Semisolid formulations based on solid-in-oil-in-water systems containing proteins Article Swipe
Mónica Araújo
,
Ana Camila Marques
,
José Manuel Sousa Lobo
,
Maria Helena Amaral
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1590/s2175-97902022e191093
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1590/s2175-97902022e191093
In recent years, improvements have been made, through biotechnological processes, in the production and development of peptides capable of increasing collagen and elastin synthesis for anti-aging skin care. However, proteins have many limitations due to their structural, chemical and physical fragility to external aggressions, which may cause conformational changes, leading to loss of biological activity. Therefore, it is important to create delivery systems that protect these biomolecules from damage, allowing them to reach their target. This work aimed to develop a system able to carry bovine serum albumin (BSA), used as a model of a protein, and to incorporate this system in a semisolid formulation suitable for skin application. A microemulgel based on a solid-in-oil-in-water (S/O/W) microemulsion was prepared. Firstly, the association efficiency (AE) of lyophilized BSA-sucrose ester complex and the size of S/O nanodispersion were assessed; then, the characterization and stability evaluation of the final semisolid formulation through evaluation of pH, texture and rheological behavior were performed. The average value of AE was 54.74% ± 2.17. It was possible to develop an S/O/W microemulsion, which allowed the subsequent development of an S/O/W microemulgel that assured suitable pH, texture and rheological characteristics for skin application.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1590/s2175-97902022e191093
- https://www.scielo.br/j/bjps/a/BZwRq5hmyGg5ktHGhJmk79C/?lang=en&format=pdf
- OA Status
- diamond
- References
- 13
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4286728516
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4286728516Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1590/s2175-97902022e191093Digital Object Identifier
- Title
-
Semisolid formulations based on solid-in-oil-in-water systems containing proteinsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-01-01Full publication date if available
- Authors
-
Mónica Araújo, Ana Camila Marques, José Manuel Sousa Lobo, Maria Helena AmaralList of authors in order
- Landing page
-
https://doi.org/10.1590/s2175-97902022e191093Publisher landing page
- PDF URL
-
https://www.scielo.br/j/bjps/a/BZwRq5hmyGg5ktHGhJmk79C/?lang=en&format=pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://www.scielo.br/j/bjps/a/BZwRq5hmyGg5ktHGhJmk79C/?lang=en&format=pdfDirect OA link when available
- Concepts
-
Microemulsion, Bovine serum albumin, Biomolecule, Rheology, Chemistry, Fragility, Chemical engineering, Chromatography, Materials science, Biochemistry, Pulmonary surfactant, Composite material, Physical chemistry, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
13Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4286728516 |
|---|---|
| doi | https://doi.org/10.1590/s2175-97902022e191093 |
| ids.doi | https://doi.org/10.1590/s2175-97902022e191093 |
| ids.openalex | https://openalex.org/W4286728516 |
| fwci | 0.0 |
| type | article |
| title | Semisolid formulations based on solid-in-oil-in-water systems containing proteins |
| biblio.issue | |
| biblio.volume | 58 |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T10411 |
| topics[0].field.id | https://openalex.org/fields/11 |
| topics[0].field.display_name | Agricultural and Biological Sciences |
| topics[0].score | 0.9936000108718872 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1106 |
| topics[0].subfield.display_name | Food Science |
| topics[0].display_name | Proteins in Food Systems |
| topics[1].id | https://openalex.org/T12048 |
| topics[1].field.id | https://openalex.org/fields/11 |
| topics[1].field.display_name | Agricultural and Biological Sciences |
| topics[1].score | 0.9708999991416931 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1106 |
| topics[1].subfield.display_name | Food Science |
| topics[1].display_name | Microencapsulation and Drying Processes |
| topics[2].id | https://openalex.org/T12114 |
| topics[2].field.id | https://openalex.org/fields/11 |
| topics[2].field.display_name | Agricultural and Biological Sciences |
| topics[2].score | 0.9660000205039978 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1106 |
| topics[2].subfield.display_name | Food Science |
| topics[2].display_name | Sensory Analysis and Statistical Methods |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C190119865 |
| concepts[0].level | 3 |
| concepts[0].score | 0.7348704934120178 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q338019 |
| concepts[0].display_name | Microemulsion |
| concepts[1].id | https://openalex.org/C86807702 |
| concepts[1].level | 2 |
| concepts[1].score | 0.6986929774284363 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q2620381 |
| concepts[1].display_name | Bovine serum albumin |
| concepts[2].id | https://openalex.org/C49853544 |
| concepts[2].level | 2 |
| concepts[2].score | 0.6806995272636414 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q206229 |
| concepts[2].display_name | Biomolecule |
| concepts[3].id | https://openalex.org/C200990466 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6167430877685547 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q271707 |
| concepts[3].display_name | Rheology |
| concepts[4].id | https://openalex.org/C185592680 |
| concepts[4].level | 0 |
| concepts[4].score | 0.5076028108596802 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[4].display_name | Chemistry |
| concepts[5].id | https://openalex.org/C80191262 |
| concepts[5].level | 2 |
| concepts[5].score | 0.4350122809410095 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q5477668 |
| concepts[5].display_name | Fragility |
| concepts[6].id | https://openalex.org/C42360764 |
| concepts[6].level | 1 |
| concepts[6].score | 0.43330246210098267 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q83588 |
| concepts[6].display_name | Chemical engineering |
| concepts[7].id | https://openalex.org/C43617362 |
| concepts[7].level | 1 |
| concepts[7].score | 0.4064677953720093 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q170050 |
| concepts[7].display_name | Chromatography |
| concepts[8].id | https://openalex.org/C192562407 |
| concepts[8].level | 0 |
| concepts[8].score | 0.38288548588752747 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q228736 |
| concepts[8].display_name | Materials science |
| concepts[9].id | https://openalex.org/C55493867 |
| concepts[9].level | 1 |
| concepts[9].score | 0.20570632815361023 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[9].display_name | Biochemistry |
| concepts[10].id | https://openalex.org/C58226133 |
| concepts[10].level | 2 |
| concepts[10].score | 0.17057475447654724 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q1324199 |
| concepts[10].display_name | Pulmonary surfactant |
| concepts[11].id | https://openalex.org/C159985019 |
| concepts[11].level | 1 |
| concepts[11].score | 0.13098466396331787 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q181790 |
| concepts[11].display_name | Composite material |
| concepts[12].id | https://openalex.org/C147789679 |
| concepts[12].level | 1 |
| concepts[12].score | 0.0 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q11372 |
| concepts[12].display_name | Physical chemistry |
| concepts[13].id | https://openalex.org/C127413603 |
| concepts[13].level | 0 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q11023 |
| concepts[13].display_name | Engineering |
| keywords[0].id | https://openalex.org/keywords/microemulsion |
| keywords[0].score | 0.7348704934120178 |
| keywords[0].display_name | Microemulsion |
| keywords[1].id | https://openalex.org/keywords/bovine-serum-albumin |
| keywords[1].score | 0.6986929774284363 |
| keywords[1].display_name | Bovine serum albumin |
| keywords[2].id | https://openalex.org/keywords/biomolecule |
| keywords[2].score | 0.6806995272636414 |
| keywords[2].display_name | Biomolecule |
| keywords[3].id | https://openalex.org/keywords/rheology |
| keywords[3].score | 0.6167430877685547 |
| keywords[3].display_name | Rheology |
| keywords[4].id | https://openalex.org/keywords/chemistry |
| keywords[4].score | 0.5076028108596802 |
| keywords[4].display_name | Chemistry |
| keywords[5].id | https://openalex.org/keywords/fragility |
| keywords[5].score | 0.4350122809410095 |
| keywords[5].display_name | Fragility |
| keywords[6].id | https://openalex.org/keywords/chemical-engineering |
| keywords[6].score | 0.43330246210098267 |
| keywords[6].display_name | Chemical engineering |
| keywords[7].id | https://openalex.org/keywords/chromatography |
| keywords[7].score | 0.4064677953720093 |
| keywords[7].display_name | Chromatography |
| keywords[8].id | https://openalex.org/keywords/materials-science |
| keywords[8].score | 0.38288548588752747 |
| keywords[8].display_name | Materials science |
| keywords[9].id | https://openalex.org/keywords/biochemistry |
| keywords[9].score | 0.20570632815361023 |
| keywords[9].display_name | Biochemistry |
| keywords[10].id | https://openalex.org/keywords/pulmonary-surfactant |
| keywords[10].score | 0.17057475447654724 |
| keywords[10].display_name | Pulmonary surfactant |
| keywords[11].id | https://openalex.org/keywords/composite-material |
| keywords[11].score | 0.13098466396331787 |
| keywords[11].display_name | Composite material |
| language | en |
| locations[0].id | doi:10.1590/s2175-97902022e191093 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S120884445 |
| locations[0].source.issn | 1984-8250, 2175-9790 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1984-8250 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Brazilian Journal of Pharmaceutical Sciences |
| locations[0].source.host_organization | https://openalex.org/P4310312331 |
| locations[0].source.host_organization_name | University of São Paulo |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310312331 |
| locations[0].source.host_organization_lineage_names | University of São Paulo |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.scielo.br/j/bjps/a/BZwRq5hmyGg5ktHGhJmk79C/?lang=en&format=pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Brazilian Journal of Pharmaceutical Sciences |
| locations[0].landing_page_url | https://doi.org/10.1590/s2175-97902022e191093 |
| indexed_in | crossref, doaj |
| authorships[0].author.id | https://openalex.org/A5101181838 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Mónica Araújo |
| authorships[0].countries | PT |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I182534213 |
| authorships[0].affiliations[0].raw_affiliation_string | UCIBIO - Applied Molecular Biosciences Unit, MedTech - Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal, Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal |
| authorships[0].institutions[0].id | https://openalex.org/I182534213 |
| authorships[0].institutions[0].ror | https://ror.org/043pwc612 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I182534213 |
| authorships[0].institutions[0].country_code | PT |
| authorships[0].institutions[0].display_name | Universidade do Porto |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Mónica Araújo |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | UCIBIO - Applied Molecular Biosciences Unit, MedTech - Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal, Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal |
| authorships[1].author.id | https://openalex.org/A5051706075 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-1247-6738 |
| authorships[1].author.display_name | Ana Camila Marques |
| authorships[1].countries | PT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I182534213 |
| authorships[1].affiliations[0].raw_affiliation_string | UCIBIO - Applied Molecular Biosciences Unit, MedTech - Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal, Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal |
| authorships[1].institutions[0].id | https://openalex.org/I182534213 |
| authorships[1].institutions[0].ror | https://ror.org/043pwc612 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I182534213 |
| authorships[1].institutions[0].country_code | PT |
| authorships[1].institutions[0].display_name | Universidade do Porto |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Ana Camila Marques |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | UCIBIO - Applied Molecular Biosciences Unit, MedTech - Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal, Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal |
| authorships[2].author.id | https://openalex.org/A5032970936 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-9518-8397 |
| authorships[2].author.display_name | José Manuel Sousa Lobo |
| authorships[2].countries | PT |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I182534213 |
| authorships[2].affiliations[0].raw_affiliation_string | UCIBIO - Applied Molecular Biosciences Unit, MedTech - Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal, Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal |
| authorships[2].institutions[0].id | https://openalex.org/I182534213 |
| authorships[2].institutions[0].ror | https://ror.org/043pwc612 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I182534213 |
| authorships[2].institutions[0].country_code | PT |
| authorships[2].institutions[0].display_name | Universidade do Porto |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | José Manuel Sousa Lobo |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | UCIBIO - Applied Molecular Biosciences Unit, MedTech - Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal, Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal |
| authorships[3].author.id | https://openalex.org/A5013280045 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-3209-3366 |
| authorships[3].author.display_name | Maria Helena Amaral |
| authorships[3].countries | PT |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I182534213 |
| authorships[3].affiliations[0].raw_affiliation_string | UCIBIO - Applied Molecular Biosciences Unit, MedTech - Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal, Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal |
| authorships[3].institutions[0].id | https://openalex.org/I182534213 |
| authorships[3].institutions[0].ror | https://ror.org/043pwc612 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I182534213 |
| authorships[3].institutions[0].country_code | PT |
| authorships[3].institutions[0].display_name | Universidade do Porto |
| authorships[3].author_position | last |
| authorships[3].raw_author_name | Maria Helena Amaral |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | UCIBIO - Applied Molecular Biosciences Unit, MedTech - Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal, Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.scielo.br/j/bjps/a/BZwRq5hmyGg5ktHGhJmk79C/?lang=en&format=pdf |
| open_access.oa_status | diamond |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Semisolid formulations based on solid-in-oil-in-water systems containing proteins |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10411 |
| primary_topic.field.id | https://openalex.org/fields/11 |
| primary_topic.field.display_name | Agricultural and Biological Sciences |
| primary_topic.score | 0.9936000108718872 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1106 |
| primary_topic.subfield.display_name | Food Science |
| primary_topic.display_name | Proteins in Food Systems |
| related_works | https://openalex.org/W2899084033, https://openalex.org/W2748952813, https://openalex.org/W4243288993, https://openalex.org/W2344072586, https://openalex.org/W2969885540, https://openalex.org/W2074525408, https://openalex.org/W137445036, https://openalex.org/W2382059409, https://openalex.org/W2027873163, https://openalex.org/W4286728516 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1590/s2175-97902022e191093 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S120884445 |
| best_oa_location.source.issn | 1984-8250, 2175-9790 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1984-8250 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Brazilian Journal of Pharmaceutical Sciences |
| best_oa_location.source.host_organization | https://openalex.org/P4310312331 |
| best_oa_location.source.host_organization_name | University of São Paulo |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310312331 |
| best_oa_location.source.host_organization_lineage_names | University of São Paulo |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.scielo.br/j/bjps/a/BZwRq5hmyGg5ktHGhJmk79C/?lang=en&format=pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Brazilian Journal of Pharmaceutical Sciences |
| best_oa_location.landing_page_url | https://doi.org/10.1590/s2175-97902022e191093 |
| primary_location.id | doi:10.1590/s2175-97902022e191093 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S120884445 |
| primary_location.source.issn | 1984-8250, 2175-9790 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1984-8250 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Brazilian Journal of Pharmaceutical Sciences |
| primary_location.source.host_organization | https://openalex.org/P4310312331 |
| primary_location.source.host_organization_name | University of São Paulo |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310312331 |
| primary_location.source.host_organization_lineage_names | University of São Paulo |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.scielo.br/j/bjps/a/BZwRq5hmyGg5ktHGhJmk79C/?lang=en&format=pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Brazilian Journal of Pharmaceutical Sciences |
| primary_location.landing_page_url | https://doi.org/10.1590/s2175-97902022e191093 |
| publication_date | 2022-01-01 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W2162245990, https://openalex.org/W2892220014, https://openalex.org/W2554685366, https://openalex.org/W2507396270, https://openalex.org/W2299222472, https://openalex.org/W2301887387, https://openalex.org/W2757037296, https://openalex.org/W2918266931, https://openalex.org/W2617896390, https://openalex.org/W2082040440, https://openalex.org/W2800438504, https://openalex.org/W2600344469, https://openalex.org/W2033885016 |
| referenced_works_count | 13 |
| abstract_inverted_index.A | 109 |
| abstract_inverted_index.a | 80, 91, 94, 102, 113 |
| abstract_inverted_index.AE | 162 |
| abstract_inverted_index.In | 0 |
| abstract_inverted_index.It | 167 |
| abstract_inverted_index.an | 172, 181 |
| abstract_inverted_index.as | 90 |
| abstract_inverted_index.in | 10, 101 |
| abstract_inverted_index.is | 57 |
| abstract_inverted_index.it | 56 |
| abstract_inverted_index.of | 15, 18, 52, 93, 124, 132, 143, 150, 161, 180 |
| abstract_inverted_index.on | 112 |
| abstract_inverted_index.to | 34, 41, 50, 59, 71, 78, 83, 97, 170 |
| abstract_inverted_index.± | 165 |
| abstract_inverted_index.S/O | 133 |
| abstract_inverted_index.The | 158 |
| abstract_inverted_index.and | 13, 21, 38, 96, 129, 140, 153, 189 |
| abstract_inverted_index.due | 33 |
| abstract_inverted_index.for | 24, 106, 192 |
| abstract_inverted_index.may | 45 |
| abstract_inverted_index.pH, | 151, 187 |
| abstract_inverted_index.the | 11, 120, 130, 138, 144, 177 |
| abstract_inverted_index.was | 117, 163, 168 |
| abstract_inverted_index.(AE) | 123 |
| abstract_inverted_index.This | 75 |
| abstract_inverted_index.able | 82 |
| abstract_inverted_index.been | 5 |
| abstract_inverted_index.from | 67 |
| abstract_inverted_index.have | 4, 30 |
| abstract_inverted_index.loss | 51 |
| abstract_inverted_index.many | 31 |
| abstract_inverted_index.size | 131 |
| abstract_inverted_index.skin | 26, 107, 193 |
| abstract_inverted_index.that | 63, 184 |
| abstract_inverted_index.them | 70 |
| abstract_inverted_index.this | 99 |
| abstract_inverted_index.used | 89 |
| abstract_inverted_index.were | 135, 156 |
| abstract_inverted_index.work | 76 |
| abstract_inverted_index.2.17. | 166 |
| abstract_inverted_index.S/O/W | 173, 182 |
| abstract_inverted_index.aimed | 77 |
| abstract_inverted_index.based | 111 |
| abstract_inverted_index.care. | 27 |
| abstract_inverted_index.carry | 84 |
| abstract_inverted_index.cause | 46 |
| abstract_inverted_index.ester | 127 |
| abstract_inverted_index.final | 145 |
| abstract_inverted_index.made, | 6 |
| abstract_inverted_index.model | 92 |
| abstract_inverted_index.reach | 72 |
| abstract_inverted_index.serum | 86 |
| abstract_inverted_index.their | 35, 73 |
| abstract_inverted_index.then, | 137 |
| abstract_inverted_index.these | 65 |
| abstract_inverted_index.value | 160 |
| abstract_inverted_index.which | 44, 175 |
| abstract_inverted_index.(BSA), | 88 |
| abstract_inverted_index.54.74% | 164 |
| abstract_inverted_index.bovine | 85 |
| abstract_inverted_index.create | 60 |
| abstract_inverted_index.recent | 1 |
| abstract_inverted_index.system | 81, 100 |
| abstract_inverted_index.years, | 2 |
| abstract_inverted_index.(S/O/W) | 115 |
| abstract_inverted_index.albumin | 87 |
| abstract_inverted_index.allowed | 176 |
| abstract_inverted_index.assured | 185 |
| abstract_inverted_index.average | 159 |
| abstract_inverted_index.capable | 17 |
| abstract_inverted_index.complex | 128 |
| abstract_inverted_index.damage, | 68 |
| abstract_inverted_index.develop | 79, 171 |
| abstract_inverted_index.elastin | 22 |
| abstract_inverted_index.leading | 49 |
| abstract_inverted_index.protect | 64 |
| abstract_inverted_index.systems | 62 |
| abstract_inverted_index.target. | 74 |
| abstract_inverted_index.texture | 152, 188 |
| abstract_inverted_index.through | 7, 148 |
| abstract_inverted_index.Firstly, | 119 |
| abstract_inverted_index.However, | 28 |
| abstract_inverted_index.allowing | 69 |
| abstract_inverted_index.behavior | 155 |
| abstract_inverted_index.changes, | 48 |
| abstract_inverted_index.chemical | 37 |
| abstract_inverted_index.collagen | 20 |
| abstract_inverted_index.delivery | 61 |
| abstract_inverted_index.external | 42 |
| abstract_inverted_index.peptides | 16 |
| abstract_inverted_index.physical | 39 |
| abstract_inverted_index.possible | 169 |
| abstract_inverted_index.protein, | 95 |
| abstract_inverted_index.proteins | 29 |
| abstract_inverted_index.suitable | 105, 186 |
| abstract_inverted_index.activity. | 54 |
| abstract_inverted_index.assessed; | 136 |
| abstract_inverted_index.fragility | 40 |
| abstract_inverted_index.important | 58 |
| abstract_inverted_index.prepared. | 118 |
| abstract_inverted_index.semisolid | 103, 146 |
| abstract_inverted_index.stability | 141 |
| abstract_inverted_index.synthesis | 23 |
| abstract_inverted_index.Therefore, | 55 |
| abstract_inverted_index.anti-aging | 25 |
| abstract_inverted_index.biological | 53 |
| abstract_inverted_index.efficiency | 122 |
| abstract_inverted_index.evaluation | 142, 149 |
| abstract_inverted_index.increasing | 19 |
| abstract_inverted_index.performed. | 157 |
| abstract_inverted_index.processes, | 9 |
| abstract_inverted_index.production | 12 |
| abstract_inverted_index.subsequent | 178 |
| abstract_inverted_index.BSA-sucrose | 126 |
| abstract_inverted_index.association | 121 |
| abstract_inverted_index.development | 14, 179 |
| abstract_inverted_index.formulation | 104, 147 |
| abstract_inverted_index.incorporate | 98 |
| abstract_inverted_index.limitations | 32 |
| abstract_inverted_index.lyophilized | 125 |
| abstract_inverted_index.rheological | 154, 190 |
| abstract_inverted_index.structural, | 36 |
| abstract_inverted_index.aggressions, | 43 |
| abstract_inverted_index.application. | 108, 194 |
| abstract_inverted_index.biomolecules | 66 |
| abstract_inverted_index.improvements | 3 |
| abstract_inverted_index.microemulgel | 110, 183 |
| abstract_inverted_index.microemulsion | 116 |
| abstract_inverted_index.conformational | 47 |
| abstract_inverted_index.microemulsion, | 174 |
| abstract_inverted_index.nanodispersion | 134 |
| abstract_inverted_index.characteristics | 191 |
| abstract_inverted_index.biotechnological | 8 |
| abstract_inverted_index.characterization | 139 |
| abstract_inverted_index.solid-in-oil-in-water | 114 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/6 |
| sustainable_development_goals[0].score | 0.5699999928474426 |
| sustainable_development_goals[0].display_name | Clean water and sanitation |
| citation_normalized_percentile.value | 0.09324204 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |