Scalalactams A–D, Scalarane Sesterterpenes with a γ-Lactam Moiety from a Korean Spongia Sp. Marine Sponge Article Swipe

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Inho Yang , Jusung Lee , Jihye Lee , Dongyup Hahn , Jungwook Chin , Dong Hwan Won , Jaeyoung Ko , Hyukjae Choi , Ahreum Hong , Sang‐Jip Nam , Heonjoong Kang ·

YOU? · · 2018 · Open Access · · DOI: https://doi.org/10.3390/molecules23123187

Intensive study on the chemical components of a Korean marine sponge, Spongia sp., has led to the isolation of four new scalarane sesterterpenes, scalalactams A–D (1–4). Their chemical structures were elucidated from the analysis of spectroscopic data including 1D-and 2D-NMR as well as MS data. Scalalactams A–D (1–4) possess a scalarane carbon skeleton with a rare structural feature of a γ-lactam moiety within the molecules. Scalalactams A and B (1 and 2) have an extended isopropanyl chain at the lactam ring, and scalalactams C and D (3 and 4) possess a phenethyl group at the lactam ring moiety. Scalalactams A–D (1–4) did not show FXR antagonistic activity nor cytotoxicity up to 100 μM.

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Sponge Moiety Stereochemistry Chemistry Biology Paleontology

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Type: article
Language: en
Landing Page: https://doi.org/10.3390/molecules23123187
PDF: https://www.mdpi.com/1420-3049/23/12/3187/pdf?version=1544954755
OA Status: gold
Cited By: 13
References: 39
Related Works: 10
OpenAlex ID: https://openalex.org/W2903329267

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OpenAlex ID: https://openalex.org/W2903329267

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DOI: https://doi.org/10.3390/molecules23123187

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Title: Scalalactams A–D, Scalarane Sesterterpenes with a γ-Lactam Moiety from a Korean Spongia Sp. Marine Sponge

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Type: article

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Language: en

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Publication year: 2018

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Publication date: 2018-12-03

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Authors: Inho Yang, Jusung Lee, Jihye Lee, Dongyup Hahn, Jungwook Chin, Dong Hwan Won, Jaeyoung Ko, Hyukjae Choi, Ahreum Hong, Sang‐Jip Nam, Heonjoong Kang

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Landing page: https://doi.org/10.3390/molecules23123187

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Concepts: Sponge, Moiety, Stereochemistry, Chemistry, Biology, Paleontology

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Cited by: 13

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