Self-assembled nanoplatform-mediated co-delivery of brusatol to sensitize sorafenib for hepatocellular carcinoma treatment Article Swipe
Fengrui Liu
,
Senlin Li
,
Chengcheng Huang
,
Zhenfei Bi
,
Xiao Xiang
,
Shuqi Zhang
,
Ruihao Yang
,
Zheng Lu
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1039/d5ra00108k
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1039/d5ra00108k
We developed a glutathione (GSH) responsive nanoplatform for the co-delivery of sorafenib (Sor) and brusatol (Bru). This nanoplatform enhanced Bru’s efficacy and increased Sor’s sensitivity. This innovative approach enhanced Sor’s effectiveness in hepatocellular carcinoma (HCC) treatment.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1039/d5ra00108k
- https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra00108k
- OA Status
- gold
- References
- 74
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409409416
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409409416Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1039/d5ra00108kDigital Object Identifier
- Title
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Self-assembled nanoplatform-mediated co-delivery of brusatol to sensitize sorafenib for hepatocellular carcinoma treatmentWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-01-01Full publication date if available
- Authors
-
Fengrui Liu, Senlin Li, Chengcheng Huang, Zhenfei Bi, Xiao Xiang, Shuqi Zhang, Ruihao Yang, Zheng LuList of authors in order
- Landing page
-
https://doi.org/10.1039/d5ra00108kPublisher landing page
- PDF URL
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https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra00108kDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra00108kDirect OA link when available
- Concepts
-
Sorafenib, Hepatocellular carcinoma, Chemistry, Glutathione, Pharmacology, Cancer research, Medicine, Biochemistry, EnzymeTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
74Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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