Scalable biological-cognitive profiling for Alzheimer’s disease in the population Article Swipe
Karin Lohi
,
Aino Aaltonen
,
Sanna‐Kaisa Herukka
,
Tarja Kokkola
,
Sari Kärkkäinen
,
Mia Urjansson
,
Aarno Palotie
,
Heiko Runz
,
Jaakko Kaprio
,
Valtteri Julkunen
,
Toni Saari
,
Eero Vuoksimaa
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.08.20.25333966
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.08.20.25333966
Plasma phosphorylated tau217 has been suggested as a core biomarker for establishing biological Alzheimer’s disease diagnosis. This blood biomarker has not been studied together with scalable cognitive assessment tools in population-based samples. We investigated the prevalence of cognitive and Alzheimer’s disease biomarker abnormality and associations between plasma phosphorylated tau217 and remotely measured cognitive function in individuals without dementia. We used a population-based cross-sectional sample of 65–85-year-olds (n=692, 57% females) excluding those with previously diagnosed Alzheimer’s disease or other dementia-causing neurodegenerative disease. Cognition was measured with telephone-administered word list recall task (episodic memory) and animal naming (semantic fluency). Plasma phosphorylated tau217 was determined with the ALZpath assay. The prevalence of individuals with abnormalities in tests measuring episodic memory, semantic fluency and plasma phosphorylated tau217 was 10–13%. Higher plasma phosphorylated tau217 was related to lower scores in telephone-administered cognitive tests. We found a substantial minority of a population-based sample of individuals without a clinical diagnosis of Alzheimer’s disease to have cognitive and plasma phosphorylated tau217 profiles suggesting underlying Alzheimer’s disease. Combining plasma phosphorylated tau217 with remote cognitive assessment could be a scalable, accessible, and cost-effective protocol for screening individuals with undiagnosed or risk for Alzheimer’s disease.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.08.20.25333966
- https://www.medrxiv.org/content/medrxiv/early/2025/08/24/2025.08.20.25333966.full.pdf
- OA Status
- green
- References
- 25
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413480325
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4413480325Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2025.08.20.25333966Digital Object Identifier
- Title
-
Scalable biological-cognitive profiling for Alzheimer’s disease in the populationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-08-24Full publication date if available
- Authors
-
Karin Lohi, Aino Aaltonen, Sanna‐Kaisa Herukka, Tarja Kokkola, Sari Kärkkäinen, Mia Urjansson, Aarno Palotie, Heiko Runz, Jaakko Kaprio, Valtteri Julkunen, Toni Saari, Eero VuoksimaaList of authors in order
- Landing page
-
https://doi.org/10.1101/2025.08.20.25333966Publisher landing page
- PDF URL
-
https://www.medrxiv.org/content/medrxiv/early/2025/08/24/2025.08.20.25333966.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.medrxiv.org/content/medrxiv/early/2025/08/24/2025.08.20.25333966.full.pdfDirect OA link when available
- Concepts
-
Profiling (computer programming), Scalability, Disease, Alzheimer's disease, Cognition, Computer science, Population, Computational biology, Neuroscience, Medicine, Biology, Internal medicine, Programming language, Environmental health, DatabaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
25Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4413480325 |
|---|---|
| doi | https://doi.org/10.1101/2025.08.20.25333966 |
| ids.doi | https://doi.org/10.1101/2025.08.20.25333966 |
| ids.openalex | https://openalex.org/W4413480325 |
| fwci | 0.0 |
| type | article |
| title | Scalable biological-cognitive profiling for Alzheimer’s disease in the population |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T12702 |
| topics[0].field.id | https://openalex.org/fields/28 |
| topics[0].field.display_name | Neuroscience |
| topics[0].score | 0.5252000093460083 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2808 |
| topics[0].subfield.display_name | Neurology |
| topics[0].display_name | Brain Tumor Detection and Classification |
| topics[1].id | https://openalex.org/T12254 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.4975000023841858 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Machine Learning in Bioinformatics |
| topics[2].id | https://openalex.org/T13937 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.477400004863739 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Genetics, Bioinformatics, and Biomedical Research |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C187191949 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7402666211128235 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1138496 |
| concepts[0].display_name | Profiling (computer programming) |
| concepts[1].id | https://openalex.org/C48044578 |
| concepts[1].level | 2 |
| concepts[1].score | 0.52374267578125 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q727490 |
| concepts[1].display_name | Scalability |
| concepts[2].id | https://openalex.org/C2779134260 |
| concepts[2].level | 2 |
| concepts[2].score | 0.48979902267456055 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[2].display_name | Disease |
| concepts[3].id | https://openalex.org/C502032728 |
| concepts[3].level | 3 |
| concepts[3].score | 0.46723324060440063 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q11081 |
| concepts[3].display_name | Alzheimer's disease |
| concepts[4].id | https://openalex.org/C169900460 |
| concepts[4].level | 2 |
| concepts[4].score | 0.43773406744003296 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q2200417 |
| concepts[4].display_name | Cognition |
| concepts[5].id | https://openalex.org/C41008148 |
| concepts[5].level | 0 |
| concepts[5].score | 0.42648160457611084 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q21198 |
| concepts[5].display_name | Computer science |
| concepts[6].id | https://openalex.org/C2908647359 |
| concepts[6].level | 2 |
| concepts[6].score | 0.42382895946502686 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q2625603 |
| concepts[6].display_name | Population |
| concepts[7].id | https://openalex.org/C70721500 |
| concepts[7].level | 1 |
| concepts[7].score | 0.41135379672050476 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[7].display_name | Computational biology |
| concepts[8].id | https://openalex.org/C169760540 |
| concepts[8].level | 1 |
| concepts[8].score | 0.3260687589645386 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[8].display_name | Neuroscience |
| concepts[9].id | https://openalex.org/C71924100 |
| concepts[9].level | 0 |
| concepts[9].score | 0.31645962595939636 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[9].display_name | Medicine |
| concepts[10].id | https://openalex.org/C86803240 |
| concepts[10].level | 0 |
| concepts[10].score | 0.2910792827606201 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[10].display_name | Biology |
| concepts[11].id | https://openalex.org/C126322002 |
| concepts[11].level | 1 |
| concepts[11].score | 0.17967769503593445 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[11].display_name | Internal medicine |
| concepts[12].id | https://openalex.org/C199360897 |
| concepts[12].level | 1 |
| concepts[12].score | 0.06905931234359741 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q9143 |
| concepts[12].display_name | Programming language |
| concepts[13].id | https://openalex.org/C99454951 |
| concepts[13].level | 1 |
| concepts[13].score | 0.05096760392189026 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q932068 |
| concepts[13].display_name | Environmental health |
| concepts[14].id | https://openalex.org/C77088390 |
| concepts[14].level | 1 |
| concepts[14].score | 0.0 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q8513 |
| concepts[14].display_name | Database |
| keywords[0].id | https://openalex.org/keywords/profiling |
| keywords[0].score | 0.7402666211128235 |
| keywords[0].display_name | Profiling (computer programming) |
| keywords[1].id | https://openalex.org/keywords/scalability |
| keywords[1].score | 0.52374267578125 |
| keywords[1].display_name | Scalability |
| keywords[2].id | https://openalex.org/keywords/disease |
| keywords[2].score | 0.48979902267456055 |
| keywords[2].display_name | Disease |
| keywords[3].id | https://openalex.org/keywords/alzheimers-disease |
| keywords[3].score | 0.46723324060440063 |
| keywords[3].display_name | Alzheimer's disease |
| keywords[4].id | https://openalex.org/keywords/cognition |
| keywords[4].score | 0.43773406744003296 |
| keywords[4].display_name | Cognition |
| keywords[5].id | https://openalex.org/keywords/computer-science |
| keywords[5].score | 0.42648160457611084 |
| keywords[5].display_name | Computer science |
| keywords[6].id | https://openalex.org/keywords/population |
| keywords[6].score | 0.42382895946502686 |
| keywords[6].display_name | Population |
| keywords[7].id | https://openalex.org/keywords/computational-biology |
| keywords[7].score | 0.41135379672050476 |
| keywords[7].display_name | Computational biology |
| keywords[8].id | https://openalex.org/keywords/neuroscience |
| keywords[8].score | 0.3260687589645386 |
| keywords[8].display_name | Neuroscience |
| keywords[9].id | https://openalex.org/keywords/medicine |
| keywords[9].score | 0.31645962595939636 |
| keywords[9].display_name | Medicine |
| keywords[10].id | https://openalex.org/keywords/biology |
| keywords[10].score | 0.2910792827606201 |
| keywords[10].display_name | Biology |
| keywords[11].id | https://openalex.org/keywords/internal-medicine |
| keywords[11].score | 0.17967769503593445 |
| keywords[11].display_name | Internal medicine |
| keywords[12].id | https://openalex.org/keywords/programming-language |
| keywords[12].score | 0.06905931234359741 |
| keywords[12].display_name | Programming language |
| keywords[13].id | https://openalex.org/keywords/environmental-health |
| keywords[13].score | 0.05096760392189026 |
| keywords[13].display_name | Environmental health |
| language | en |
| locations[0].id | doi:10.1101/2025.08.20.25333966 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | cc-by-nc-nd |
| locations[0].pdf_url | https://www.medrxiv.org/content/medrxiv/early/2025/08/24/2025.08.20.25333966.full.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2025.08.20.25333966 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5119408012 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Karin Lohi |
| authorships[0].countries | FI |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I133731052, https://openalex.org/I4210133586 |
| authorships[0].affiliations[0].raw_affiliation_string | Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki |
| authorships[0].institutions[0].id | https://openalex.org/I4210133586 |
| authorships[0].institutions[0].ror | https://ror.org/030sbze61 |
| authorships[0].institutions[0].type | facility |
| authorships[0].institutions[0].lineage | https://openalex.org/I133731052, https://openalex.org/I4210133586 |
| authorships[0].institutions[0].country_code | FI |
| authorships[0].institutions[0].display_name | Institute for Molecular Medicine Finland |
| authorships[0].institutions[1].id | https://openalex.org/I133731052 |
| authorships[0].institutions[1].ror | https://ror.org/040af2s02 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I133731052 |
| authorships[0].institutions[1].country_code | FI |
| authorships[0].institutions[1].display_name | University of Helsinki |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Karin Lohi |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki |
| authorships[1].author.id | https://openalex.org/A5063356239 |
| authorships[1].author.orcid | https://orcid.org/0009-0000-4543-8645 |
| authorships[1].author.display_name | Aino Aaltonen |
| authorships[1].countries | FI |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I133731052, https://openalex.org/I4210133586 |
| authorships[1].affiliations[0].raw_affiliation_string | Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki |
| authorships[1].institutions[0].id | https://openalex.org/I4210133586 |
| authorships[1].institutions[0].ror | https://ror.org/030sbze61 |
| authorships[1].institutions[0].type | facility |
| authorships[1].institutions[0].lineage | https://openalex.org/I133731052, https://openalex.org/I4210133586 |
| authorships[1].institutions[0].country_code | FI |
| authorships[1].institutions[0].display_name | Institute for Molecular Medicine Finland |
| authorships[1].institutions[1].id | https://openalex.org/I133731052 |
| authorships[1].institutions[1].ror | https://ror.org/040af2s02 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I133731052 |
| authorships[1].institutions[1].country_code | FI |
| authorships[1].institutions[1].display_name | University of Helsinki |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Aino Aaltonen |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki |
| authorships[2].author.id | https://openalex.org/A5056012003 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-3308-8662 |
| authorships[2].author.display_name | Sanna‐Kaisa Herukka |
| authorships[2].countries | FI |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I175532246 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland |
| authorships[2].institutions[0].id | https://openalex.org/I175532246 |
| authorships[2].institutions[0].ror | https://ror.org/00cyydd11 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I175532246 |
| authorships[2].institutions[0].country_code | FI |
| authorships[2].institutions[0].display_name | University of Eastern Finland |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Sanna-Kaisa Herukka |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland |
| authorships[3].author.id | https://openalex.org/A5059442267 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-3303-3912 |
| authorships[3].author.display_name | Tarja Kokkola |
| authorships[3].countries | FI |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I175532246 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland |
| authorships[3].institutions[0].id | https://openalex.org/I175532246 |
| authorships[3].institutions[0].ror | https://ror.org/00cyydd11 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I175532246 |
| authorships[3].institutions[0].country_code | FI |
| authorships[3].institutions[0].display_name | University of Eastern Finland |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Tarja Kokkola |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland |
| authorships[4].author.id | https://openalex.org/A5034212138 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Sari Kärkkäinen |
| authorships[4].countries | FI |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I175532246 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland |
| authorships[4].institutions[0].id | https://openalex.org/I175532246 |
| authorships[4].institutions[0].ror | https://ror.org/00cyydd11 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I175532246 |
| authorships[4].institutions[0].country_code | FI |
| authorships[4].institutions[0].display_name | University of Eastern Finland |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Sari Kärkkäinen |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland |
| authorships[5].author.id | https://openalex.org/A5025305192 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Mia Urjansson |
| authorships[5].countries | FI |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I133731052, https://openalex.org/I4210133586 |
| authorships[5].affiliations[0].raw_affiliation_string | Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki |
| authorships[5].institutions[0].id | https://openalex.org/I4210133586 |
| authorships[5].institutions[0].ror | https://ror.org/030sbze61 |
| authorships[5].institutions[0].type | facility |
| authorships[5].institutions[0].lineage | https://openalex.org/I133731052, https://openalex.org/I4210133586 |
| authorships[5].institutions[0].country_code | FI |
| authorships[5].institutions[0].display_name | Institute for Molecular Medicine Finland |
| authorships[5].institutions[1].id | https://openalex.org/I133731052 |
| authorships[5].institutions[1].ror | https://ror.org/040af2s02 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I133731052 |
| authorships[5].institutions[1].country_code | FI |
| authorships[5].institutions[1].display_name | University of Helsinki |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Mia Urjansson |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki |
| authorships[6].author.id | https://openalex.org/A5085708490 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-2527-5874 |
| authorships[6].author.display_name | Aarno Palotie |
| authorships[6].countries | FI |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I133731052 |
| authorships[6].affiliations[0].raw_affiliation_string | University of Helsinki |
| authorships[6].institutions[0].id | https://openalex.org/I133731052 |
| authorships[6].institutions[0].ror | https://ror.org/040af2s02 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I133731052 |
| authorships[6].institutions[0].country_code | FI |
| authorships[6].institutions[0].display_name | University of Helsinki |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Aarno Palotie |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | University of Helsinki |
| authorships[7].author.id | https://openalex.org/A5089969264 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-2133-7345 |
| authorships[7].author.display_name | Heiko Runz |
| authorships[7].countries | DE |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210138560 |
| authorships[7].affiliations[0].raw_affiliation_string | European Molecular Biological Laboratories (EMBL), Heidelberg, Germany |
| authorships[7].institutions[0].id | https://openalex.org/I4210138560 |
