Salvia officinalis L. exerts oncostatic effects in rodent and in vitro models of breast carcinoma Article Swipe
Peter Kubatka
,
Alena Mazuráková
,
Lenka Koklesová
,
Tomáš Kuruc
,
Marek Samec
,
Karol Kajo
,
Klaudia Kotorová
,
Marián Adamkov
,
Karel Šmejkal
,
Emil Švajdlenka
,
Dana Dvorská
,
Dušan Braný
,
Eva Baranovičová
,
Vladimíra Sadloňová
,
Ján Mojžíš
,
Martin Kello
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2024.1216199
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2024.1216199
Introduction: Based on extensive data from oncology research, the use of phytochemicals or plant-based nutraceuticals is considered an innovative tool for cancer management. This research aimed to analyze the oncostatic properties of Salvia officinalis L. [Lamiaceae; Salviae officinalis herba] using animal and in vitro models of breast carcinoma (BC). Methods: The effects of dietary administered S. officinalis in two concentrations (0.1%/SAL 0.1/and 1%/SAL 1/) were assessed in both syngeneic 4T1 mouse and chemically induced rat models of BC. The histopathological and molecular evaluations of rodent carcinoma specimens were performed after the autopsy. Besides, numerous in vitro analyses using two human cancer cell lines were performed. Results and Conclusion: The dominant metabolites found in S. officinalis propylene glycol extract (SPGE) were representatives of phenolics, specifically rosmarinic, protocatechuic, and salicylic acids. Furthermore, the occurrence of triterpenoids ursolic and oleanolic acid was proved in SPGE. In a mouse model, a non-significant tumor volume decrease after S. officinalis treatment was associated with a significant reduction in the mitotic activity index of 4T1 tumors by 37.5% (SAL 0.1) and 31.5% (SAL 1) vs. controls (set as a blank group with not applied salvia in the diet). In addition, salvia at higher doses significantly decreased necrosis/whole tumor area ratio by 46% when compared to control tumor samples. In a rat chemoprevention study, S. officinalis at a higher dose significantly lengthened the latency of tumors by 8.5 days and significantly improved the high/low-grade carcinomas ratio vs. controls in both doses. Analyses of the mechanisms of anticancer activities of S . officinalis included well-validated prognostic, predictive, and diagnostic biomarkers that are applied in both oncology practice and preclinical investigation. Our assessment in vivo revealed numerous significant changes after a comparison of treated vs. untreated cancer cells. In this regard, we found an overexpression in caspase-3, an increased Bax/Bcl-2 ratio, and a decrease in MDA, ALDH1, and EpCam expression. In addition, salvia reduced TGF-β serum levels in rats (decrease in IL-6 and TNF-α levels were with borderline significance). Evaluation of epigenetic modifications in rat cancer specimens in vivo revealed a decline in the lysine methylations of H3K4m3 and an increase in lysine acetylation in H4K16ac levels in treated groups. Salvia decreased the relative levels of oncogenic miR21 and tumor-suppressive miR145 (miR210, miR22, miR34a, and miR155 were not significantly altered). The methylation of ATM and PTEN promoters was decreased after S. officinalis treatment ( PITX2, RASSF1 , and TIMP3 promoters were not altered). Analyzing plasma metabolomics profile in tumor-bearing rats, we found reduced levels of ketoacids derived from BCAAs after salvia treatment. In vitro analyses revealed significant anti-cancer effects of SPGE extract in MCF‐7 and MDA-MB-231 cell lines (cytotoxicity, caspase‐3/-7, Bcl‐2, Annexin V/PI, cell cycle, BrdU, and mitochondrial membrane potential). Our study demonstrates the significant chemopreventive and treatment effects of salvia haulm using animal or in vitro BC models.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fphar.2024.1216199
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1216199/pdf
- OA Status
- gold
- Cited By
- 10
- References
- 102
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4392123938
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4392123938Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fphar.2024.1216199Digital Object Identifier
- Title
-
Salvia officinalis L. exerts oncostatic effects in rodent and in vitro models of breast carcinomaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
-
2024-02-23Full publication date if available
- Authors
-
Peter Kubatka, Alena Mazuráková, Lenka Koklesová, Tomáš Kuruc, Marek Samec, Karol Kajo, Klaudia Kotorová, Marián Adamkov, Karel Šmejkal, Emil Švajdlenka, Dana Dvorská, Dušan Braný, Eva Baranovičová, Vladimíra Sadloňová, Ján Mojžíš, Martin KelloList of authors in order
- Landing page
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https://doi.org/10.3389/fphar.2024.1216199Publisher landing page
- PDF URL
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https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1216199/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1216199/pdfDirect OA link when available
- Concepts
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Salvia officinalis, Rosmarinic acid, Officinalis, Lamiaceae, Traditional medicine, Pharmacology, Phytotherapy, Medicine, Salvia, Ursolic acid, Biology, Pathology, Botany, Biochemistry, Alternative medicine, AntioxidantTop concepts (fields/topics) attached by OpenAlex
- Cited by
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10Total citation count in OpenAlex
- Citations by year (recent)
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2025: 6, 2024: 4Per-year citation counts (last 5 years)
- References (count)
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102Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.TIMP3 | 398 |
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| abstract_inverted_index.1%/SAL | 62 |
| abstract_inverted_index.ALDH1, | 306 |
| abstract_inverted_index.H3K4m3 | 347 |
| abstract_inverted_index.PITX2, | 394 |
| abstract_inverted_index.RASSF1 | 395 |
| abstract_inverted_index.Salvia | 32, 360 |
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| abstract_inverted_index.TNF-α | 323 |
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| abstract_inverted_index.breast | 46 |
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| abstract_inverted_index.miR155 | 375 |
| abstract_inverted_index.miR22, | 372 |
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| abstract_inverted_index.models | 44, 75 |
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| abstract_inverted_index.regard, | 290 |
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| abstract_inverted_index.dominant | 109 |
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| abstract_inverted_index.revealed | 275, 339, 425 |
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| abstract_inverted_index.Analyzing | 403 |
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| abstract_inverted_index.addition, | 192, 311 |
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| abstract_inverted_index.carcinoma | 47, 85 |
| abstract_inverted_index.decreased | 198, 361, 388 |
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| abstract_inverted_index.syngeneic | 68 |
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