SCDT-37. MODULATION OF CONVECTION ENHANCED DELIVERY (CED) DISTRIBUTION USING FOCUSED ULTRASOUND (FUS) Article Swipe
Melanie Schweitzer
,
Mihaela Stavarache
,
Nicholas Petersen
,
Spyridon Bakas
,
Apostolos John Tsiouris
,
Christos Davatzikos
,
Michael G. Kaplitt
,
Mark M. Souweidane
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1093/neuonc/nox168.1118
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1093/neuonc/nox168.1118
INTRODUCTION: Ineffective drug delivery across the blood brain barrier (BBB) is one purported factor that contributes to the lack of therapeutic benefit of systemic chemotherapy for brain tumors. Convection enhanced delivery (CED) is an appealing form of therapeutic drug delivery to the brain that bypasses the BBB while avoiding systemic toxicity. When considering highly diffuse and infiltrative tumors, adequate tumor coverage might not always be possible. Catheter design, infusion parameters, and multi-centric targeting have all been explored as means to alter distribution following CED. The ability to actively modulate infusion volume would be an appealing feature of a CED-based platform. We hypothesize that magnetic resonance-guided focused ultrasound (MRgFUS) may provide a means for modulating CED distribution. METHODS: A combination of contrast agent (Gd-Magnevist) mixed with Methylene Blue Dye was stereotactically injected into a pre-determined location within the brain of naïve Sprague-Dawley rats. Pre- and post-injection MRgFUS volumes were acquired to monitor the effects of the FUS and to define the sonication target. An area situated three millimeters posterior to the infusion site was chosen as the sonication target and FUS was applied simultaneously with microbubble administration via a tail vein catheter. Control animals did not undergo sonication, but they received an intra-tail vein injection of microbubbles and all subsequent MRI scans. Animals were sacrificed and their brains harvested for histological analysis. Quantitative volumetric modeling of infusion and percent increase calculations were performed using the Cancer Imaging Phenomics Toolkit (CaPTk). RESULTS: The average relative volume expansion between pre- and post-injection volumes in the experimental and the control animals were 135.52% and 105%, respectively. CONCLUSIONS: The results confirm that sonication increased the volume of parenchyma covered by infusate. This preliminary work supports the possibility of using MRgFUS to contour distribution patterns during CED in an effort to enhance therapeutic goals.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/neuonc/nox168.1118
- https://academic.oup.com/neuro-oncology/article-pdf/19/suppl_6/vi272/21591196/nox168.1118.pdf
- OA Status
- bronze
- Cited By
- 2
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2767236573
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Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2767236573Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/neuonc/nox168.1118Digital Object Identifier
- Title
-
SCDT-37. MODULATION OF CONVECTION ENHANCED DELIVERY (CED) DISTRIBUTION USING FOCUSED ULTRASOUND (FUS)Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-11-01Full publication date if available
- Authors
-
Melanie Schweitzer, Mihaela Stavarache, Nicholas Petersen, Spyridon Bakas, Apostolos John Tsiouris, Christos Davatzikos, Michael G. Kaplitt, Mark M. SouweidaneList of authors in order
- Landing page
-
https://doi.org/10.1093/neuonc/nox168.1118Publisher landing page
- PDF URL
-
https://academic.oup.com/neuro-oncology/article-pdf/19/suppl_6/vi272/21591196/nox168.1118.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://academic.oup.com/neuro-oncology/article-pdf/19/suppl_6/vi272/21591196/nox168.1118.pdfDirect OA link when available
- Concepts
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Modulation (music), Distribution (mathematics), Ultrasound, Biomedical engineering, Materials science, Medicine, Acoustics, Physics, Radiology, Mathematics, Mathematical analysisTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
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2023: 1, 2020: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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