Seasonal variation of pediatric asthma exacerbations and its association with asthma phenotypes Article Swipe
Firdian Makrufardi
,
Desy Rusmawatiningtyas
,
Indah Kartika Murni
,
Eggi Arguni
,
Yuan‐Chien Lin
,
Kin‐Fai Ho
,
Kian Fan Chung
,
Sheng-Chieh Lin
,
Hsiao‐Chi Chuang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41390-025-04073-2
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41390-025-04073-2
Background The objective of this study was to examine the associations of blood inflammatory phenotypes with acute pediatric asthma exacerbations during different seasons and the COVID-19 pandemic. Methods A retrospective study was conducted involving 32,160 pediatric asthma patients from January 2008 to December 2021. Asthma blood inflammatory phenotypes were categorized based on low (L) and high (H) eosinophils (E) and neutrophils (N) (LBE/HBE: ≥ 0.25 × 10 9 /L and LBN/HBN: ≥ 5 × 10 9 /L, respectively) and logistic regression was used to examine the odds ratio (OR) of outcome variables. Results A 10 9 /L increase of neutrophils and eosinophils was associated with a 1.015-fold (95% CI: 1.009–1.021) and a 1.057-fold increase in the OR (95% CI: 1.026–1.088) for asthma exacerbations of hospitalized pediatric asthma patients. An increase in HBE/LBN phenotype was associated with a respective 1.232-fold (95% CI: 1.081–1.404) and 1.248-fold (95% CI: 1.101–1.414) increase in the OR for asthma exacerbations of hospitalized pediatric asthma patients before the COVID-19 pandemic in the winter and autumn seasons. However, an increase of LBE/LBN phenotype was associated with a respective 0.873-fold (95% CI: 0.769–0.991), 0.872-fold (95% CI: 0.771–0.986), and 0.813-fold (95% CI: 0.709–0.932) decrease in the OR for asthma exacerbations in the winter, spring and summer seasons. Conclusions HBE/LBN phenotype had a higher risk of asthma exacerbations among hospitalized pediatric asthma patients in the winter and autumn, while LBE/LBN phenotype had a lower risk in the winter, spring, and summer. Impact Blood eosinophils and neutrophils have been indicated to have a potential influence on pediatric asthma development and severity. HBE/LBN phenotype was associated with increased asthma exacerbations among hospitalized pediatric asthma patients during winter and autumn. Eosinophil and neutrophil predominance exhibited a higher influence on pediatric asthma exacerbations.
Related Topics
Concepts
Asthma
Medicine
Odds ratio
Logistic regression
Phenotype
Immunology
Internal medicine
Asthma exacerbations
Pandemic
Coronavirus disease 2019 (COVID-19)
Gene
Biology
Disease
Biochemistry
Infectious disease (medical specialty)
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41390-025-04073-2
- https://www.nature.com/articles/s41390-025-04073-2.pdf
- OA Status
- hybrid
- References
- 44
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410140194
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4410140194Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41390-025-04073-2Digital Object Identifier
- Title
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Seasonal variation of pediatric asthma exacerbations and its association with asthma phenotypesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-05-07Full publication date if available
- Authors
-
Firdian Makrufardi, Desy Rusmawatiningtyas, Indah Kartika Murni, Eggi Arguni, Yuan‐Chien Lin, Kin‐Fai Ho, Kian Fan Chung, Sheng-Chieh Lin, Hsiao‐Chi ChuangList of authors in order
- Landing page
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https://doi.org/10.1038/s41390-025-04073-2Publisher landing page
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https://www.nature.com/articles/s41390-025-04073-2.pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://www.nature.com/articles/s41390-025-04073-2.pdfDirect OA link when available
- Concepts
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Asthma, Medicine, Odds ratio, Logistic regression, Phenotype, Immunology, Internal medicine, Asthma exacerbations, Pandemic, Coronavirus disease 2019 (COVID-19), Gene, Biology, Disease, Biochemistry, Infectious disease (medical specialty)Top concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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44Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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