SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells Article Swipe

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Long C. Nguyen , David M. Renner , Diane Silva , Dongbo Yang , Nicholas A. Parenti , Kaeri M. Medina , Vlad Nicolaescu , Haley Gula , Nir Drayman , Andrea Valdespino , Adil Mohamed , Christopher Dann , Kristin Wannemo , Lydia Robinson-Mailman , Alan Gonzalez , Letícia Stock , Mengrui Cao , Z. Qiao , Raymond E. Moellering , Savaş Tay , Glenn Randall , Michael F. Beers , Marsha Rich Rosner , Scott A. Oakes , Susan R. Weiss ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.1128/mbio.02415-22

SARS-CoV-2 is the third lethal respiratory coronavirus, after MERS-CoV and SARS-CoV, to emerge this century, causing millions of deaths worldwide. Other common coronaviruses such as HCoV-OC43 cause less severe respiratory disease.

Related Topics

Infectious Diseases (Medical Specialty)

Concepts

Endoplasmic reticulum Coronavirus Unfolded protein response Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) XBP1 Coronavirus disease 2019 (COVID-19) Virology Betacoronavirus 2019-20 coronavirus outbreak Severe acute respiratory syndrome coronavirus Lung Biology Immunology Disease Medicine Cell biology Genetics Gene Pathology Infectious disease (medical specialty) RNA Internal medicine Outbreak RNA splicing

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Type: article
Language: en
Landing Page: https://doi.org/10.1128/mbio.02415-22
OA Status: gold
Cited By: 24
References: 82
Related Works: 10
OpenAlex ID: https://openalex.org/W4296782458

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OpenAlex ID: https://openalex.org/W4296782458

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DOI: https://doi.org/10.1128/mbio.02415-22

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Title: SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells

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Type: article

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Language: en

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Publication year: 2022

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Publication date: 2022-09-20

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Authors: Long C. Nguyen, David M. Renner, Diane Silva, Dongbo Yang, Nicholas A. Parenti, Kaeri M. Medina, Vlad Nicolaescu, Haley Gula, Nir Drayman, Andrea Valdespino, Adil Mohamed, Christopher Dann, Kristin Wannemo, Lydia Robinson-Mailman, Alan Gonzalez, Letícia Stock, Mengrui Cao, Z. Qiao, Raymond E. Moellering, Savaş Tay, Glenn Randall, Michael F. Beers, Marsha Rich Rosner, Scott A. Oakes, Susan R. Weiss

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Landing page: https://doi.org/10.1128/mbio.02415-22

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Open access: Yes

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OA status: gold

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OA URL: https://doi.org/10.1128/mbio.02415-22

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Concepts: Endoplasmic reticulum, Coronavirus, Unfolded protein response, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), XBP1, Coronavirus disease 2019 (COVID-19), Virology, Betacoronavirus, 2019-20 coronavirus outbreak, Severe acute respiratory syndrome coronavirus, Lung, Biology, Immunology, Disease, Medicine, Cell biology, Genetics, Gene, Pathology, Infectious disease (medical specialty), RNA, Internal medicine, Outbreak, RNA splicing

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Cited by: 24

Total citation count in OpenAlex
Citations by year (recent): 2025: 7, 2024: 12, 2023: 4, 2022: 1

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References (count): 82

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Related works (count): 10

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