Selective Menin Deletion in the Hippocampal CA1 Region Leads to Disruption of Contextual Memory in the MEN1 Conditional Knockout Mouse: Behavioral Restoration and Gain of Function following the Reintroduction of MEN1 Gene Article Swipe
Anosha Kiran Ulfat
,
Shadab Batool
,
Fahad Iqbal
,
Naweed I. Syed
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/cells11244019
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/cells11244019
Cholinergic neuronal networks in the hippocampus play a key role in the regulation of learning and memory in mammals. Perturbations of these networks, in turn, underlie neurodegenerative diseases. However, the mechanisms remain largely undefined. We have recently demonstrated that an in vitro MEN1 gene deletion perturbs nicotinic cholinergic plasticity at the hippocampal glutamatergic synapses. Furthermore, MEN1 neuronal conditional knockout in freely behaving animals has also been shown to result in learning and memory deficits, though the evidence remains equivocal. In this study, using an AVV viral vector transcription approach, we provide direct evidence that MEN1 gene deletion in the CA1 region of the hippocampus indeed leads to contextual fear conditioning deficits in conditional knockout animals. This loss of function was, however, recovered when the same animals were re-injected to overexpress MEN1. This study provides the first direct evidence for the sufficiency and necessity of MEN1 in fear conditioning, and further endorses the role of menin in the regulation of cholinergic synaptic machinery in the hippocampus. These data underscore the importance of further exploring and revisiting the cholinergic hypothesis that underlies neurodegenerative diseases that affect learning and memory.
Related Topics
Concepts
Neuroscience
MEN1
Hippocampus
Conditional gene knockout
Cholinergic
Glutamatergic
Fear conditioning
Knockout mouse
Gene knockout
Hippocampal formation
Biology
Psychology
Gene
Phenotype
Genetics
Amygdala
Receptor
Glutamate receptor
Multiple endocrine neoplasia
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cells11244019
- https://www.mdpi.com/2073-4409/11/24/4019/pdf?version=1670840846
- OA Status
- gold
- References
- 44
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4311156291
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4311156291Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/cells11244019Digital Object Identifier
- Title
-
Selective Menin Deletion in the Hippocampal CA1 Region Leads to Disruption of Contextual Memory in the MEN1 Conditional Knockout Mouse: Behavioral Restoration and Gain of Function following the Reintroduction of MEN1 GeneWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-12-12Full publication date if available
- Authors
-
Anosha Kiran Ulfat, Shadab Batool, Fahad Iqbal, Naweed I. SyedList of authors in order
- Landing page
-
https://doi.org/10.3390/cells11244019Publisher landing page
- PDF URL
-
https://www.mdpi.com/2073-4409/11/24/4019/pdf?version=1670840846Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2073-4409/11/24/4019/pdf?version=1670840846Direct OA link when available
- Concepts
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Neuroscience, MEN1, Hippocampus, Conditional gene knockout, Cholinergic, Glutamatergic, Fear conditioning, Knockout mouse, Gene knockout, Hippocampal formation, Biology, Psychology, Gene, Phenotype, Genetics, Amygdala, Receptor, Glutamate receptor, Multiple endocrine neoplasiaTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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44Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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