SARS-CoV-2 infects, replicates, elevates angiotensin II and activates immune cells in human testes Article Swipe
Guilherme Mattos Jardim Costa
,
Samyra Maria dos Santos Nassif Lacerda
,
André Felipe Almeida Figueiredo
,
Natália Teixeira Wnuk
,
Marcos Rocha Gouvêa Brener
,
Gabriel Henrique Campolina-Silva
,
Andrea Kauffmann-Zeh
,
Lucila Grossi Gonçalves Pacífico
,
Alice F. Versiani
,
Lídia M. Andrade
,
Maísa Mota Antunes
,
Fernanda Rezende Souza
,
Geovanni Dantas Cassali
,
Andre L. Caldeira‐Brant
,
Hélio Chiarini‐Garcia
,
Vivian Vasconcelos Costa
,
Flávio Guimarães da Fonseca
,
Maurício Lacerda Nogueira
,
Guilherme Rodrigues Fernandes Campos
,
Lucas M. Kangussu
,
Estefânia M. N. Martins
,
Loudiana Mosqueira Antônio
,
Cíntia Bittar
,
Paula Rahal
,
Renato Santana Aguiar
,
Bárbara P. Mendes
,
Marcela S. Procópio
,
T Furtado
,
Yuri L. Guimaraes
,
Gustavo Batista Menezes
,
Ana Martínez-Marchal
,
Miguel A. Brieño‐Enríquez
,
Kyle E. Orwig
,
Marcelo H. Furtado
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.02.05.22270327
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.02.05.22270327
Although much has been published since the first cases of COVID-19, there remain unanswered questions regarding SARS-CoV-2 impact on testes and the potential consequences for reproductive health. We investigated testicular alterations in deceased COVID-19-patients, the precise location of the virus, its replicative activity, and the molecules involved in the pathogenesis. We found that SARS-CoV-2 testicular tropism is higher than previously thought and that reliable viral detection in the testis requires sensitive nanosensoring or RT-qPCR using a specific methodology. Macrophages and spermatogonial cells are the main SARS-CoV-2 lodging sites and where new virions form inside the Endoplasmic Reticulum Golgi Intermediate Complex. Moreover, we showed infiltrative infected monocytes migrating into the testicular parenchyma. SARS-CoV-2 maintains its replicative and infective abilities long after the patient’s infection, suggesting that the testes may serve as a viral sanctuary. Further, infected testes show thickening of the tunica propria, germ cell apoptosis, Sertoli cell barrier loss, evident hemorrhage, angiogenesis, Leydig cell inhibition, inflammation, and fibrosis. Finally, our findings indicate that high angiotensin II levels and activation of mast cells and macrophages may be critical for testicular pathogenesis. Importantly, our data suggest that patients who become critically ill exhibit severe damages and may harbor the active virus in testes.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2022.02.05.22270327
- https://www.medrxiv.org/content/medrxiv/early/2022/02/08/2022.02.05.22270327.full.pdf
- OA Status
- green
- Cited By
- 11
- References
- 47
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4210859379
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4210859379Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2022.02.05.22270327Digital Object Identifier
- Title
-
SARS-CoV-2 infects, replicates, elevates angiotensin II and activates immune cells in human testesWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-02-08Full publication date if available
- Authors
-
Guilherme Mattos Jardim Costa, Samyra Maria dos Santos Nassif Lacerda, André Felipe Almeida Figueiredo, Natália Teixeira Wnuk, Marcos Rocha Gouvêa Brener, Gabriel Henrique Campolina-Silva, Andrea Kauffmann-Zeh, Lucila Grossi Gonçalves Pacífico, Alice F. Versiani, Lídia M. Andrade, Maísa Mota Antunes, Fernanda Rezende Souza, Geovanni Dantas Cassali, Andre L. Caldeira‐Brant, Hélio Chiarini‐Garcia, Vivian Vasconcelos Costa, Flávio Guimarães da Fonseca, Maurício Lacerda Nogueira, Guilherme Rodrigues Fernandes Campos, Lucas M. Kangussu, Estefânia M. N. Martins, Loudiana Mosqueira Antônio, Cíntia Bittar, Paula Rahal, Renato Santana Aguiar, Bárbara P. Mendes, Marcela S. Procópio, T Furtado, Yuri L. Guimaraes, Gustavo Batista Menezes, Ana Martínez-Marchal, Miguel A. Brieño‐Enríquez, Kyle E. Orwig, Marcelo H. FurtadoList of authors in order
- Landing page
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https://doi.org/10.1101/2022.02.05.22270327Publisher landing page
- PDF URL
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https://www.medrxiv.org/content/medrxiv/early/2022/02/08/2022.02.05.22270327.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.medrxiv.org/content/medrxiv/early/2022/02/08/2022.02.05.22270327.full.pdfDirect OA link when available
- Concepts
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Biology, Pathogenesis, Endoplasmic reticulum, Immune system, Inflammation, Sertoli cell, Tropism, Golgi apparatus, Immunology, Virus, Cell biology, Virology, Spermatogenesis, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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11Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 1, 2023: 2, 2022: 6Per-year citation counts (last 5 years)
- References (count)
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47Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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