SAR Study and Molecular Mechanism Investigation of Novel Naphthoquinone-furan-2-cyanoacryloyl Hybrids with Antitumor Activity Article Swipe
Pingxian Liu
,
Dongmei Fan
,
Wenliang Qiao
,
Xinlian He
,
Lidan Zhang
,
Yunhan Jiang
,
Tao Yang
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/pharmaceutics14102104
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/pharmaceutics14102104
A series of novel naphthoquinone-furan-2-cyanoacryloyl hybrids were designed; they were synthesized and preliminarily evaluated for their anti-proliferative activities in vitro against several cancer cell lines and normal cells. The most potent compound, 5c, inhibited the proliferation of HeLa cells (IC50 value of 3.10 ± 0.02 μM) and colony survival, and it induced apoptosis while having relatively weaker effects on normal cells. Compound 5c also triggered ROS generation and accumulation, thus partially contributing to the observed cell apoptosis. A Western blotting analysis demonstrated that compound 5c inhibited the phosphorylation of STAT3. Furthermore, a biolayer interferometry (BLI) analysis confirmed that compound 5c had a direct effect on STAT3, with a KD value of 13.0 μM. Molecular docking showed that 5c specifically occupied the subpockets in the SH2 domain, thereby blocking the whole transmission signaling process. Overall, this study provides an important structural reference for the development of effective antitumor agents.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/pharmaceutics14102104
- https://www.mdpi.com/1999-4923/14/10/2104/pdf?version=1664618718
- OA Status
- gold
- Cited By
- 2
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4303961738
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4303961738Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/pharmaceutics14102104Digital Object Identifier
- Title
-
SAR Study and Molecular Mechanism Investigation of Novel Naphthoquinone-furan-2-cyanoacryloyl Hybrids with Antitumor ActivityWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-10-01Full publication date if available
- Authors
-
Pingxian Liu, Dongmei Fan, Wenliang Qiao, Xinlian He, Lidan Zhang, Yunhan Jiang, Tao YangList of authors in order
- Landing page
-
https://doi.org/10.3390/pharmaceutics14102104Publisher landing page
- PDF URL
-
https://www.mdpi.com/1999-4923/14/10/2104/pdf?version=1664618718Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1999-4923/14/10/2104/pdf?version=1664618718Direct OA link when available
- Concepts
-
HeLa, Apoptosis, Chemistry, In vitro, Cell culture, Naphthoquinone, Cell biology, Phosphorylation, Furan, Blot, STAT3, Cancer research, Molecular biology, Biochemistry, Biology, Genetics, Gene, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2023: 1Per-year citation counts (last 5 years)
- References (count)
-
42Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4303961738 |
|---|---|
| doi | https://doi.org/10.3390/pharmaceutics14102104 |
| ids.doi | https://doi.org/10.3390/pharmaceutics14102104 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/36297539 |
| ids.openalex | https://openalex.org/W4303961738 |
| fwci | 0.43919665 |
| type | article |
| title | SAR Study and Molecular Mechanism Investigation of Novel Naphthoquinone-furan-2-cyanoacryloyl Hybrids with Antitumor Activity |
| biblio.issue | 10 |
| biblio.volume | 14 |
| biblio.last_page | 2104 |
| biblio.first_page | 2104 |
| grants[0].funder | https://openalex.org/F4320321001 |
| grants[0].award_id | 21977076 |
| grants[0].funder_display_name | National Natural Science Foundation of China |
| topics[0].id | https://openalex.org/T12356 |
| topics[0].field.id | https://openalex.org/fields/30 |
| topics[0].field.display_name | Pharmacology, Toxicology and Pharmaceutics |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/3005 |
| topics[0].subfield.display_name | Toxicology |
| topics[0].display_name | Bioactive Compounds and Antitumor Agents |
| topics[1].id | https://openalex.org/T10274 |
| topics[1].field.id | https://openalex.org/fields/16 |
| topics[1].field.display_name | Chemistry |
| topics[1].score | 0.9976000189781189 |
| topics[1].domain.id | https://openalex.org/domains/3 |
| topics[1].domain.display_name | Physical Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1605 |
| topics[1].subfield.display_name | Organic Chemistry |
| topics[1].display_name | Synthesis and biological activity |
| topics[2].id | https://openalex.org/T11503 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9932000041007996 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2730 |
| topics[2].subfield.display_name | Oncology |
| topics[2].display_name | Cytokine Signaling Pathways and Interactions |
| funders[0].id | https://openalex.org/F4320321001 |
| funders[0].ror | https://ror.org/01h0zpd94 |
| funders[0].display_name | National Natural Science Foundation of China |
| is_xpac | False |
| apc_list.value | 2600 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2815 |
| apc_paid.value | 2600 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2815 |
| concepts[0].id | https://openalex.org/C2777366897 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8293145895004272 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q847482 |
| concepts[0].display_name | HeLa |
| concepts[1].id | https://openalex.org/C190283241 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7041791677474976 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q14599311 |
| concepts[1].display_name | Apoptosis |
| concepts[2].id | https://openalex.org/C185592680 |
| concepts[2].level | 0 |
| concepts[2].score | 0.6251093745231628 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[2].display_name | Chemistry |
| concepts[3].id | https://openalex.org/C202751555 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5173367857933044 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q221681 |
| concepts[3].display_name | In vitro |
| concepts[4].id | https://openalex.org/C81885089 |
| concepts[4].level | 2 |
| concepts[4].score | 0.4629673957824707 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q189082 |
| concepts[4].display_name | Cell culture |
| concepts[5].id | https://openalex.org/C2776183150 |
| concepts[5].level | 2 |
| concepts[5].score | 0.45977839827537537 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q10862682 |
| concepts[5].display_name | Naphthoquinone |
| concepts[6].id | https://openalex.org/C95444343 |
| concepts[6].level | 1 |
| concepts[6].score | 0.4203072786331177 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[6].display_name | Cell biology |
| concepts[7].id | https://openalex.org/C11960822 |
| concepts[7].level | 2 |
| concepts[7].score | 0.4186491072177887 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q242736 |
| concepts[7].display_name | Phosphorylation |
| concepts[8].id | https://openalex.org/C2778659115 |
| concepts[8].level | 2 |
| concepts[8].score | 0.41727450489997864 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q243992 |
| concepts[8].display_name | Furan |
| concepts[9].id | https://openalex.org/C85265743 |
| concepts[9].level | 3 |
| concepts[9].score | 0.4138951301574707 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q885458 |
| concepts[9].display_name | Blot |
| concepts[10].id | https://openalex.org/C2778923194 |
| concepts[10].level | 3 |
| concepts[10].score | 0.4113498628139496 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q14912019 |
| concepts[10].display_name | STAT3 |
| concepts[11].id | https://openalex.org/C502942594 |
| concepts[11].level | 1 |
| concepts[11].score | 0.36537420749664307 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[11].display_name | Cancer research |
| concepts[12].id | https://openalex.org/C153911025 |
| concepts[12].level | 1 |
| concepts[12].score | 0.3387115001678467 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7202 |
| concepts[12].display_name | Molecular biology |
| concepts[13].id | https://openalex.org/C55493867 |
| concepts[13].level | 1 |
| concepts[13].score | 0.33097022771835327 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[13].display_name | Biochemistry |
| concepts[14].id | https://openalex.org/C86803240 |
| concepts[14].level | 0 |
| concepts[14].score | 0.22650697827339172 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[14].display_name | Biology |
| concepts[15].id | https://openalex.org/C54355233 |
| concepts[15].level | 1 |
| concepts[15].score | 0.10237258672714233 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[15].display_name | Genetics |
| concepts[16].id | https://openalex.org/C104317684 |
| concepts[16].level | 2 |
| concepts[16].score | 0.10114836692810059 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[16].display_name | Gene |
| concepts[17].id | https://openalex.org/C178790620 |
| concepts[17].level | 1 |
| concepts[17].score | 0.0 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q11351 |
| concepts[17].display_name | Organic chemistry |
| keywords[0].id | https://openalex.org/keywords/hela |
| keywords[0].score | 0.8293145895004272 |
| keywords[0].display_name | HeLa |
| keywords[1].id | https://openalex.org/keywords/apoptosis |
| keywords[1].score | 0.7041791677474976 |
| keywords[1].display_name | Apoptosis |
| keywords[2].id | https://openalex.org/keywords/chemistry |
| keywords[2].score | 0.6251093745231628 |
| keywords[2].display_name | Chemistry |
| keywords[3].id | https://openalex.org/keywords/in-vitro |
| keywords[3].score | 0.5173367857933044 |
| keywords[3].display_name | In vitro |
| keywords[4].id | https://openalex.org/keywords/cell-culture |
| keywords[4].score | 0.4629673957824707 |
| keywords[4].display_name | Cell culture |
| keywords[5].id | https://openalex.org/keywords/naphthoquinone |
| keywords[5].score | 0.45977839827537537 |
| keywords[5].display_name | Naphthoquinone |
| keywords[6].id | https://openalex.org/keywords/cell-biology |
| keywords[6].score | 0.4203072786331177 |
| keywords[6].display_name | Cell biology |
| keywords[7].id | https://openalex.org/keywords/phosphorylation |
| keywords[7].score | 0.4186491072177887 |
| keywords[7].display_name | Phosphorylation |
| keywords[8].id | https://openalex.org/keywords/furan |
| keywords[8].score | 0.41727450489997864 |
| keywords[8].display_name | Furan |
| keywords[9].id | https://openalex.org/keywords/blot |
| keywords[9].score | 0.4138951301574707 |
| keywords[9].display_name | Blot |
| keywords[10].id | https://openalex.org/keywords/stat3 |
| keywords[10].score | 0.4113498628139496 |
| keywords[10].display_name | STAT3 |
| keywords[11].id | https://openalex.org/keywords/cancer-research |
| keywords[11].score | 0.36537420749664307 |
| keywords[11].display_name | Cancer research |
| keywords[12].id | https://openalex.org/keywords/molecular-biology |
| keywords[12].score | 0.3387115001678467 |
| keywords[12].display_name | Molecular biology |
| keywords[13].id | https://openalex.org/keywords/biochemistry |
| keywords[13].score | 0.33097022771835327 |
| keywords[13].display_name | Biochemistry |
| keywords[14].id | https://openalex.org/keywords/biology |
| keywords[14].score | 0.22650697827339172 |
| keywords[14].display_name | Biology |
| keywords[15].id | https://openalex.org/keywords/genetics |
| keywords[15].score | 0.10237258672714233 |
| keywords[15].display_name | Genetics |
| keywords[16].id | https://openalex.org/keywords/gene |
| keywords[16].score | 0.10114836692810059 |
| keywords[16].display_name | Gene |
| language | en |
| locations[0].id | doi:10.3390/pharmaceutics14102104 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S30283931 |
| locations[0].source.issn | 1999-4923 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1999-4923 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Pharmaceutics |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/1999-4923/14/10/2104/pdf?version=1664618718 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Pharmaceutics |
| locations[0].landing_page_url | https://doi.org/10.3390/pharmaceutics14102104 |
| locations[1].id | pmid:36297539 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Pharmaceutics |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/36297539 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:9609996 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Pharmaceutics |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/9609996 |
| locations[3].id | pmh:oai:mdpi.com:/1999-4923/14/10/2104/ |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400947 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | True |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | MDPI (MDPI AG) |
| locations[3].source.host_organization | https://openalex.org/I4210097602 |
| locations[3].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[3].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[3].license | cc-by |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/cc-by |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Pharmaceutics; Volume 14; Issue 10; Pages: 2104 |
| locations[3].landing_page_url | https://dx.doi.org/10.3390/pharmaceutics14102104 |
| locations[4].id | pmh:oai:doaj.org/article:b42dadcc3f1344af9ef274618d30b235 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S4306401280 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[4].source.host_organization | |
| locations[4].source.host_organization_name | |
| locations[4].source.host_organization_lineage | |
| locations[4].license | cc-by-sa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | article |
| locations[4].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Pharmaceutics, Vol 14, Iss 10, p 2104 (2022) |
| locations[4].landing_page_url | https://doaj.org/article/b42dadcc3f1344af9ef274618d30b235 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5019888609 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Pingxian Liu |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| authorships[0].affiliations[0].raw_affiliation_string | Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| authorships[0].affiliations[1].raw_affiliation_string | Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[0].institutions[0].id | https://openalex.org/I24185976 |
| authorships[0].institutions[0].ror | https://ror.org/011ashp19 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I24185976 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Sichuan University |
| authorships[0].institutions[1].id | https://openalex.org/I4210089761 |
| authorships[0].institutions[1].ror | https://ror.org/007mrxy13 |
| authorships[0].institutions[1].type | healthcare |
| authorships[0].institutions[1].lineage | https://openalex.org/I4210089761 |
| authorships[0].institutions[1].country_code | CN |
| authorships[0].institutions[1].display_name | West China Hospital of Sichuan University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Pingxian Liu |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China, Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[1].author.id | https://openalex.org/A5100590873 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Dongmei Fan |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| authorships[1].affiliations[0].raw_affiliation_string | Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| authorships[1].affiliations[1].raw_affiliation_string | Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[1].institutions[0].id | https://openalex.org/I24185976 |
| authorships[1].institutions[0].ror | https://ror.org/011ashp19 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I24185976 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Sichuan University |
| authorships[1].institutions[1].id | https://openalex.org/I4210089761 |
| authorships[1].institutions[1].ror | https://ror.org/007mrxy13 |
| authorships[1].institutions[1].type | healthcare |
| authorships[1].institutions[1].lineage | https://openalex.org/I4210089761 |
| authorships[1].institutions[1].country_code | CN |
| authorships[1].institutions[1].display_name | West China Hospital of Sichuan University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Dongmei Fan |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China, Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[2].author.id | https://openalex.org/A5067761483 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-2099-2188 |
| authorships[2].author.display_name | Wenliang Qiao |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I24185976 |
| authorships[2].affiliations[0].raw_affiliation_string | Laboratory of Lung Cancer, Lung Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[2].institutions[0].id | https://openalex.org/I24185976 |
| authorships[2].institutions[0].ror | https://ror.org/011ashp19 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I24185976 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Sichuan University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Wenliang Qiao |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Laboratory of Lung Cancer, Lung Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[3].author.id | https://openalex.org/A5102361108 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Xinlian He |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| authorships[3].affiliations[0].raw_affiliation_string | Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4391768003 |
| authorships[3].affiliations[1].raw_affiliation_string | State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[3].affiliations[2].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| authorships[3].affiliations[2].raw_affiliation_string | Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[3].institutions[0].id | https://openalex.org/I4391768003 |
| authorships[3].institutions[0].ror | https://ror.org/00x43yy22 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I24185976, https://openalex.org/I4391768003 |
| authorships[3].institutions[0].country_code | |
| authorships[3].institutions[0].display_name | State Key Laboratory of Biotherapy |
| authorships[3].institutions[1].id | https://openalex.org/I24185976 |
| authorships[3].institutions[1].ror | https://ror.org/011ashp19 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I24185976 |
| authorships[3].institutions[1].country_code | CN |
| authorships[3].institutions[1].display_name | Sichuan University |
| authorships[3].institutions[2].id | https://openalex.org/I4210089761 |
| authorships[3].institutions[2].ror | https://ror.org/007mrxy13 |
| authorships[3].institutions[2].type | healthcare |
| authorships[3].institutions[2].lineage | https://openalex.org/I4210089761 |
| authorships[3].institutions[2].country_code | CN |
| authorships[3].institutions[2].display_name | West China Hospital of Sichuan University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Xinlian He |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China, Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[4].author.id | https://openalex.org/A5100600481 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-5230-9016 |
| authorships[4].author.display_name | Lidan Zhang |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| authorships[4].affiliations[0].raw_affiliation_string | Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| authorships[4].affiliations[1].raw_affiliation_string | Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[4].affiliations[2].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4391768003 |
| authorships[4].affiliations[2].raw_affiliation_string | State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[4].institutions[0].id | https://openalex.org/I4391768003 |
| authorships[4].institutions[0].ror | https://ror.org/00x43yy22 |
| authorships[4].institutions[0].type | facility |
| authorships[4].institutions[0].lineage | https://openalex.org/I24185976, https://openalex.org/I4391768003 |
| authorships[4].institutions[0].country_code | |
| authorships[4].institutions[0].display_name | State Key Laboratory of Biotherapy |
| authorships[4].institutions[1].id | https://openalex.org/I24185976 |
| authorships[4].institutions[1].ror | https://ror.org/011ashp19 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I24185976 |
| authorships[4].institutions[1].country_code | CN |
| authorships[4].institutions[1].display_name | Sichuan University |
| authorships[4].institutions[2].id | https://openalex.org/I4210089761 |
| authorships[4].institutions[2].ror | https://ror.org/007mrxy13 |
| authorships[4].institutions[2].type | healthcare |
| authorships[4].institutions[2].lineage | https://openalex.org/I4210089761 |
| authorships[4].institutions[2].country_code | CN |
| authorships[4].institutions[2].display_name | West China Hospital of Sichuan University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Lidan Zhang |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China, Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[5].author.id | https://openalex.org/A5100740085 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-8117-8692 |
| authorships[5].author.display_name | Yunhan Jiang |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| authorships[5].affiliations[0].raw_affiliation_string | Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| authorships[5].affiliations[1].raw_affiliation_string | Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[5].affiliations[2].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| authorships[5].affiliations[2].raw_affiliation_string | Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[5].institutions[0].id | https://openalex.org/I24185976 |
| authorships[5].institutions[0].ror | https://ror.org/011ashp19 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I24185976 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | Sichuan University |
| authorships[5].institutions[1].id | https://openalex.org/I4210089761 |
| authorships[5].institutions[1].ror | https://ror.org/007mrxy13 |
| authorships[5].institutions[1].type | healthcare |
| authorships[5].institutions[1].lineage | https://openalex.org/I4210089761 |
| authorships[5].institutions[1].country_code | CN |
| authorships[5].institutions[1].display_name | West China Hospital of Sichuan University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Yunhan Jiang |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China, Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[6].author.id | https://openalex.org/A5100698416 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-5389-9513 |
| authorships[6].author.display_name | Tao Yang |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| authorships[6].affiliations[0].raw_affiliation_string | Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4391768003 |
| authorships[6].affiliations[1].raw_affiliation_string | State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[6].affiliations[2].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| authorships[6].affiliations[2].raw_affiliation_string | Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China |
| authorships[6].institutions[0].id | https://openalex.org/I4391768003 |
| authorships[6].institutions[0].ror | https://ror.org/00x43yy22 |
| authorships[6].institutions[0].type | facility |
| authorships[6].institutions[0].lineage | https://openalex.org/I24185976, https://openalex.org/I4391768003 |
| authorships[6].institutions[0].country_code | |
| authorships[6].institutions[0].display_name | State Key Laboratory of Biotherapy |
| authorships[6].institutions[1].id | https://openalex.org/I24185976 |
| authorships[6].institutions[1].ror | https://ror.org/011ashp19 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I24185976 |
| authorships[6].institutions[1].country_code | CN |
| authorships[6].institutions[1].display_name | Sichuan University |
| authorships[6].institutions[2].id | https://openalex.org/I4210089761 |
| authorships[6].institutions[2].ror | https://ror.org/007mrxy13 |
| authorships[6].institutions[2].type | healthcare |
| authorships[6].institutions[2].lineage | https://openalex.org/I4210089761 |
| authorships[6].institutions[2].country_code | CN |
| authorships[6].institutions[2].display_name | West China Hospital of Sichuan University |
| authorships[6].author_position | last |
| authorships[6].raw_author_name | Tao Yang |
| authorships[6].is_corresponding | True |
| authorships[6].raw_affiliation_strings | Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China, Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/1999-4923/14/10/2104/pdf?version=1664618718 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | SAR Study and Molecular Mechanism Investigation of Novel Naphthoquinone-furan-2-cyanoacryloyl Hybrids with Antitumor Activity |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T12356 |
| primary_topic.field.id | https://openalex.org/fields/30 |
| primary_topic.field.display_name | Pharmacology, Toxicology and Pharmaceutics |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/3005 |
| primary_topic.subfield.display_name | Toxicology |
| primary_topic.display_name | Bioactive Compounds and Antitumor Agents |
| related_works | https://openalex.org/W2319590788, https://openalex.org/W2373307992, https://openalex.org/W2357943637, https://openalex.org/W2372231441, https://openalex.org/W2375824005, https://openalex.org/W2350526420, https://openalex.org/W2381761676, https://openalex.org/W2350373849, https://openalex.org/W2361676330, https://openalex.org/W2350990105 |
| cited_by_count | 2 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 1 |
| locations_count | 5 |
| best_oa_location.id | doi:10.3390/pharmaceutics14102104 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S30283931 |
| best_oa_location.source.issn | 1999-4923 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1999-4923 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Pharmaceutics |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/1999-4923/14/10/2104/pdf?version=1664618718 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Pharmaceutics |
| best_oa_location.landing_page_url | https://doi.org/10.3390/pharmaceutics14102104 |
| primary_location.id | doi:10.3390/pharmaceutics14102104 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S30283931 |
| primary_location.source.issn | 1999-4923 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1999-4923 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Pharmaceutics |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/1999-4923/14/10/2104/pdf?version=1664618718 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Pharmaceutics |
| primary_location.landing_page_url | https://doi.org/10.3390/pharmaceutics14102104 |
| publication_date | 2022-10-01 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W2936034288, https://openalex.org/W6654984273, https://openalex.org/W1987751343, https://openalex.org/W6717142686, https://openalex.org/W2621051455, https://openalex.org/W2580141764, https://openalex.org/W2509469063, https://openalex.org/W2077999767, https://openalex.org/W2766675128, https://openalex.org/W2620358092, https://openalex.org/W2964414741, https://openalex.org/W2165596895, https://openalex.org/W2091176685, https://openalex.org/W2074487201, https://openalex.org/W2103079856, https://openalex.org/W2068492235, https://openalex.org/W4224982951, https://openalex.org/W2148269081, https://openalex.org/W2419052259, https://openalex.org/W2947592586, https://openalex.org/W2118646921, https://openalex.org/W2000589020, https://openalex.org/W2751156518, https://openalex.org/W2143518795, https://openalex.org/W3126168278, https://openalex.org/W2949213103, https://openalex.org/W3116717064, https://openalex.org/W2082325637, https://openalex.org/W2419447319, https://openalex.org/W2079565612, https://openalex.org/W2901265038, https://openalex.org/W2953304606, https://openalex.org/W3175064583, https://openalex.org/W1995351861, https://openalex.org/W3165943209, https://openalex.org/W2606456252, https://openalex.org/W4286252235, https://openalex.org/W2010169031, https://openalex.org/W2583446434, https://openalex.org/W4244139502, https://openalex.org/W2017927824, https://openalex.org/W2161450171 |
| referenced_works_count | 42 |
| abstract_inverted_index.A | 0, 77 |
| abstract_inverted_index.a | 91, 101, 107 |
| abstract_inverted_index.5c | 62, 84, 99, 117 |
| abstract_inverted_index.KD | 108 |
| abstract_inverted_index.an | 137 |
| abstract_inverted_index.in | 18, 122 |
| abstract_inverted_index.it | 50 |
| abstract_inverted_index.of | 2, 36, 41, 88, 110, 144 |
| abstract_inverted_index.on | 58, 104 |
| abstract_inverted_index.to | 72 |
| abstract_inverted_index.± | 43 |
| abstract_inverted_index.5c, | 32 |
| abstract_inverted_index.ROS | 65 |
| abstract_inverted_index.SH2 | 124 |
| abstract_inverted_index.The | 28 |
| abstract_inverted_index.and | 11, 25, 46, 49, 67 |
| abstract_inverted_index.for | 14, 141 |
| abstract_inverted_index.had | 100 |
| abstract_inverted_index.the | 34, 73, 86, 120, 123, 128, 142 |
| abstract_inverted_index.0.02 | 44 |
| abstract_inverted_index.13.0 | 111 |
| abstract_inverted_index.3.10 | 42 |
| abstract_inverted_index.HeLa | 37 |
| abstract_inverted_index.also | 63 |
| abstract_inverted_index.cell | 23, 75 |
| abstract_inverted_index.most | 29 |
| abstract_inverted_index.that | 82, 97, 116 |
| abstract_inverted_index.they | 8 |
| abstract_inverted_index.this | 134 |
| abstract_inverted_index.thus | 69 |
| abstract_inverted_index.were | 6, 9 |
| abstract_inverted_index.with | 106 |
| abstract_inverted_index.μM) | 45 |
| abstract_inverted_index.μM. | 112 |
| abstract_inverted_index.(BLI) | 94 |
| abstract_inverted_index.(IC50 | 39 |
| abstract_inverted_index.cells | 38 |
| abstract_inverted_index.lines | 24 |
| abstract_inverted_index.novel | 3 |
| abstract_inverted_index.study | 135 |
| abstract_inverted_index.their | 15 |
| abstract_inverted_index.value | 40, 109 |
| abstract_inverted_index.vitro | 19 |
| abstract_inverted_index.while | 53 |
| abstract_inverted_index.whole | 129 |
| abstract_inverted_index.STAT3, | 105 |
| abstract_inverted_index.STAT3. | 89 |
| abstract_inverted_index.cancer | 22 |
| abstract_inverted_index.cells. | 27, 60 |
| abstract_inverted_index.colony | 47 |
| abstract_inverted_index.direct | 102 |
| abstract_inverted_index.effect | 103 |
| abstract_inverted_index.having | 54 |
| abstract_inverted_index.normal | 26, 59 |
| abstract_inverted_index.potent | 30 |
| abstract_inverted_index.series | 1 |
| abstract_inverted_index.showed | 115 |
| abstract_inverted_index.weaker | 56 |
| abstract_inverted_index.Western | 78 |
| abstract_inverted_index.against | 20 |
| abstract_inverted_index.agents. | 147 |
| abstract_inverted_index.docking | 114 |
| abstract_inverted_index.domain, | 125 |
| abstract_inverted_index.effects | 57 |
| abstract_inverted_index.hybrids | 5 |
| abstract_inverted_index.induced | 51 |
| abstract_inverted_index.several | 21 |
| abstract_inverted_index.thereby | 126 |
| abstract_inverted_index.Compound | 61 |
| abstract_inverted_index.Overall, | 133 |
| abstract_inverted_index.analysis | 80, 95 |
| abstract_inverted_index.biolayer | 92 |
| abstract_inverted_index.blocking | 127 |
| abstract_inverted_index.blotting | 79 |
| abstract_inverted_index.compound | 83, 98 |
| abstract_inverted_index.observed | 74 |
| abstract_inverted_index.occupied | 119 |
| abstract_inverted_index.process. | 132 |
| abstract_inverted_index.provides | 136 |
| abstract_inverted_index.Molecular | 113 |
| abstract_inverted_index.antitumor | 146 |
| abstract_inverted_index.apoptosis | 52 |
| abstract_inverted_index.compound, | 31 |
| abstract_inverted_index.confirmed | 96 |
| abstract_inverted_index.designed; | 7 |
| abstract_inverted_index.effective | 145 |
| abstract_inverted_index.evaluated | 13 |
| abstract_inverted_index.important | 138 |
| abstract_inverted_index.inhibited | 33, 85 |
| abstract_inverted_index.partially | 70 |
| abstract_inverted_index.reference | 140 |
| abstract_inverted_index.signaling | 131 |
| abstract_inverted_index.survival, | 48 |
| abstract_inverted_index.triggered | 64 |
| abstract_inverted_index.activities | 17 |
| abstract_inverted_index.apoptosis. | 76 |
| abstract_inverted_index.generation | 66 |
| abstract_inverted_index.relatively | 55 |
| abstract_inverted_index.structural | 139 |
| abstract_inverted_index.subpockets | 121 |
| abstract_inverted_index.development | 143 |
| abstract_inverted_index.synthesized | 10 |
| abstract_inverted_index.Furthermore, | 90 |
| abstract_inverted_index.contributing | 71 |
| abstract_inverted_index.demonstrated | 81 |
| abstract_inverted_index.specifically | 118 |
| abstract_inverted_index.transmission | 130 |
| abstract_inverted_index.accumulation, | 68 |
| abstract_inverted_index.preliminarily | 12 |
| abstract_inverted_index.proliferation | 35 |
| abstract_inverted_index.interferometry | 93 |
| abstract_inverted_index.phosphorylation | 87 |
| abstract_inverted_index.anti-proliferative | 16 |
| abstract_inverted_index.naphthoquinone-furan-2-cyanoacryloyl | 4 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5100698416 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761, https://openalex.org/I4391768003 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.4699999988079071 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.53404792 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |