Sequential Measurements of Pentraxin 3 Serum Levels in Patients with Ventilator-Associated Pneumonia: A Nested Case-Control Study Article Swipe

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Procalcitonin Medicine Ventilator-associated pneumonia PTX3 Nested case-control study Pneumonia Intensive care unit Internal medicine Predictive value C-reactive protein Case-control study Intensive care medicine Sepsis Inflammation

Hüseyin Bilgin , Murat Haliloğlu , Ali Yaman , Pınar Ay , Beliz Bilgili , Mustafa Kemal Arslantaş , Filiz Türe Özdemir , Goncagül Haklar , İsmail Cinel , Lütfiye Mülazımoğlu ·

YOU? · · 2018 · Open Access · · DOI: https://doi.org/10.1155/2018/4074169 · OA: W2801795889

Purpose . The main purpose of this study was to investigate the dynamics of pentraxin 3 (PTX3) compared with procalcitonin (PCT) and C-reactive protein (CRP) in patients with suspicion of ventilator-associated pneumonia (VAP). Materials and Methods . We designed a nested case-control study. This study was performed in the Surgical Intensive Care Unit of a tertiary care academic university and teaching hospital. Ninety-one adults who were mechanically ventilated for >48 hours were enrolled in the study. VAP diagnosis was established among 28 patients following the 2005 ATS/IDSA guidelines. Results . The median PTX3 plasma level was 2.66 ng/mL in VAP adults compared to 0.25 ng/mL in non-VAP adults (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math>). Procalcitonin and CRP levels did not significantly differ. Pentraxin 3, with a 2.56 ng/mL breakpoint, had 85% sensitivity, 86% specificity, 75% positive predictive value, and 92.9% negative predictive value for VAP diagnosis (AUC = 0.78). Conclusions . With the suspicion of VAP, a pentraxin 3 plasma breakpoint of 2.56 ng/mL could contribute to the decision of whether to start antibiotics.