Sensory TRP Channels in Three Dimensions Article Swipe
Melinda M. Diver
,
John V. Lin King
,
David Julius
,
Yifan Cheng
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1146/annurev-biochem-032620-105738
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1146/annurev-biochem-032620-105738
Transient receptor potential (TRP) ion channels are sophisticated signaling machines that detect a wide variety of environmental and physiological signals. Every cell in the body expresses one or more members of the extended TRP channel family, which consists of over 30 subtypes, each likely possessing distinct pharmacological, biophysical, and/or structural attributes. While the function of some TRP subtypes remains enigmatic, those involved in sensory signaling are perhaps best characterized and have served as models for understanding how these excitatory ion channels serve as polymodal signal integrators. With the recent resolution revolution in cryo–electron microscopy, these and other TRP channel subtypes are now yielding their secrets to detailed atomic analysis, which is beginning to reveal structural underpinnings of stimulus detection and gating, ion permeation, and allosteric mechanisms governing signal integration. These insights are providing a framework for designing and evaluating modality-specific pharmacological agents for treating sensory and other TRP channel–associated disorders.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1146/annurev-biochem-032620-105738
- https://www.annualreviews.org/doi/pdf/10.1146/annurev-biochem-032620-105738
- OA Status
- bronze
- Cited By
- 65
- References
- 124
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4221099663
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4221099663Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1146/annurev-biochem-032620-105738Digital Object Identifier
- Title
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Sensory TRP Channels in Three DimensionsWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-03-15Full publication date if available
- Authors
-
Melinda M. Diver, John V. Lin King, David Julius, Yifan ChengList of authors in order
- Landing page
-
https://doi.org/10.1146/annurev-biochem-032620-105738Publisher landing page
- PDF URL
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https://www.annualreviews.org/doi/pdf/10.1146/annurev-biochem-032620-105738Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
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https://www.annualreviews.org/doi/pdf/10.1146/annurev-biochem-032620-105738Direct OA link when available
- Concepts
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Transient receptor potential channel, Ion channel, Allosteric regulation, Neuroscience, Sensory system, Gating, Stimulus (psychology), Ligand-gated ion channel, Biology, Chemistry, Biophysics, Receptor, Psychology, Biochemistry, PsychotherapistTop concepts (fields/topics) attached by OpenAlex
- Cited by
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65Total citation count in OpenAlex
- Citations by year (recent)
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2025: 26, 2024: 18, 2023: 19, 2022: 2Per-year citation counts (last 5 years)
- References (count)
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124Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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