Sedation Therapy in Intensive Care Units: Harnessing the Power of Antioxidants to Combat Oxidative Stress Article Swipe
Gen Inoue
,
Yuhei Ohtaki
,
Kazue Satoh
,
Yuki Odanaka
,
Akihito Katoh
,
Keisuke Suzuki
,
Yoshitake Tomita
,
Manabu Eiraku
,
Kazuki Kikuchi
,
Kouhei Harano
,
Masaharu Yagi
,
Naoki Uchida
,
Kenji Dohi
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines11082129
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines11082129
In critically ill patients requiring intensive care, increased oxidative stress plays an important role in pathogenesis. Sedatives are widely used for sedation in many of these patients. Some sedatives are known antioxidants. However, no studies have evaluated the direct scavenging activity of various sedative agents on different free radicals. This study aimed to determine whether common sedatives (propofol, thiopental, and dexmedetomidine (DEX)) have direct free radical scavenging activity against various free radicals using in vitro electron spin resonance. Superoxide, hydroxyl radical, singlet oxygen, and nitric oxide (NO) direct scavenging activities were measured. All sedatives scavenged different types of free radicals. DEX, a new sedative, also scavenged hydroxyl radicals. Thiopental scavenged all types of free radicals, including NO, whereas propofol did not scavenge superoxide radicals. In this retrospective analysis, we observed changes in oxidative antioxidant markers following the administration of thiopental in patients with severe head trauma. We identified the direct radical-scavenging activity of various sedatives used in clinical settings. Furthermore, we reported a representative case of traumatic brain injury wherein thiopental administration dramatically affected oxidative-stress-related biomarkers. This study suggests that, in the future, sedatives containing thiopental may be redeveloped as an antioxidant therapy through further clinical research.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/biomedicines11082129
- https://www.mdpi.com/2227-9059/11/8/2129/pdf?version=1690513903
- OA Status
- gold
- Cited By
- 11
- References
- 67
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4385343887
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4385343887Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/biomedicines11082129Digital Object Identifier
- Title
-
Sedation Therapy in Intensive Care Units: Harnessing the Power of Antioxidants to Combat Oxidative StressWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-07-28Full publication date if available
- Authors
-
Gen Inoue, Yuhei Ohtaki, Kazue Satoh, Yuki Odanaka, Akihito Katoh, Keisuke Suzuki, Yoshitake Tomita, Manabu Eiraku, Kazuki Kikuchi, Kouhei Harano, Masaharu Yagi, Naoki Uchida, Kenji DohiList of authors in order
- Landing page
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https://doi.org/10.3390/biomedicines11082129Publisher landing page
- PDF URL
-
https://www.mdpi.com/2227-9059/11/8/2129/pdf?version=1690513903Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2227-9059/11/8/2129/pdf?version=1690513903Direct OA link when available
- Concepts
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Oxidative stress, Antioxidant, Radical, Pharmacology, Chemistry, Sedative, Nitric oxide, Medicine, Sedation, Superoxide, Anesthesia, Propofol, Hydroxyl radical, Biochemistry, Organic chemistry, EnzymeTop concepts (fields/topics) attached by OpenAlex
- Cited by
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11Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5, 2024: 4, 2023: 2Per-year citation counts (last 5 years)
- References (count)
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67Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.observed | 129 |
| abstract_inverted_index.patients | 3, 141 |
| abstract_inverted_index.propofol | 118 |
| abstract_inverted_index.radical, | 80 |
| abstract_inverted_index.radicals | 71 |
| abstract_inverted_index.reported | 161 |
| abstract_inverted_index.scavenge | 121 |
| abstract_inverted_index.sedation | 21 |
| abstract_inverted_index.sedative | 43 |
| abstract_inverted_index.suggests | 178 |
| abstract_inverted_index.Sedatives | 16 |
| abstract_inverted_index.analysis, | 127 |
| abstract_inverted_index.determine | 53 |
| abstract_inverted_index.different | 46, 95 |
| abstract_inverted_index.evaluated | 36 |
| abstract_inverted_index.following | 135 |
| abstract_inverted_index.important | 12 |
| abstract_inverted_index.including | 115 |
| abstract_inverted_index.increased | 7 |
| abstract_inverted_index.intensive | 5 |
| abstract_inverted_index.measured. | 91 |
| abstract_inverted_index.oxidative | 8, 132 |
| abstract_inverted_index.patients. | 26 |
| abstract_inverted_index.radicals, | 114 |
| abstract_inverted_index.radicals. | 48, 99, 107, 123 |
| abstract_inverted_index.requiring | 4 |
| abstract_inverted_index.research. | 196 |
| abstract_inverted_index.scavenged | 94, 105, 109 |
| abstract_inverted_index.sedative, | 103 |
| abstract_inverted_index.sedatives | 28, 56, 93, 154, 183 |
| abstract_inverted_index.settings. | 158 |
| abstract_inverted_index.traumatic | 166 |
| abstract_inverted_index.(propofol, | 57 |
| abstract_inverted_index.Thiopental | 108 |
| abstract_inverted_index.activities | 89 |
| abstract_inverted_index.containing | 184 |
| abstract_inverted_index.critically | 1 |
| abstract_inverted_index.identified | 147 |
| abstract_inverted_index.resonance. | 77 |
| abstract_inverted_index.scavenging | 39, 66, 88 |
| abstract_inverted_index.superoxide | 122 |
| abstract_inverted_index.thiopental | 139, 170, 185 |
| abstract_inverted_index.Superoxide, | 78 |
| abstract_inverted_index.antioxidant | 133, 191 |
| abstract_inverted_index.biomarkers. | 175 |
| abstract_inverted_index.redeveloped | 188 |
| abstract_inverted_index.thiopental, | 58 |
| abstract_inverted_index.Furthermore, | 159 |
| abstract_inverted_index.dramatically | 172 |
| abstract_inverted_index.antioxidants. | 31 |
| abstract_inverted_index.pathogenesis. | 15 |
| abstract_inverted_index.retrospective | 126 |
| abstract_inverted_index.administration | 137, 171 |
| abstract_inverted_index.representative | 163 |
| abstract_inverted_index.dexmedetomidine | 60 |
| abstract_inverted_index.radical-scavenging | 150 |
| abstract_inverted_index.oxidative-stress-related | 174 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5037373569 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 13 |
| corresponding_institution_ids | https://openalex.org/I115498069, https://openalex.org/I119182057 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6299999952316284 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.90752782 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |