SCIM: universal single-cell matching with unpaired feature sets Article Swipe

PDF

Stefan G. Stark , Joanna Ficek , Francesco Locatello , Ximena Bonilla , Stéphane Chevrier , Franziska Singer , Rudolf Aebersold , Faisal Alquaddoomi , Jonas Albinus , Ilaria Alborelli , Sonali Andani , Per-Olof Attinger , Marina Bacac , Daniel Baumhoer , Beatrice Beck‐Schimmer , Niko Beerenwinkel , Christian Beisel , Lara Bernasconi , Anne Bertolini , Bernd Bodenmiller , Ximena Bonilla , Ruben Casanova , Stéphane Chevrier , Natalia Chicherova , Maya D’Costa , Esther Danenberg , Natalie R. Davidson , Mengkun Gan , Reinhard Dummer , Stefanie Engler , Martin Erkens , Katja Eschbach , Cinzia Esposito , André Fedier , Pedro Ferreira , Joanna Ficek , Anja Frei , Bruno S. Frey , Sandra Goetze , Linda Grob , Gabriele Gut , Detlef Günther , Martina Haberecker , Pirmin Haeuptle , Viola Heinzelmann‐Schwarz , Sylvia Herter , René Holtackers , Tamara Huesser , Anja Irmisch , Francis Jacob , Alice K. Jacobs , Tim M. Jaeger , Katharina Jahn , Alva Rani James , Philip Jermann , André Kahles , Abdullah Kahraman , Viktor H. Koelzer , Werner Kuebler , Jack Kuipers , Christian P. Kunze , Christian Kurzeder , Kjong-Van Lehmann , Mitchell Levesque , Sebastian Lugert , Gerd Maass , Markus G. Manz , Philipp Markolin , Julien Mena , Ulrike Menzel , Julian M. Metzler , Nicola Miglino , Emanuela S. Milani , Holger Moch , Simone Muenst , Riccardo Murri , Charlotte K.Y. Ng , Stefan Nicolet , Marta Nowak , Patrick G. A. Pedrioli , Lucas Pelkmans , Salvatore Piscuoglio , Michael Prummer , Mathilde Ritter , Christian Rommel , María L. Rosano-González , Gunnar Rätsch , Natascha Santacroce , Jacobo Sarabia del Castillo , Ramona Schlenker , Petra Schwalie , Severin Schwan , Tobias Schär , Gabriela Senti , Franziska Singer , Sujana Sivapatham , Berend Snijder , Bettina Sobottka , Vipin T. Sreedharan , Stefan G. Stark ·

YOU? · · 2020 · Open Access · · DOI: https://doi.org/10.1093/bioinformatics/btaa843

Motivation Recent technological advances have led to an increase in the production and availability of single-cell data. The ability to integrate a set of multi-technology measurements would allow the identification of biologically or clinically meaningful observations through the unification of the perspectives afforded by each technology. In most cases, however, profiling technologies consume the used cells and thus pairwise correspondences between datasets are lost. Due to the sheer size single-cell datasets can acquire, scalable algorithms that are able to universally match single-cell measurements carried out in one cell to its corresponding sibling in another technology are needed. Results We propose Single-Cell data Integration via Matching (SCIM), a scalable approach to recover such correspondences in two or more technologies. SCIM assumes that cells share a common (low-dimensional) underlying structure and that the underlying cell distribution is approximately constant across technologies. It constructs a technology-invariant latent space using an autoencoder framework with an adversarial objective. Multi-modal datasets are integrated by pairing cells across technologies using a bipartite matching scheme that operates on the low-dimensional latent representations. We evaluate SCIM on a simulated cellular branching process and show that the cell-to-cell matches derived by SCIM reflect the same pseudotime on the simulated dataset. Moreover, we apply our method to two real-world scenarios, a melanoma tumor sample and a human bone marrow sample, where we pair cells from a scRNA dataset to their sibling cells in a CyTOF dataset achieving 90% and 78% cell-matching accuracy for each one of the samples, respectively. Availability and implementation https://github.com/ratschlab/scim. Supplementary information Supplementary data are available at Bioinformatics online.

Related Topics

Computer Science

Autoencoder

Data Mining

Artificial Intelligence

Concepts

Computer science Pairwise comparison Scalability Autoencoder Matching (statistics) Data mining Pattern recognition (psychology) Artificial intelligence Mathematics Deep learning Statistics Database

Metadata

Type: article
Language: en
Landing Page: https://doi.org/10.1093/bioinformatics/btaa843
PDF: https://academic.oup.com/bioinformatics/article-pdf/36/Supplement_2/i919/35336849/btaa843.pdf
OA Status: hybrid
Cited By: 63
References: 49
Related Works: 10
OpenAlex ID: https://openalex.org/W3113863876

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W3113863876

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1093/bioinformatics/btaa843

Digital Object Identifier
Title: SCIM: universal single-cell matching with unpaired feature sets

Work title
Type: article

OpenAlex work type
Language: en

Primary language
Publication year: 2020

Year of publication
Publication date: 2020-09-14

Full publication date if available
Authors: Stefan G. Stark, Joanna Ficek, Francesco Locatello, Ximena Bonilla, Stéphane Chevrier, Franziska Singer, Rudolf Aebersold, Faisal Alquaddoomi, Jonas Albinus, Ilaria Alborelli, Sonali Andani, Per-Olof Attinger, Marina Bacac, Daniel Baumhoer, Beatrice Beck‐Schimmer, Niko Beerenwinkel, Christian Beisel, Lara Bernasconi, Anne Bertolini, Bernd Bodenmiller, Ximena Bonilla, Ruben Casanova, Stéphane Chevrier, Natalia Chicherova, Maya D’Costa, Esther Danenberg, Natalie R. Davidson, Mengkun Gan, Reinhard Dummer, Stefanie Engler, Martin Erkens, Katja Eschbach, Cinzia Esposito, André Fedier, Pedro Ferreira, Joanna Ficek, Anja Frei, Bruno S. Frey, Sandra Goetze, Linda Grob, Gabriele Gut, Detlef Günther, Martina Haberecker, Pirmin Haeuptle, Viola Heinzelmann‐Schwarz, Sylvia Herter, René Holtackers, Tamara Huesser, Anja Irmisch, Francis Jacob, Alice K. Jacobs, Tim M. Jaeger, Katharina Jahn, Alva Rani James, Philip Jermann, André Kahles, Abdullah Kahraman, Viktor H. Koelzer, Werner Kuebler, Jack Kuipers, Christian P. Kunze, Christian Kurzeder, Kjong-Van Lehmann, Mitchell Levesque, Sebastian Lugert, Gerd Maass, Markus G. Manz, Philipp Markolin, Julien Mena, Ulrike Menzel, Julian M. Metzler, Nicola Miglino, Emanuela S. Milani, Holger Moch, Simone Muenst, Riccardo Murri, Charlotte K.Y. Ng, Stefan Nicolet, Marta Nowak, Patrick G. A. Pedrioli, Lucas Pelkmans, Salvatore Piscuoglio, Michael Prummer, Mathilde Ritter, Christian Rommel, María L. Rosano-González, Gunnar Rätsch, Natascha Santacroce, Jacobo Sarabia del Castillo, Ramona Schlenker, Petra Schwalie, Severin Schwan, Tobias Schär, Gabriela Senti, Franziska Singer, Sujana Sivapatham, Berend Snijder, Bettina Sobottka, Vipin T. Sreedharan, Stefan G. Stark

List of authors in order
Landing page: https://doi.org/10.1093/bioinformatics/btaa843

Publisher landing page
PDF URL: https://academic.oup.com/bioinformatics/article-pdf/36/Supplement_2/i919/35336849/btaa843.pdf

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: hybrid

Open access status per OpenAlex
OA URL: https://academic.oup.com/bioinformatics/article-pdf/36/Supplement_2/i919/35336849/btaa843.pdf

Direct OA link when available
Concepts: Computer science, Pairwise comparison, Scalability, Autoencoder, Matching (statistics), Data mining, Pattern recognition (psychology), Artificial intelligence, Mathematics, Deep learning, Statistics, Database

Top concepts (fields/topics) attached by OpenAlex
Cited by: 63

Total citation count in OpenAlex
Citations by year (recent): 2025: 12, 2024: 12, 2023: 15, 2022: 12, 2021: 11

Per-year citation counts (last 5 years)
References (count): 49

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W3113863876
doi	https://doi.org/10.1093/bioinformatics/btaa843
ids.doi	https://doi.org/10.1093/bioinformatics/btaa843
ids.mag	3113863876
ids.pmid	https://pubmed.ncbi.nlm.nih.gov/33381818
ids.openalex	https://openalex.org/W3113863876
fwci	3.90107893
mesh[0].qualifier_ui
mesh[0].descriptor_ui	D000465
mesh[0].is_major_topic	False
mesh[0].qualifier_name
mesh[0].descriptor_name	Algorithms
mesh[1].qualifier_ui
mesh[1].descriptor_ui	D020869
mesh[1].is_major_topic	False
mesh[1].qualifier_name
mesh[1].descriptor_name	Gene Expression Profiling
mesh[2].qualifier_ui
mesh[2].descriptor_ui	D006801
mesh[2].is_major_topic	False
mesh[2].qualifier_name
mesh[2].descriptor_name	Humans
mesh[3].qualifier_ui
mesh[3].descriptor_ui	D017423
mesh[3].is_major_topic	False
mesh[3].qualifier_name
mesh[3].descriptor_name	Sequence Analysis, RNA
mesh[4].qualifier_ui
mesh[4].descriptor_ui	D059010
mesh[4].is_major_topic	True
mesh[4].qualifier_name
mesh[4].descriptor_name	Single-Cell Analysis
mesh[5].qualifier_ui
mesh[5].descriptor_ui	D012984
mesh[5].is_major_topic	True
mesh[5].qualifier_name
mesh[5].descriptor_name	Software
mesh[6].qualifier_ui
mesh[6].descriptor_ui	D000465
mesh[6].is_major_topic	False
mesh[6].qualifier_name
mesh[6].descriptor_name	Algorithms
mesh[7].qualifier_ui
mesh[7].descriptor_ui	D020869
mesh[7].is_major_topic	False
mesh[7].qualifier_name
mesh[7].descriptor_name	Gene Expression Profiling
mesh[8].qualifier_ui
mesh[8].descriptor_ui	D006801
mesh[8].is_major_topic	False
mesh[8].qualifier_name
mesh[8].descriptor_name	Humans
mesh[9].qualifier_ui
mesh[9].descriptor_ui	D017423
mesh[9].is_major_topic	False
mesh[9].qualifier_name
mesh[9].descriptor_name	Sequence Analysis, RNA
mesh[10].qualifier_ui
mesh[10].descriptor_ui	D059010
mesh[10].is_major_topic	True
mesh[10].qualifier_name
mesh[10].descriptor_name	Single-Cell Analysis
mesh[11].qualifier_ui
mesh[11].descriptor_ui	D012984
mesh[11].is_major_topic	True
mesh[11].qualifier_name
mesh[11].descriptor_name	Software
type	article
title	SCIM: universal single-cell matching with unpaired feature sets
biblio.issue	Supplement_2
biblio.volume	36
biblio.last_page	i927
biblio.first_page	i919
topics[0].id	https://openalex.org/T11289
topics[0].field.id	https://openalex.org/fields/13
topics[0].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[0].score	1.0
topics[0].domain.id	https://openalex.org/domains/1
topics[0].domain.display_name	Life Sciences
topics[0].subfield.id	https://openalex.org/subfields/1312
topics[0].subfield.display_name	Molecular Biology
topics[0].display_name	Single-cell and spatial transcriptomics
topics[1].id	https://openalex.org/T12859
topics[1].field.id	https://openalex.org/fields/13
topics[1].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[1].score	0.9926000237464905
topics[1].domain.id	https://openalex.org/domains/1
topics[1].domain.display_name	Life Sciences
topics[1].subfield.id	https://openalex.org/subfields/1304
topics[1].subfield.display_name	Biophysics
topics[1].display_name	Cell Image Analysis Techniques
topics[2].id	https://openalex.org/T11287
topics[2].field.id	https://openalex.org/fields/13
topics[2].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[2].score	0.9842000007629395
topics[2].domain.id	https://openalex.org/domains/1
topics[2].domain.display_name	Life Sciences
topics[2].subfield.id	https://openalex.org/subfields/1306
topics[2].subfield.display_name	Cancer Research
topics[2].display_name	Cancer Genomics and Diagnostics
funders[0].id	https://openalex.org/F4320323874
funders[0].ror	https://ror.org/02crff812
funders[0].display_name	Universität Zürich
funders[1].id	https://openalex.org/F4320331705
funders[1].ror
funders[1].display_name	Max Planck ETH Center for Learning Systems
is_xpac	False
apc_list.value	3618
apc_list.currency	USD
apc_list.value_usd	3618
apc_paid.value	3618
apc_paid.currency	USD
apc_paid.value_usd	3618
concepts[0].id	https://openalex.org/C41008148
concepts[0].level	0
concepts[0].score	0.6804841160774231
concepts[0].wikidata	https://www.wikidata.org/wiki/Q21198
concepts[0].display_name	Computer science
concepts[1].id	https://openalex.org/C184898388
concepts[1].level	2
concepts[1].score	0.5400378108024597
concepts[1].wikidata	https://www.wikidata.org/wiki/Q1435712
concepts[1].display_name	Pairwise comparison
concepts[2].id	https://openalex.org/C48044578
concepts[2].level	2
concepts[2].score	0.5048566460609436
concepts[2].wikidata	https://www.wikidata.org/wiki/Q727490
concepts[2].display_name	Scalability
concepts[3].id	https://openalex.org/C101738243
concepts[3].level	3
concepts[3].score	0.48978710174560547
concepts[3].wikidata	https://www.wikidata.org/wiki/Q786435
concepts[3].display_name	Autoencoder
concepts[4].id	https://openalex.org/C165064840
concepts[4].level	2
concepts[4].score	0.46149858832359314
concepts[4].wikidata	https://www.wikidata.org/wiki/Q1321061
concepts[4].display_name	Matching (statistics)
concepts[5].id	https://openalex.org/C124101348
concepts[5].level	1
concepts[5].score	0.40160438418388367
concepts[5].wikidata	https://www.wikidata.org/wiki/Q172491
concepts[5].display_name	Data mining
concepts[6].id	https://openalex.org/C153180895
concepts[6].level	2
concepts[6].score	0.391554057598114
concepts[6].wikidata	https://www.wikidata.org/wiki/Q7148389
concepts[6].display_name	Pattern recognition (psychology)
concepts[7].id	https://openalex.org/C154945302
concepts[7].level	1
concepts[7].score	0.38086849451065063
concepts[7].wikidata	https://www.wikidata.org/wiki/Q11660
concepts[7].display_name	Artificial intelligence
concepts[8].id	https://openalex.org/C33923547
concepts[8].level	0
concepts[8].score	0.19952359795570374
concepts[8].wikidata	https://www.wikidata.org/wiki/Q395
concepts[8].display_name	Mathematics
concepts[9].id	https://openalex.org/C108583219
concepts[9].level	2
concepts[9].score	0.16711443662643433
concepts[9].wikidata	https://www.wikidata.org/wiki/Q197536
concepts[9].display_name	Deep learning
concepts[10].id	https://openalex.org/C105795698
concepts[10].level	1
concepts[10].score	0.10957691073417664
concepts[10].wikidata	https://www.wikidata.org/wiki/Q12483
concepts[10].display_name	Statistics
concepts[11].id	https://openalex.org/C77088390
concepts[11].level	1
concepts[11].score	0.0
concepts[11].wikidata	https://www.wikidata.org/wiki/Q8513
concepts[11].display_name	Database
keywords[0].id	https://openalex.org/keywords/computer-science
keywords[0].score	0.6804841160774231
keywords[0].display_name	Computer science
keywords[1].id	https://openalex.org/keywords/pairwise-comparison
keywords[1].score	0.5400378108024597
keywords[1].display_name	Pairwise comparison
keywords[2].id	https://openalex.org/keywords/scalability
keywords[2].score	0.5048566460609436
keywords[2].display_name	Scalability
keywords[3].id	https://openalex.org/keywords/autoencoder
keywords[3].score	0.48978710174560547
keywords[3].display_name	Autoencoder
keywords[4].id	https://openalex.org/keywords/matching
keywords[4].score	0.46149858832359314
keywords[4].display_name	Matching (statistics)
keywords[5].id	https://openalex.org/keywords/data-mining
keywords[5].score	0.40160438418388367
keywords[5].display_name	Data mining
keywords[6].id	https://openalex.org/keywords/pattern-recognition
keywords[6].score	0.391554057598114
keywords[6].display_name	Pattern recognition (psychology)
keywords[7].id	https://openalex.org/keywords/artificial-intelligence
keywords[7].score	0.38086849451065063
keywords[7].display_name	Artificial intelligence
keywords[8].id	https://openalex.org/keywords/mathematics
keywords[8].score	0.19952359795570374
keywords[8].display_name	Mathematics
keywords[9].id	https://openalex.org/keywords/deep-learning
keywords[9].score	0.16711443662643433
keywords[9].display_name	Deep learning
keywords[10].id	https://openalex.org/keywords/statistics
keywords[10].score	0.10957691073417664
keywords[10].display_name	Statistics
language	en
locations[0].id	doi:10.1093/bioinformatics/btaa843
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S52395412
locations[0].source.issn	1367-4803, 1367-4811
locations[0].source.type	journal
locations[0].source.is_oa	False
locations[0].source.issn_l	1367-4803
locations[0].source.is_core	True
locations[0].source.is_in_doaj	True
locations[0].source.display_name	Bioinformatics
locations[0].source.host_organization	https://openalex.org/P4310311648
locations[0].source.host_organization_name	Oxford University Press
locations[0].source.host_organization_lineage	https://openalex.org/P4310311648, https://openalex.org/P4310311647
locations[0].source.host_organization_lineage_names	Oxford University Press, University of Oxford
locations[0].license	cc-by
locations[0].pdf_url	https://academic.oup.com/bioinformatics/article-pdf/36/Supplement_2/i919/35336849/btaa843.pdf
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	Bioinformatics
locations[0].landing_page_url	https://doi.org/10.1093/bioinformatics/btaa843
locations[1].id	pmid:33381818
locations[1].is_oa	False
locations[1].source.id	https://openalex.org/S4306525036
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	PubMed
locations[1].source.host_organization	https://openalex.org/I1299303238
locations[1].source.host_organization_name	National Institutes of Health
locations[1].source.host_organization_lineage	https://openalex.org/I1299303238
locations[1].license
locations[1].pdf_url
locations[1].version	publishedVersion
locations[1].raw_type
locations[1].license_id
locations[1].is_accepted	True
locations[1].is_published	True
locations[1].raw_source_name	Bioinformatics (Oxford, England)
locations[1].landing_page_url	https://pubmed.ncbi.nlm.nih.gov/33381818
locations[2].id	pmh:oai:europepmc.org:6692830
locations[2].is_oa	True
locations[2].source.id	https://openalex.org/S4306400806
locations[2].source.issn
locations[2].source.type	repository
locations[2].source.is_oa	False
locations[2].source.issn_l
locations[2].source.is_core	False
locations[2].source.is_in_doaj	False
locations[2].source.display_name	Europe PMC (PubMed Central)
locations[2].source.host_organization	https://openalex.org/I1303153112
locations[2].source.host_organization_name	European Bioinformatics Institute
locations[2].source.host_organization_lineage	https://openalex.org/I1303153112
locations[2].license	cc-by
locations[2].pdf_url
locations[2].version	submittedVersion
locations[2].raw_type	Text
locations[2].license_id	https://openalex.org/licenses/cc-by
locations[2].is_accepted	False
locations[2].is_published	False
locations[2].raw_source_name
locations[2].landing_page_url	http://europepmc.org/pmc/articles/PMC7773480
locations[3].id	pmh:oai:pubmedcentral.nih.gov:7773480
locations[3].is_oa	True
locations[3].source.id	https://openalex.org/S2764455111
locations[3].source.issn
locations[3].source.type	repository
locations[3].source.is_oa	False
locations[3].source.issn_l
locations[3].source.is_core	False
locations[3].source.is_in_doaj	False
locations[3].source.display_name	PubMed Central
locations[3].source.host_organization	https://openalex.org/I1299303238
locations[3].source.host_organization_name	National Institutes of Health
locations[3].source.host_organization_lineage	https://openalex.org/I1299303238
locations[3].license	other-oa
locations[3].pdf_url
locations[3].version	submittedVersion
locations[3].raw_type	Text
locations[3].license_id	https://openalex.org/licenses/other-oa
locations[3].is_accepted	False
locations[3].is_published	False
locations[3].raw_source_name	Bioinformatics
locations[3].landing_page_url	https://www.ncbi.nlm.nih.gov/pmc/articles/7773480
indexed_in	crossref, doaj, pubmed
authorships[0].author.id	https://openalex.org/A5038601102
authorships[0].author.orcid	https://orcid.org/0000-0003-2478-9512
authorships[0].author.display_name	Stefan G. Stark
authorships[0].countries	CH
authorships[0].affiliations[0].institution_ids	https://openalex.org/I35440088
authorships[0].affiliations[0].raw_affiliation_string	Department of Computer Science , ETH Zürich, 8092 Zürich, Switzerland
authorships[0].affiliations[1].institution_ids	https://openalex.org/I4210118307
authorships[0].affiliations[1].raw_affiliation_string	Life Science Zurich Graduate School, PhD Program Molecular & Translational Biomedicine , 8057 Zürich, Switzerland
authorships[0].affiliations[2].institution_ids	https://openalex.org/I12708293
authorships[0].affiliations[2].raw_affiliation_string	Swiss Institute of Bioinformatics, Quartier Sorge Bâtiment Amphipôle , 1015 Lausanne, Switzerland
authorships[0].institutions[0].id	https://openalex.org/I35440088
authorships[0].institutions[0].ror	https://ror.org/05a28rw58
authorships[0].institutions[0].type	education
authorships[0].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[0].institutions[0].country_code	CH
authorships[0].institutions[0].display_name	ETH Zurich
authorships[0].institutions[1].id	https://openalex.org/I4210118307
authorships[0].institutions[1].ror	https://ror.org/02jxpdd90
authorships[0].institutions[1].type	education
authorships[0].institutions[1].lineage	https://openalex.org/I4210118307
authorships[0].institutions[1].country_code	CH
authorships[0].institutions[1].display_name	Life Science Zurich
authorships[0].institutions[2].id	https://openalex.org/I12708293
authorships[0].institutions[2].ror	https://ror.org/002n09z45
authorships[0].institutions[2].type	nonprofit
authorships[0].institutions[2].lineage	https://openalex.org/I12708293
authorships[0].institutions[2].country_code	CH
authorships[0].institutions[2].display_name	SIB Swiss Institute of Bioinformatics
authorships[0].author_position	first
authorships[0].raw_author_name	Stefan G Stark
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	Department of Computer Science , ETH Zürich, 8092 Zürich, Switzerland, Life Science Zurich Graduate School, PhD Program Molecular & Translational Biomedicine , 8057 Zürich, Switzerland, Swiss Institute of Bioinformatics, Quartier Sorge Bâtiment Amphipôle , 1015 Lausanne, Switzerland
authorships[1].author.id	https://openalex.org/A5019755983
authorships[1].author.orcid	https://orcid.org/0000-0002-9895-2119
authorships[1].author.display_name	Joanna Ficek
authorships[1].countries	CH, DE
authorships[1].affiliations[0].institution_ids	https://openalex.org/I35440088
authorships[1].affiliations[0].raw_affiliation_string	Department of Computer Science , ETH Zürich, 8092 Zürich, Switzerland
authorships[1].affiliations[1].institution_ids	https://openalex.org/I4210135521
authorships[1].affiliations[1].raw_affiliation_string	Max Planck Institute for Intelligent Systems, Empirical Inference Department , 72076 Tübingen, Germany
authorships[1].affiliations[2].institution_ids	https://openalex.org/I12708293
authorships[1].affiliations[2].raw_affiliation_string	Swiss Institute of Bioinformatics, Quartier Sorge Bâtiment Amphipôle , 1015 Lausanne, Switzerland
authorships[1].affiliations[3].institution_ids	https://openalex.org/I4210118307
authorships[1].affiliations[3].raw_affiliation_string	Life Science Zurich Graduate School, PhD Program Molecular & Translational Biomedicine , 8057 Zürich, Switzerland
authorships[1].institutions[0].id	https://openalex.org/I35440088
authorships[1].institutions[0].ror	https://ror.org/05a28rw58
authorships[1].institutions[0].type	education
authorships[1].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[1].institutions[0].country_code	CH
authorships[1].institutions[0].display_name	ETH Zurich
authorships[1].institutions[1].id	https://openalex.org/I4210118307
authorships[1].institutions[1].ror	https://ror.org/02jxpdd90
authorships[1].institutions[1].type	education
authorships[1].institutions[1].lineage	https://openalex.org/I4210118307
authorships[1].institutions[1].country_code	CH
authorships[1].institutions[1].display_name	Life Science Zurich
authorships[1].institutions[2].id	https://openalex.org/I12708293
authorships[1].institutions[2].ror	https://ror.org/002n09z45
authorships[1].institutions[2].type	nonprofit
authorships[1].institutions[2].lineage	https://openalex.org/I12708293
authorships[1].institutions[2].country_code	CH
authorships[1].institutions[2].display_name	SIB Swiss Institute of Bioinformatics
authorships[1].institutions[3].id	https://openalex.org/I4210135521
authorships[1].institutions[3].ror	https://ror.org/04fq9j139
authorships[1].institutions[3].type	facility
authorships[1].institutions[3].lineage	https://openalex.org/I149899117, https://openalex.org/I4210135521
authorships[1].institutions[3].country_code	DE
authorships[1].institutions[3].display_name	Max Planck Institute for Intelligent Systems
authorships[1].author_position	middle
authorships[1].raw_author_name	Joanna Ficek
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	Department of Computer Science , ETH Zürich, 8092 Zürich, Switzerland, Life Science Zurich Graduate School, PhD Program Molecular & Translational Biomedicine , 8057 Zürich, Switzerland, Max Planck Institute for Intelligent Systems, Empirical Inference Department , 72076 Tübingen, Germany, Swiss Institute of Bioinformatics, Quartier Sorge Bâtiment Amphipôle , 1015 Lausanne, Switzerland
authorships[2].author.id	https://openalex.org/A5073157306
authorships[2].author.orcid	https://orcid.org/0000-0002-4850-0683
authorships[2].author.display_name	Francesco Locatello
authorships[2].countries	CH
authorships[2].affiliations[0].institution_ids	https://openalex.org/I35440088
authorships[2].affiliations[0].raw_affiliation_string	Center for Learning Systems , ETH Zürich, 8092 Zürich, Switzerland
authorships[2].affiliations[1].institution_ids	https://openalex.org/I35440088
authorships[2].affiliations[1].raw_affiliation_string	Department of Computer Science , ETH Zürich, 8092 Zürich, Switzerland
authorships[2].affiliations[2].institution_ids	https://openalex.org/I202697423
authorships[2].affiliations[2].raw_affiliation_string	Department of Quantitative Biomedicine, University of Zürich , 8057 Zürich, Switzerland
authorships[2].institutions[0].id	https://openalex.org/I35440088
authorships[2].institutions[0].ror	https://ror.org/05a28rw58
authorships[2].institutions[0].type	education
authorships[2].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[2].institutions[0].country_code	CH
authorships[2].institutions[0].display_name	ETH Zurich
authorships[2].institutions[1].id	https://openalex.org/I202697423
authorships[2].institutions[1].ror	https://ror.org/02crff812
authorships[2].institutions[1].type	education
authorships[2].institutions[1].lineage	https://openalex.org/I202697423
authorships[2].institutions[1].country_code	CH
authorships[2].institutions[1].display_name	University of Zurich
authorships[2].author_position	middle
authorships[2].raw_author_name	Francesco Locatello
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	Center for Learning Systems , ETH Zürich, 8092 Zürich, Switzerland, Department of Computer Science , ETH Zürich, 8092 Zürich, Switzerland, Department of Quantitative Biomedicine, University of Zürich , 8057 Zürich, Switzerland
authorships[3].author.id	https://openalex.org/A5049334079
authorships[3].author.orcid	https://orcid.org/0000-0002-4950-6825
authorships[3].author.display_name	Ximena Bonilla
authorships[3].countries	CH
authorships[3].affiliations[0].institution_ids	https://openalex.org/I35440088
authorships[3].affiliations[0].raw_affiliation_string	Department of Computer Science , ETH Zürich, 8092 Zürich, Switzerland
authorships[3].affiliations[1].institution_ids	https://openalex.org/I12708293
authorships[3].affiliations[1].raw_affiliation_string	Swiss Institute of Bioinformatics, Quartier Sorge Bâtiment Amphipôle , 1015 Lausanne, Switzerland
authorships[3].affiliations[2].institution_ids	https://openalex.org/I4210118307
authorships[3].affiliations[2].raw_affiliation_string	Life Science Zurich Graduate School, PhD Program Molecular & Translational Biomedicine , 8057 Zürich, Switzerland
authorships[3].institutions[0].id	https://openalex.org/I35440088
authorships[3].institutions[0].ror	https://ror.org/05a28rw58
authorships[3].institutions[0].type	education
authorships[3].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[3].institutions[0].country_code	CH
authorships[3].institutions[0].display_name	ETH Zurich
authorships[3].institutions[1].id	https://openalex.org/I4210118307
authorships[3].institutions[1].ror	https://ror.org/02jxpdd90
authorships[3].institutions[1].type	education
authorships[3].institutions[1].lineage	https://openalex.org/I4210118307
authorships[3].institutions[1].country_code	CH
authorships[3].institutions[1].display_name	Life Science Zurich
authorships[3].institutions[2].id	https://openalex.org/I12708293
authorships[3].institutions[2].ror	https://ror.org/002n09z45
authorships[3].institutions[2].type	nonprofit
authorships[3].institutions[2].lineage	https://openalex.org/I12708293
authorships[3].institutions[2].country_code	CH
authorships[3].institutions[2].display_name	SIB Swiss Institute of Bioinformatics
authorships[3].author_position	middle
authorships[3].raw_author_name	Ximena Bonilla
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	Department of Computer Science , ETH Zürich, 8092 Zürich, Switzerland, Life Science Zurich Graduate School, PhD Program Molecular & Translational Biomedicine , 8057 Zürich, Switzerland, Swiss Institute of Bioinformatics, Quartier Sorge Bâtiment Amphipôle , 1015 Lausanne, Switzerland
authorships[4].author.id	https://openalex.org/A5069576688
authorships[4].author.orcid	https://orcid.org/0000-0002-9216-7910
authorships[4].author.display_name	Stéphane Chevrier
authorships[4].countries	CH
authorships[4].affiliations[0].institution_ids	https://openalex.org/I4210100468
authorships[4].affiliations[0].raw_affiliation_string	University Hospital Zürich , 8091 Zürich, Switzerl
authorships[4].institutions[0].id	https://openalex.org/I4210100468
authorships[4].institutions[0].ror	https://ror.org/01462r250
authorships[4].institutions[0].type	healthcare
authorships[4].institutions[0].lineage	https://openalex.org/I4210100468
authorships[4].institutions[0].country_code	CH
authorships[4].institutions[0].display_name	University Hospital of Zurich
authorships[4].author_position	middle
authorships[4].raw_author_name	Stéphane Chevrier
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	University Hospital Zürich , 8091 Zürich, Switzerl
authorships[5].author.id	https://openalex.org/A5005041697
authorships[5].author.orcid	https://orcid.org/0000-0002-6017-1595
authorships[5].author.display_name	Franziska Singer
authorships[5].countries	CH
authorships[5].affiliations[0].institution_ids	https://openalex.org/I4210100468
authorships[5].affiliations[0].raw_affiliation_string	University Hospital Zürich , 8091 Zürich Switzerland
authorships[5].affiliations[1].institution_ids	https://openalex.org/I12708293
authorships[5].affiliations[1].raw_affiliation_string	Swiss Institute of Bioinformatics, Quartier Sorge Bâtiment Amphipôle , 1015 Lausanne, Switzerland
authorships[5].institutions[0].id	https://openalex.org/I12708293
authorships[5].institutions[0].ror	https://ror.org/002n09z45
authorships[5].institutions[0].type	nonprofit
authorships[5].institutions[0].lineage	https://openalex.org/I12708293
authorships[5].institutions[0].country_code	CH
authorships[5].institutions[0].display_name	SIB Swiss Institute of Bioinformatics
authorships[5].institutions[1].id	https://openalex.org/I4210100468
authorships[5].institutions[1].ror	https://ror.org/01462r250
authorships[5].institutions[1].type	healthcare
authorships[5].institutions[1].lineage	https://openalex.org/I4210100468
authorships[5].institutions[1].country_code	CH
authorships[5].institutions[1].display_name	University Hospital of Zurich
authorships[5].author_position	middle
authorships[5].raw_author_name	Franziska Singer
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	Swiss Institute of Bioinformatics, Quartier Sorge Bâtiment Amphipôle , 1015 Lausanne, Switzerland, University Hospital Zürich , 8091 Zürich Switzerland
authorships[6].author.id	https://openalex.org/A5057298655
authorships[6].author.orcid
authorships[6].author.display_name	Rudolf Aebersold
authorships[6].countries	CH
authorships[6].affiliations[0].institution_ids	https://openalex.org/I35440088
authorships[6].affiliations[0].raw_affiliation_string	ETH Zurich, Department of Biology , Wolfgang-Pauli-Strasse 27, 8093 Zurich , Switzerland
authorships[6].institutions[0].id	https://openalex.org/I35440088
authorships[6].institutions[0].ror	https://ror.org/05a28rw58
authorships[6].institutions[0].type	education
authorships[6].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[6].institutions[0].country_code	CH
authorships[6].institutions[0].display_name	ETH Zurich
authorships[6].author_position	middle
authorships[6].raw_author_name	Rudolf Aebersold
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	ETH Zurich, Department of Biology , Wolfgang-Pauli-Strasse 27, 8093 Zurich , Switzerland
authorships[7].author.id	https://openalex.org/A5001950261
authorships[7].author.orcid	https://orcid.org/0000-0003-4297-8747
authorships[7].author.display_name	Faisal Alquaddoomi
authorships[7].countries	CH
authorships[7].affiliations[0].institution_ids	https://openalex.org/I35440088
authorships[7].affiliations[0].raw_affiliation_string	ETH Zurich, NEXUS Personalized Health Technologies , John-von-Neumann-Weg 9, 8093 Zurich , Switzerland
authorships[7].affiliations[1].raw_affiliation_string	, John-von-Neumann-Weg 9, 8093 Zurich , Switzerland
authorships[7].affiliations[2].institution_ids	https://openalex.org/I12708293
authorships[7].affiliations[2].raw_affiliation_string	Swiss Institute of Bioinformatics, Zurich , Switzerland
authorships[7].institutions[0].id	https://openalex.org/I35440088
authorships[7].institutions[0].ror	https://ror.org/05a28rw58
authorships[7].institutions[0].type	education
authorships[7].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[7].institutions[0].country_code	CH
authorships[7].institutions[0].display_name	ETH Zurich
authorships[7].institutions[1].id	https://openalex.org/I12708293
authorships[7].institutions[1].ror	https://ror.org/002n09z45
authorships[7].institutions[1].type	nonprofit
authorships[7].institutions[1].lineage	https://openalex.org/I12708293
authorships[7].institutions[1].country_code	CH
authorships[7].institutions[1].display_name	SIB Swiss Institute of Bioinformatics
authorships[7].author_position	middle
authorships[7].raw_author_name	Faisal S Al-Quaddoomi
authorships[7].is_corresponding	False
authorships[7].raw_affiliation_strings	, John-von-Neumann-Weg 9, 8093 Zurich , Switzerland, ETH Zurich, NEXUS Personalized Health Technologies , John-von-Neumann-Weg 9, 8093 Zurich , Switzerland, Swiss Institute of Bioinformatics, Zurich , Switzerland
authorships[8].author.id	https://openalex.org/A5002326210
authorships[8].author.orcid
authorships[8].author.display_name	Jonas Albinus
authorships[8].countries	CH
authorships[8].affiliations[0].institution_ids	https://openalex.org/I35440088
authorships[8].affiliations[0].raw_affiliation_string	ETH Zurich, Department of Health Sciences and Technology , Otto-Stern-Weg 3, 8093 Zurich , Switzerland
authorships[8].institutions[0].id	https://openalex.org/I35440088
authorships[8].institutions[0].ror	https://ror.org/05a28rw58
authorships[8].institutions[0].type	education
authorships[8].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[8].institutions[0].country_code	CH
authorships[8].institutions[0].display_name	ETH Zurich
authorships[8].author_position	middle
authorships[8].raw_author_name	Jonas Albinus
authorships[8].is_corresponding	False
authorships[8].raw_affiliation_strings	ETH Zurich, Department of Health Sciences and Technology , Otto-Stern-Weg 3, 8093 Zurich , Switzerland
authorships[9].author.id	https://openalex.org/A5051330037
authorships[9].author.orcid	https://orcid.org/0000-0001-7849-3958
authorships[9].author.display_name	Ilaria Alborelli
authorships[9].countries	CH
authorships[9].affiliations[0].institution_ids	https://openalex.org/I2802542264
authorships[9].affiliations[0].raw_affiliation_string	University Hospital Basel, Institute of Medical Genetics and Pathology , Schönbeinstrasse 40, 4031 Basel , Switzerland
authorships[9].affiliations[1].raw_affiliation_string	, Schönbeinstrasse 40, 4031 Basel , Switzerland
authorships[9].institutions[0].id	https://openalex.org/I2802542264
authorships[9].institutions[0].ror	https://ror.org/04k51q396
authorships[9].institutions[0].type	healthcare
authorships[9].institutions[0].lineage	https://openalex.org/I2802542264
authorships[9].institutions[0].country_code	CH
authorships[9].institutions[0].display_name	University Hospital of Basel
authorships[9].author_position	middle
authorships[9].raw_author_name	Ilaria Alborelli
authorships[9].is_corresponding	False
authorships[9].raw_affiliation_strings	, Schönbeinstrasse 40, 4031 Basel , Switzerland, University Hospital Basel, Institute of Medical Genetics and Pathology , Schönbeinstrasse 40, 4031 Basel , Switzerland
authorships[10].author.id	https://openalex.org/A5026343128
authorships[10].author.orcid
authorships[10].author.display_name	Sonali Andani
authorships[10].countries	CH
authorships[10].affiliations[0].institution_ids	https://openalex.org/I4210096263
authorships[10].affiliations[0].raw_affiliation_string	, Grenzacherstrasse 124, 4070 Basel , Switzerland
authorships[10].affiliations[1].institution_ids	https://openalex.org/I118019719
authorships[10].affiliations[1].raw_affiliation_string	F. Hoffmann-La Roche Ltd , Grenzacherstrasse 124, 4070 Basel , Switzerland
authorships[10].affiliations[2].institution_ids	https://openalex.org/I35440088
authorships[10].affiliations[2].raw_affiliation_string	ETH Zurich, Department of Biology , Wolfgang-Pauli-Strasse 27, 8093 Zurich , Switzerland
authorships[10].affiliations[3].institution_ids	https://openalex.org/I12708293
authorships[10].affiliations[3].raw_affiliation_string	Swiss Institute of Bioinformatics, Zurich , Switzerland
authorships[10].affiliations[4].institution_ids	https://openalex.org/I35440088
authorships[10].affiliations[4].raw_affiliation_string	ETH Zurich, Department of Computer Science, Institute of Machine Learning, Universitätstrasse 6 , 8092 Zurich , Switzerland
authorships[10].affiliations[5].institution_ids	https://openalex.org/I4210100468
authorships[10].affiliations[5].raw_affiliation_string	University Hospital Zurich, Biomedical Informatics , Schmelzbergstrasse 26, 8006 Zurich , Switzerland
authorships[10].institutions[0].id	https://openalex.org/I35440088
authorships[10].institutions[0].ror	https://ror.org/05a28rw58
authorships[10].institutions[0].type	education
authorships[10].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[10].institutions[0].country_code	CH
authorships[10].institutions[0].display_name	ETH Zurich
authorships[10].institutions[1].id	https://openalex.org/I4210096263
authorships[10].institutions[1].ror	https://ror.org/00krb3q77
authorships[10].institutions[1].type	other
authorships[10].institutions[1].lineage	https://openalex.org/I4210096263
authorships[10].institutions[1].country_code	CH
authorships[10].institutions[1].display_name	Freiwillige Akademische Gesellschaft
authorships[10].institutions[2].id	https://openalex.org/I118019719
authorships[10].institutions[2].ror	https://ror.org/00by1q217
authorships[10].institutions[2].type	company
authorships[10].institutions[2].lineage	https://openalex.org/I118019719
authorships[10].institutions[2].country_code	CH
authorships[10].institutions[2].display_name	Roche (Switzerland)
authorships[10].institutions[3].id	https://openalex.org/I12708293
authorships[10].institutions[3].ror	https://ror.org/002n09z45
authorships[10].institutions[3].type	nonprofit
authorships[10].institutions[3].lineage	https://openalex.org/I12708293
authorships[10].institutions[3].country_code	CH
authorships[10].institutions[3].display_name	SIB Swiss Institute of Bioinformatics
authorships[10].institutions[4].id	https://openalex.org/I4210100468
authorships[10].institutions[4].ror	https://ror.org/01462r250
authorships[10].institutions[4].type	healthcare
authorships[10].institutions[4].lineage	https://openalex.org/I4210100468
authorships[10].institutions[4].country_code	CH
authorships[10].institutions[4].display_name	University Hospital of Zurich
authorships[10].author_position	middle
authorships[10].raw_author_name	Sonali Andani
authorships[10].is_corresponding	False
authorships[10].raw_affiliation_strings	, Grenzacherstrasse 124, 4070 Basel , Switzerland, ETH Zurich, Department of Biology , Wolfgang-Pauli-Strasse 27, 8093 Zurich , Switzerland, ETH Zurich, Department of Computer Science, Institute of Machine Learning, Universitätstrasse 6 , 8092 Zurich , Switzerland, F. Hoffmann-La Roche Ltd , Grenzacherstrasse 124, 4070 Basel , Switzerland, Swiss Institute of Bioinformatics, Zurich , Switzerland, University Hospital Zurich, Biomedical Informatics , Schmelzbergstrasse 26, 8006 Zurich , Switzerland
authorships[11].author.id	https://openalex.org/A5042722665
authorships[11].author.orcid
authorships[11].author.display_name	Per-Olof Attinger
authorships[11].countries	CH
authorships[11].affiliations[0].institution_ids	https://openalex.org/I4210096263
authorships[11].affiliations[0].raw_affiliation_string	, Grenzacherstrasse 124, 4070 Basel , Switzerland
authorships[11].affiliations[1].institution_ids	https://openalex.org/I118019719
authorships[11].affiliations[1].raw_affiliation_string	F. Hoffmann-La Roche Ltd , Grenzacherstrasse 124, 4070 Basel , Switzerland
authorships[11].institutions[0].id	https://openalex.org/I4210096263
authorships[11].institutions[0].ror	https://ror.org/00krb3q77
authorships[11].institutions[0].type	other
authorships[11].institutions[0].lineage	https://openalex.org/I4210096263
authorships[11].institutions[0].country_code	CH
authorships[11].institutions[0].display_name	Freiwillige Akademische Gesellschaft
authorships[11].institutions[1].id	https://openalex.org/I118019719
authorships[11].institutions[1].ror	https://ror.org/00by1q217
authorships[11].institutions[1].type	company
authorships[11].institutions[1].lineage	https://openalex.org/I118019719
authorships[11].institutions[1].country_code	CH
authorships[11].institutions[1].display_name	Roche (Switzerland)
authorships[11].author_position	middle
authorships[11].raw_author_name	Per-Olof Attinger
authorships[11].is_corresponding	False
authorships[11].raw_affiliation_strings	, Grenzacherstrasse 124, 4070 Basel , Switzerland, F. Hoffmann-La Roche Ltd , Grenzacherstrasse 124, 4070 Basel , Switzerland
authorships[12].author.id	https://openalex.org/A5002292400
authorships[12].author.orcid	https://orcid.org/0000-0003-0581-9579
authorships[12].author.display_name	Marina Bacac
authorships[12].countries	CH
authorships[12].affiliations[0].raw_affiliation_string	, Wagistrasse 10, 8952 Schlieren , Switzerland
authorships[12].affiliations[1].institution_ids	https://openalex.org/I118019719
authorships[12].affiliations[1].raw_affiliation_string	Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich , Wagistrasse 10, 8952 Schlieren , Switzerland
authorships[12].institutions[0].id	https://openalex.org/I118019719
authorships[12].institutions[0].ror	https://ror.org/00by1q217
authorships[12].institutions[0].type	company
authorships[12].institutions[0].lineage	https://openalex.org/I118019719
authorships[12].institutions[0].country_code	CH
authorships[12].institutions[0].display_name	Roche (Switzerland)
authorships[12].author_position	middle
authorships[12].raw_author_name	Marina Bacac
authorships[12].is_corresponding	False
authorships[12].raw_affiliation_strings	, Wagistrasse 10, 8952 Schlieren , Switzerland, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich , Wagistrasse 10, 8952 Schlieren , Switzerland
authorships[13].author.id	https://openalex.org/A5015379488
authorships[13].author.orcid	https://orcid.org/0000-0002-2137-7507
authorships[13].author.display_name	Daniel Baumhoer
authorships[13].countries	CH
authorships[13].affiliations[0].institution_ids	https://openalex.org/I2802542264
authorships[13].affiliations[0].raw_affiliation_string	University Hospital Basel, Institute of Medical Genetics and Pathology , Schönbeinstrasse 40, 4031 Basel , Switzerland
authorships[13].affiliations[1].raw_affiliation_string	, Schönbeinstrasse 40, 4031 Basel , Switzerland
authorships[13].institutions[0].id	https://openalex.org/I2802542264
authorships[13].institutions[0].ror	https://ror.org/04k51q396
authorships[13].institutions[0].type	healthcare
authorships[13].institutions[0].lineage	https://openalex.org/I2802542264
authorships[13].institutions[0].country_code	CH
authorships[13].institutions[0].display_name	University Hospital of Basel
authorships[13].author_position	middle
authorships[13].raw_author_name	Daniel Baumhoer
authorships[13].is_corresponding	False
authorships[13].raw_affiliation_strings	, Schönbeinstrasse 40, 4031 Basel , Switzerland, University Hospital Basel, Institute of Medical Genetics and Pathology , Schönbeinstrasse 40, 4031 Basel , Switzerland
authorships[14].author.id	https://openalex.org/A5017647895
authorships[14].author.orcid	https://orcid.org/0000-0002-0648-6115
authorships[14].author.display_name	Beatrice Beck‐Schimmer
authorships[14].countries	CH
authorships[14].affiliations[0].institution_ids	https://openalex.org/I202697423
authorships[14].affiliations[0].raw_affiliation_string	University of Zurich, VP Medicine , Künstlergasse 15, 8001 Zurich , Switzerland
authorships[14].institutions[0].id	https://openalex.org/I202697423
authorships[14].institutions[0].ror	https://ror.org/02crff812
authorships[14].institutions[0].type	education
authorships[14].institutions[0].lineage	https://openalex.org/I202697423
authorships[14].institutions[0].country_code	CH
authorships[14].institutions[0].display_name	University of Zurich
authorships[14].author_position	middle
authorships[14].raw_author_name	Beatrice Beck-Schimmer
authorships[14].is_corresponding	False
authorships[14].raw_affiliation_strings	University of Zurich, VP Medicine , Künstlergasse 15, 8001 Zurich , Switzerland
authorships[15].author.id	https://openalex.org/A5035497488
authorships[15].author.orcid	https://orcid.org/0000-0002-0573-6119
authorships[15].author.display_name	Niko Beerenwinkel
authorships[15].countries	CH
authorships[15].affiliations[0].institution_ids	https://openalex.org/I35440088
authorships[15].affiliations[0].raw_affiliation_string	ETH Zurich, Department of Biosystems Science and Engineering , Mattenstrasse 26, 4058 Basel , Switzerland
authorships[15].institutions[0].id	https://openalex.org/I35440088
authorships[15].institutions[0].ror	https://ror.org/05a28rw58
authorships[15].institutions[0].type	education
authorships[15].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[15].institutions[0].country_code	CH
authorships[15].institutions[0].display_name	ETH Zurich
authorships[15].author_position	middle
authorships[15].raw_author_name	Niko Beerenwinkel
authorships[15].is_corresponding	False
authorships[15].raw_affiliation_strings	ETH Zurich, Department of Biosystems Science and Engineering , Mattenstrasse 26, 4058 Basel , Switzerland
authorships[16].author.id	https://openalex.org/A5053668445
authorships[16].author.orcid	https://orcid.org/0000-0001-5360-2193
authorships[16].author.display_name	Christian Beisel
authorships[16].countries	CH
authorships[16].affiliations[0].institution_ids	https://openalex.org/I35440088
authorships[16].affiliations[0].raw_affiliation_string	ETH Zurich, Department of Biosystems Science and Engineering , Mattenstrasse 26, 4058 Basel , Switzerland
authorships[16].institutions[0].id	https://openalex.org/I35440088
authorships[16].institutions[0].ror	https://ror.org/05a28rw58
authorships[16].institutions[0].type	education
authorships[16].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[16].institutions[0].country_code	CH
authorships[16].institutions[0].display_name	ETH Zurich
authorships[16].author_position	middle
authorships[16].raw_author_name	Christian Beisel
authorships[16].is_corresponding	False
authorships[16].raw_affiliation_strings	ETH Zurich, Department of Biosystems Science and Engineering , Mattenstrasse 26, 4058 Basel , Switzerland
authorships[17].author.id	https://openalex.org/A5024054789
authorships[17].author.orcid
authorships[17].author.display_name	Lara Bernasconi
authorships[17].countries	CH
authorships[17].affiliations[0].raw_affiliation_string	, Rämistrasse 100, 8091 Zurich , Switzerland
authorships[17].affiliations[1].institution_ids	https://openalex.org/I4210100468
authorships[17].affiliations[1].raw_affiliation_string	University Hospital Zurich, Clinical Trials Center , Rämistrasse 100, 8091 Zurich , Switzerland
authorships[17].institutions[0].id	https://openalex.org/I4210100468
authorships[17].institutions[0].ror	https://ror.org/01462r250
authorships[17].institutions[0].type	healthcare
authorships[17].institutions[0].lineage	https://openalex.org/I4210100468
authorships[17].institutions[0].country_code	CH
authorships[17].institutions[0].display_name	University Hospital of Zurich
authorships[17].author_position	middle
authorships[17].raw_author_name	Lara Bernasconi
authorships[17].is_corresponding	False
authorships[17].raw_affiliation_strings	, Rämistrasse 100, 8091 Zurich , Switzerland, University Hospital Zurich, Clinical Trials Center , Rämistrasse 100, 8091 Zurich , Switzerland
authorships[18].author.id	https://openalex.org/A5059488186
authorships[18].author.orcid	https://orcid.org/0000-0003-0691-0489
authorships[18].author.display_name	Anne Bertolini
authorships[18].countries	CH
authorships[18].affiliations[0].institution_ids	https://openalex.org/I12708293
authorships[18].affiliations[0].raw_affiliation_string	Swiss Institute of Bioinformatics, Zurich , Switzerland
authorships[18].affiliations[1].institution_ids	https://openalex.org/I35440088
authorships[18].affiliations[1].raw_affiliation_string	ETH Zurich, NEXUS Personalized Health Technologies , John-von-Neumann-Weg 9, 8093 Zurich , Switzerland
authorships[18].affiliations[2].raw_affiliation_string	, John-von-Neumann-Weg 9, 8093 Zurich , Switzerland
authorships[18].institutions[0].id	https://openalex.org/I35440088
authorships[18].institutions[0].ror	https://ror.org/05a28rw58
authorships[18].institutions[0].type	education
authorships[18].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[18].institutions[0].country_code	CH
authorships[18].institutions[0].display_name	ETH Zurich
authorships[18].institutions[1].id	https://openalex.org/I12708293
authorships[18].institutions[1].ror	https://ror.org/002n09z45
authorships[18].institutions[1].type	nonprofit
authorships[18].institutions[1].lineage	https://openalex.org/I12708293
authorships[18].institutions[1].country_code	CH
authorships[18].institutions[1].display_name	SIB Swiss Institute of Bioinformatics
authorships[18].author_position	middle
authorships[18].raw_author_name	Anne Bertolini
authorships[18].is_corresponding	False
authorships[18].raw_affiliation_strings	, John-von-Neumann-Weg 9, 8093 Zurich , Switzerland, ETH Zurich, NEXUS Personalized Health Technologies , John-von-Neumann-Weg 9, 8093 Zurich , Switzerland, Swiss Institute of Bioinformatics, Zurich , Switzerland
authorships[19].author.id	https://openalex.org/A5010642463
authorships[19].author.orcid	https://orcid.org/0000-0002-6325-7861
authorships[19].author.display_name	Bernd Bodenmiller
authorships[19].countries	CH
authorships[19].affiliations[0].institution_ids	https://openalex.org/I202697423
authorships[19].affiliations[0].raw_affiliation_string	University of Zurich, Department of Quantitative Biomedicine , Winterthurerstrasse 190, 8057 Zurich , Switzerland
authorships[19].institutions[0].id	https://openalex.org/I202697423
authorships[19].institutions[0].ror	https://ror.org/02crff812
authorships[19].institutions[0].type	education
authorships[19].institutions[0].lineage	https://openalex.org/I202697423
authorships[19].institutions[0].country_code	CH
authorships[19].institutions[0].display_name	University of Zurich
authorships[19].author_position	middle
authorships[19].raw_author_name	Bernd Bodenmiller
authorships[19].is_corresponding	False
authorships[19].raw_affiliation_strings	University of Zurich, Department of Quantitative Biomedicine , Winterthurerstrasse 190, 8057 Zurich , Switzerland
authorships[20].author.id	https://openalex.org/A5049334079
authorships[20].author.orcid	https://orcid.org/0000-0002-4950-6825
authorships[20].author.display_name	Ximena Bonilla
authorships[20].countries	CH
authorships[20].affiliations[0].institution_ids	https://openalex.org/I35440088
authorships[20].affiliations[0].raw_affiliation_string	ETH Zurich, Department of Biology , Wolfgang-Pauli-Strasse 27, 8093 Zurich , Switzerland
authorships[20].affiliations[1].institution_ids	https://openalex.org/I35440088
authorships[20].affiliations[1].raw_affiliation_string	ETH Zurich, Department of Computer Science, Institute of Machine Learning, Universitätstrasse 6 , 8092 Zurich , Switzerland
authorships[20].affiliations[2].institution_ids	https://openalex.org/I4210100468
authorships[20].affiliations[2].raw_affiliation_string	University Hospital Zurich, Biomedical Informatics , Schmelzbergstrasse 26, 8006 Zurich , Switzerland
authorships[20].affiliations[3].institution_ids	https://openalex.org/I12708293
authorships[20].affiliations[3].raw_affiliation_string	Swiss Institute of Bioinformatics, Zurich , Switzerland
authorships[20].institutions[0].id	https://openalex.org/I35440088
authorships[20].institutions[0].ror	https://ror.org/05a28rw58
authorships[20].institutions[0].type	education
authorships[20].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[20].institutions[0].country_code	CH
authorships[20].institutions[0].display_name	ETH Zurich
authorships[20].institutions[1].id	https://openalex.org/I12708293
authorships[20].institutions[1].ror	https://ror.org/002n09z45
authorships[20].institutions[1].type	nonprofit
authorships[20].institutions[1].lineage	https://openalex.org/I12708293
authorships[20].institutions[1].country_code	CH
authorships[20].institutions[1].display_name	SIB Swiss Institute of Bioinformatics
authorships[20].institutions[2].id	https://openalex.org/I4210100468
authorships[20].institutions[2].ror	https://ror.org/01462r250
authorships[20].institutions[2].type	healthcare
authorships[20].institutions[2].lineage	https://openalex.org/I4210100468
authorships[20].institutions[2].country_code	CH
authorships[20].institutions[2].display_name	University Hospital of Zurich
authorships[20].author_position	middle
authorships[20].raw_author_name	Ximena Bonilla
authorships[20].is_corresponding	False
authorships[20].raw_affiliation_strings	ETH Zurich, Department of Biology , Wolfgang-Pauli-Strasse 27, 8093 Zurich , Switzerland, ETH Zurich, Department of Computer Science, Institute of Machine Learning, Universitätstrasse 6 , 8092 Zurich , Switzerland, Swiss Institute of Bioinformatics, Zurich , Switzerland, University Hospital Zurich, Biomedical Informatics , Schmelzbergstrasse 26, 8006 Zurich , Switzerland
authorships[21].author.id	https://openalex.org/A5039484803
authorships[21].author.orcid	https://orcid.org/0000-0002-3957-8120
authorships[21].author.display_name	Ruben Casanova
authorships[21].countries	CH
authorships[21].affiliations[0].institution_ids	https://openalex.org/I202697423
authorships[21].affiliations[0].raw_affiliation_string	University of Zurich, Department of Quantitative Biomedicine , Winterthurerstrasse 190, 8057 Zurich , Switzerland
authorships[21].institutions[0].id	https://openalex.org/I202697423
authorships[21].institutions[0].ror	https://ror.org/02crff812
authorships[21].institutions[0].type	education
authorships[21].institutions[0].lineage	https://openalex.org/I202697423
authorships[21].institutions[0].country_code	CH
authorships[21].institutions[0].display_name	University of Zurich
authorships[21].author_position	middle
authorships[21].raw_author_name	Ruben Casanova
authorships[21].is_corresponding	False
authorships[21].raw_affiliation_strings	University of Zurich, Department of Quantitative Biomedicine , Winterthurerstrasse 190, 8057 Zurich , Switzerland
authorships[22].author.id	https://openalex.org/A5069576688
authorships[22].author.orcid	https://orcid.org/0000-0002-9216-7910
authorships[22].author.display_name	Stéphane Chevrier
authorships[22].countries	CH
authorships[22].affiliations[0].institution_ids	https://openalex.org/I202697423
authorships[22].affiliations[0].raw_affiliation_string	University of Zurich, Department of Quantitative Biomedicine , Winterthurerstrasse 190, 8057 Zurich , Switzerland
authorships[22].institutions[0].id	https://openalex.org/I202697423
authorships[22].institutions[0].ror	https://ror.org/02crff812
authorships[22].institutions[0].type	education
authorships[22].institutions[0].lineage	https://openalex.org/I202697423
authorships[22].institutions[0].country_code	CH
authorships[22].institutions[0].display_name	University of Zurich
authorships[22].author_position	middle
authorships[22].raw_author_name	Stéphane Chevrier
authorships[22].is_corresponding	False
authorships[22].raw_affiliation_strings	University of Zurich, Department of Quantitative Biomedicine , Winterthurerstrasse 190, 8057 Zurich , Switzerland
authorships[23].author.id	https://openalex.org/A5015204578
authorships[23].author.orcid
authorships[23].author.display_name	Natalia Chicherova
authorships[23].countries	CH
authorships[23].affiliations[0].institution_ids	https://openalex.org/I12708293
authorships[23].affiliations[0].raw_affiliation_string	Swiss Institute of Bioinformatics, Zurich , Switzerland
authorships[23].affiliations[1].raw_affiliation_string	, John-von-Neumann-Weg 9, 8093 Zurich , Switzerland
authorships[23].affiliations[2].institution_ids	https://openalex.org/I35440088
authorships[23].affiliations[2].raw_affiliation_string	ETH Zurich, NEXUS Personalized Health Technologies , John-von-Neumann-Weg 9, 8093 Zurich , Switzerland
authorships[23].institutions[0].id	https://openalex.org/I35440088
authorships[23].institutions[0].ror	https://ror.org/05a28rw58
authorships[23].institutions[0].type	education
authorships[23].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[23].institutions[0].country_code	CH
authorships[23].institutions[0].display_name	ETH Zurich
authorships[23].institutions[1].id	https://openalex.org/I12708293
authorships[23].institutions[1].ror	https://ror.org/002n09z45
authorships[23].institutions[1].type	nonprofit
authorships[23].institutions[1].lineage	https://openalex.org/I12708293
authorships[23].institutions[1].country_code	CH
authorships[23].institutions[1].display_name	SIB Swiss Institute of Bioinformatics
authorships[23].author_position	middle
authorships[23].raw_author_name	Natalia Chicherova
authorships[23].is_corresponding	False
authorships[23].raw_affiliation_strings	, John-von-Neumann-Weg 9, 8093 Zurich , Switzerland, ETH Zurich, NEXUS Personalized Health Technologies , John-von-Neumann-Weg 9, 8093 Zurich , Switzerland, Swiss Institute of Bioinformatics, Zurich , Switzerland
authorships[24].author.id	https://openalex.org/A5062938215
authorships[24].author.orcid
authorships[24].author.display_name	Maya D’Costa
authorships[24].countries	CH
authorships[24].affiliations[0].institution_ids	https://openalex.org/I118019719
authorships[24].affiliations[0].raw_affiliation_string	F. Hoffmann-La Roche Ltd , Grenzacherstrasse 124, 4070 Basel , Switzerland
authorships[24].affiliations[1].institution_ids	https://openalex.org/I4210096263
authorships[24].affiliations[1].raw_affiliation_string	, Grenzacherstrasse 124, 4070 Basel , Switzerland
authorships[24].institutions[0].id	https://openalex.org/I4210096263
authorships[24].institutions[0].ror	https://ror.org/00krb3q77
authorships[24].institutions[0].type	other
authorships[24].institutions[0].lineage	https://openalex.org/I4210096263
authorships[24].institutions[0].country_code	CH
authorships[24].institutions[0].display_name	Freiwillige Akademische Gesellschaft
authorships[24].institutions[1].id	https://openalex.org/I118019719
authorships[24].institutions[1].ror	https://ror.org/00by1q217
authorships[24].institutions[1].type	company
authorships[24].institutions[1].lineage	https://openalex.org/I118019719
authorships[24].institutions[1].country_code	CH
authorships[24].institutions[1].display_name	Roche (Switzerland)
authorships[24].author_position	middle
authorships[24].raw_author_name	Maya D'Costa
authorships[24].is_corresponding	False
authorships[24].raw_affiliation_strings	, Grenzacherstrasse 124, 4070 Basel , Switzerland, F. Hoffmann-La Roche Ltd , Grenzacherstrasse 124, 4070 Basel , Switzerland
authorships[25].author.id	https://openalex.org/A5039424527
authorships[25].author.orcid	https://orcid.org/0000-0002-1799-4457
authorships[25].author.display_name	Esther Danenberg
authorships[25].countries	CH
authorships[25].affiliations[0].institution_ids	https://openalex.org/I202697423
authorships[25].affiliations[0].raw_affiliation_string	University of Zurich, Institute of Molecular Life Sciences , Winterthurerstrasse 190, 8057 Zurich , Switzerland
authorships[25].affiliations[1].raw_affiliation_string	, Winterthurerstrasse 190, 8057 Zurich , Switzerland
authorships[25].institutions[0].id	https://openalex.org/I202697423
authorships[25].institutions[0].ror	https://ror.org/02crff812
authorships[25].institutions[0].type	education
authorships[25].institutions[0].lineage	https://openalex.org/I202697423
authorships[25].institutions[0].country_code	CH
authorships[25].institutions[0].display_name	University of Zurich
authorships[25].author_position	middle
authorships[25].raw_author_name	Esther Danenberg
authorships[25].is_corresponding	False
authorships[25].raw_affiliation_strings	, Winterthurerstrasse 190, 8057 Zurich , Switzerland, University of Zurich, Institute of Molecular Life Sciences , Winterthurerstrasse 190, 8057 Zurich , Switzerland
authorships[26].author.id	https://openalex.org/A5076892999
authorships[26].author.orcid	https://orcid.org/0000-0002-1745-8072
authorships[26].author.display_name	Natalie R. Davidson
authorships[26].countries	CH
authorships[26].affiliations[0].institution_ids	https://openalex.org/I12708293
authorships[26].affiliations[0].raw_affiliation_string	Swiss Institute of Bioinformatics, Zurich , Switzerland
authorships[26].affiliations[1].institution_ids	https://openalex.org/I35440088
authorships[26].affiliations[1].raw_affiliation_string	ETH Zurich, Department of Computer Science, Institute of Machine Learning, Universitätstrasse 6 , 8092 Zurich , Switzerland
authorships[26].affiliations[2].institution_ids	https://openalex.org/I4210100468
authorships[26].affiliations[2].raw_affiliation_string	University Hospital Zurich, Biomedical Informatics , Schmelzbergstrasse 26, 8006 Zurich , Switzerland
authorships[26].affiliations[3].institution_ids	https://openalex.org/I35440088
authorships[26].affiliations[3].raw_affiliation_string	ETH Zurich, Department of Biology , Wolfgang-Pauli-Strasse 27, 8093 Zurich , Switzerland
authorships[26].institutions[0].id	https://openalex.org/I35440088
authorships[26].institutions[0].ror	https://ror.org/05a28rw58
authorships[26].institutions[0].type	education
authorships[26].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[26].institutions[0].country_code	CH
authorships[26].institutions[0].display_name	ETH Zurich
authorships[26].institutions[1].id	https://openalex.org/I12708293
authorships[26].institutions[1].ror	https://ror.org/002n09z45
authorships[26].institutions[1].type	nonprofit
authorships[26].institutions[1].lineage	https://openalex.org/I12708293
authorships[26].institutions[1].country_code	CH
authorships[26].institutions[1].display_name	SIB Swiss Institute of Bioinformatics
authorships[26].institutions[2].id	https://openalex.org/I4210100468
authorships[26].institutions[2].ror	https://ror.org/01462r250
authorships[26].institutions[2].type	healthcare
authorships[26].institutions[2].lineage	https://openalex.org/I4210100468
authorships[26].institutions[2].country_code	CH
authorships[26].institutions[2].display_name	University Hospital of Zurich
authorships[26].author_position	middle
authorships[26].raw_author_name	Natalie Davidson
authorships[26].is_corresponding	False
authorships[26].raw_affiliation_strings	ETH Zurich, Department of Biology , Wolfgang-Pauli-Strasse 27, 8093 Zurich , Switzerland, ETH Zurich, Department of Computer Science, Institute of Machine Learning, Universitätstrasse 6 , 8092 Zurich , Switzerland, Swiss Institute of Bioinformatics, Zurich , Switzerland, University Hospital Zurich, Biomedical Informatics , Schmelzbergstrasse 26, 8006 Zurich , Switzerland
authorships[27].author.id	https://openalex.org/A5110909292
authorships[27].author.orcid
authorships[27].author.display_name	Mengkun Gan
authorships[27].countries	CH
authorships[27].affiliations[0].institution_ids	https://openalex.org/I35440088
authorships[27].affiliations[0].raw_affiliation_string	ETH Zurich, Department of Biosystems Science and Engineering , Mattenstrasse 26, 4058 Basel , Switzerland
authorships[27].institutions[0].id	https://openalex.org/I35440088
authorships[27].institutions[0].ror	https://ror.org/05a28rw58
authorships[27].institutions[0].type	education
authorships[27].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[27].institutions[0].country_code	CH
authorships[27].institutions[0].display_name	ETH Zurich
authorships[27].author_position	middle
authorships[27].raw_author_name	Monica-Andreea Dră gan
authorships[27].is_corresponding	False
authorships[27].raw_affiliation_strings	ETH Zurich, Department of Biosystems Science and Engineering , Mattenstrasse 26, 4058 Basel , Switzerland
authorships[28].author.id	https://openalex.org/A5089297467
authorships[28].author.orcid	https://orcid.org/0000-0002-2279-6906
authorships[28].author.display_name	Reinhard Dummer
authorships[28].countries	CH
authorships[28].affiliations[0].institution_ids	https://openalex.org/I35440088
authorships[28].affiliations[0].raw_affiliation_string	ETH Zurich, Department of Biology , Wolfgang-Pauli-Strasse 27, 8093 Zurich , Switzerland
authorships[28].affiliations[1].institution_ids	https://openalex.org/I35440088
authorships[28].affiliations[1].raw_affiliation_string	ETH Zurich, Department of Health Sciences and Technology , Otto-Stern-Weg 3, 8093 Zurich , Switzerland
authorships[28].institutions[0].id	https://openalex.org/I35440088
authorships[28].institutions[0].ror	https://ror.org/05a28rw58
authorships[28].institutions[0].type	education
authorships[28].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[28].institutions[0].country_code	CH
authorships[28].institutions[0].display_name	ETH Zurich
authorships[28].author_position	middle
authorships[28].raw_author_name	Reinhard Dummer
authorships[28].is_corresponding	False
authorships[28].raw_affiliation_strings	ETH Zurich, Department of Biology , Wolfgang-Pauli-Strasse 27, 8093 Zurich , Switzerland, ETH Zurich, Department of Health Sciences and Technology , Otto-Stern-Weg 3, 8093 Zurich , Switzerland
authorships[29].author.id	https://openalex.org/A5005136695
authorships[29].author.orcid	https://orcid.org/0009-0002-3908-8356
authorships[29].author.display_name	Stefanie Engler
authorships[29].countries	CH
authorships[29].affiliations[0].institution_ids	https://openalex.org/I202697423
authorships[29].affiliations[0].raw_affiliation_string	University of Zurich, Department of Quantitative Biomedicine , Winterthurerstrasse 190, 8057 Zurich , Switzerland
authorships[29].institutions[0].id	https://openalex.org/I202697423
authorships[29].institutions[0].ror	https://ror.org/02crff812
authorships[29].institutions[0].type	education
authorships[29].institutions[0].lineage	https://openalex.org/I202697423
authorships[29].institutions[0].country_code	CH
authorships[29].institutions[0].display_name	University of Zurich
authorships[29].author_position	middle
authorships[29].raw_author_name	Stefanie Engler
authorships[29].is_corresponding	False
authorships[29].raw_affiliation_strings	University of Zurich, Department of Quantitative Biomedicine , Winterthurerstrasse 190, 8057 Zurich , Switzerland
authorships[30].author.id	https://openalex.org/A5029424034
authorships[30].author.orcid
authorships[30].author.display_name	Martin Erkens
authorships[30].countries	CH
authorships[30].affiliations[0].institution_ids	https://openalex.org/I4210096263
authorships[30].affiliations[0].raw_affiliation_string	, Grenzacherstrasse 124, 4070 Basel , Switzerland
authorships[30].affiliations[1].institution_ids	https://openalex.org/I118019719
authorships[30].affiliations[1].raw_affiliation_string	Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel , Grenzacherstrasse 124, 4070 Basel , Switzerland
authorships[30].institutions[0].id	https://openalex.org/I4210096263
authorships[30].institutions[0].ror	https://ror.org/00krb3q77
authorships[30].institutions[0].type	other
authorships[30].institutions[0].lineage	https://openalex.org/I4210096263
authorships[30].institutions[0].country_code	CH
authorships[30].institutions[0].display_name	Freiwillige Akademische Gesellschaft
authorships[30].institutions[1].id	https://openalex.org/I118019719
authorships[30].institutions[1].ror	https://ror.org/00by1q217
authorships[30].institutions[1].type	company
authorships[30].institutions[1].lineage	https://openalex.org/I118019719
authorships[30].institutions[1].country_code	CH
authorships[30].institutions[1].display_name	Roche (Switzerland)
authorships[30].author_position	middle
authorships[30].raw_author_name	Martin Erkens
authorships[30].is_corresponding	False
authorships[30].raw_affiliation_strings	, Grenzacherstrasse 124, 4070 Basel , Switzerland, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel , Grenzacherstrasse 124, 4070 Basel , Switzerland
authorships[31].author.id	https://openalex.org/A5028404075
authorships[31].author.orcid
authorships[31].author.display_name	Katja Eschbach
authorships[31].countries	CH
authorships[31].affiliations[0].institution_ids	https://openalex.org/I35440088
authorships[31].affiliations[0].raw_affiliation_string	ETH Zurich, Department of Biosystems Science and Engineering , Mattenstrasse 26, 4058 Basel , Switzerland
authorships[31].institutions[0].id	https://openalex.org/I35440088
authorships[31].institutions[0].ror	https://ror.org/05a28rw58
authorships[31].institutions[0].type	education
authorships[31].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[31].institutions[0].country_code	CH
authorships[31].institutions[0].display_name	ETH Zurich
authorships[31].author_position	middle
authorships[31].raw_author_name	Katja Eschbach
authorships[31].is_corresponding	False
authorships[31].raw_affiliation_strings	ETH Zurich, Department of Biosystems Science and Engineering , Mattenstrasse 26, 4058 Basel , Switzerland
authorships[32].author.id	https://openalex.org/A5023768805
authorships[32].author.orcid
authorships[32].author.display_name	Cinzia Esposito
authorships[32].countries	CH
authorships[32].affiliations[0].institution_ids	https://openalex.org/I202697423
authorships[32].affiliations[0].raw_affiliation_string	University of Zurich, Institute of Molecular Life Sciences , Winterthurerstrasse 190, 8057 Zurich , Switzerland
authorships[32].affiliations[1].raw_affiliation_string	, Winterthurerstrasse 190, 8057 Zurich , Switzerland
authorships[32].institutions[0].id	https://openalex.org/I202697423
authorships[32].institutions[0].ror	https://ror.org/02crff812
authorships[32].institutions[0].type	education
authorships[32].institutions[0].lineage	https://openalex.org/I202697423
authorships[32].institutions[0].country_code	CH
authorships[32].institutions[0].display_name	University of Zurich
authorships[32].author_position	middle
authorships[32].raw_author_name	Cinzia Esposito
authorships[32].is_corresponding	False
authorships[32].raw_affiliation_strings	, Winterthurerstrasse 190, 8057 Zurich , Switzerland, University of Zurich, Institute of Molecular Life Sciences , Winterthurerstrasse 190, 8057 Zurich , Switzerland
authorships[33].author.id	https://openalex.org/A5003887396
authorships[33].author.orcid	https://orcid.org/0000-0002-5613-8629
authorships[33].author.display_name	André Fedier
authorships[33].countries	CH
authorships[33].affiliations[0].institution_ids	https://openalex.org/I1850255, https://openalex.org/I2802542264
authorships[33].affiliations[0].raw_affiliation_string	University Hospital Basel and University of Basel, Department of Biomedicine , Hebelstrasse 20, 4031 Basel , Switzerland
authorships[33].institutions[0].id	https://openalex.org/I2802542264
authorships[33].institutions[0].ror	https://ror.org/04k51q396
authorships[33].institutions[0].type	healthcare
authorships[33].institutions[0].lineage	https://openalex.org/I2802542264
authorships[33].institutions[0].country_code	CH
authorships[33].institutions[0].display_name	University Hospital of Basel
authorships[33].institutions[1].id	https://openalex.org/I1850255
authorships[33].institutions[1].ror	https://ror.org/02s6k3f65
authorships[33].institutions[1].type	education
authorships[33].institutions[1].lineage	https://openalex.org/I1850255
authorships[33].institutions[1].country_code	CH
authorships[33].institutions[1].display_name	University of Basel
authorships[33].author_position	middle
authorships[33].raw_author_name	André Fedier
authorships[33].is_corresponding	False
authorships[33].raw_affiliation_strings	University Hospital Basel and University of Basel, Department of Biomedicine , Hebelstrasse 20, 4031 Basel , Switzerland
authorships[34].author.id	https://openalex.org/A5045484651
authorships[34].author.orcid	https://orcid.org/0000-0003-0559-6125
authorships[34].author.display_name	Pedro Ferreira
authorships[34].countries	CH
authorships[34].affiliations[0].institution_ids	https://openalex.org/I35440088
authorships[34].affiliations[0].raw_affiliation_string	ETH Zurich, Department of Biosystems Science and Engineering , Mattenstrasse 26, 4058 Basel , Switzerland
authorships[34].institutions[0].id	https://openalex.org/I35440088
authorships[34].institutions[0].ror	https://ror.org/05a28rw58
authorships[34].institutions[0].type	education
authorships[34].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[34].institutions[0].country_code	CH
authorships[34].institutions[0].display_name	ETH Zurich
authorships[34].author_position	middle
authorships[34].raw_author_name	Pedro Ferreira
authorships[34].is_corresponding	False
authorships[34].raw_affiliation_strings	ETH Zurich, Department of Biosystems Science and Engineering , Mattenstrasse 26, 4058 Basel , Switzerland
authorships[35].author.id	https://openalex.org/A5019755983
authorships[35].author.orcid	https://orcid.org/0000-0002-9895-2119
authorships[35].author.display_name	Joanna Ficek
authorships[35].countries	CH
authorships[35].affiliations[0].institution_ids	https://openalex.org/I35440088
authorships[35].affiliations[0].raw_affiliation_string	ETH Zurich, Department of Biology , Wolfgang-Pauli-Strasse 27, 8093 Zurich , Switzerland
authorships[35].affiliations[1].institution_ids	https://openalex.org/I35440088
authorships[35].affiliations[1].raw_affiliation_string	ETH Zurich, Department of Computer Science, Institute of Machine Learning, Universitätstrasse 6 , 8092 Zurich , Switzerland
authorships[35].affiliations[2].institution_ids	https://openalex.org/I12708293
authorships[35].affiliations[2].raw_affiliation_string	Swiss Institute of Bioinformatics, Zurich , Switzerland
authorships[35].affiliations[3].institution_ids	https://openalex.org/I4210100468
authorships[35].affiliations[3].raw_affiliation_string	University Hospital Zurich, Biomedical Informatics , Schmelzbergstrasse 26, 8006 Zurich , Switzerland
authorships[35].institutions[0].id	https://openalex.org/I35440088
authorships[35].institutions[0].ror	https://ror.org/05a28rw58
authorships[35].institutions[0].type	education
authorships[35].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[35].institutions[0].country_code	CH
authorships[35].institutions[0].display_name	ETH Zurich
authorships[35].institutions[1].id	https://openalex.org/I12708293
authorships[35].institutions[1].ror	https://ror.org/002n09z45
authorships[35].institutions[1].type	nonprofit
authorships[35].institutions[1].lineage	https://openalex.org/I12708293
authorships[35].institutions[1].country_code	CH
authorships[35].institutions[1].display_name	SIB Swiss Institute of Bioinformatics
authorships[35].institutions[2].id	https://openalex.org/I4210100468
authorships[35].institutions[2].ror	https://ror.org/01462r250
authorships[35].institutions[2].type	healthcare
authorships[35].institutions[2].lineage	https://openalex.org/I4210100468
authorships[35].institutions[2].country_code	CH
authorships[35].institutions[2].display_name	University Hospital of Zurich
authorships[35].author_position	middle
authorships[35].raw_author_name	Joanna Ficek
authorships[35].is_corresponding	False
authorships[35].raw_affiliation_strings	ETH Zurich, Department of Biology , Wolfgang-Pauli-Strasse 27, 8093 Zurich , Switzerland, ETH Zurich, Department of Computer Science, Institute of Machine Learning, Universitätstrasse 6 , 8092 Zurich , Switzerland, Swiss Institute of Bioinformatics, Zurich , Switzerland, University Hospital Zurich, Biomedical Informatics , Schmelzbergstrasse 26, 8006 Zurich , Switzerland
authorships[36].author.id	https://openalex.org/A5046878109
authorships[36].author.orcid	https://orcid.org/0000-0002-7134-1000
authorships[36].author.display_name	Anja Frei
authorships[36].countries	CH
authorships[36].affiliations[0].institution_ids	https://openalex.org/I118019719
authorships[36].affiliations[0].raw_affiliation_string	F. Hoffmann-La Roche Ltd , Grenzacherstrasse 124, 4070 Basel , Switzerland
authorships[36].affiliations[1].institution_ids	https://openalex.org/I4210096263
authorships[36].affiliations[1].raw_affiliation_string	, Grenzacherstrasse 124, 4070 Basel , Switzerland
authorships[36].affiliations[2].institution_ids	https://openalex.org/I35440088
authorships[36].affiliations[2].raw_affiliation_string	ETH Zurich, Department of Biology , Wolfgang-Pauli-Strasse 27, 8093 Zurich , Switzerland
authorships[36].institutions[0].id	https://openalex.org/I35440088
authorships[36].institutions[0].ror	https://ror.org/05a28rw58
authorships[36].institutions[0].type	education
authorships[36].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[36].institutions[0].country_code	CH
authorships[36].institutions[0].display_name	ETH Zurich
authorships[36].institutions[1].id	https://openalex.org/I4210096263
authorships[36].institutions[1].ror	https://ror.org/00krb3q77
authorships[36].institutions[1].type	other
authorships[36].institutions[1].lineage	https://openalex.org/I4210096263
authorships[36].institutions[1].country_code	CH
authorships[36].institutions[1].display_name	Freiwillige Akademische Gesellschaft
authorships[36].institutions[2].id	https://openalex.org/I118019719
authorships[36].institutions[2].ror	https://ror.org/00by1q217
authorships[36].institutions[2].type	company
authorships[36].institutions[2].lineage	https://openalex.org/I118019719
authorships[36].institutions[2].country_code	CH
authorships[36].institutions[2].display_name	Roche (Switzerland)
authorships[36].author_position	middle
authorships[36].raw_author_name	Anja L Frei
authorships[36].is_corresponding	False
authorships[36].raw_affiliation_strings	, Grenzacherstrasse 124, 4070 Basel , Switzerland, ETH Zurich, Department of Biology , Wolfgang-Pauli-Strasse 27, 8093 Zurich , Switzerland, F. Hoffmann-La Roche Ltd , Grenzacherstrasse 124, 4070 Basel , Switzerland
authorships[37].author.id	https://openalex.org/A5048188229
authorships[37].author.orcid	https://orcid.org/0000-0001-5380-6655
authorships[37].author.display_name	Bruno S. Frey
authorships[37].countries	DE
authorships[37].affiliations[0].raw_affiliation_string	, Nonnenwald 2, 82377 Penzberg , Germany
authorships[37].affiliations[1].institution_ids	https://openalex.org/I4210094361
authorships[37].affiliations[1].raw_affiliation_string	Roche Diagnostics GmbH , Nonnenwald 2, 82377 Penzberg , Germany
authorships[37].institutions[0].id	https://openalex.org/I4210094361
authorships[37].institutions[0].ror	https://ror.org/00sh68184
authorships[37].institutions[0].type	company
authorships[37].institutions[0].lineage	https://openalex.org/I118019719, https://openalex.org/I4210094361
authorships[37].institutions[0].country_code	DE
authorships[37].institutions[0].display_name	Roche Pharma AG (Germany)
authorships[37].author_position	middle
authorships[37].raw_author_name	Bruno Frey
authorships[37].is_corresponding	False
authorships[37].raw_affiliation_strings	, Nonnenwald 2, 82377 Penzberg , Germany, Roche Diagnostics GmbH , Nonnenwald 2, 82377 Penzberg , Germany
authorships[38].author.id	https://openalex.org/A5038565479
authorships[38].author.orcid	https://orcid.org/0000-0001-6880-8020
authorships[38].author.display_name	Sandra Goetze
authorships[38].countries	CH
authorships[38].affiliations[0].institution_ids	https://openalex.org/I35440088
authorships[38].affiliations[0].raw_affiliation_string	ETH Zurich, Department of Health Sciences and Technology , Otto-Stern-Weg 3, 8093 Zurich , Switzerland
authorships[38].institutions[0].id	https://openalex.org/I35440088
authorships[38].institutions[0].ror	https://ror.org/05a28rw58
authorships[38].institutions[0].type	education
authorships[38].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[38].institutions[0].country_code	CH
authorships[38].institutions[0].display_name	ETH Zurich
authorships[38].author_position	middle
authorships[38].raw_author_name	Sandra Goetze
authorships[38].is_corresponding	False
authorships[38].raw_affiliation_strings	ETH Zurich, Department of Health Sciences and Technology , Otto-Stern-Weg 3, 8093 Zurich , Switzerland
authorships[39].author.id	https://openalex.org/A5014610359
authorships[39].author.orcid	https://orcid.org/0000-0003-3817-7613
authorships[39].author.display_name	Linda Grob
authorships[39].countries	CH
authorships[39].affiliations[0].institution_ids	https://openalex.org/I12708293
authorships[39].affiliations[0].raw_affiliation_string	Swiss Institute of Bioinformatics, Zurich , Switzerland
authorships[39].affiliations[1].raw_affiliation_string	, John-von-Neumann-Weg 9, 8093 Zurich , Switzerland
authorships[39].affiliations[2].institution_ids	https://openalex.org/I35440088
authorships[39].affiliations[2].raw_affiliation_string	ETH Zurich, NEXUS Personalized Health Technologies , John-von-Neumann-Weg 9, 8093 Zurich , Switzerland
authorships[39].institutions[0].id	https://openalex.org/I35440088
authorships[39].institutions[0].ror	https://ror.org/05a28rw58
authorships[39].institutions[0].type	education
authorships[39].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[39].institutions[0].country_code	CH
authorships[39].institutions[0].display_name	ETH Zurich
authorships[39].institutions[1].id	https://openalex.org/I12708293
authorships[39].institutions[1].ror	https://ror.org/002n09z45
authorships[39].institutions[1].type	nonprofit
authorships[39].institutions[1].lineage	https://openalex.org/I12708293
authorships[39].institutions[1].country_code	CH
authorships[39].institutions[1].display_name	SIB Swiss Institute of Bioinformatics
authorships[39].author_position	middle
authorships[39].raw_author_name	Linda Grob
authorships[39].is_corresponding	False
authorships[39].raw_affiliation_strings	, John-von-Neumann-Weg 9, 8093 Zurich , Switzerland, ETH Zurich, NEXUS Personalized Health Technologies , John-von-Neumann-Weg 9, 8093 Zurich , Switzerland, Swiss Institute of Bioinformatics, Zurich , Switzerland
authorships[40].author.id	https://openalex.org/A5049255125
authorships[40].author.orcid	https://orcid.org/0000-0001-8991-0040
authorships[40].author.display_name	Gabriele Gut
authorships[40].countries	CH
authorships[40].affiliations[0].raw_affiliation_string	, Winterthurerstrasse 190, 8057 Zurich , Switzerland
authorships[40].affiliations[1].institution_ids	https://openalex.org/I202697423
authorships[40].affiliations[1].raw_affiliation_string	University of Zurich, Institute of Molecular Life Sciences , Winterthurerstrasse 190, 8057 Zurich , Switzerland
authorships[40].institutions[0].id	https://openalex.org/I202697423
authorships[40].institutions[0].ror	https://ror.org/02crff812
authorships[40].institutions[0].type	education
authorships[40].institutions[0].lineage	https://openalex.org/I202697423
authorships[40].institutions[0].country_code	CH
authorships[40].institutions[0].display_name	University of Zurich
authorships[40].author_position	middle
authorships[40].raw_author_name	Gabriele Gut
authorships[40].is_corresponding	False
authorships[40].raw_affiliation_strings	, Winterthurerstrasse 190, 8057 Zurich , Switzerland, University of Zurich, Institute of Molecular Life Sciences , Winterthurerstrasse 190, 8057 Zurich , Switzerland
authorships[41].author.id	https://openalex.org/A5034219005
authorships[41].author.orcid	https://orcid.org/0000-0001-7867-4310
authorships[41].author.display_name	Detlef Günther
authorships[41].countries	CH
authorships[41].affiliations[0].institution_ids	https://openalex.org/I35440088
authorships[41].affiliations[0].raw_affiliation_string	ETH Zurich, Department of Chemistry and Applied Biosciences , Vladimir-Prelog-Weg 1-5/10, 8093 Zurich , Switzerland
authorships[41].institutions[0].id	https://openalex.org/I35440088
authorships[41].institutions[0].ror	https://ror.org/05a28rw58
authorships[41].institutions[0].type	education
authorships[41].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[41].institutions[0].country_code	CH
authorships[41].institutions[0].display_name	ETH Zurich
authorships[41].author_position	middle
authorships[41].raw_author_name	Detlef Günther
authorships[41].is_corresponding	False
authorships[41].raw_affiliation_strings	ETH Zurich, Department of Chemistry and Applied Biosciences , Vladimir-Prelog-Weg 1-5/10, 8093 Zurich , Switzerland
authorships[42].author.id	https://openalex.org/A5060606013
authorships[42].author.orcid	https://orcid.org/0000-0001-5704-7721
authorships[42].author.display_name	Martina Haberecker
authorships[42].countries	CH
authorships[42].affiliations[0].institution_ids	https://openalex.org/I118019719
authorships[42].affiliations[0].raw_affiliation_string	F. Hoffmann-La Roche Ltd , Grenzacherstrasse 124, 4070 Basel , Switzerland
authorships[42].affiliations[1].institution_ids	https://openalex.org/I35440088
authorships[42].affiliations[1].raw_affiliation_string	ETH Zurich, Department of Biology , Wolfgang-Pauli-Strasse 27, 8093 Zurich , Switzerland
authorships[42].affiliations[2].institution_ids	https://openalex.org/I4210096263
authorships[42].affiliations[2].raw_affiliation_string	, Grenzacherstrasse 124, 4070 Basel , Switzerland
authorships[42].institutions[0].id	https://openalex.org/I35440088
authorships[42].institutions[0].ror	https://ror.org/05a28rw58
authorships[42].institutions[0].type	education
authorships[42].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[42].institutions[0].country_code	CH
authorships[42].institutions[0].display_name	ETH Zurich
authorships[42].institutions[1].id	https://openalex.org/I4210096263
authorships[42].institutions[1].ror	https://ror.org/00krb3q77
authorships[42].institutions[1].type	other
authorships[42].institutions[1].lineage	https://openalex.org/I4210096263
authorships[42].institutions[1].country_code	CH
authorships[42].institutions[1].display_name	Freiwillige Akademische Gesellschaft
authorships[42].institutions[2].id	https://openalex.org/I118019719
authorships[42].institutions[2].ror	https://ror.org/00by1q217
authorships[42].institutions[2].type	company
authorships[42].institutions[2].lineage	https://openalex.org/I118019719
authorships[42].institutions[2].country_code	CH
authorships[42].institutions[2].display_name	Roche (Switzerland)
authorships[42].author_position	middle
authorships[42].raw_author_name	Martina Haberecker
authorships[42].is_corresponding	False
authorships[42].raw_affiliation_strings	, Grenzacherstrasse 124, 4070 Basel , Switzerland, ETH Zurich, Department of Biology , Wolfgang-Pauli-Strasse 27, 8093 Zurich , Switzerland, F. Hoffmann-La Roche Ltd , Grenzacherstrasse 124, 4070 Basel , Switzerland
authorships[43].author.id	https://openalex.org/A5077969371
authorships[43].author.orcid
authorships[43].author.display_name	Pirmin Haeuptle
authorships[43].countries	CH
authorships[43].affiliations[0].raw_affiliation_string	, Rheinstrasse 26, 4410 Liestal , Switzerland
authorships[43].affiliations[1].institution_ids	https://openalex.org/I4210103657
authorships[43].affiliations[1].raw_affiliation_string	Cantonal Hospital Baselland, Medical University Clinic , Rheinstrasse 26, 4410 Liestal , Switzerland
authorships[43].institutions[0].id	https://openalex.org/I4210103657
authorships[43].institutions[0].ror	https://ror.org/01azdfc53
authorships[43].institutions[0].type	facility
authorships[43].institutions[0].lineage	https://openalex.org/I4210103657
authorships[43].institutions[0].country_code	CH
authorships[43].institutions[0].display_name	Psychiatry Baselland
authorships[43].author_position	middle
authorships[43].raw_author_name	Pirmin Haeuptle
authorships[43].is_corresponding	False
authorships[43].raw_affiliation_strings	, Rheinstrasse 26, 4410 Liestal , Switzerland, Cantonal Hospital Baselland, Medical University Clinic , Rheinstrasse 26, 4410 Liestal , Switzerland
authorships[44].author.id	https://openalex.org/A5057030543
authorships[44].author.orcid	https://orcid.org/0000-0002-4056-3225
authorships[44].author.display_name	Viola Heinzelmann‐Schwarz
authorships[44].countries	CH
authorships[44].affiliations[0].institution_ids	https://openalex.org/I2802542264
authorships[44].affiliations[0].raw_affiliation_string	University Hospital Basel, Gynecological Cancer Center , Spitalstrasse 21, 4031 Basel , Switzerland
authorships[44].affiliations[1].institution_ids	https://openalex.org/I4210152508
authorships[44].affiliations[1].raw_affiliation_string	, Spitalstrasse 21, 4031 Basel , Switzerland
authorships[44].affiliations[2].institution_ids	https://openalex.org/I1850255, https://openalex.org/I2802542264
authorships[44].affiliations[2].raw_affiliation_string	University Hospital Basel and University of Basel, Department of Biomedicine , Hebelstrasse 20, 4031 Basel , Switzerland
authorships[44].institutions[0].id	https://openalex.org/I4210152508
authorships[44].institutions[0].ror	https://ror.org/04tdwrq43
authorships[44].institutions[0].type	healthcare
authorships[44].institutions[0].lineage	https://openalex.org/I4210152508
authorships[44].institutions[0].country_code	CH
authorships[44].institutions[0].display_name	Bethesda Spital
authorships[44].institutions[1].id	https://openalex.org/I2802542264
authorships[44].institutions[1].ror	https://ror.org/04k51q396
authorships[44].institutions[1].type	healthcare
authorships[44].institutions[1].lineage	https://openalex.org/I2802542264
authorships[44].institutions[1].country_code	CH
authorships[44].institutions[1].display_name	University Hospital of Basel
authorships[44].institutions[2].id	https://openalex.org/I1850255
authorships[44].institutions[2].ror	https://ror.org/02s6k3f65
authorships[44].institutions[2].type	education
authorships[44].institutions[2].lineage	https://openalex.org/I1850255
authorships[44].institutions[2].country_code	CH
authorships[44].institutions[2].display_name	University of Basel
authorships[44].author_position	middle
authorships[44].raw_author_name	Viola Heinzelmann-Schwarz
authorships[44].is_corresponding	False
authorships[44].raw_affiliation_strings	, Spitalstrasse 21, 4031 Basel , Switzerland, University Hospital Basel and University of Basel, Department of Biomedicine , Hebelstrasse 20, 4031 Basel , Switzerland, University Hospital Basel, Gynecological Cancer Center , Spitalstrasse 21, 4031 Basel , Switzerland
authorships[45].author.id	https://openalex.org/A5006906885
authorships[45].author.orcid
authorships[45].author.display_name	Sylvia Herter
authorships[45].countries	CH
authorships[45].affiliations[0].raw_affiliation_string	, Wagistrasse 10, 8952 Schlieren , Switzerland
authorships[45].affiliations[1].institution_ids	https://openalex.org/I118019719
authorships[45].affiliations[1].raw_affiliation_string	Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich , Wagistrasse 10, 8952 Schlieren , Switzerland
authorships[45].institutions[0].id	https://openalex.org/I118019719
authorships[45].institutions[0].ror	https://ror.org/00by1q217
authorships[45].institutions[0].type	company
authorships[45].institutions[0].lineage	https://openalex.org/I118019719
authorships[45].institutions[0].country_code	CH
authorships[45].institutions[0].display_name	Roche (Switzerland)
authorships[45].author_position	middle
authorships[45].raw_author_name	Sylvia Herter
authorships[45].is_corresponding	False
authorships[45].raw_affiliation_strings	, Wagistrasse 10, 8952 Schlieren , Switzerland, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich , Wagistrasse 10, 8952 Schlieren , Switzerland
authorships[46].author.id	https://openalex.org/A5000438273
authorships[46].author.orcid	https://orcid.org/0009-0006-7599-6684
authorships[46].author.display_name	René Holtackers
authorships[46].countries	CH
authorships[46].affiliations[0].institution_ids	https://openalex.org/I202697423
authorships[46].affiliations[0].raw_affiliation_string	University of Zurich, Institute of Molecular Life Sciences , Winterthurerstrasse 190, 8057 Zurich , Switzerland
authorships[46].affiliations[1].raw_affiliation_string	, Winterthurerstrasse 190, 8057 Zurich , Switzerland
authorships[46].institutions[0].id	https://openalex.org/I202697423
authorships[46].institutions[0].ror	https://ror.org/02crff812
authorships[46].institutions[0].type	education
authorships[46].institutions[0].lineage	https://openalex.org/I202697423
authorships[46].institutions[0].country_code	CH
authorships[46].institutions[0].display_name	University of Zurich
authorships[46].author_position	middle
authorships[46].raw_author_name	Rene Holtackers
authorships[46].is_corresponding	False
authorships[46].raw_affiliation_strings	, Winterthurerstrasse 190, 8057 Zurich , Switzerland, University of Zurich, Institute of Molecular Life Sciences , Winterthurerstrasse 190, 8057 Zurich , Switzerland
authorships[47].author.id	https://openalex.org/A5045573675
authorships[47].author.orcid
authorships[47].author.display_name	Tamara Huesser
authorships[47].countries	CH
authorships[47].affiliations[0].institution_ids	https://openalex.org/I118019719
authorships[47].affiliations[0].raw_affiliation_string	Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich , Wagistrasse 10, 8952 Schlieren , Switzerland
authorships[47].affiliations[1].raw_affiliation_string	, Wagistrasse 10, 8952 Schlieren , Switzerland
authorships[47].institutions[0].id	https://openalex.org/I118019719
authorships[47].institutions[0].ror	https://ror.org/00by1q217
authorships[47].institutions[0].type	company
authorships[47].institutions[0].lineage	https://openalex.org/I118019719
authorships[47].institutions[0].country_code	CH
authorships[47].institutions[0].display_name	Roche (Switzerland)
authorships[47].author_position	middle
authorships[47].raw_author_name	Tamara Huesser
authorships[47].is_corresponding	False
authorships[47].raw_affiliation_strings	, Wagistrasse 10, 8952 Schlieren , Switzerland, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich , Wagistrasse 10, 8952 Schlieren , Switzerland
authorships[48].author.id	https://openalex.org/A5066422713
authorships[48].author.orcid	https://orcid.org/0000-0001-9820-1844
authorships[48].author.display_name	Anja Irmisch
authorships[48].countries	CH
authorships[48].affiliations[0].institution_ids	https://openalex.org/I35440088
authorships[48].affiliations[0].raw_affiliation_string	ETH Zurich, Department of Health Sciences and Technology , Otto-Stern-Weg 3, 8093 Zurich , Switzerland
authorships[48].affiliations[1].institution_ids	https://openalex.org/I35440088
authorships[48].affiliations[1].raw_affiliation_string	ETH Zurich, Department of Biology , Wolfgang-Pauli-Strasse 27, 8093 Zurich , Switzerland
authorships[48].institutions[0].id	https://openalex.org/I35440088
authorships[48].institutions[0].ror	https://ror.org/05a28rw58
authorships[48].institutions[0].type	education
authorships[48].institutions[0].lineage	https://openalex.org/I2799323385, https://openalex.org/I35440088
authorships[48].institutions[0].country_code	CH
authorships[48].institutions[0].display_name	ETH Zurich
authorships[48].author_position	middle
authorships[48].raw_author_name	Anja Irmisch
authorships[48].is_corresponding	False
authorships[48].raw_affiliation_strings	ETH Zurich, Department of Biology , Wolfgang-Pauli-Strasse 27, 8093 Zurich , Switzerland, ETH Zurich, Department of Health Sciences and Technology , Otto-Stern-Weg 3, 8093 Zurich , Switzerland
authorships[49].author.id	https://openalex.org/A5040470585
authorships[49].author.orcid	https://orcid.org/0000-0002-0446-1942
authorships[49].author.display_name	Francis Jacob
authorships[49].countries	CH
authorships[49].affiliations[0].institution_ids	https://openalex.org/I1850255, https://openalex.org/I2802542264
authorships[49].affiliations[0].raw_affiliation_string	University Hospital Basel and University of Basel, Department of Biomedicine , Hebelstrasse 20, 4031 Basel , Switzerland
authorships[49].institutions[0].id	https://openalex.org/I2802542264
authorships[49].institutions[0].ror	https://ror.org/04k51q396
authorships[49].institutions[0].type	healthcare
authorships[49].institutions[0].lineage	https://openalex.org/I2802542264
authorships[49].institutions[0].country_code	CH
authorships[49].institutions[0].display_name	University Hospital of Basel
authorships[49].institutions[1].id	https://openalex.org/I1850255
authorships[49].institutions[1].ror	https://ror.org/02s6k3f65
authorships[49].institutions[1].type	education
authorships[49].institutions[1].lineage	https://openalex.org/I1850255
authorships[49].institutions[1].country_code	CH
authorships[49].institutions[1].display_name	University of Basel
authorships[49].author_position	middle
authorships[49].raw_author_name	Francis Jacob
authorships[49].is_corresponding	False
authorships[49].raw_affiliation_strings	University Hospital Basel and University of Basel, Department of Biomedicine , Hebelstrasse 20, 4031 Basel , Switzerland
has_content.pdf	True
has_content.grobid_xml	True
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://academic.oup.com/bioinformatics/article-pdf/36/Supplement_2/i919/35336849/btaa843.pdf
open_access.oa_status	hybrid
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	SCIM: universal single-cell matching with unpaired feature sets
has_fulltext	False
is_retracted	False
updated_date	2025-11-23T05:10:03.516525
primary_topic.id	https://openalex.org/T11289
primary_topic.field.id	https://openalex.org/fields/13
primary_topic.field.display_name	Biochemistry, Genetics and Molecular Biology
primary_topic.score	1.0
primary_topic.domain.id	https://openalex.org/domains/1
primary_topic.domain.display_name	Life Sciences
primary_topic.subfield.id	https://openalex.org/subfields/1312
primary_topic.subfield.display_name	Molecular Biology
primary_topic.display_name	Single-cell and spatial transcriptomics
related_works	https://openalex.org/W3013693939, https://openalex.org/W2566616303, https://openalex.org/W2159052453, https://openalex.org/W3131327266, https://openalex.org/W2734887215, https://openalex.org/W2803255133, https://openalex.org/W4297051394, https://openalex.org/W2752972570, https://openalex.org/W2010725720, https://openalex.org/W4310066305
cited_by_count	63
counts_by_year[0].year	2025
counts_by_year[0].cited_by_count	12
counts_by_year[1].year	2024
counts_by_year[1].cited_by_count	12
counts_by_year[2].year	2023
counts_by_year[2].cited_by_count	15
counts_by_year[3].year	2022
counts_by_year[3].cited_by_count	12
counts_by_year[4].year	2021
counts_by_year[4].cited_by_count	11
counts_by_year[5].year	2020
counts_by_year[5].cited_by_count	1
locations_count	4
best_oa_location.id	doi:10.1093/bioinformatics/btaa843
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S52395412
best_oa_location.source.issn	1367-4803, 1367-4811
best_oa_location.source.type	journal
best_oa_location.source.is_oa	False
best_oa_location.source.issn_l	1367-4803
best_oa_location.source.is_core	True
best_oa_location.source.is_in_doaj	True
best_oa_location.source.display_name	Bioinformatics
best_oa_location.source.host_organization	https://openalex.org/P4310311648
best_oa_location.source.host_organization_name	Oxford University Press
best_oa_location.source.host_organization_lineage	https://openalex.org/P4310311648, https://openalex.org/P4310311647
best_oa_location.source.host_organization_lineage_names	Oxford University Press, University of Oxford
best_oa_location.license	cc-by
best_oa_location.pdf_url	https://academic.oup.com/bioinformatics/article-pdf/36/Supplement_2/i919/35336849/btaa843.pdf
best_oa_location.version	publishedVersion
best_oa_location.raw_type	journal-article
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	True
best_oa_location.raw_source_name	Bioinformatics
best_oa_location.landing_page_url	https://doi.org/10.1093/bioinformatics/btaa843
primary_location.id	doi:10.1093/bioinformatics/btaa843
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S52395412
primary_location.source.issn	1367-4803, 1367-4811
primary_location.source.type	journal
primary_location.source.is_oa	False
primary_location.source.issn_l	1367-4803
primary_location.source.is_core	True
primary_location.source.is_in_doaj	True
primary_location.source.display_name	Bioinformatics
primary_location.source.host_organization	https://openalex.org/P4310311648
primary_location.source.host_organization_name	Oxford University Press
primary_location.source.host_organization_lineage	https://openalex.org/P4310311648, https://openalex.org/P4310311647
primary_location.source.host_organization_lineage_names	Oxford University Press, University of Oxford
primary_location.license	cc-by
primary_location.pdf_url	https://academic.oup.com/bioinformatics/article-pdf/36/Supplement_2/i919/35336849/btaa843.pdf
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	Bioinformatics
primary_location.landing_page_url	https://doi.org/10.1093/bioinformatics/btaa843
publication_date	2020-09-14
publication_year	2020
referenced_works	https://openalex.org/W2038254572, https://openalex.org/W1602702667, https://openalex.org/W2940982798, https://openalex.org/W3043558371, https://openalex.org/W2611919322, https://openalex.org/W2794660702, https://openalex.org/W2104363966, https://openalex.org/W2053129129, https://openalex.org/W6765779288, https://openalex.org/W3005957343, https://openalex.org/W6631190155, https://openalex.org/W6640963894, https://openalex.org/W1654189297, https://openalex.org/W2166541787, https://openalex.org/W6763509818, https://openalex.org/W6756663807, https://openalex.org/W6762464624, https://openalex.org/W3010981820, https://openalex.org/W6748582592, https://openalex.org/W2889594596, https://openalex.org/W2951084686, https://openalex.org/W2966593302, https://openalex.org/W2766959028, https://openalex.org/W2739492614, https://openalex.org/W2949177718, https://openalex.org/W2149573463, https://openalex.org/W2332292689, https://openalex.org/W6745535286, https://openalex.org/W2150879893, https://openalex.org/W2968352143, https://openalex.org/W2950030509, https://openalex.org/W2948469692, https://openalex.org/W6760396648, https://openalex.org/W2997207862, https://openalex.org/W2978997241, https://openalex.org/W2187089797, https://openalex.org/W2559655401, https://openalex.org/W2785678896, https://openalex.org/W2791457355, https://openalex.org/W3120224790, https://openalex.org/W1522301498, https://openalex.org/W2930634306, https://openalex.org/W4301206121, https://openalex.org/W3122308234, https://openalex.org/W1977545325, https://openalex.org/W2950662112, https://openalex.org/W1959608418, https://openalex.org/W2951004968, https://openalex.org/W2612972698
referenced_works_count	49
abstract_inverted_index.a	22, 107, 124, 142, 164, 179, 210, 215, 225, 233
abstract_inverted_index.In	47
abstract_inverted_index.It	140
abstract_inverted_index.We	99, 175
abstract_inverted_index.an	8, 147, 151
abstract_inverted_index.at	259
abstract_inverted_index.by	44, 158, 191
abstract_inverted_index.in	10, 86, 93, 114, 232
abstract_inverted_index.is	135
abstract_inverted_index.of	15, 24, 31, 40, 245
abstract_inverted_index.on	170, 178, 197
abstract_inverted_index.or	33, 116
abstract_inverted_index.to	7, 20, 66, 79, 89, 110, 206, 228
abstract_inverted_index.we	202, 221
abstract_inverted_index.78%	239
abstract_inverted_index.90%	237
abstract_inverted_index.Due	65
abstract_inverted_index.The	18
abstract_inverted_index.and	13, 57, 129, 184, 214, 238, 250
abstract_inverted_index.are	63, 77, 96, 156, 257
abstract_inverted_index.can	72
abstract_inverted_index.for	242
abstract_inverted_index.its	90
abstract_inverted_index.led	6
abstract_inverted_index.one	87, 244
abstract_inverted_index.our	204
abstract_inverted_index.out	85
abstract_inverted_index.set	23
abstract_inverted_index.the	11, 29, 38, 41, 54, 67, 131, 171, 187, 194, 198, 246
abstract_inverted_index.two	115, 207
abstract_inverted_index.via	104
abstract_inverted_index.SCIM	119, 177, 192
abstract_inverted_index.able	78
abstract_inverted_index.bone	217
abstract_inverted_index.cell	88, 133
abstract_inverted_index.data	102, 256
abstract_inverted_index.each	45, 243
abstract_inverted_index.from	224
abstract_inverted_index.have	5
abstract_inverted_index.more	117
abstract_inverted_index.most	48
abstract_inverted_index.pair	222
abstract_inverted_index.same	195
abstract_inverted_index.show	185
abstract_inverted_index.size	69
abstract_inverted_index.such	112
abstract_inverted_index.that	76, 121, 130, 168, 186
abstract_inverted_index.thus	58
abstract_inverted_index.used	55
abstract_inverted_index.with	150
abstract_inverted_index.CyTOF	234
abstract_inverted_index.allow	28
abstract_inverted_index.apply	203
abstract_inverted_index.cells	56, 122, 160, 223, 231
abstract_inverted_index.data.	17
abstract_inverted_index.human	216
abstract_inverted_index.lost.	64
abstract_inverted_index.match	81
abstract_inverted_index.scRNA	226
abstract_inverted_index.share	123
abstract_inverted_index.sheer	68
abstract_inverted_index.space	145
abstract_inverted_index.their	229
abstract_inverted_index.tumor	212
abstract_inverted_index.using	146, 163
abstract_inverted_index.where	220
abstract_inverted_index.would	27
abstract_inverted_index.Recent	2
abstract_inverted_index.across	138, 161
abstract_inverted_index.cases,	49
abstract_inverted_index.common	125
abstract_inverted_index.latent	144, 173
abstract_inverted_index.marrow	218
abstract_inverted_index.method	205
abstract_inverted_index.sample	213
abstract_inverted_index.scheme	167
abstract_inverted_index.(SCIM),	106
abstract_inverted_index.Results	98
abstract_inverted_index.ability	19
abstract_inverted_index.another	94
abstract_inverted_index.assumes	120
abstract_inverted_index.between	61
abstract_inverted_index.carried	84
abstract_inverted_index.consume	53
abstract_inverted_index.dataset	227, 235
abstract_inverted_index.derived	190
abstract_inverted_index.matches	189
abstract_inverted_index.needed.	97
abstract_inverted_index.online.	261
abstract_inverted_index.pairing	159
abstract_inverted_index.process	183
abstract_inverted_index.propose	100
abstract_inverted_index.recover	111
abstract_inverted_index.reflect	193
abstract_inverted_index.sample,	219
abstract_inverted_index.sibling	92, 230
abstract_inverted_index.through	37
abstract_inverted_index.Abstract	0
abstract_inverted_index.Matching	105
abstract_inverted_index.accuracy	241
abstract_inverted_index.acquire,	73
abstract_inverted_index.advances	4
abstract_inverted_index.afforded	43
abstract_inverted_index.approach	109
abstract_inverted_index.cellular	181
abstract_inverted_index.constant	137
abstract_inverted_index.dataset.	200
abstract_inverted_index.datasets	62, 71, 155
abstract_inverted_index.evaluate	176
abstract_inverted_index.however,	50
abstract_inverted_index.increase	9
abstract_inverted_index.matching	166
abstract_inverted_index.melanoma	211
abstract_inverted_index.operates	169
abstract_inverted_index.pairwise	59
abstract_inverted_index.samples,	247
abstract_inverted_index.scalable	74, 108
abstract_inverted_index.Moreover,	201
abstract_inverted_index.achieving	236
abstract_inverted_index.available	258
abstract_inverted_index.bipartite	165
abstract_inverted_index.branching	182
abstract_inverted_index.framework	149
abstract_inverted_index.integrate	21
abstract_inverted_index.profiling	51
abstract_inverted_index.simulated	180, 199
abstract_inverted_index.structure	128
abstract_inverted_index.Motivation	1
abstract_inverted_index.algorithms	75
abstract_inverted_index.clinically	34
abstract_inverted_index.constructs	141
abstract_inverted_index.integrated	157
abstract_inverted_index.meaningful	35
abstract_inverted_index.objective.	153
abstract_inverted_index.production	12
abstract_inverted_index.pseudotime	196
abstract_inverted_index.real-world	208
abstract_inverted_index.scenarios,	209
abstract_inverted_index.technology	95
abstract_inverted_index.underlying	127, 132
abstract_inverted_index.Integration	103
abstract_inverted_index.Multi-modal	154
abstract_inverted_index.Single-Cell	101
abstract_inverted_index.adversarial	152
abstract_inverted_index.autoencoder	148
abstract_inverted_index.information	254
abstract_inverted_index.single-cell	16, 70, 82
abstract_inverted_index.technology.	46
abstract_inverted_index.unification	39
abstract_inverted_index.universally	80
abstract_inverted_index.Availability	249
abstract_inverted_index.availability	14
abstract_inverted_index.biologically	32
abstract_inverted_index.cell-to-cell	188
abstract_inverted_index.distribution	134
abstract_inverted_index.measurements	26, 83
abstract_inverted_index.observations	36
abstract_inverted_index.perspectives	42
abstract_inverted_index.technologies	52, 162
abstract_inverted_index.Supplementary	253, 255
abstract_inverted_index.approximately	136
abstract_inverted_index.cell-matching	240
abstract_inverted_index.corresponding	91
abstract_inverted_index.respectively.	248
abstract_inverted_index.technological	3
abstract_inverted_index.technologies.	118, 139
abstract_inverted_index.Bioinformatics	260
abstract_inverted_index.identification	30
abstract_inverted_index.implementation	251
abstract_inverted_index.correspondences	60, 113
abstract_inverted_index.low-dimensional	172
abstract_inverted_index.multi-technology	25
abstract_inverted_index.representations.	174
abstract_inverted_index.(low-dimensional)	126
abstract_inverted_index.technology-invariant	143
abstract_inverted_index.https://github.com/ratschlab/scim.	252
cited_by_percentile_year.max	99
cited_by_percentile_year.min	89
corresponding_author_ids	https://openalex.org/A5022555275, https://openalex.org/A5022555275, https://openalex.org/A5035416263, https://openalex.org/A5035416263, https://openalex.org/A5057848295
countries_distinct_count	2
institutions_distinct_count	126
corresponding_institution_ids	https://openalex.org/I118564535, https://openalex.org/I12708293, https://openalex.org/I202697423, https://openalex.org/I2802542264, https://openalex.org/I35440088, https://openalex.org/I4210100468, https://openalex.org/I4210118307
sustainable_development_goals[0].id	https://metadata.un.org/sdg/9
sustainable_development_goals[0].score	0.6000000238418579
sustainable_development_goals[0].display_name	Industry, innovation and infrastructure
citation_normalized_percentile.value	0.9397877
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	True