Scaffolds fabricated via two-photon polymerisation for regulating cell morphology and differentiation Article Swipe
Zheyu Yao
,
Xiuzhen Zhang
,
Wenhui Yu
,
Zhen Xiao
,
Wenli Zhou
,
Dongfeng Qi
,
Wuhong Xin
,
Weilong Cao
,
Hongyu Zheng
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1080/17452759.2024.2447934
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1080/17452759.2024.2447934
Three-dimensional (3D) cell culture scaffolds play a key role in guiding cell fate. The fine-tunability of these scaffolds is essential for accurately replicating in vivo conditions and revealing cellular behaviours. In this study, two-photon polymerisation (TPP) technology was employed to create 3D scaffolds with woodpile and honeycomb architectures. The influence of scaffold geometry and pore dimensions on the proliferation, morphology, orientation, and differentiation of human mesenchymal stem cells (hMSCs) was investigated through multi-staining fluorescence and 3D confocal imaging technique. It was revealed that hMSCs cultured within these 3D scaffolds demonstrated higher density up to 15.04 ± 1.46 cells/100 × 100 μm2 after a 6-day culture compared to their 2D counterparts (7.47 ± 1.42 cells/100 × 100 μm2). Furthermore, hMSCs grown on the woodpile scaffolds displayed elongated morphology, with approximately 50% aligning along the columns. In contrast, hMSCs cultivated on honeycomb structures exhibited triangular and crescent cellular shapes, with a random orientation. Notably, compared to the control group, the cells on the scaffolds exhibited smaller nucleus areas, lower circularity, and aspect ratios, but these values increased as pore size increased. Furthermore, ALP staining showed a greater tendency for osteogenic differentiation with larger pore sizes. These TPP-fabricated 3D scaffolds hold immense promise for advancing understanding of cellular behaviour.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1080/17452759.2024.2447934
- OA Status
- gold
- Cited By
- 1
- References
- 62
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4406858350Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1080/17452759.2024.2447934Digital Object Identifier
- Title
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Scaffolds fabricated via two-photon polymerisation for regulating cell morphology and differentiationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-01-27Full publication date if available
- Authors
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Zheyu Yao, Xiuzhen Zhang, Wenhui Yu, Zhen Xiao, Wenli Zhou, Dongfeng Qi, Wuhong Xin, Weilong Cao, Hongyu ZhengList of authors in order
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https://doi.org/10.1080/17452759.2024.2447934Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1080/17452759.2024.2447934Direct OA link when available
- Concepts
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Morphology (biology), Materials science, Polymerization, Two-photon excitation microscopy, Nanotechnology, Composite material, Engineering, Polymer, Biology, Electrical engineering, Genetics, ExcitationTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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