Sensitive and Specific Detection of Ewing Sarcoma Minimal Residual Disease in Ovarian and Testicular Tissues in an In Vitro Model Article Swipe
Laure Chaput
,
Victoria Grèze
,
Pascale Halle
,
Nina Radosevic‐Robin
,
Bruno Pereira
,
Lauren Véronèse
,
Hervé Lejeune
,
Philippe Durand
,
Guillaume Martin
,
Sandra Sanfilippo
,
Michel Canis
,
Justyna Kanold
,
Andréï Tchirkov
,
Florence Brugnon
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3390/cancers11111807
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3390/cancers11111807
Ewing sarcoma (EWS) is a common pediatric solid tumor with high metastatic potential. Due to toxic effects of treatments on reproductive functions, the cryopreservation of ovarian tissue (OT) or testicular tissue (TT) is recommended to preserve fertility. However, the risk of reintroducing residual metastatic tumor cells should be evaluated before fertility restoration. Our goal was to validate a sensitive and specific approach for EWS minimal residual disease (MRD) detection in frozen germinal tissues. Thawed OT (n = 12) and TT (n = 14) were contaminated with tumor RD-ES cells (10, 100, and 1000 cells) and EWS-FLI1 tumor-specific transcript was quantified with RT-qPCR. All contaminated samples were found to be positive, with a strong correlation between RD-ES cell numbers and EWS-FLI1 levels in OT (r = 0.93) and TT (r = 0.96) (p < 0.001). No transcript was detected in uncontaminated control samples. The invasive potential of Ewing cells was evaluated using co-culture techniques. After co-culturing, tumor cells were detected in OT/TT with histology, FISH, and RT-qPCR. In addition, four OT and four TT samples from children with metastatic EWS were tested, and no MRD was found using RT-qPCR and histology. We demonstrated the high sensitivity and specificity of RT-qPCR to detect EWS MRD in OT/TT samples. Clinical trial: NCT 02400970.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers11111807
- https://www.mdpi.com/2072-6694/11/11/1807/pdf?version=1573983510
- OA Status
- gold
- Cited By
- 5
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2983474715
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2983474715Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/cancers11111807Digital Object Identifier
- Title
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Sensitive and Specific Detection of Ewing Sarcoma Minimal Residual Disease in Ovarian and Testicular Tissues in an In Vitro ModelWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
-
2019-11-17Full publication date if available
- Authors
-
Laure Chaput, Victoria Grèze, Pascale Halle, Nina Radosevic‐Robin, Bruno Pereira, Lauren Véronèse, Hervé Lejeune, Philippe Durand, Guillaume Martin, Sandra Sanfilippo, Michel Canis, Justyna Kanold, Andréï Tchirkov, Florence BrugnonList of authors in order
- Landing page
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https://doi.org/10.3390/cancers11111807Publisher landing page
- PDF URL
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https://www.mdpi.com/2072-6694/11/11/1807/pdf?version=1573983510Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2072-6694/11/11/1807/pdf?version=1573983510Direct OA link when available
- Concepts
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In vitro, Sarcoma, Medicine, Pathology, Residual, Biology, Cancer research, Computer science, Biochemistry, AlgorithmTop concepts (fields/topics) attached by OpenAlex
- Cited by
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5Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2023: 1, 2022: 2, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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32Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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