Sequence Variation in the DDAH1 Gene Predisposes for Delayed Cerebral Ischemia in Subarachnoidal Hemorrhage Article Swipe
Juliane Hannemann
,
Daniel Appel
,
Miriam Seeberger-Steinmeister
,
Tabea Brüning
,
Julia Zummack
,
Rainer H. Böger
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/jcm9123900
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/jcm9123900
Delayed cerebral ischemia (DCI) often causes poor long-term neurological outcome after subarachnoidal hemorrhage (SAH). Asymmetric dimethylarginine (ADMA) inhibits nitric oxide synthase (NOS) and is associated with DCI after SAH. We studied single nucleotide polymorphisms (SNPs) in the NOS3, DDAH1, DDAH2, PRMT1, and AGXT2 genes that are part of the L-arginine–ADMA–NO pathway, and their association with DCI. We measured L-arginine, ADMA and symmetric dimethylarginine (SDMA) in plasma and cerebrospinal fluid (CSF) of 51 SAH patients at admission; follow-up was until 30 days post-discharge. The primary outcome was the incidence of DCI, defined as new infarctions on cranial computed tomography, which occurred in 18 of 51 patients. Clinical scores did not significantly differ in patients with or without DCI. However, DCI patients had higher plasma ADMA and SDMA levels and higher CSF SDMA levels at admission. DDAH1 SNPs were associated with plasma ADMA, whilst AGXT2 SNPs were associated with plasma SDMA. Carriers of the minor allele of DDAH1 rs233112 had a significantly increased relative risk of DCI (Relative Risk = 2.61 (1.25–5.43), p = 0.002). We conclude that the DDAH1 gene is associated with ADMA concentration and the incidence of DCI in SAH patients, suggesting a pathophysiological link between gene, biomarker, and clinical outcome in patients with SAH.
Related Topics
Concepts
Medicine
Asymmetric dimethylarginine
Internal medicine
Cerebrospinal fluid
Single-nucleotide polymorphism
Incidence (geometry)
Cardiology
Pathophysiology
Biomarker
Ischemia
Gastroenterology
Anesthesia
Endocrinology
Arginine
Genotype
Gene
Amino acid
Optics
Chemistry
Biochemistry
Physics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm9123900
- https://www.mdpi.com/2077-0383/9/12/3900/pdf?version=1606871160
- OA Status
- gold
- Cited By
- 9
- References
- 80
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3107398345
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3107398345Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/jcm9123900Digital Object Identifier
- Title
-
Sequence Variation in the DDAH1 Gene Predisposes for Delayed Cerebral Ischemia in Subarachnoidal HemorrhageWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-12-01Full publication date if available
- Authors
-
Juliane Hannemann, Daniel Appel, Miriam Seeberger-Steinmeister, Tabea Brüning, Julia Zummack, Rainer H. BögerList of authors in order
- Landing page
-
https://doi.org/10.3390/jcm9123900Publisher landing page
- PDF URL
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https://www.mdpi.com/2077-0383/9/12/3900/pdf?version=1606871160Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2077-0383/9/12/3900/pdf?version=1606871160Direct OA link when available
- Concepts
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Medicine, Asymmetric dimethylarginine, Internal medicine, Cerebrospinal fluid, Single-nucleotide polymorphism, Incidence (geometry), Cardiology, Pathophysiology, Biomarker, Ischemia, Gastroenterology, Anesthesia, Endocrinology, Arginine, Genotype, Gene, Amino acid, Optics, Chemistry, Biochemistry, PhysicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
9Total citation count in OpenAlex
- Citations by year (recent)
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2022: 3, 2021: 6Per-year citation counts (last 5 years)
- References (count)
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80Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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