SARS-CoV-2 Variant of Concern 202012/01 Has about Twofold Replicative Advantage and Acquires Concerning Mutations Article Swipe
Frederic Grabowski
,
Grzegorz Preibisch
,
Stanisław Giziński
,
Marek Kochańczyk
,
Tomasz Lipniacki
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/v13030392
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/v13030392
The novel SARS-CoV-2 Variant of Concern (VOC)-202012/01 (also known as B.1.1.7), first collected in United Kingdom on 20 September 2020, is a rapidly growing lineage that in January 2021 constituted 86% of all SARS-CoV-2 genomes sequenced in England. The VOC has been detected in 40 out of 46 countries that reported at least 50 genomes in January 2021. We have estimated that the replicative advantage of the VOC is in the range 1.83–2.18 [95% CI: 1.71–2.40] with respect to the 20A.EU1 variant that dominated in England in November 2020, and in range 1.65–1.72 [95% CI: 1.46–2.04] in Wales, Scotland, Denmark, and USA. As the VOC strain will likely spread globally towards fixation, it is important to monitor its molecular evolution. We have estimated growth rates of expanding mutations acquired by the VOC lineage to find that the L18F substitution in spike has initiated a fast growing VOC substrain. The L18F substitution is of significance because it has been found to compromise binding of neutralizing antibodies. Of concern are immune escape mutations acquired by the VOC: E484K, F490S, S494P (in the receptor binding motif of spike) and Q677H, Q675H (in the proximity of the polybasic cleavage site at the S1/S2 boundary). These mutants may hinder efficiency of existing vaccines and expand in response to the increasing after-infection or vaccine-induced seroprevalence.
Related Topics
Concepts
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Seroprevalence
Coronavirus disease 2019 (COVID-19)
Biology
Virology
Lineage (genetic)
Spike Protein
Genome
Genetics
Evolutionary biology
Antibody
Medicine
Gene
Serology
Internal medicine
Infectious disease (medical specialty)
Disease
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/v13030392
- https://www.mdpi.com/1999-4915/13/3/392/pdf?version=1615892275
- OA Status
- gold
- Cited By
- 113
- References
- 33
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3134363787
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3134363787Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/v13030392Digital Object Identifier
- Title
-
SARS-CoV-2 Variant of Concern 202012/01 Has about Twofold Replicative Advantage and Acquires Concerning MutationsWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-03-01Full publication date if available
- Authors
-
Frederic Grabowski, Grzegorz Preibisch, Stanisław Giziński, Marek Kochańczyk, Tomasz LipniackiList of authors in order
- Landing page
-
https://doi.org/10.3390/v13030392Publisher landing page
- PDF URL
-
https://www.mdpi.com/1999-4915/13/3/392/pdf?version=1615892275Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1999-4915/13/3/392/pdf?version=1615892275Direct OA link when available
- Concepts
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Seroprevalence, Coronavirus disease 2019 (COVID-19), Biology, Virology, Lineage (genetic), Spike Protein, Genome, Genetics, Evolutionary biology, Antibody, Medicine, Gene, Serology, Internal medicine, Infectious disease (medical specialty), DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
113Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 9, 2023: 16, 2022: 36, 2021: 49Per-year citation counts (last 5 years)
- References (count)
-
33Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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