CALML5 is a novel diagnostic marker for differentiating thymic squamous cell carcinoma from type B3 thymoma
Article Swipe
Koichiro Kanamori
,
Kentaro Suina
,
Takehito Shukuya
,
Fumiyuki Takahashi
,
Takuo Hayashi
,
Kieko Hara
,
Tsuyoshi Saito
,
Yoichiro Mitsuishi
,
Shoko Shimamura
,
Wira Winardi
,
Ken Tajima
,
Ryo Ko
,
Tomoyasu Mimori
,
Tetsuhiko Asao
,
Masayoshi Itoh
,
Hideya Kawaji
,
Yoshiyuki Suehara
,
Kazuya Takamochi
,
Kenji Suzuki
,
Kazuhisa Takahashi
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1111/1759-7714.14853
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1111/1759-7714.14853
Background Thymic squamous cell carcinoma and type B3 thymoma are primary neoplasms of the anterior mediastinum that are sometimes difficult to differentiate from one another histologically. However, only a few immunohistochemical markers are available for the differential diagnosis. The purpose of this study was to discover a novel marker for differentiating between thymic squamous cell carcinoma and type B3 thymoma. Methods We used histological samples of thymic carcinomas ( n = 26) and type B3 thymomas ( n = 38) which were resected between 1986 and 2017. To search for candidates of differential markers, gene expression levels were evaluated in samples using promoter analysis by cap analysis of gene expression (CAGE) sequencing. Results Promoter level expression of CALML5 genes was significantly higher in thymic carcinomas than in type B3 thymomas. We further validated the results of the CAGE analysis in all 26 thymic carcinomas and 38 type B3 thymomas by immunohistochemistry (IHC). CALML5 was strongly expressed in the cytoplasm in 19 of 26 cases with thymic carcinoma, whereas positivity at the protein level was shown in two of 38 type B3 thymomas. Thus, the sensitivity (73.1%) and specificity (94.7%) of CALML5 as markers for immunohistochemical diagnosis of thymic carcinoma were extremely high. Conclusion We identified CALML5 as a potential marker for differentiating thymic squamous cell carcinoma from type B3 thymoma. It is assumed that future clinical use of CALML5 may improve the diagnostic accuracy of differentiating between these two diseases.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/1759-7714.14853
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1759-7714.14853
- OA Status
- gold
- Cited By
- 11
- References
- 33
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4327596671
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4327596671Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/1759-7714.14853Digital Object Identifier
- Title
-
CALML5 is a novel diagnostic marker for differentiating thymic squamous cell carcinoma from typeB3 thymomaWork title - Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-03-16Full publication date if available
- Authors
-
Koichiro Kanamori, Kentaro Suina, Takehito Shukuya, Fumiyuki Takahashi, Takuo Hayashi, Kieko Hara, Tsuyoshi Saito, Yoichiro Mitsuishi, Shoko Shimamura, Wira Winardi, Ken Tajima, Ryo Ko, Tomoyasu Mimori, Tetsuhiko Asao, Masayoshi Itoh, Hideya Kawaji, Yoshiyuki Suehara, Kazuya Takamochi, Kenji Suzuki, Kazuhisa TakahashiList of authors in order
- Landing page
-
https://doi.org/10.1111/1759-7714.14853Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1759-7714.14853Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1759-7714.14853Direct OA link when available
- Concepts
-
Thymoma, Thymic carcinoma, Immunohistochemistry, Medicine, Pathology, Differential diagnosis, CarcinomaTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
11Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 4, 2023: 2Per-year citation counts (last 5 years)
- References (count)
-
33Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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