Second annual report from the ISSPP PIPAC database Article Swipe
Michael Bau Mortensen
,
Francesco Casella
,
Özgül Düzgün
,
Olivier Gléhen
,
Peter J. Hewett
,
Martin Hübner
,
Magnus Skov Jørgensen
,
Alfred Königsrainer
,
Miguel Ruiz Marín
,
Marc Pocard
,
Günther A. Rezniczek
,
Jimmy Bok Yan So
,
Claus Wilki Fristrup
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1515/pp-2023-0047
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1515/pp-2023-0047
Objectives To monitor the results of PIPAC directed therapy based on data from the International Society for the Study of the Pleura and Peritoneum (ISSPP) PIPAC database. Methods Analysis of data from patients entered between June 15th, 2020, and February 28th, 2023. Results Twelve centers reported 2,456 PIPAC procedures in 809 patients (median 2, range 1–18) with peritoneal metastasis (PM) from different primary tumors. Approximately 90 % had systemic chemotherapy prior to PIPAC. Twenty-eight percent were treated in prospective protocols. Overall non-access rate was 3.5 %. Concomitant surgical procedures were performed during PIPAC in 1.6 % of the patients. Median length of stay was 2 days. A total of 95 surgical complications were recorded, but only 22 % of these were graded ≥3b. Seventeen-hundred-and-three adverse events were noted, and 8 % were classified ≥3. The rate of complete or major histological response (peritoneal regression grade score, PRGS≤2) increased between the first and the third PIPAC in the group of patients who were evaluated by PRGS, and a PRGS ≤2 or a reduction of the mean PRGS of at least 1 between first and third PIPAC were observed in 80 %. Disease progression (50 %) or technical issues (19 %) were the most important reasons for stopping PIPAC treatment. Median overall survival from first PIPAC directed treatment varied from 10.7 months (CI 8.7–12.5) in gastric cancer to 27.1 months (16.4–50.5) in mesothelioma. Conclusions The ISSPP PIPAC database provides substantial real-world data supporting the use of PIPAC directed therapy in patients with PM from different primary tumors.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1515/pp-2023-0047
- https://www.degruyter.com/document/doi/10.1515/pp-2023-0047/pdf
- OA Status
- diamond
- Cited By
- 9
- References
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- Related Works
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- OpenAlex ID
- https://openalex.org/W4389625906
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4389625906Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1515/pp-2023-0047Digital Object Identifier
- Title
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Second annual report from the ISSPP PIPAC databaseWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-12-01Full publication date if available
- Authors
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Michael Bau Mortensen, Francesco Casella, Özgül Düzgün, Olivier Gléhen, Peter J. Hewett, Martin Hübner, Magnus Skov Jørgensen, Alfred Königsrainer, Miguel Ruiz Marín, Marc Pocard, Günther A. Rezniczek, Jimmy Bok Yan So, Claus Wilki FristrupList of authors in order
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https://doi.org/10.1515/pp-2023-0047Publisher landing page
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https://www.degruyter.com/document/doi/10.1515/pp-2023-0047/pdfDirect link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://www.degruyter.com/document/doi/10.1515/pp-2023-0047/pdfDirect OA link when available
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Database, Environmental science, Computer scienceTop concepts (fields/topics) attached by OpenAlex
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9Total citation count in OpenAlex
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2025: 6, 2024: 3Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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