object Identifier
- Title
-
Safety of endovascular therapy in ischemic stroke patients ⩾90 years: A cohort study from the EVA-TRISP collaborationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-08-13Full publication date if available
- Authors
-
Jasmine Jost, Lukas Enz, Martina Goeldlin, Philipp Baumgartner, Davide Strambo, Nabila Wali, Nicolas Martinez‐Majander, Georg Kägi, Laura Vandelli, Christoph Riegler, Danna Krupka, Matteo Paolucci, Mauro Magoni, Giovanni Bianco, Hamza Jubran, D Jovanović, Tomas Klail, Laura P. Westphal, Alexander Salerno, Leon A. Rinkel, Laura Mannismäki, Tolga Dittrich, Livio Picchetto, Regina von Rennenberg, Miguel Serôdio, Stefano Forlivesi, Dikran Mardighian, Carlo W. Cereda, Ronen R. Leker, Višnja Padjen, Mira Katan, Marios‐Nikos Psychogios, Urs Fischer, Tomas Dobrocky, Mirjam R. Heldner, Patrik Michel, Paul J. Nederkoorn, Sami Curtze, Gian Marco De Marchis, Guido Bigliardi, Christian H. Nolte, João Pedro Marto, Andrea Zini, Alessandro Pezzini, Susanne Wegener, Marcel Arnold, Stefan T. Engelter, Henrik GensickeList of authors in order
- Landing page
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https://doi.org/10.1177/23969873251360607Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1177/23969873251360607Direct OA link when available
- Concepts
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Modified Rankin Scale, Medicine, Odds ratio, Stroke (engine), Internal medicine, Logistic regression, Observational study, Confidence interval, Odds, Ischemic stroke, Ischemia, Mechanical engineering, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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61Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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