Semaphorin 4D is a potential biomarker in pediatric leukemia and promotes leukemogenesis by activating PI3K/AKT and ERK signaling pathways Article Swipe
Hongchao Jiang
,
Jiaolian Tang
,
Lijuan Qiu
,
Zhen Zhang
,
Shulan Shi
,
Xue Li
,
Liyue Kui
,
Ti‐Long Huang
,
Weiwei Nan
,
Bailing Zhou
,
Canchun Zhao
,
Ming Yu
,
Qiangming Sun
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3892/or.2021.7952
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3892/or.2021.7952
Semaphorin 4D (Sema4D) is highly expressed in a variety of tumors and is associated with high invasion, poor prognosis and poor therapeutic response. However, the expression and role of Sema4D in leukemia remains unclear. The present study investigated the expression of Sema4D in pediatric leukemia and its effects in leukemia cells. The results demonstrated that Sema4D protein was highly expressed in peripheral blood mononuclear cells of patients with pediatric leukemia, and high levels of soluble Sema4D were also observed in the plasma of these patients. Sema4D knockdown induced cell cycle arrest in G0/G1 phase, inhibited proliferation and promoted apoptosis in BALL‑1 cells, while Sema4D overexpression exhibited the opposite effect. In Jurkat cells, Sema4D knockdown inhibited proliferation and promoted apoptosis, while Sema4D overexpression decreased the abundance of the cells in the G0/G1 phase of the cell cycle and promoted proliferation. Sema4D overexpression also increased the migratory capacity of Jurkat cells and the invasive capacity of BALL‑1 cells. The phosphorylation level of PI3K was decreased in both Sema4D knocked‑down Jurkat and BALL‑1 cells, and the phosphorylation level of ERK was decreased in Sema4D knocked‑down BALL‑1 cells. The phosphorylation levels of PI3K, ERK and AKT were elevated in patients with pediatric leukemia, and were correlated to the increased Sema4D expression. Sema4D overexpression was associated with a shorter overall survival in patients with acute myeloid leukemia. Overall, the results of the present study indicated that Sema4D serves an important role in leukemia development by activating PI3K/AKT and ERK signaling, and it may be used as a potential target for the diagnosis and treatment of leukemia.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3892/or.2021.7952
- https://www.spandidos-publications.com/10.3892/or.2021.7952/download
- OA Status
- hybrid
- Cited By
- 27
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3121843541
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Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3121843541Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3892/or.2021.7952Digital Object Identifier
- Title
-
Semaphorin 4D is a potential biomarker in pediatric leukemia and promotes leukemogenesis by activating PI3K/AKT and ERK signaling pathwaysWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-01-27Full publication date if available
- Authors
-
Hongchao Jiang, Jiaolian Tang, Lijuan Qiu, Zhen Zhang, Shulan Shi, Xue Li, Liyue Kui, Ti‐Long Huang, Weiwei Nan, Bailing Zhou, Canchun Zhao, Ming Yu, Qiangming SunList of authors in order
- Landing page
-
https://doi.org/10.3892/or.2021.7952Publisher landing page
- PDF URL
-
https://www.spandidos-publications.com/10.3892/or.2021.7952/downloadDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://www.spandidos-publications.com/10.3892/or.2021.7952/downloadDirect OA link when available
- Concepts
-
Jurkat cells, Leukemia, Cell cycle, Protein kinase B, Cancer research, PI3K/AKT/mTOR pathway, Biology, MAPK/ERK pathway, Oncogene, Cell growth, Apoptosis, Gene knockdown, Signal transduction, Immunology, Cell biology, T cell, Immune system, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
27Total citation count in OpenAlex
- Citations by year (recent)
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2025: 8, 2024: 3, 2023: 8, 2022: 4, 2021: 4Per-year citation counts (last 5 years)
- References (count)
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52Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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