Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux Article Swipe
Mélanie R. Tardif
,
Julie Andrea Chapeton-Montes
,
Alma Posvandzic
,
Nathalie Pagé
,
Caroline Gilbert
,
Philippe A. Tessier
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1155/2015/296149
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1155/2015/296149
S100A8/A9 (calprotectin) and S100A12 proinflammatory mediators are found at inflammatory sites and in the serum of patients with inflammatory or autoimmune diseases. These cytoplasmic proteins are secreted by neutrophils at sites of inflammation via alternative secretion pathways of which little is known. This study examined the nature of the stimuli leading to S100A8/A9 and S100A12 secretion as well as the mechanism involved in this alternative secretion pathway. Chemotactic agents, cytokines, and particulate molecules were used to stimulate human neutrophils. MSU crystals, PMA, and H 2 O 2 induced the release of S100A8, S100A9, and S100A12 homodimers, as well as S100A8/A9 heterodimer. High concentrations of S100A8/A9 and S100A12 were secreted in response to nanoparticles like MSU, silica, TiO 2 , fullerene, and single-wall carbon nanotubes as well as in response to microbe-derived molecules, such as zymosan or HKCA. However, neutrophils exposed to the chemotactic factors fMLP failed to secrete S100A8/A9 or S100A12. Secretion of S100A8/A9 was dependent on the production of reactive oxygen species and required K + exchanges through the ATP-sensitive K + channel. Altogether, these findings suggest that S100A12 and S100A8/A9 are secreted independently either via distinct mechanisms of secretion or following the activation of different signal transduction pathways.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1155/2015/296149
- https://downloads.hindawi.com/journals/jir/2015/296149.pdf
- OA Status
- gold
- Cited By
- 91
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2219022509
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2219022509Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1155/2015/296149Digital Object Identifier
- Title
-
Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium EffluxWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2015Year of publication
- Publication date
-
2015-01-01Full publication date if available
- Authors
-
Mélanie R. Tardif, Julie Andrea Chapeton-Montes, Alma Posvandzic, Nathalie Pagé, Caroline Gilbert, Philippe A. TessierList of authors in order
- Landing page
-
https://doi.org/10.1155/2015/296149Publisher landing page
- PDF URL
-
https://downloads.hindawi.com/journals/jir/2015/296149.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://downloads.hindawi.com/journals/jir/2015/296149.pdfDirect OA link when available
- Concepts
-
Secretion, S100A8, S100A9, Proinflammatory cytokine, Cell biology, Calprotectin, Inflammation, Zymosan, Chemotaxis, NADPH oxidase, Biology, Chemistry, Reactive oxygen species, Biochemistry, Immunology, Receptor, Medicine, Internal medicine, Disease, In vitro, Inflammatory bowel diseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
91Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 10, 2024: 11, 2023: 16, 2022: 5, 2021: 13Per-year citation counts (last 5 years)
- References (count)
-
52Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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