| authorships[7].institutions[0].ror | https://ror.org/03mstc592 |
| authorships[7].institutions[0].type | government |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210138560 |
| authorships[7].institutions[0].country_code | DE |
| authorships[7].institutions[0].display_name | European Molecular Biology Laboratory |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Heiko Runz |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | European Molecular Biological Laboratories (EMBL), Heidelberg, Germany |
| authorships[8].author.id | https://openalex.org/A5002275174 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-3716-2455 |
| authorships[8].author.display_name | Jaakko Kaprio |
| authorships[8].countries | FI |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I133731052 |
| authorships[8].affiliations[0].raw_affiliation_string | University of Helsinki/FIMM |
| authorships[8].institutions[0].id | https://openalex.org/I133731052 |
| authorships[8].institutions[0].ror | https://ror.org/040af2s02 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I133731052 |
| authorships[8].institutions[0].country_code | FI |
| authorships[8].institutions[0].display_name | University of Helsinki |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Jaakko Kaprio |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | University of Helsinki/FIMM |
| authorships[9].author.id | https://openalex.org/A5042850649 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-8727-8536 |
| authorships[9].author.display_name | Valtteri Julkunen |
| authorships[9].countries | FI |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I175532246, https://openalex.org/I4210107997, https://openalex.org/I4389424196 |
| authorships[9].affiliations[0].raw_affiliation_string | University of Eastern Finland |
| authorships[9].institutions[0].id | https://openalex.org/I4389424196 |
| authorships[9].institutions[0].ror | |
| authorships[9].institutions[0].type | |
| authorships[9].institutions[0].lineage | https://openalex.org/I4389424196 |
| authorships[9].institutions[0].country_code | |
| authorships[9].institutions[0].display_name | Deleted Institution |
| authorships[9].institutions[1].id | https://openalex.org/I4210107997 |
| authorships[9].institutions[1].ror | https://ror.org/014rks409 |
| authorships[9].institutions[1].type | education |
| authorships[9].institutions[1].lineage | https://openalex.org/I4210107997 |
| authorships[9].institutions[1].country_code | FI |
| authorships[9].institutions[1].display_name | Finland University |
| authorships[9].institutions[2].id | https://openalex.org/I175532246 |
| authorships[9].institutions[2].ror | https://ror.org/00cyydd11 |
| authorships[9].institutions[2].type | education |
| authorships[9].institutions[2].lineage | https://openalex.org/I175532246 |
| authorships[9].institutions[2].country_code | FI |
| authorships[9].institutions[2].display_name | University of Eastern Finland |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Valtteri Julkunen |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | University of Eastern Finland |
| authorships[10].author.id | https://openalex.org/A5069350743 |
| authorships[10].author.orcid | https://orcid.org/0000-0001-7721-3336 |
| authorships[10].author.display_name | Toni Saari |
| authorships[10].countries | FI |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I133731052 |
| authorships[10].affiliations[0].raw_affiliation_string | University of Helsinki |
| authorships[10].institutions[0].id | https://openalex.org/I133731052 |
| authorships[10].institutions[0].ror | https://ror.org/040af2s02 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I133731052 |
| authorships[10].institutions[0].country_code | FI |
| authorships[10].institutions[0].display_name | University of Helsinki |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Toni T Saari |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | University of Helsinki |
| authorships[11].author.id | https://openalex.org/A5018060788 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-6534-3667 |
| authorships[11].author.display_name | Eero Vuoksimaa |
| authorships[11].countries | FI |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I133731052, https://openalex.org/I4210133586 |
| authorships[11].affiliations[0].raw_affiliation_string | Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki |
| authorships[11].institutions[0].id | https://openalex.org/I4210133586 |
| authorships[11].institutions[0].ror | https://ror.org/030sbze61 |
| authorships[11].institutions[0].type | facility |
| authorships[11].institutions[0].lineage | https://openalex.org/I133731052, https://openalex.org/I4210133586 |
| authorships[11].institutions[0].country_code | FI |
| authorships[11].institutions[0].display_name | Institute for Molecular Medicine Finland |
| authorships[11].institutions[1].id | https://openalex.org/I133731052 |
| authorships[11].institutions[1].ror | https://ror.org/040af2s02 |
| authorships[11].institutions[1].type | education |
| authorships[11].institutions[1].lineage | https://openalex.org/I133731052 |
| authorships[11].institutions[1].country_code | FI |
| authorships[11].institutions[1].display_name | University of Helsinki |
| authorships[11].author_position | last |
| authorships[11].raw_author_name | Eero Vuoksimaa |
| authorships[11].is_corresponding | True |
| authorships[11].raw_affiliation_strings | Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.medrxiv.org/content/medrxiv/early/2025/08/24/2025.08.20.25333966.full.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Scalable biological-cognitive profiling for Alzheimer’s disease in the population |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T12702 |
| primary_topic.field.id | https://openalex.org/fields/28 |
| primary_topic.field.display_name | Neuroscience |
| primary_topic.score | 0.5252000093460083 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2808 |
| primary_topic.subfield.display_name | Neurology |
| primary_topic.display_name | Brain Tumor Detection and Classification |
| related_works | https://openalex.org/W2389214306, https://openalex.org/W2161444195, https://openalex.org/W2965083567, https://openalex.org/W4235240664, https://openalex.org/W1838576100, https://openalex.org/W2095886385, https://openalex.org/W2889616422, https://openalex.org/W2089704382, https://openalex.org/W1983399550, https://openalex.org/W97075385 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1101/2025.08.20.25333966 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402567 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| best_oa_location.source.host_organization | https://openalex.org/I2750212522 |
| best_oa_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | https://www.medrxiv.org/content/medrxiv/early/2025/08/24/2025.08.20.25333966.full.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1101/2025.08.20.25333966 |
| primary_location.id | doi:10.1101/2025.08.20.25333966 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | https://www.medrxiv.org/content/medrxiv/early/2025/08/24/2025.08.20.25333966.full.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2025.08.20.25333966 |
| publication_date | 2025-08-24 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W4283746837, https://openalex.org/W4401164724, https://openalex.org/W4211050998, https://openalex.org/W4400126480, https://openalex.org/W2798054687, https://openalex.org/W4403358303, https://openalex.org/W4392809360, https://openalex.org/W4403986853, https://openalex.org/W4281558685, https://openalex.org/W4399652199, https://openalex.org/W1751963152, https://openalex.org/W1986286400, https://openalex.org/W4309971704, https://openalex.org/W4399561322, https://openalex.org/W4391101037, https://openalex.org/W4400833630, https://openalex.org/W4385516413, https://openalex.org/W2758123802, https://openalex.org/W2157269757, https://openalex.org/W4410708529, https://openalex.org/W2168357345, https://openalex.org/W4403854232, https://openalex.org/W4296249578, https://openalex.org/W4410313580, https://openalex.org/W2907630650 |
| referenced_works_count | 25 |
| abstract_inverted_index.a | 8, 61, 141, 145, 151, 179 |
| abstract_inverted_index.We | 33, 59, 139 |
| abstract_inverted_index.as | 7 |
| abstract_inverted_index.be | 178 |
| abstract_inverted_index.in | 30, 55, 113, 135 |
| abstract_inverted_index.of | 37, 65, 109, 144, 148, 154 |
| abstract_inverted_index.or | 77, 190 |
| abstract_inverted_index.to | 132, 157 |
| abstract_inverted_index.57% | 68 |
| abstract_inverted_index.The | 107 |
| abstract_inverted_index.and | 39, 44, 50, 93, 120, 160, 182 |
| abstract_inverted_index.for | 11, 185, 192 |
| abstract_inverted_index.has | 4, 20 |
| abstract_inverted_index.not | 21 |
| abstract_inverted_index.the | 35, 104 |
| abstract_inverted_index.was | 83, 101, 124, 130 |
| abstract_inverted_index.This | 17 |
| abstract_inverted_index.been | 5, 22 |
| abstract_inverted_index.core | 9 |
| abstract_inverted_index.have | 158 |
| abstract_inverted_index.list | 88 |
| abstract_inverted_index.risk | 191 |
| abstract_inverted_index.task | 90 |
| abstract_inverted_index.used | 60 |
| abstract_inverted_index.with | 25, 72, 85, 103, 111, 173, 188 |
| abstract_inverted_index.word | 87 |
| abstract_inverted_index.blood | 18 |
| abstract_inverted_index.could | 177 |
| abstract_inverted_index.found | 140 |
| abstract_inverted_index.lower | 133 |
| abstract_inverted_index.other | 78 |
| abstract_inverted_index.tests | 114 |
| abstract_inverted_index.those | 71 |
| abstract_inverted_index.tools | 29 |
| abstract_inverted_index.Higher | 126 |
| abstract_inverted_index.Plasma | 1, 98 |
| abstract_inverted_index.animal | 94 |
| abstract_inverted_index.assay. | 106 |
| abstract_inverted_index.naming | 95 |
| abstract_inverted_index.plasma | 47, 121, 127, 161, 170 |
| abstract_inverted_index.recall | 89 |
| abstract_inverted_index.remote | 174 |
| abstract_inverted_index.sample | 64, 147 |
| abstract_inverted_index.scores | 134 |
| abstract_inverted_index.tau217 | 3, 49, 100, 123, 129, 163, 172 |
| abstract_inverted_index.tests. | 138 |
| abstract_inverted_index.(n=692, | 67 |
| abstract_inverted_index.ALZpath | 105 |
| abstract_inverted_index.between | 46 |
| abstract_inverted_index.disease | 15, 41, 76, 156 |
| abstract_inverted_index.fluency | 119 |
| abstract_inverted_index.memory) | 92 |
| abstract_inverted_index.memory, | 117 |
| abstract_inverted_index.related | 131 |
| abstract_inverted_index.studied | 23 |
| abstract_inverted_index.without | 57, 150 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.clinical | 152 |
| abstract_inverted_index.disease. | 81, 168, 194 |
| abstract_inverted_index.episodic | 116 |
| abstract_inverted_index.females) | 69 |
| abstract_inverted_index.function | 54 |
| abstract_inverted_index.measured | 52, 84 |
| abstract_inverted_index.minority | 143 |
| abstract_inverted_index.profiles | 164 |
| abstract_inverted_index.protocol | 184 |
| abstract_inverted_index.remotely | 51 |
| abstract_inverted_index.samples. | 32 |
| abstract_inverted_index.scalable | 26 |
| abstract_inverted_index.semantic | 118 |
| abstract_inverted_index.together | 24 |
| abstract_inverted_index.(episodic | 91 |
| abstract_inverted_index.(semantic | 96 |
| abstract_inverted_index.10–13%. | 125 |
| abstract_inverted_index.Cognition | 82 |
| abstract_inverted_index.Combining | 169 |
| abstract_inverted_index.biomarker | 10, 19, 42 |
| abstract_inverted_index.cognitive | 27, 38, 53, 137, 159, 175 |
| abstract_inverted_index.dementia. | 58 |
| abstract_inverted_index.diagnosed | 74 |
| abstract_inverted_index.diagnosis | 153 |
| abstract_inverted_index.excluding | 70 |
| abstract_inverted_index.fluency). | 97 |
| abstract_inverted_index.measuring | 115 |
| abstract_inverted_index.scalable, | 180 |
| abstract_inverted_index.screening | 186 |
| abstract_inverted_index.suggested | 6 |
| abstract_inverted_index.assessment | 28, 176 |
| abstract_inverted_index.biological | 13 |
| abstract_inverted_index.determined | 102 |
| abstract_inverted_index.diagnosis. | 16 |
| abstract_inverted_index.prevalence | 36, 108 |
| abstract_inverted_index.previously | 73 |
| abstract_inverted_index.suggesting | 165 |
| abstract_inverted_index.underlying | 166 |
| abstract_inverted_index.abnormality | 43 |
| abstract_inverted_index.accessible, | 181 |
| abstract_inverted_index.individuals | 56, 110, 149, 187 |
| abstract_inverted_index.substantial | 142 |
| abstract_inverted_index.undiagnosed | 189 |
| abstract_inverted_index.associations | 45 |
| abstract_inverted_index.establishing | 12 |
| abstract_inverted_index.investigated | 34 |
| abstract_inverted_index.Alzheimer’s | 14, 40, 75, 155, 167, 193 |
| abstract_inverted_index.abnormalities | 112 |
| abstract_inverted_index.cost-effective | 183 |
| abstract_inverted_index.phosphorylated | 2, 48, 99, 122, 128, 162, 171 |
| abstract_inverted_index.cross-sectional | 63 |
| abstract_inverted_index.dementia-causing | 79 |
| abstract_inverted_index.population-based | 31, 62, 146 |
| abstract_inverted_index.65–85-year-olds | 66 |
| abstract_inverted_index.neurodegenerative | 80 |
| abstract_inverted_index.telephone-administered | 86, 136 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5018060788 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I133731052, https://openalex.org/I4210133586 |
| citation_normalized_percentile.value | 0.46240951 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |