Selenium supplementation and placebo are equally effective in improving quality of life in patients with hypothyroidism Article Swipe
Camilla Bøgelund Larsen
,
Kristian Hillert Winther
,
Per Karkov Cramon
,
Åse Krogh Rasmussen
,
Ulla Feldt-Rasmussen
,
Nils Knudsen
,
Jakob Bue Bjørner
,
Lutz Schomburg
,
Kamil Demircan
,
Thilo Samson Chillon
,
Jeppe Gram
,
Stinus Hansen
,
Frans Brandt
,
Birte Nygaard
,
Torquil Watt
,
Laszlo Hegedüs
,
Steen Joop Bonnema
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1530/etj-23-0175
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1530/etj-23-0175
Purpose We investigated whether selenium supplementation improves quality-of-life (QoL) in patients with autoimmune thyroiditis (ID:NCT02013479). Methods We included 412 patients ≥18 years with serum thyroid peroxidase antibody (TPOAb) level ≥100 IU/mL in a multicentre double-blinded randomised clinical trial. The patients were allocated 1:1 to daily supplementation with either 200 μg selenium as selenium-enriched yeast or matching placebo tablets for 12 months, as add-on to levothyroxine (LT4) treatment. QoL, assessed by the Thyroid-related Patient-Reported-Outcome questionnaire (ThyPRO-39), was measured at baseline, after 6 weeks, and after 3, 6, 12, and 18 months. Results In total, 332 patients (81%) completed the intervention period, of whom 82% were women. Although QoL improved during the trial, no difference in any of the ThyPRO-39 scales was found between the selenium group and the placebo group after 12 months of intervention. In addition, employing linear mixed model regression no difference between the two groups was observed in the ThyPRO-39 composite score (28.8 (95% CI: 24.5–33.6) and 28.0 (24.5–33.1), respectively; P = 0.602). Stratifying the patients according to duration of the disease at inclusion, ThyPRO-39 composite score, TPOAb level, or selenium status at baseline did not significantly change the results. TPOAb levels after 12 months of intervention were lower in the selenium group than in the placebo group (1995 (95% CI: 1512–2512) vs 2344 kIU/L (1862–2951); P = 0.016) but did not influence LT4 dosage or free triiodothyronine–free thyroxine ratio. Conclusion In hypothyroid patients on LT4 therapy due to autoimmune thyroiditis, daily supplementation with 200 μg selenium or placebo for 12 months improved QoL to the same extent.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1530/etj-23-0175
- https://etj.bioscientifica.com/downloadpdf/view/journals/etj/aop/etj-23-0175/etj-23-0175.pdf
- OA Status
- diamond
- Cited By
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- References
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- Related Works
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- OpenAlex ID
- https://openalex.org/W4390817486
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4390817486Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1530/etj-23-0175Digital Object Identifier
- Title
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Selenium supplementation and placebo are equally effective in improving quality of life in patients with hypothyroidismWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-01-12Full publication date if available
- Authors
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Camilla Bøgelund Larsen, Kristian Hillert Winther, Per Karkov Cramon, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen, Nils Knudsen, Jakob Bue Bjørner, Lutz Schomburg, Kamil Demircan, Thilo Samson Chillon, Jeppe Gram, Stinus Hansen, Frans Brandt, Birte Nygaard, Torquil Watt, Laszlo Hegedüs, Steen Joop BonnemaList of authors in order
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https://doi.org/10.1530/etj-23-0175Publisher landing page
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https://etj.bioscientifica.com/downloadpdf/view/journals/etj/aop/etj-23-0175/etj-23-0175.pdfDirect link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://etj.bioscientifica.com/downloadpdf/view/journals/etj/aop/etj-23-0175/etj-23-0175.pdfDirect OA link when available
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Medicine, Placebo, Quality of life (healthcare), Pediatrics, Internal medicine, Physiology, Endocrinology, Alternative medicine, Pathology, NursingTop concepts (fields/topics) attached by OpenAlex
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20Total citation count in OpenAlex
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2025: 9, 2024: 11Per-year citation counts (last 5 years)
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71Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| publication_year | 2024 |
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