Selected ion monitoring for orbitrap-based metabolomics Article Swipe
Wenyun Lu
,
Matthew J. McBride
,
Won Dong Lee
,
Xi Xing
,
Xincheng Xu
,
Anna M. Oschmann
,
Xi Li
,
Caroline Bartman
,
Yihui Shen
,
Joshua D. Rabinowitz
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.26434/chemrxiv-2024-gfgsm-v2
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.26434/chemrxiv-2024-gfgsm-v2
Orbitrap mass spectrometry in full scan mode enables simultaneous detection of hundreds of metabolites and their isotope-labeled forms. Yet sensitivity remains limiting for many metabolites, including low concentration species, poor ionizers, and low fractional abundance isotope-labeled forms in isotope tracing studies. Here we explore selected ion monitoring (SIM) as a means of sensitivity enhancement. The analytes of interest are enriched in the orbitrap analyzer by using the quadrupole as a mass filter to select particular ions. In tissue extracts, SIM significantly enhances the detection of ions of low intensity as indicated by improved signal-to-noise (S/N) ratios and measurement precision. In addition, SIM improves the accuracy of isotope-ratio measurements. SIM, however, must be deployed with care, as excessive accumulation in the orbitrap of similar m/z ions can lead, via space charge effects, to decreased performance (signal loss, mass shift, ion coalescence). Ion accumulation can be controlled by adjusting settings including injection time and target ion quantity. Overall, we suggest using full scan to ensure broad metabolic coverage, in tandem with SIM for accurate quantitation of targeted low-intensity ions, and provide methods deploying this approach to enhance metabolome coverage.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.26434/chemrxiv-2024-gfgsm-v2
- https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/65cd1a1d66c1381729a7519c/original/selected-ion-monitoring-for-orbitrap-based-metabolomics.pdf
- OA Status
- gold
- Cited By
- 1
- References
- 39
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391842105
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4391842105Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.26434/chemrxiv-2024-gfgsm-v2Digital Object Identifier
- Title
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Selected ion monitoring for orbitrap-based metabolomicsWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-02-15Full publication date if available
- Authors
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Wenyun Lu, Matthew J. McBride, Won Dong Lee, Xi Xing, Xincheng Xu, Anna M. Oschmann, Xi Li, Caroline Bartman, Yihui Shen, Joshua D. RabinowitzList of authors in order
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https://doi.org/10.26434/chemrxiv-2024-gfgsm-v2Publisher landing page
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https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/65cd1a1d66c1381729a7519c/original/selected-ion-monitoring-for-orbitrap-based-metabolomics.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/65cd1a1d66c1381729a7519c/original/selected-ion-monitoring-for-orbitrap-based-metabolomics.pdfDirect OA link when available
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Orbitrap, Metabolomics, Computer science, Environmental science, Chemistry, Chromatography, Mass spectrometryTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2024: 1Per-year citation counts (last 5 years)
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39Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W4391842105, https://openalex.org/W4319294976, https://openalex.org/W2081465448, https://openalex.org/W2171704671, https://openalex.org/W2906160137, https://openalex.org/W3108831716, https://openalex.org/W2060121473, https://openalex.org/W1984053258, https://openalex.org/W2111115065, https://openalex.org/W2022067114, https://openalex.org/W2782223698, https://openalex.org/W2098667036, https://openalex.org/W4386457667, https://openalex.org/W3174306026, https://openalex.org/W2789180076, https://openalex.org/W3040653733, https://openalex.org/W4388042674, https://openalex.org/W2127469533, https://openalex.org/W3048369682, https://openalex.org/W2165047551, https://openalex.org/W4234725657, https://openalex.org/W4291280663, https://openalex.org/W1480100581, https://openalex.org/W4387093021, https://openalex.org/W2936632334, https://openalex.org/W2944840932, https://openalex.org/W2064336237, https://openalex.org/W2991580150, https://openalex.org/W4251891402, https://openalex.org/W2801170851, https://openalex.org/W3024889646, https://openalex.org/W2315534050, https://openalex.org/W2001265990, https://openalex.org/W2027603999, https://openalex.org/W2737993744, https://openalex.org/W1994124478, https://openalex.org/W2556428520, https://openalex.org/W1965920457, https://openalex.org/W2071534982 |
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