Selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumors Article Swipe
Leyre Zubiri
,
José Ignacio Bilbao
,
Javier Rodríguez
,
Bruno Sangro
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.2217/hep-2017-0025
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.2217/hep-2017-0025
The hormone secretion in pancreatic neuroendocrine tumors (pNET) causes an important interference in patients' quality of life. We present two cases of pNET metastatic to the liver (a pancreatic endocrine carcinoma with a severe hormonal syndrome and an insulinoma with severe crisis of hypoglycemia and coma) refractory to conventional treatments, which were finally solved with selective internal radiation therapy (SIRT), a nonstandard level 1 therapy. We show two examples of an excellent control of symptoms together with a long survival after treatment with SIRT. The evidence supporting the use of this therapy is level 2. Our case reports strongly support the use of SIRT for the severe clinical syndrome in pNET metastatic to the liver and refractory to somatostatin analogs.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2217/hep-2017-0025
- https://www.futuremedicine.com/doi/pdf/10.2217/hep-2017-0025
- OA Status
- gold
- Cited By
- 3
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2892915741
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2892915741Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.2217/hep-2017-0025Digital Object Identifier
- Title
-
Selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumorsWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-04-01Full publication date if available
- Authors
-
Leyre Zubiri, José Ignacio Bilbao, Javier Rodríguez, Bruno SangroList of authors in order
- Landing page
-
https://doi.org/10.2217/hep-2017-0025Publisher landing page
- PDF URL
-
https://www.futuremedicine.com/doi/pdf/10.2217/hep-2017-0025Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.futuremedicine.com/doi/pdf/10.2217/hep-2017-0025Direct OA link when available
- Concepts
-
Medicine, Neuroendocrine tumors, Insulinoma, Somatostatin, Radiation therapy, Internal medicine, Refractory (planetary science), Hormone, Hypoglycemia, Endocrine system, Oncology, Gastroenterology, Endocrinology, Pancreas, Insulin, Physics, AstrobiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1, 2023: 1, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
35Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764873731 |
| best_oa_location.source.issn | 2045-0923, 2045-0931 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2045-0923 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Hepatic Oncology |
| best_oa_location.source.host_organization | https://openalex.org/P4310321119 |
| best_oa_location.source.host_organization_name | Future Medicine |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310321119 |
| best_oa_location.source.host_organization_lineage_names | Future Medicine |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | https://www.futuremedicine.com/doi/pdf/10.2217/hep-2017-0025 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Hepatic Oncology |
| best_oa_location.landing_page_url | https://doi.org/10.2217/hep-2017-0025 |
| primary_location.id | doi:10.2217/hep-2017-0025 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2764873731 |
| primary_location.source.issn | 2045-0923, 2045-0931 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2045-0923 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Hepatic Oncology |
| primary_location.source.host_organization | https://openalex.org/P4310321119 |
| primary_location.source.host_organization_name | Future Medicine |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310321119 |
| primary_location.source.host_organization_lineage_names | Future Medicine |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | https://www.futuremedicine.com/doi/pdf/10.2217/hep-2017-0025 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Hepatic Oncology |
| primary_location.landing_page_url | https://doi.org/10.2217/hep-2017-0025 |
| publication_date | 2018-04-01 |
| publication_year | 2018 |
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| referenced_works_count | 35 |
| abstract_inverted_index.1 | 63 |
| abstract_inverted_index.a | 32, 60, 77 |
| abstract_inverted_index.(a | 27 |
| abstract_inverted_index.2. | 94 |
| abstract_inverted_index.We | 17, 65 |
| abstract_inverted_index.an | 9, 37, 70 |
| abstract_inverted_index.in | 3, 12, 109 |
| abstract_inverted_index.is | 92 |
| abstract_inverted_index.of | 15, 21, 42, 69, 73, 89, 102 |
| abstract_inverted_index.to | 24, 47, 112, 117 |
| abstract_inverted_index.Our | 95 |
| abstract_inverted_index.The | 0, 84 |
| abstract_inverted_index.and | 36, 44, 115 |
| abstract_inverted_index.for | 104 |
| abstract_inverted_index.the | 25, 87, 100, 105, 113 |
| abstract_inverted_index.two | 19, 67 |
| abstract_inverted_index.use | 88, 101 |
| abstract_inverted_index.SIRT | 103 |
| abstract_inverted_index.case | 96 |
| abstract_inverted_index.long | 78 |
| abstract_inverted_index.pNET | 22, 110 |
| abstract_inverted_index.show | 66 |
| abstract_inverted_index.this | 90 |
| abstract_inverted_index.were | 51 |
| abstract_inverted_index.with | 31, 39, 54, 76, 82 |
| abstract_inverted_index.SIRT. | 83 |
| abstract_inverted_index.after | 80 |
| abstract_inverted_index.cases | 20 |
| abstract_inverted_index.coma) | 45 |
| abstract_inverted_index.level | 62, 93 |
| abstract_inverted_index.life. | 16 |
| abstract_inverted_index.liver | 26, 114 |
| abstract_inverted_index.which | 50 |
| abstract_inverted_index.(pNET) | 7 |
| abstract_inverted_index.causes | 8 |
| abstract_inverted_index.crisis | 41 |
| abstract_inverted_index.severe | 33, 40, 106 |
| abstract_inverted_index.solved | 53 |
| abstract_inverted_index.tumors | 6 |
| abstract_inverted_index.(SIRT), | 59 |
| abstract_inverted_index.control | 72 |
| abstract_inverted_index.finally | 52 |
| abstract_inverted_index.hormone | 1 |
| abstract_inverted_index.present | 18 |
| abstract_inverted_index.quality | 14 |
| abstract_inverted_index.reports | 97 |
| abstract_inverted_index.support | 99 |
| abstract_inverted_index.therapy | 58, 91 |
| abstract_inverted_index.analogs. | 119 |
| abstract_inverted_index.clinical | 107 |
| abstract_inverted_index.evidence | 85 |
| abstract_inverted_index.examples | 68 |
| abstract_inverted_index.hormonal | 34 |
| abstract_inverted_index.internal | 56 |
| abstract_inverted_index.strongly | 98 |
| abstract_inverted_index.survival | 79 |
| abstract_inverted_index.symptoms | 74 |
| abstract_inverted_index.syndrome | 35, 108 |
| abstract_inverted_index.therapy. | 64 |
| abstract_inverted_index.together | 75 |
| abstract_inverted_index.carcinoma | 30 |
| abstract_inverted_index.endocrine | 29 |
| abstract_inverted_index.excellent | 71 |
| abstract_inverted_index.important | 10 |
| abstract_inverted_index.patients' | 13 |
| abstract_inverted_index.radiation | 57 |
| abstract_inverted_index.secretion | 2 |
| abstract_inverted_index.selective | 55 |
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| abstract_inverted_index.insulinoma | 38 |
| abstract_inverted_index.metastatic | 23, 111 |
| abstract_inverted_index.pancreatic | 4, 28 |
| abstract_inverted_index.refractory | 46, 116 |
| abstract_inverted_index.supporting | 86 |
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| abstract_inverted_index.conventional | 48 |
| abstract_inverted_index.hypoglycemia | 43 |
| abstract_inverted_index.interference | 11 |
| abstract_inverted_index.somatostatin | 118 |
| abstract_inverted_index.neuroendocrine | 5 |
| cited_by_percentile_year.max | 94 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8500000238418579 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.14294097 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |