Schwann cells contribute to keloid formation Article Swipe

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Martin Direder , Tamara Weiss , Dragan Copic , Vera Vorstandlechner , Maria Laggner , Caterina Selina Mildner , Katharina Klas , Daniel Bormann , Werner Haslik , Christine Radtke , Matthias Farlik , Lisa E. Shaw , Bahar Golabi , Erwin Tschachler , Konrad Hötzenecker , Hendrik Jan Ankersmit , Michael Mildner ·

YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.1101/2021.08.09.21261701

Keloids are disfiguring, hypertrophic scars with yet poorly understood pathomechanisms, which could lead to severe functional impairments. Here we analyzed the characteristics of keloidal cells by single cell sequencing and discovered the presence of an abundant population of Schwann cells that persisted in the hypertrophic scar tissue after wound healing. In contrast to normal skin, keloidal Schwann cells possess a repair-like phenotype and high cellular plasticity. Our data support the hypothesis that keloidal Schwann cells contribute to the formation of the extracellular matrix and are able to affect M2 polarization of macrophages. Indeed, we show that macrophages in keloids predominantly display a M2 polarization and produce factors that inhibit Schwann cell differentiation. Our data suggest a contribution of this cross-talk to the continuous expansion of keloids, and that targeting Schwann cells might represent an interesting novel treatment option for keloids.

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Keloid Extracellular matrix Schwann cell Scars Phenotype Biology Population Cell biology Wound healing Pathology Immunology Medicine Genetics Gene Environmental health

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1101/2021.08.09.21261701
PDF: https://www.medrxiv.org/content/medrxiv/early/2021/08/10/2021.08.09.21261701.full.pdf
OA Status: green
Cited By: 5
References: 97
Related Works: 10
OpenAlex ID: https://openalex.org/W3187544918

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OpenAlex ID: https://openalex.org/W3187544918

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DOI: https://doi.org/10.1101/2021.08.09.21261701

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Title: Schwann cells contribute to keloid formation

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Type: preprint

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Language: en

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Publication year: 2021

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Publication date: 2021-08-10

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Authors: Martin Direder, Tamara Weiss, Dragan Copic, Vera Vorstandlechner, Maria Laggner, Caterina Selina Mildner, Katharina Klas, Daniel Bormann, Werner Haslik, Christine Radtke, Matthias Farlik, Lisa E. Shaw, Bahar Golabi, Erwin Tschachler, Konrad Hötzenecker, Hendrik Jan Ankersmit, Michael Mildner

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Landing page: https://doi.org/10.1101/2021.08.09.21261701

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PDF URL: https://www.medrxiv.org/content/medrxiv/early/2021/08/10/2021.08.09.21261701.full.pdf

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OA URL: https://www.medrxiv.org/content/medrxiv/early/2021/08/10/2021.08.09.21261701.full.pdf

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Concepts: Keloid, Extracellular matrix, Schwann cell, Scars, Phenotype, Biology, Population, Cell biology, Wound healing, Pathology, Immunology, Medicine, Genetics, Gene, Environmental health

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Cited by: 5

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Citations by year (recent): 2024: 1, 2022: 4

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References (count): 97

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Related works (count): 10

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