SARS-CoV-2 genetic diversity in Venezuela: Predominance of D614G variants and analysis of one outbreak Article Swipe
Carmen L. Loureiro
,
Rossana C. Jaspe
,
Pierina D ́Angelo
,
José Luis Zambrano
,
Lieska Rodríguez
,
Víctor Alarcón
,
Mariangel Delgado
,
Marwan Aguilar
,
Domingo Garzaro
,
Héctor R. Rangel
,
Flor H. Pujol
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0247196
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0247196
SARS-CoV-2 is the new coronavirus responsible for COVID-19 disease. The first two cases of COVID-19 were detected in Venezuela on March 13, 2020. The aim of this study was the genetic characterization of Venezuelan SARS-CoV-2 isolates. A total of 7 full SARS-CoV-2 genome sequences were obtained by Sanger sequencing, from patients of different regions of Venezuela, mainly from the beginning of the epidemic. Ten out of 11 isolates (6 complete genomes and 4 partial spike genomic regions) belonged to lineage B, bearing the D614G mutation in the Spike protein. Isolates from the first outbreak that occurred in the Margarita Island harbored an in-frame deletion in its sequence, without amino acids 83–85 of the NSP1 of the ORF1. The search for deletions in 48,635 sequences showed that the NSP1 gene exhibit the highest frequency of deletions along the whole genome. Structural analysis suggests a change in the N-terminal domain with the presence of this deletion. In contrast, isolates circulating later in this island lacked the deletion, suggesting new introductions to the island after this first outbreak. In conclusion, a high diversity of SARS-CoV-2 isolates were found circulating in Venezuela, with predominance of the D614G mutation. The first small outbreak in Margarita Island seemed to be associated with a strain carrying a small deletion in the NSP1 protein, but these isolates do not seem to be responsible for the larger outbreak which started in July.
Related Topics
Concepts
Outbreak
Biology
Lineage (genetic)
Genome
Genetics
Virology
Genetic diversity
Sanger sequencing
Mutation
Whole genome sequencing
Sequence analysis
Genotype
Gene
Population
Medicine
Environmental health
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0247196
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0247196&type=printable
- OA Status
- gold
- Cited By
- 18
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3129734862
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3129734862Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1371/journal.pone.0247196Digital Object Identifier
- Title
-
SARS-CoV-2 genetic diversity in Venezuela: Predominance of D614G variants and analysis of one outbreakWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-02-19Full publication date if available
- Authors
-
Carmen L. Loureiro, Rossana C. Jaspe, Pierina D ́Angelo, José Luis Zambrano, Lieska Rodríguez, Víctor Alarcón, Mariangel Delgado, Marwan Aguilar, Domingo Garzaro, Héctor R. Rangel, Flor H. PujolList of authors in order
- Landing page
-
https://doi.org/10.1371/journal.pone.0247196Publisher landing page
- PDF URL
-
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0247196&type=printableDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0247196&type=printableDirect OA link when available
- Concepts
-
Outbreak, Biology, Lineage (genetic), Genome, Genetics, Virology, Genetic diversity, Sanger sequencing, Mutation, Whole genome sequencing, Sequence analysis, Genotype, Gene, Population, Medicine, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
18Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 2, 2023: 1, 2022: 8, 2021: 7Per-year citation counts (last 5 years)
- References (count)
-
30Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3129734862 |
|---|---|
| doi | https://doi.org/10.1371/journal.pone.0247196 |
| ids.doi | https://doi.org/10.1371/journal.pone.0247196 |
| ids.mag | 3129734862 |
| ids.openalex | https://openalex.org/W3129734862 |
| fwci | 1.31658662 |
| type | article |
| title | SARS-CoV-2 genetic diversity in Venezuela: Predominance of D614G variants and analysis of one outbreak |
| biblio.issue | 2 |
| biblio.volume | 16 |
| biblio.last_page | e0247196 |
| biblio.first_page | e0247196 |
| topics[0].id | https://openalex.org/T10118 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998000264167786 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2725 |
| topics[0].subfield.display_name | Infectious Diseases |
| topics[0].display_name | SARS-CoV-2 and COVID-19 Research |
| topics[1].id | https://openalex.org/T11754 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9714000225067139 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2725 |
| topics[1].subfield.display_name | Infectious Diseases |
| topics[1].display_name | SARS-CoV-2 detection and testing |
| topics[2].id | https://openalex.org/T10041 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.96670001745224 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2725 |
| topics[2].subfield.display_name | Infectious Diseases |
| topics[2].display_name | COVID-19 Clinical Research Studies |
| is_xpac | False |
| apc_list.value | 1805 |
| apc_list.currency | USD |
| apc_list.value_usd | 1805 |
| apc_paid.value | 1805 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 1805 |
| concepts[0].id | https://openalex.org/C116675565 |
| concepts[0].level | 2 |
| concepts[0].score | 0.8319003582000732 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q3241045 |
| concepts[0].display_name | Outbreak |
| concepts[1].id | https://openalex.org/C86803240 |
| concepts[1].level | 0 |
| concepts[1].score | 0.7489429116249084 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[1].display_name | Biology |
| concepts[2].id | https://openalex.org/C2776817793 |
| concepts[2].level | 3 |
| concepts[2].score | 0.6228724718093872 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q6553369 |
| concepts[2].display_name | Lineage (genetic) |
| concepts[3].id | https://openalex.org/C141231307 |
| concepts[3].level | 3 |
| concepts[3].score | 0.6204982995986938 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q7020 |
| concepts[3].display_name | Genome |
| concepts[4].id | https://openalex.org/C54355233 |
| concepts[4].level | 1 |
| concepts[4].score | 0.6019976139068604 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[4].display_name | Genetics |
| concepts[5].id | https://openalex.org/C159047783 |
| concepts[5].level | 1 |
| concepts[5].score | 0.5670183300971985 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7215 |
| concepts[5].display_name | Virology |
| concepts[6].id | https://openalex.org/C81977670 |
| concepts[6].level | 3 |
| concepts[6].score | 0.5259471535682678 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q585259 |
| concepts[6].display_name | Genetic diversity |
| concepts[7].id | https://openalex.org/C76818968 |
| concepts[7].level | 4 |
| concepts[7].score | 0.48829102516174316 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q181940 |
| concepts[7].display_name | Sanger sequencing |
| concepts[8].id | https://openalex.org/C501734568 |
| concepts[8].level | 3 |
| concepts[8].score | 0.4628531038761139 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q42918 |
| concepts[8].display_name | Mutation |
| concepts[9].id | https://openalex.org/C24432333 |
| concepts[9].level | 4 |
| concepts[9].score | 0.4557161331176758 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q2068526 |
| concepts[9].display_name | Whole genome sequencing |
| concepts[10].id | https://openalex.org/C61053724 |
| concepts[10].level | 3 |
| concepts[10].score | 0.4224485754966736 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q1154615 |
| concepts[10].display_name | Sequence analysis |
| concepts[11].id | https://openalex.org/C135763542 |
| concepts[11].level | 3 |
| concepts[11].score | 0.41623160243034363 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q106016 |
| concepts[11].display_name | Genotype |
| concepts[12].id | https://openalex.org/C104317684 |
| concepts[12].level | 2 |
| concepts[12].score | 0.3857702910900116 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[12].display_name | Gene |
| concepts[13].id | https://openalex.org/C2908647359 |
| concepts[13].level | 2 |
| concepts[13].score | 0.06690886616706848 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q2625603 |
| concepts[13].display_name | Population |
| concepts[14].id | https://openalex.org/C71924100 |
| concepts[14].level | 0 |
| concepts[14].score | 0.06570360064506531 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[14].display_name | Medicine |
| concepts[15].id | https://openalex.org/C99454951 |
| concepts[15].level | 1 |
| concepts[15].score | 0.0 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q932068 |
| concepts[15].display_name | Environmental health |
| keywords[0].id | https://openalex.org/keywords/outbreak |
| keywords[0].score | 0.8319003582000732 |
| keywords[0].display_name | Outbreak |
| keywords[1].id | https://openalex.org/keywords/biology |
| keywords[1].score | 0.7489429116249084 |
| keywords[1].display_name | Biology |
| keywords[2].id | https://openalex.org/keywords/lineage |
| keywords[2].score | 0.6228724718093872 |
| keywords[2].display_name | Lineage (genetic) |
| keywords[3].id | https://openalex.org/keywords/genome |
| keywords[3].score | 0.6204982995986938 |
| keywords[3].display_name | Genome |
| keywords[4].id | https://openalex.org/keywords/genetics |
| keywords[4].score | 0.6019976139068604 |
| keywords[4].display_name | Genetics |
| keywords[5].id | https://openalex.org/keywords/virology |
| keywords[5].score | 0.5670183300971985 |
| keywords[5].display_name | Virology |
| keywords[6].id | https://openalex.org/keywords/genetic-diversity |
| keywords[6].score | 0.5259471535682678 |
| keywords[6].display_name | Genetic diversity |
| keywords[7].id | https://openalex.org/keywords/sanger-sequencing |
| keywords[7].score | 0.48829102516174316 |
| keywords[7].display_name | Sanger sequencing |
| keywords[8].id | https://openalex.org/keywords/mutation |
| keywords[8].score | 0.4628531038761139 |
| keywords[8].display_name | Mutation |
| keywords[9].id | https://openalex.org/keywords/whole-genome-sequencing |
| keywords[9].score | 0.4557161331176758 |
| keywords[9].display_name | Whole genome sequencing |
| keywords[10].id | https://openalex.org/keywords/sequence-analysis |
| keywords[10].score | 0.4224485754966736 |
| keywords[10].display_name | Sequence analysis |
| keywords[11].id | https://openalex.org/keywords/genotype |
| keywords[11].score | 0.41623160243034363 |
| keywords[11].display_name | Genotype |
| keywords[12].id | https://openalex.org/keywords/gene |
| keywords[12].score | 0.3857702910900116 |
| keywords[12].display_name | Gene |
| keywords[13].id | https://openalex.org/keywords/population |
| keywords[13].score | 0.06690886616706848 |
| keywords[13].display_name | Population |
| keywords[14].id | https://openalex.org/keywords/medicine |
| keywords[14].score | 0.06570360064506531 |
| keywords[14].display_name | Medicine |
| language | en |
| locations[0].id | doi:10.1371/journal.pone.0247196 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S202381698 |
| locations[0].source.issn | 1932-6203 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1932-6203 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | PLoS ONE |
| locations[0].source.host_organization | https://openalex.org/P4310315706 |
| locations[0].source.host_organization_name | Public Library of Science |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310315706 |
| locations[0].source.host_organization_lineage_names | Public Library of Science |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0247196&type=printable |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | PLOS ONE |
| locations[0].landing_page_url | https://doi.org/10.1371/journal.pone.0247196 |
| locations[1].id | pmh:oai:doaj.org/article:ebfb8c503e92456d8b949f675ed4b10a |
| locations[1].is_oa | True |
| locations[1].source.id | https://openalex.org/S4306401280 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[1].source.host_organization | |
| locations[1].source.host_organization_name | |
| locations[1].license | cc-by-sa |
| locations[1].pdf_url | |
| locations[1].version | submittedVersion |
| locations[1].raw_type | article |
| locations[1].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[1].is_accepted | False |
| locations[1].is_published | False |
| locations[1].raw_source_name | PLoS ONE, Vol 16, Iss 2, p e0247196 (2021) |
| locations[1].landing_page_url | https://doaj.org/article/ebfb8c503e92456d8b949f675ed4b10a |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:7895374 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | PLoS One |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/7895374 |
| indexed_in | crossref, doaj |
| authorships[0].author.id | https://openalex.org/A5062211051 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-3665-1107 |
| authorships[0].author.display_name | Carmen L. Loureiro |
| authorships[0].countries | VE |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I191242182 |
| authorships[0].affiliations[0].raw_affiliation_string | Laboratorio de Virología Molecular, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Caracas, Miranda, Venezuela |
| authorships[0].institutions[0].id | https://openalex.org/I191242182 |
| authorships[0].institutions[0].ror | https://ror.org/02ntheh91 |
| authorships[0].institutions[0].type | facility |
| authorships[0].institutions[0].lineage | https://openalex.org/I191242182 |
| authorships[0].institutions[0].country_code | VE |
| authorships[0].institutions[0].display_name | Instituto Venezolano de Investigaciones Científicas |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Carmen L. Loureiro |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Laboratorio de Virología Molecular, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Caracas, Miranda, Venezuela |
| authorships[1].author.id | https://openalex.org/A5077047611 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-4816-1378 |
| authorships[1].author.display_name | Rossana C. Jaspe |
| authorships[1].countries | VE |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I191242182 |
| authorships[1].affiliations[0].raw_affiliation_string | Laboratorio de Virología Molecular, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Caracas, Miranda, Venezuela |
| authorships[1].institutions[0].id | https://openalex.org/I191242182 |
| authorships[1].institutions[0].ror | https://ror.org/02ntheh91 |
| authorships[1].institutions[0].type | facility |
| authorships[1].institutions[0].lineage | https://openalex.org/I191242182 |
| authorships[1].institutions[0].country_code | VE |
| authorships[1].institutions[0].display_name | Instituto Venezolano de Investigaciones Científicas |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Rossana C. Jaspe |
| authorships[1].is_corresponding | True |
| authorships[1].raw_affiliation_strings | Laboratorio de Virología Molecular, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Caracas, Miranda, Venezuela |
| authorships[2].author.id | https://openalex.org/A5021839062 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Pierina D ́Angelo |
| authorships[2].countries | VE |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210131015 |
| authorships[2].affiliations[0].raw_affiliation_string | Instituto Nacional de Higiene "Rafael Rangel", Caracas, Miranda, Venezuela |
| authorships[2].institutions[0].id | https://openalex.org/I4210131015 |
| authorships[2].institutions[0].ror | https://ror.org/02ybb5327 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210131015 |
| authorships[2].institutions[0].country_code | VE |
| authorships[2].institutions[0].display_name | Universidad Nacional Experimental Francisco de Miranda |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Pierina D´Angelo |
| authorships[2].is_corresponding | True |
| authorships[2].raw_affiliation_strings | Instituto Nacional de Higiene "Rafael Rangel", Caracas, Miranda, Venezuela |
| authorships[3].author.id | https://openalex.org/A5015387064 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-9884-2940 |
| authorships[3].author.display_name | José Luis Zambrano |
| authorships[3].countries | VE |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I191242182 |
| authorships[3].affiliations[0].raw_affiliation_string | Laboratorio de Biología de Virus, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Caracas, Miranda, Venezuela |
| authorships[3].institutions[0].id | https://openalex.org/I191242182 |
| authorships[3].institutions[0].ror | https://ror.org/02ntheh91 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I191242182 |
| authorships[3].institutions[0].country_code | VE |
| authorships[3].institutions[0].display_name | Instituto Venezolano de Investigaciones Científicas |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | José L. Zambrano |
| authorships[3].is_corresponding | True |
| authorships[3].raw_affiliation_strings | Laboratorio de Biología de Virus, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Caracas, Miranda, Venezuela |
| authorships[4].author.id | https://openalex.org/A5074222059 |
| authorships[4].author.orcid | https://orcid.org/0009-0002-6721-855X |
| authorships[4].author.display_name | Lieska Rodríguez |
| authorships[4].countries | VE |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210131015 |
| authorships[4].affiliations[0].raw_affiliation_string | Instituto Nacional de Higiene "Rafael Rangel", Caracas, Miranda, Venezuela |
| authorships[4].institutions[0].id | https://openalex.org/I4210131015 |
| authorships[4].institutions[0].ror | https://ror.org/02ybb5327 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210131015 |
| authorships[4].institutions[0].country_code | VE |
| authorships[4].institutions[0].display_name | Universidad Nacional Experimental Francisco de Miranda |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Lieska Rodriguez |
| authorships[4].is_corresponding | True |
| authorships[4].raw_affiliation_strings | Instituto Nacional de Higiene "Rafael Rangel", Caracas, Miranda, Venezuela |
| authorships[5].author.id | https://openalex.org/A5035250341 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-4418-6690 |
| authorships[5].author.display_name | Víctor Alarcón |
| authorships[5].countries | VE |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210131015 |
| authorships[5].affiliations[0].raw_affiliation_string | Instituto Nacional de Higiene "Rafael Rangel", Caracas, Miranda, Venezuela |
| authorships[5].institutions[0].id | https://openalex.org/I4210131015 |
| authorships[5].institutions[0].ror | https://ror.org/02ybb5327 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210131015 |
| authorships[5].institutions[0].country_code | VE |
| authorships[5].institutions[0].display_name | Universidad Nacional Experimental Francisco de Miranda |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Víctor Alarcon |
| authorships[5].is_corresponding | True |
| authorships[5].raw_affiliation_strings | Instituto Nacional de Higiene "Rafael Rangel", Caracas, Miranda, Venezuela |
| authorships[6].author.id | https://openalex.org/A5036749757 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-8089-5873 |
| authorships[6].author.display_name | Mariangel Delgado |
| authorships[6].countries | VE |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I191242182 |
| authorships[6].affiliations[0].raw_affiliation_string | Unidad Unidad de Microscopia Electrónica y Confocal, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Caracas, Miranda, Venezuela |
| authorships[6].institutions[0].id | https://openalex.org/I191242182 |
| authorships[6].institutions[0].ror | https://ror.org/02ntheh91 |
| authorships[6].institutions[0].type | facility |
| authorships[6].institutions[0].lineage | https://openalex.org/I191242182 |
| authorships[6].institutions[0].country_code | VE |
| authorships[6].institutions[0].display_name | Instituto Venezolano de Investigaciones Científicas |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Mariangel Delgado |
| authorships[6].is_corresponding | True |
| authorships[6].raw_affiliation_strings | Unidad Unidad de Microscopia Electrónica y Confocal, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Caracas, Miranda, Venezuela |
| authorships[7].author.id | https://openalex.org/A5084750750 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Marwan Aguilar |
| authorships[7].countries | VE |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210131015 |
| authorships[7].affiliations[0].raw_affiliation_string | Instituto Nacional de Higiene "Rafael Rangel", Caracas, Miranda, Venezuela |
| authorships[7].institutions[0].id | https://openalex.org/I4210131015 |
| authorships[7].institutions[0].ror | https://ror.org/02ybb5327 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210131015 |
| authorships[7].institutions[0].country_code | VE |
| authorships[7].institutions[0].display_name | Universidad Nacional Experimental Francisco de Miranda |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Marwan Aguilar |
| authorships[7].is_corresponding | True |
| authorships[7].raw_affiliation_strings | Instituto Nacional de Higiene "Rafael Rangel", Caracas, Miranda, Venezuela |
| authorships[8].author.id | https://openalex.org/A5032047197 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-9956-5786 |
| authorships[8].author.display_name | Domingo Garzaro |
| authorships[8].countries | VE |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I191242182 |
| authorships[8].affiliations[0].raw_affiliation_string | Laboratorio de Virología Molecular, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Caracas, Miranda, Venezuela |
| authorships[8].institutions[0].id | https://openalex.org/I191242182 |
| authorships[8].institutions[0].ror | https://ror.org/02ntheh91 |
| authorships[8].institutions[0].type | facility |
| authorships[8].institutions[0].lineage | https://openalex.org/I191242182 |
| authorships[8].institutions[0].country_code | VE |
| authorships[8].institutions[0].display_name | Instituto Venezolano de Investigaciones Científicas |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Domingo Garzaro |
| authorships[8].is_corresponding | True |
| authorships[8].raw_affiliation_strings | Laboratorio de Virología Molecular, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Caracas, Miranda, Venezuela |
| authorships[9].author.id | https://openalex.org/A5050699813 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-5937-9690 |
| authorships[9].author.display_name | Héctor R. Rangel |
| authorships[9].countries | VE |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I191242182 |
| authorships[9].affiliations[0].raw_affiliation_string | Laboratorio de Virología Molecular, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Caracas, Miranda, Venezuela |
| authorships[9].institutions[0].id | https://openalex.org/I191242182 |
| authorships[9].institutions[0].ror | https://ror.org/02ntheh91 |
| authorships[9].institutions[0].type | facility |
| authorships[9].institutions[0].lineage | https://openalex.org/I191242182 |
| authorships[9].institutions[0].country_code | VE |
| authorships[9].institutions[0].display_name | Instituto Venezolano de Investigaciones Científicas |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Héctor R. Rangel |
| authorships[9].is_corresponding | True |
| authorships[9].raw_affiliation_strings | Laboratorio de Virología Molecular, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Caracas, Miranda, Venezuela |
| authorships[10].author.id | https://openalex.org/A5068542517 |
| authorships[10].author.orcid | https://orcid.org/0000-0001-6086-6883 |
| authorships[10].author.display_name | Flor H. Pujol |
| authorships[10].countries | VE |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I191242182 |
| authorships[10].affiliations[0].raw_affiliation_string | Laboratorio de Virología Molecular, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Caracas, Miranda, Venezuela |
| authorships[10].institutions[0].id | https://openalex.org/I191242182 |
| authorships[10].institutions[0].ror | https://ror.org/02ntheh91 |
| authorships[10].institutions[0].type | facility |
| authorships[10].institutions[0].lineage | https://openalex.org/I191242182 |
| authorships[10].institutions[0].country_code | VE |
| authorships[10].institutions[0].display_name | Instituto Venezolano de Investigaciones Científicas |
| authorships[10].author_position | last |
| authorships[10].raw_author_name | Flor H. Pujol |
| authorships[10].is_corresponding | True |
| authorships[10].raw_affiliation_strings | Laboratorio de Virología Molecular, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Caracas, Miranda, Venezuela |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0247196&type=printable |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2021-03-01T00:00:00 |
| display_name | SARS-CoV-2 genetic diversity in Venezuela: Predominance of D614G variants and analysis of one outbreak |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10118 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2725 |
| primary_topic.subfield.display_name | Infectious Diseases |
| primary_topic.display_name | SARS-CoV-2 and COVID-19 Research |
| related_works | https://openalex.org/W2322817607, https://openalex.org/W2546271652, https://openalex.org/W2563724974, https://openalex.org/W4296822203, https://openalex.org/W4402809326, https://openalex.org/W2029432214, https://openalex.org/W2790156482, https://openalex.org/W4306843370, https://openalex.org/W3125680817, https://openalex.org/W4323566954 |
| cited_by_count | 18 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 1 |
| counts_by_year[2].year | 2022 |
| counts_by_year[2].cited_by_count | 8 |
| counts_by_year[3].year | 2021 |
| counts_by_year[3].cited_by_count | 7 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1371/journal.pone.0247196 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S202381698 |
| best_oa_location.source.issn | 1932-6203 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1932-6203 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | PLoS ONE |
| best_oa_location.source.host_organization | https://openalex.org/P4310315706 |
| best_oa_location.source.host_organization_name | Public Library of Science |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310315706 |
| best_oa_location.source.host_organization_lineage_names | Public Library of Science |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0247196&type=printable |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | PLOS ONE |
| best_oa_location.landing_page_url | https://doi.org/10.1371/journal.pone.0247196 |
| primary_location.id | doi:10.1371/journal.pone.0247196 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S202381698 |
| primary_location.source.issn | 1932-6203 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1932-6203 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | PLoS ONE |
| primary_location.source.host_organization | https://openalex.org/P4310315706 |
| primary_location.source.host_organization_name | Public Library of Science |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310315706 |
| primary_location.source.host_organization_lineage_names | Public Library of Science |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0247196&type=printable |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | PLOS ONE |
| primary_location.landing_page_url | https://doi.org/10.1371/journal.pone.0247196 |
| publication_date | 2021-02-19 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W3093795020, https://openalex.org/W1965669216, https://openalex.org/W2601559170, https://openalex.org/W2143420602, https://openalex.org/W2799524357, https://openalex.org/W3043124965, https://openalex.org/W3022687324, https://openalex.org/W2804822363, https://openalex.org/W3039901154, https://openalex.org/W3023694260, https://openalex.org/W3087777459, https://openalex.org/W3087753222, https://openalex.org/W3020188044, https://openalex.org/W3036337530, https://openalex.org/W3025620739, https://openalex.org/W3035786310, https://openalex.org/W3033472139, https://openalex.org/W3039352801, https://openalex.org/W3038958209, https://openalex.org/W3067557104, https://openalex.org/W3006839750, https://openalex.org/W3081661306, https://openalex.org/W1974963408, https://openalex.org/W3043427328, https://openalex.org/W2125470890, https://openalex.org/W3083872269, https://openalex.org/W3044168259, https://openalex.org/W3049233984, https://openalex.org/W3103187010, https://openalex.org/W3048571801 |
| referenced_works_count | 30 |
| abstract_inverted_index.4 | 72 |
| abstract_inverted_index.7 | 39 |
| abstract_inverted_index.A | 36 |
| abstract_inverted_index.a | 142, 177, 206, 209 |
| abstract_inverted_index.(6 | 68 |
| abstract_inverted_index.11 | 66 |
| abstract_inverted_index.B, | 80 |
| abstract_inverted_index.In | 154, 175 |
| abstract_inverted_index.an | 101 |
| abstract_inverted_index.be | 203, 223 |
| abstract_inverted_index.by | 46 |
| abstract_inverted_index.do | 219 |
| abstract_inverted_index.in | 17, 85, 96, 104, 121, 144, 159, 186, 198, 212, 231 |
| abstract_inverted_index.is | 1 |
| abstract_inverted_index.of | 13, 25, 32, 38, 51, 54, 60, 65, 111, 114, 133, 151, 180, 190 |
| abstract_inverted_index.on | 19 |
| abstract_inverted_index.to | 78, 168, 202, 222 |
| abstract_inverted_index.13, | 21 |
| abstract_inverted_index.Ten | 63 |
| abstract_inverted_index.The | 9, 23, 117, 194 |
| abstract_inverted_index.aim | 24 |
| abstract_inverted_index.and | 71 |
| abstract_inverted_index.but | 216 |
| abstract_inverted_index.for | 6, 119, 225 |
| abstract_inverted_index.its | 105 |
| abstract_inverted_index.new | 3, 166 |
| abstract_inverted_index.not | 220 |
| abstract_inverted_index.out | 64 |
| abstract_inverted_index.the | 2, 29, 58, 61, 82, 86, 91, 97, 112, 115, 126, 130, 136, 145, 149, 163, 169, 191, 213, 226 |
| abstract_inverted_index.two | 11 |
| abstract_inverted_index.was | 28 |
| abstract_inverted_index.NSP1 | 113, 127, 214 |
| abstract_inverted_index.from | 49, 57, 90 |
| abstract_inverted_index.full | 40 |
| abstract_inverted_index.gene | 128 |
| abstract_inverted_index.high | 178 |
| abstract_inverted_index.seem | 221 |
| abstract_inverted_index.that | 94, 125 |
| abstract_inverted_index.this | 26, 152, 160, 172 |
| abstract_inverted_index.were | 15, 44, 183 |
| abstract_inverted_index.with | 148, 188, 205 |
| abstract_inverted_index.2020. | 22 |
| abstract_inverted_index.D614G | 83, 192 |
| abstract_inverted_index.July. | 232 |
| abstract_inverted_index.March | 20 |
| abstract_inverted_index.ORF1. | 116 |
| abstract_inverted_index.Spike | 87 |
| abstract_inverted_index.acids | 109 |
| abstract_inverted_index.after | 171 |
| abstract_inverted_index.along | 135 |
| abstract_inverted_index.amino | 108 |
| abstract_inverted_index.cases | 12 |
| abstract_inverted_index.first | 10, 92, 173, 195 |
| abstract_inverted_index.found | 184 |
| abstract_inverted_index.later | 158 |
| abstract_inverted_index.small | 196, 210 |
| abstract_inverted_index.spike | 74 |
| abstract_inverted_index.study | 27 |
| abstract_inverted_index.these | 217 |
| abstract_inverted_index.total | 37 |
| abstract_inverted_index.which | 229 |
| abstract_inverted_index.whole | 137 |
| abstract_inverted_index.48,635 | 122 |
| abstract_inverted_index.Island | 99, 200 |
| abstract_inverted_index.Sanger | 47 |
| abstract_inverted_index.change | 143 |
| abstract_inverted_index.domain | 147 |
| abstract_inverted_index.genome | 42 |
| abstract_inverted_index.island | 161, 170 |
| abstract_inverted_index.lacked | 162 |
| abstract_inverted_index.larger | 227 |
| abstract_inverted_index.mainly | 56 |
| abstract_inverted_index.search | 118 |
| abstract_inverted_index.seemed | 201 |
| abstract_inverted_index.showed | 124 |
| abstract_inverted_index.strain | 207 |
| abstract_inverted_index.83–85 | 110 |
| abstract_inverted_index.bearing | 81 |
| abstract_inverted_index.exhibit | 129 |
| abstract_inverted_index.genetic | 30 |
| abstract_inverted_index.genome. | 138 |
| abstract_inverted_index.genomes | 70 |
| abstract_inverted_index.genomic | 75 |
| abstract_inverted_index.highest | 131 |
| abstract_inverted_index.lineage | 79 |
| abstract_inverted_index.partial | 73 |
| abstract_inverted_index.regions | 53 |
| abstract_inverted_index.started | 230 |
| abstract_inverted_index.without | 107 |
| abstract_inverted_index.COVID-19 | 7, 14 |
| abstract_inverted_index.Isolates | 89 |
| abstract_inverted_index.analysis | 140 |
| abstract_inverted_index.belonged | 77 |
| abstract_inverted_index.carrying | 208 |
| abstract_inverted_index.complete | 69 |
| abstract_inverted_index.deletion | 103, 211 |
| abstract_inverted_index.detected | 16 |
| abstract_inverted_index.disease. | 8 |
| abstract_inverted_index.harbored | 100 |
| abstract_inverted_index.in-frame | 102 |
| abstract_inverted_index.isolates | 67, 156, 182, 218 |
| abstract_inverted_index.mutation | 84 |
| abstract_inverted_index.obtained | 45 |
| abstract_inverted_index.occurred | 95 |
| abstract_inverted_index.outbreak | 93, 197, 228 |
| abstract_inverted_index.patients | 50 |
| abstract_inverted_index.presence | 150 |
| abstract_inverted_index.protein, | 215 |
| abstract_inverted_index.protein. | 88 |
| abstract_inverted_index.regions) | 76 |
| abstract_inverted_index.suggests | 141 |
| abstract_inverted_index.Margarita | 98, 199 |
| abstract_inverted_index.Venezuela | 18 |
| abstract_inverted_index.beginning | 59 |
| abstract_inverted_index.contrast, | 155 |
| abstract_inverted_index.deletion, | 164 |
| abstract_inverted_index.deletion. | 153 |
| abstract_inverted_index.deletions | 120, 134 |
| abstract_inverted_index.different | 52 |
| abstract_inverted_index.diversity | 179 |
| abstract_inverted_index.epidemic. | 62 |
| abstract_inverted_index.frequency | 132 |
| abstract_inverted_index.isolates. | 35 |
| abstract_inverted_index.mutation. | 193 |
| abstract_inverted_index.outbreak. | 174 |
| abstract_inverted_index.sequence, | 106 |
| abstract_inverted_index.sequences | 43, 123 |
| abstract_inverted_index.N-terminal | 146 |
| abstract_inverted_index.SARS-CoV-2 | 0, 34, 41, 181 |
| abstract_inverted_index.Structural | 139 |
| abstract_inverted_index.Venezuela, | 55, 187 |
| abstract_inverted_index.Venezuelan | 33 |
| abstract_inverted_index.associated | 204 |
| abstract_inverted_index.suggesting | 165 |
| abstract_inverted_index.circulating | 157, 185 |
| abstract_inverted_index.conclusion, | 176 |
| abstract_inverted_index.coronavirus | 4 |
| abstract_inverted_index.responsible | 5, 224 |
| abstract_inverted_index.sequencing, | 48 |
| abstract_inverted_index.predominance | 189 |
| abstract_inverted_index.introductions | 167 |
| abstract_inverted_index.characterization | 31 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5015387064, https://openalex.org/A5032047197, https://openalex.org/A5074222059, https://openalex.org/A5062211051, https://openalex.org/A5050699813, https://openalex.org/A5084750750, https://openalex.org/A5077047611, https://openalex.org/A5021839062, https://openalex.org/A5036749757, https://openalex.org/A5068542517, https://openalex.org/A5035250341 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| corresponding_institution_ids | https://openalex.org/I191242182, https://openalex.org/I4210131015 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8600000143051147 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.82102819 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |