Self-Redirection of Metabolic Flux toward Squalene and Ethanol Pathways by Engineered Yeast Article Swipe
Robina Manzoor
,
Maqbool Ahmed
,
Naveeda Riaz
,
Bushra Hafeez Kiani
,
Kaleem Ullah
,
Yasmeen Rashid
,
Ali Nawaz
,
Muhammad Umer Farooq Awan
,
Hooria Khan
,
Umera Imtiaz
,
Yasir Rasheed
,
Imdad Kaleem
,
Aamir Rasool
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/metabo10020056
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/metabo10020056
We have previously reported that squalene overproducing yeast self-downregulate the expression of the ethanol pathway (non-essential pathway) to divert the metabolic flux to the squalene pathway. In this study, the effect of co-production of squalene and ethanol on other non-essential pathways (fusel alcohol pathway, FA) of Saccharomyces cerevisiae was evaluated. However, before that, 13 constitutive promoters, like IRA1p, PET9p, RHO1p, CMD1p, ATP16p, USA3p, RER2p, COQ1p, RIM1p, GRS1p, MAK5p, and BRN1p, were engineered using transcription factor bindings sites from strong promoters HHF2p (−300 to −669 bp) and TEF1p (−300 to −579 bp), and employed to co-overexpress squalene and ethanol pathways in S. cerevisiae. The FSE strain overexpressing the key genes of the squalene pathway accumulated 56.20 mg/L squalene, a 16.43-fold higher than wild type strain (WS). The biogenesis of lipid droplets was stimulated by overexpressing DGA1 and produced 106 mg/L squalene in the FSE strain. AFT1p and CTR1p repressible promoters were also characterized and employed to downregulate the expression of ERG1, which also enhanced the production of squalene in FSE strain up to 42.85- (148.67 mg/L) and 73.49-fold (255.11 mg/L) respectively. The FSE strain was further engineered by overexpressing the key genes of the ethanol pathway and produced 40.2 mg/mL ethanol in the FSE1 strain, 3.23-fold higher than the WS strain. The FSE1 strain also self-downregulated the expression of the FA pathway up to 73.9%, perhaps by downregulating the expression of GCN4 by 2.24-fold. We demonstrate the successful tuning of the strength of yeast promoters and highest coproduction of squalene and ethanol in yeast, and present GCN4 as a novel metabolic regulator that can be manipulated to divert the metabolic flux from the non-essential pathway to engineered pathways.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/metabo10020056
- https://www.mdpi.com/2218-1989/10/2/56/pdf?version=1582960977
- OA Status
- gold
- Cited By
- 9
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3003475562
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3003475562Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/metabo10020056Digital Object Identifier
- Title
-
Self-Redirection of Metabolic Flux toward Squalene and Ethanol Pathways by Engineered YeastWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-02-01Full publication date if available
- Authors
-
Robina Manzoor, Maqbool Ahmed, Naveeda Riaz, Bushra Hafeez Kiani, Kaleem Ullah, Yasmeen Rashid, Ali Nawaz, Muhammad Umer Farooq Awan, Hooria Khan, Umera Imtiaz, Yasir Rasheed, Imdad Kaleem, Aamir RasoolList of authors in order
- Landing page
-
https://doi.org/10.3390/metabo10020056Publisher landing page
- PDF URL
-
https://www.mdpi.com/2218-1989/10/2/56/pdf?version=1582960977Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2218-1989/10/2/56/pdf?version=1582960977Direct OA link when available
- Concepts
-
Flux (metallurgy), Yeast, Squalene, Ethanol, Metabolic pathway, Chemistry, Metabolic engineering, Computational biology, Biochemistry, Biology, Metabolism, Enzyme, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
9Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 2, 2022: 4, 2019: 1Per-year citation counts (last 5 years)
- References (count)
-
63Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3003475562 |
|---|---|
| doi | https://doi.org/10.3390/metabo10020056 |
| ids.doi | https://doi.org/10.3390/metabo10020056 |
| ids.mag | 3003475562 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/32024107 |
| ids.openalex | https://openalex.org/W3003475562 |
| fwci | 0.39010789 |
| type | article |
| title | Self-Redirection of Metabolic Flux toward Squalene and Ethanol Pathways by Engineered Yeast |
| biblio.issue | 2 |
| biblio.volume | 10 |
| biblio.last_page | 56 |
| biblio.first_page | 56 |
| grants[0].funder | https://openalex.org/F4320321001 |
| grants[0].award_id | U1632264 |
| grants[0].funder_display_name | National Natural Science Foundation of China |
| grants[1].funder | https://openalex.org/F4320326275 |
| grants[1].award_id | SGR 5550 |
| grants[1].funder_display_name | Higher Education Commision, Pakistan |
| topics[0].id | https://openalex.org/T10932 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9998000264167786 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Microbial Metabolic Engineering and Bioproduction |
| topics[1].id | https://openalex.org/T11882 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9993000030517578 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Plant biochemistry and biosynthesis |
| topics[2].id | https://openalex.org/T10750 |
| topics[2].field.id | https://openalex.org/fields/11 |
| topics[2].field.display_name | Agricultural and Biological Sciences |
| topics[2].score | 0.9951000213623047 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1106 |
| topics[2].subfield.display_name | Food Science |
| topics[2].display_name | Fermentation and Sensory Analysis |
| funders[0].id | https://openalex.org/F4320321001 |
| funders[0].ror | https://ror.org/01h0zpd94 |
| funders[0].display_name | National Natural Science Foundation of China |
| funders[1].id | https://openalex.org/F4320326275 |
| funders[1].ror | |
| funders[1].display_name | Higher Education Commision, Pakistan |
| is_xpac | False |
| apc_list.value | 2000 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2165 |
| apc_paid.value | 2000 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2165 |
| concepts[0].id | https://openalex.org/C68709404 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7127609848976135 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1134475 |
| concepts[0].display_name | Flux (metallurgy) |
| concepts[1].id | https://openalex.org/C2779222958 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7080369591712952 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q45422 |
| concepts[1].display_name | Yeast |
| concepts[2].id | https://openalex.org/C2776703722 |
| concepts[2].level | 2 |
| concepts[2].score | 0.7012657523155212 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q407560 |
| concepts[2].display_name | Squalene |
| concepts[3].id | https://openalex.org/C2780161600 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6079111695289612 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q153 |
| concepts[3].display_name | Ethanol |
| concepts[4].id | https://openalex.org/C192989942 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5808072090148926 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q68685 |
| concepts[4].display_name | Metabolic pathway |
| concepts[5].id | https://openalex.org/C185592680 |
| concepts[5].level | 0 |
| concepts[5].score | 0.5284932255744934 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[5].display_name | Chemistry |
| concepts[6].id | https://openalex.org/C6350086 |
| concepts[6].level | 3 |
| concepts[6].score | 0.41027694940567017 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q6822347 |
| concepts[6].display_name | Metabolic engineering |
| concepts[7].id | https://openalex.org/C70721500 |
| concepts[7].level | 1 |
| concepts[7].score | 0.37766170501708984 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[7].display_name | Computational biology |
| concepts[8].id | https://openalex.org/C55493867 |
| concepts[8].level | 1 |
| concepts[8].score | 0.35299158096313477 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[8].display_name | Biochemistry |
| concepts[9].id | https://openalex.org/C86803240 |
| concepts[9].level | 0 |
| concepts[9].score | 0.24084749817848206 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[9].display_name | Biology |
| concepts[10].id | https://openalex.org/C62231903 |
| concepts[10].level | 2 |
| concepts[10].score | 0.18919330835342407 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q1057 |
| concepts[10].display_name | Metabolism |
| concepts[11].id | https://openalex.org/C181199279 |
| concepts[11].level | 2 |
| concepts[11].score | 0.18891552090644836 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q8047 |
| concepts[11].display_name | Enzyme |
| concepts[12].id | https://openalex.org/C178790620 |
| concepts[12].level | 1 |
| concepts[12].score | 0.07874709367752075 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q11351 |
| concepts[12].display_name | Organic chemistry |
| keywords[0].id | https://openalex.org/keywords/flux |
| keywords[0].score | 0.7127609848976135 |
| keywords[0].display_name | Flux (metallurgy) |
| keywords[1].id | https://openalex.org/keywords/yeast |
| keywords[1].score | 0.7080369591712952 |
| keywords[1].display_name | Yeast |
| keywords[2].id | https://openalex.org/keywords/squalene |
| keywords[2].score | 0.7012657523155212 |
| keywords[2].display_name | Squalene |
| keywords[3].id | https://openalex.org/keywords/ethanol |
| keywords[3].score | 0.6079111695289612 |
| keywords[3].display_name | Ethanol |
| keywords[4].id | https://openalex.org/keywords/metabolic-pathway |
| keywords[4].score | 0.5808072090148926 |
| keywords[4].display_name | Metabolic pathway |
| keywords[5].id | https://openalex.org/keywords/chemistry |
| keywords[5].score | 0.5284932255744934 |
| keywords[5].display_name | Chemistry |
| keywords[6].id | https://openalex.org/keywords/metabolic-engineering |
| keywords[6].score | 0.41027694940567017 |
| keywords[6].display_name | Metabolic engineering |
| keywords[7].id | https://openalex.org/keywords/computational-biology |
| keywords[7].score | 0.37766170501708984 |
| keywords[7].display_name | Computational biology |
| keywords[8].id | https://openalex.org/keywords/biochemistry |
| keywords[8].score | 0.35299158096313477 |
| keywords[8].display_name | Biochemistry |
| keywords[9].id | https://openalex.org/keywords/biology |
| keywords[9].score | 0.24084749817848206 |
| keywords[9].display_name | Biology |
| keywords[10].id | https://openalex.org/keywords/metabolism |
| keywords[10].score | 0.18919330835342407 |
| keywords[10].display_name | Metabolism |
| keywords[11].id | https://openalex.org/keywords/enzyme |
| keywords[11].score | 0.18891552090644836 |
| keywords[11].display_name | Enzyme |
| keywords[12].id | https://openalex.org/keywords/organic-chemistry |
| keywords[12].score | 0.07874709367752075 |
| keywords[12].display_name | Organic chemistry |
| language | en |
| locations[0].id | doi:10.3390/metabo10020056 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2764402194 |
| locations[0].source.issn | 2218-1989 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2218-1989 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Metabolites |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/2218-1989/10/2/56/pdf?version=1582960977 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Metabolites |
| locations[0].landing_page_url | https://doi.org/10.3390/metabo10020056 |
| locations[1].id | pmid:32024107 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Metabolites |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/32024107 |
| locations[2].id | pmh:oai:mdpi.com:/2218-1989/10/2/56/ |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400947 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | True |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | MDPI (MDPI AG) |
| locations[2].source.host_organization | https://openalex.org/I4210097602 |
| locations[2].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[2].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[2].license | cc-by |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Metabolites |
| locations[2].landing_page_url | http://dx.doi.org/10.3390/metabo10020056 |
| locations[3].id | pmh:oai:doaj.org/article:7273e1620b5541a38cf974d39346f95f |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].source.host_organization_lineage | |
| locations[3].license | cc-by-sa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Metabolites, Vol 10, Iss 2, p 56 (2020) |
| locations[3].landing_page_url | https://doaj.org/article/7273e1620b5541a38cf974d39346f95f |
| locations[4].id | pmh:oai:pubmedcentral.nih.gov:7074498 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S2764455111 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | PubMed Central |
| locations[4].source.host_organization | https://openalex.org/I1299303238 |
| locations[4].source.host_organization_name | National Institutes of Health |
| locations[4].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[4].license | other-oa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | https://openalex.org/licenses/other-oa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Metabolites |
| locations[4].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/7074498 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5049198464 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-8863-490X |
| authorships[0].author.display_name | Robina Manzoor |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I125839683 |
| authorships[0].affiliations[0].raw_affiliation_string | School of Life Science, Beijing Institute of Technology, Beijing 100081, China |
| authorships[0].institutions[0].id | https://openalex.org/I125839683 |
| authorships[0].institutions[0].ror | https://ror.org/01skt4w74 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I125839683, https://openalex.org/I890469752 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Beijing Institute of Technology |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Robina Manzoor |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | School of Life Science, Beijing Institute of Technology, Beijing 100081, China |
| authorships[1].author.id | https://openalex.org/A5022734678 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Maqbool Ahmed |
| authorships[1].countries | PK |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I2801016671 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Tuberculosis, Bolan University of Medical and Health Sciences, Quetta 87300, Pakistan |
| authorships[1].institutions[0].id | https://openalex.org/I2801016671 |
| authorships[1].institutions[0].ror | https://ror.org/04karqd05 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I2801016671 |
| authorships[1].institutions[0].country_code | PK |
| authorships[1].institutions[0].display_name | Bolan University of Medical and Health Sciences |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Maqbool Ahmed |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Tuberculosis, Bolan University of Medical and Health Sciences, Quetta 87300, Pakistan |
| authorships[2].author.id | https://openalex.org/A5027441506 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-2022-0129 |
| authorships[2].author.display_name | Naveeda Riaz |
| authorships[2].countries | PK |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I121243025 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Biological Sciences, International Islamic University, Islamabad 45550, Pakistan |
| authorships[2].institutions[0].id | https://openalex.org/I121243025 |
| authorships[2].institutions[0].ror | https://ror.org/047w75g40 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I121243025 |
| authorships[2].institutions[0].country_code | PK |
| authorships[2].institutions[0].display_name | International Islamic University, Islamabad |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Naveeda Riaz |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Biological Sciences, International Islamic University, Islamabad 45550, Pakistan |
| authorships[3].author.id | https://openalex.org/A5069679670 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-0748-9745 |
| authorships[3].author.display_name | Bushra Hafeez Kiani |
| authorships[3].countries | PK |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I121243025 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Biological Sciences, International Islamic University, Islamabad 45550, Pakistan |
| authorships[3].institutions[0].id | https://openalex.org/I121243025 |
| authorships[3].institutions[0].ror | https://ror.org/047w75g40 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I121243025 |
| authorships[3].institutions[0].country_code | PK |
| authorships[3].institutions[0].display_name | International Islamic University, Islamabad |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Bushra Hafeez Kiani |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Biological Sciences, International Islamic University, Islamabad 45550, Pakistan |
| authorships[4].author.id | https://openalex.org/A5101211756 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-6828-292X |
| authorships[4].author.display_name | Kaleem Ullah |
| authorships[4].countries | PK |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I20561161 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Microbiology, University of Balochistan, Quetta 87300, Pakistan |
| authorships[4].institutions[0].id | https://openalex.org/I20561161 |
| authorships[4].institutions[0].ror | https://ror.org/04bf33n91 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I20561161 |
| authorships[4].institutions[0].country_code | PK |
| authorships[4].institutions[0].display_name | University of Balochistan |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Ullah Kaleem |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Microbiology, University of Balochistan, Quetta 87300, Pakistan |
| authorships[5].author.id | https://openalex.org/A5019539747 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-1794-154X |
| authorships[5].author.display_name | Yasmeen Rashid |
| authorships[5].countries | PK |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I193670377 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Biochemistry, University of Karachi, Karachi 75530, Pakistan |
| authorships[5].institutions[0].id | https://openalex.org/I193670377 |
| authorships[5].institutions[0].ror | https://ror.org/05bbbc791 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I193670377 |
| authorships[5].institutions[0].country_code | PK |
| authorships[5].institutions[0].display_name | University of Karachi |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Yasmeen Rashid |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Biochemistry, University of Karachi, Karachi 75530, Pakistan |
| authorships[6].author.id | https://openalex.org/A5013644373 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-5930-2714 |
| authorships[6].author.display_name | Ali Nawaz |
| authorships[6].countries | PK |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I43879129 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Industrial Biotechnology, Government College University, Lahore 53801, Pakistan |
| authorships[6].institutions[0].id | https://openalex.org/I43879129 |
| authorships[6].institutions[0].ror | https://ror.org/040gec961 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I43879129 |
| authorships[6].institutions[0].country_code | PK |
| authorships[6].institutions[0].display_name | Government College University, Lahore |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Ali Nawaz |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Industrial Biotechnology, Government College University, Lahore 53801, Pakistan |
| authorships[7].author.id | https://openalex.org/A5107993391 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-3955-2905 |
| authorships[7].author.display_name | Muhammad Umer Farooq Awan |
| authorships[7].countries | PK |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I43879129 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Botany, Government College University, Lahore 53801, Pakistan |
| authorships[7].institutions[0].id | https://openalex.org/I43879129 |
| authorships[7].institutions[0].ror | https://ror.org/040gec961 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I43879129 |
| authorships[7].institutions[0].country_code | PK |
| authorships[7].institutions[0].display_name | Government College University, Lahore |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Muhammad Umer Farooq Awan |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Botany, Government College University, Lahore 53801, Pakistan |
| authorships[8].author.id | https://openalex.org/A5080102334 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Hooria Khan |
| authorships[8].countries | PK |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I16076960 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Bioscience, COMSATS Institute of Information Technology (CIIT), Islamabad 45550, Pakistan |
| authorships[8].institutions[0].id | https://openalex.org/I16076960 |
| authorships[8].institutions[0].ror | https://ror.org/00nqqvk19 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I16076960 |
| authorships[8].institutions[0].country_code | PK |
| authorships[8].institutions[0].display_name | COMSATS University Islamabad |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Hooria Khan |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Bioscience, COMSATS Institute of Information Technology (CIIT), Islamabad 45550, Pakistan |
| authorships[9].author.id | https://openalex.org/A5019304031 |
| authorships[9].author.orcid | |
| authorships[9].author.display_name | Umera Imtiaz |
| authorships[9].countries | PK |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I43879129 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Industrial Biotechnology, Government College University, Lahore 53801, Pakistan |
| authorships[9].institutions[0].id | https://openalex.org/I43879129 |
| authorships[9].institutions[0].ror | https://ror.org/040gec961 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I43879129 |
| authorships[9].institutions[0].country_code | PK |
| authorships[9].institutions[0].display_name | Government College University, Lahore |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Umera Imtiaz |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Industrial Biotechnology, Government College University, Lahore 53801, Pakistan |
| authorships[10].author.id | https://openalex.org/A5064199769 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | Yasir Rasheed |
| authorships[10].countries | PK |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I16076960 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Bioscience, COMSATS Institute of Information Technology (CIIT), Islamabad 45550, Pakistan |
| authorships[10].institutions[0].id | https://openalex.org/I16076960 |
| authorships[10].institutions[0].ror | https://ror.org/00nqqvk19 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I16076960 |
| authorships[10].institutions[0].country_code | PK |
| authorships[10].institutions[0].display_name | COMSATS University Islamabad |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Yasir Rasheed |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Bioscience, COMSATS Institute of Information Technology (CIIT), Islamabad 45550, Pakistan |
| authorships[11].author.id | https://openalex.org/A5053403707 |
| authorships[11].author.orcid | https://orcid.org/0000-0001-6051-3383 |
| authorships[11].author.display_name | Imdad Kaleem |
| authorships[11].countries | PK |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I16076960 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Bioscience, COMSATS Institute of Information Technology (CIIT), Islamabad 45550, Pakistan |
| authorships[11].institutions[0].id | https://openalex.org/I16076960 |
| authorships[11].institutions[0].ror | https://ror.org/00nqqvk19 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I16076960 |
| authorships[11].institutions[0].country_code | PK |
| authorships[11].institutions[0].display_name | COMSATS University Islamabad |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Imdad Kaleem |
| authorships[11].is_corresponding | True |
| authorships[11].raw_affiliation_strings | Department of Bioscience, COMSATS Institute of Information Technology (CIIT), Islamabad 45550, Pakistan |
| authorships[12].author.id | https://openalex.org/A5024588676 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-2380-6088 |
| authorships[12].author.display_name | Aamir Rasool |
| authorships[12].countries | CN, PK |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I20561161 |
| authorships[12].affiliations[0].raw_affiliation_string | Institute of Biochemistry, University of Balochistan, Quetta 87300, Pakistan |
| authorships[12].affiliations[1].institution_ids | https://openalex.org/I125839683 |
| authorships[12].affiliations[1].raw_affiliation_string | Institute for Synthetic Biosystem, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China |
| authorships[12].institutions[0].id | https://openalex.org/I125839683 |
| authorships[12].institutions[0].ror | https://ror.org/01skt4w74 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I125839683, https://openalex.org/I890469752 |
| authorships[12].institutions[0].country_code | CN |
| authorships[12].institutions[0].display_name | Beijing Institute of Technology |
| authorships[12].institutions[1].id | https://openalex.org/I20561161 |
| authorships[12].institutions[1].ror | https://ror.org/04bf33n91 |
| authorships[12].institutions[1].type | education |
| authorships[12].institutions[1].lineage | https://openalex.org/I20561161 |
| authorships[12].institutions[1].country_code | PK |
| authorships[12].institutions[1].display_name | University of Balochistan |
| authorships[12].author_position | last |
| authorships[12].raw_author_name | Aamir Rasool |
| authorships[12].is_corresponding | True |
| authorships[12].raw_affiliation_strings | Institute for Synthetic Biosystem, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China, Institute of Biochemistry, University of Balochistan, Quetta 87300, Pakistan |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/2218-1989/10/2/56/pdf?version=1582960977 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Self-Redirection of Metabolic Flux toward Squalene and Ethanol Pathways by Engineered Yeast |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10932 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9998000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Microbial Metabolic Engineering and Bioproduction |
| related_works | https://openalex.org/W2905218341, https://openalex.org/W2361680643, https://openalex.org/W385704401, https://openalex.org/W1990088060, https://openalex.org/W2352726313, https://openalex.org/W3043436041, https://openalex.org/W2947043338, https://openalex.org/W3197240279, https://openalex.org/W2146372898, https://openalex.org/W2969524935 |
| cited_by_count | 9 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 2 |
| counts_by_year[2].year | 2022 |
| counts_by_year[2].cited_by_count | 4 |
| counts_by_year[3].year | 2019 |
| counts_by_year[3].cited_by_count | 1 |
| locations_count | 5 |
| best_oa_location.id | doi:10.3390/metabo10020056 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764402194 |
| best_oa_location.source.issn | 2218-1989 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2218-1989 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Metabolites |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/2218-1989/10/2/56/pdf?version=1582960977 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Metabolites |
| best_oa_location.landing_page_url | https://doi.org/10.3390/metabo10020056 |
| primary_location.id | doi:10.3390/metabo10020056 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2764402194 |
| primary_location.source.issn | 2218-1989 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2218-1989 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Metabolites |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/2218-1989/10/2/56/pdf?version=1582960977 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Metabolites |
| primary_location.landing_page_url | https://doi.org/10.3390/metabo10020056 |
| publication_date | 2020-02-01 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W2091937577, https://openalex.org/W2921649392, https://openalex.org/W2131061094, https://openalex.org/W2016916538, https://openalex.org/W2410264940, https://openalex.org/W2049836024, https://openalex.org/W2073181111, https://openalex.org/W2025248824, https://openalex.org/W2095917588, https://openalex.org/W1596164205, https://openalex.org/W2086575435, https://openalex.org/W2050406421, https://openalex.org/W2470057311, https://openalex.org/W2418010041, https://openalex.org/W2021641354, https://openalex.org/W2083669318, https://openalex.org/W2164904971, https://openalex.org/W2099741220, https://openalex.org/W2886850841, https://openalex.org/W2169768603, https://openalex.org/W2165268542, https://openalex.org/W2743773941, https://openalex.org/W2554960318, https://openalex.org/W2004623980, https://openalex.org/W2792353080, https://openalex.org/W2811323595, https://openalex.org/W1919415919, https://openalex.org/W2270868854, https://openalex.org/W2294225971, https://openalex.org/W2643339762, https://openalex.org/W2118173936, https://openalex.org/W1986764062, https://openalex.org/W1514437369, https://openalex.org/W2145922781, https://openalex.org/W2072369409, https://openalex.org/W2030168212, https://openalex.org/W2023075963, https://openalex.org/W2077837797, https://openalex.org/W6668361649, https://openalex.org/W2098671352, https://openalex.org/W2018668159, https://openalex.org/W2410817863, https://openalex.org/W2793865154, https://openalex.org/W2944774501, https://openalex.org/W2116613524, https://openalex.org/W2024559844, https://openalex.org/W2028889966, https://openalex.org/W2901121611, https://openalex.org/W2074743457, https://openalex.org/W2171339512, https://openalex.org/W2022255882, https://openalex.org/W2053620269, https://openalex.org/W1996783999, https://openalex.org/W2072485260, https://openalex.org/W2078952292, https://openalex.org/W2488324600, https://openalex.org/W1967210731, https://openalex.org/W2126492332, https://openalex.org/W2110143309, https://openalex.org/W2503857930, https://openalex.org/W2119059442, https://openalex.org/W2072033965, https://openalex.org/W2032536428 |
| referenced_works_count | 63 |
| abstract_inverted_index.a | 117, 257 |
| abstract_inverted_index.13 | 53 |
| abstract_inverted_index.FA | 219 |
| abstract_inverted_index.In | 26 |
| abstract_inverted_index.S. | 100 |
| abstract_inverted_index.WS | 208 |
| abstract_inverted_index.We | 0, 233 |
| abstract_inverted_index.as | 256 |
| abstract_inverted_index.be | 263 |
| abstract_inverted_index.by | 132, 186, 225, 231 |
| abstract_inverted_index.in | 99, 140, 167, 200, 251 |
| abstract_inverted_index.of | 11, 31, 33, 45, 109, 127, 158, 165, 191, 217, 229, 238, 241, 247 |
| abstract_inverted_index.on | 37 |
| abstract_inverted_index.to | 17, 22, 82, 88, 93, 154, 171, 222, 265, 274 |
| abstract_inverted_index.up | 170, 221 |
| abstract_inverted_index.106 | 137 |
| abstract_inverted_index.FA) | 44 |
| abstract_inverted_index.FSE | 103, 142, 168, 181 |
| abstract_inverted_index.The | 102, 125, 180, 210 |
| abstract_inverted_index.and | 35, 68, 85, 91, 96, 135, 145, 152, 175, 195, 244, 249, 253 |
| abstract_inverted_index.bp) | 84 |
| abstract_inverted_index.can | 262 |
| abstract_inverted_index.key | 107, 189 |
| abstract_inverted_index.the | 9, 12, 19, 23, 29, 106, 110, 141, 156, 163, 188, 192, 201, 207, 215, 218, 227, 235, 239, 267, 271 |
| abstract_inverted_index.was | 48, 130, 183 |
| abstract_inverted_index.40.2 | 197 |
| abstract_inverted_index.DGA1 | 134 |
| abstract_inverted_index.FSE1 | 202, 211 |
| abstract_inverted_index.GCN4 | 230, 255 |
| abstract_inverted_index.also | 150, 161, 213 |
| abstract_inverted_index.bp), | 90 |
| abstract_inverted_index.flux | 21, 269 |
| abstract_inverted_index.from | 77, 270 |
| abstract_inverted_index.have | 1 |
| abstract_inverted_index.like | 56 |
| abstract_inverted_index.mg/L | 115, 138 |
| abstract_inverted_index.than | 120, 206 |
| abstract_inverted_index.that | 4, 261 |
| abstract_inverted_index.this | 27 |
| abstract_inverted_index.type | 122 |
| abstract_inverted_index.were | 70, 149 |
| abstract_inverted_index.wild | 121 |
| abstract_inverted_index.(WS). | 124 |
| abstract_inverted_index.56.20 | 114 |
| abstract_inverted_index.AFT1p | 144 |
| abstract_inverted_index.CTR1p | 146 |
| abstract_inverted_index.ERG1, | 159 |
| abstract_inverted_index.HHF2p | 80 |
| abstract_inverted_index.TEF1p | 86 |
| abstract_inverted_index.genes | 108, 190 |
| abstract_inverted_index.lipid | 128 |
| abstract_inverted_index.mg/L) | 174, 178 |
| abstract_inverted_index.mg/mL | 198 |
| abstract_inverted_index.novel | 258 |
| abstract_inverted_index.other | 38 |
| abstract_inverted_index.sites | 76 |
| abstract_inverted_index.that, | 52 |
| abstract_inverted_index.using | 72 |
| abstract_inverted_index.which | 160 |
| abstract_inverted_index.yeast | 7, 242 |
| abstract_inverted_index.(fusel | 41 |
| abstract_inverted_index.42.85- | 172 |
| abstract_inverted_index.73.9%, | 223 |
| abstract_inverted_index.BRN1p, | 69 |
| abstract_inverted_index.CMD1p, | 60 |
| abstract_inverted_index.COQ1p, | 64 |
| abstract_inverted_index.GRS1p, | 66 |
| abstract_inverted_index.IRA1p, | 57 |
| abstract_inverted_index.MAK5p, | 67 |
| abstract_inverted_index.PET9p, | 58 |
| abstract_inverted_index.RER2p, | 63 |
| abstract_inverted_index.RHO1p, | 59 |
| abstract_inverted_index.RIM1p, | 65 |
| abstract_inverted_index.USA3p, | 62 |
| abstract_inverted_index.before | 51 |
| abstract_inverted_index.divert | 18, 266 |
| abstract_inverted_index.effect | 30 |
| abstract_inverted_index.factor | 74 |
| abstract_inverted_index.higher | 119, 205 |
| abstract_inverted_index.strain | 104, 123, 169, 182, 212 |
| abstract_inverted_index.strong | 78 |
| abstract_inverted_index.study, | 28 |
| abstract_inverted_index.tuning | 237 |
| abstract_inverted_index.yeast, | 252 |
| abstract_inverted_index.−579 | 89 |
| abstract_inverted_index.−669 | 83 |
| abstract_inverted_index.(148.67 | 173 |
| abstract_inverted_index.(255.11 | 177 |
| abstract_inverted_index.(−300 | 81, 87 |
| abstract_inverted_index.ATP16p, | 61 |
| abstract_inverted_index.alcohol | 42 |
| abstract_inverted_index.ethanol | 13, 36, 97, 193, 199, 250 |
| abstract_inverted_index.further | 184 |
| abstract_inverted_index.highest | 245 |
| abstract_inverted_index.pathway | 14, 112, 194, 220, 273 |
| abstract_inverted_index.perhaps | 224 |
| abstract_inverted_index.present | 254 |
| abstract_inverted_index.strain, | 203 |
| abstract_inverted_index.strain. | 143, 209 |
| abstract_inverted_index.However, | 50 |
| abstract_inverted_index.bindings | 75 |
| abstract_inverted_index.droplets | 129 |
| abstract_inverted_index.employed | 92, 153 |
| abstract_inverted_index.enhanced | 162 |
| abstract_inverted_index.pathway) | 16 |
| abstract_inverted_index.pathway, | 43 |
| abstract_inverted_index.pathway. | 25 |
| abstract_inverted_index.pathways | 40, 98 |
| abstract_inverted_index.produced | 136, 196 |
| abstract_inverted_index.reported | 3 |
| abstract_inverted_index.squalene | 5, 24, 34, 95, 111, 139, 166, 248 |
| abstract_inverted_index.strength | 240 |
| abstract_inverted_index.3.23-fold | 204 |
| abstract_inverted_index.metabolic | 20, 259, 268 |
| abstract_inverted_index.pathways. | 276 |
| abstract_inverted_index.promoters | 79, 148, 243 |
| abstract_inverted_index.regulator | 260 |
| abstract_inverted_index.squalene, | 116 |
| abstract_inverted_index.16.43-fold | 118 |
| abstract_inverted_index.2.24-fold. | 232 |
| abstract_inverted_index.73.49-fold | 176 |
| abstract_inverted_index.biogenesis | 126 |
| abstract_inverted_index.cerevisiae | 47 |
| abstract_inverted_index.engineered | 71, 185, 275 |
| abstract_inverted_index.evaluated. | 49 |
| abstract_inverted_index.expression | 10, 157, 216, 228 |
| abstract_inverted_index.previously | 2 |
| abstract_inverted_index.production | 164 |
| abstract_inverted_index.promoters, | 55 |
| abstract_inverted_index.stimulated | 131 |
| abstract_inverted_index.successful | 236 |
| abstract_inverted_index.accumulated | 113 |
| abstract_inverted_index.cerevisiae. | 101 |
| abstract_inverted_index.demonstrate | 234 |
| abstract_inverted_index.manipulated | 264 |
| abstract_inverted_index.repressible | 147 |
| abstract_inverted_index.constitutive | 54 |
| abstract_inverted_index.coproduction | 246 |
| abstract_inverted_index.downregulate | 155 |
| abstract_inverted_index.Saccharomyces | 46 |
| abstract_inverted_index.characterized | 151 |
| abstract_inverted_index.co-production | 32 |
| abstract_inverted_index.non-essential | 39, 272 |
| abstract_inverted_index.overproducing | 6 |
| abstract_inverted_index.respectively. | 179 |
| abstract_inverted_index.transcription | 73 |
| abstract_inverted_index.(non-essential | 15 |
| abstract_inverted_index.co-overexpress | 94 |
| abstract_inverted_index.downregulating | 226 |
| abstract_inverted_index.overexpressing | 105, 133, 187 |
| abstract_inverted_index.self-downregulate | 8 |
| abstract_inverted_index.self-downregulated | 214 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5024588676, https://openalex.org/A5053403707 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 13 |
| corresponding_institution_ids | https://openalex.org/I125839683, https://openalex.org/I16076960, https://openalex.org/I20561161 |
| citation_normalized_percentile.value | 0.56888765 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |