SERUM LEVEL OF VASCULAR CELL ADHESION MOLECULE AND P SELECTIN AS THROMBOPHILIC RISK FACTOR FOR EARLY VASCULAR ACCESS THROMBOTIC OCCLUSION IN HEMODIALYSIS PATIENTS Article Swipe
Mohamed Fouad Sherif
,
Amr Gawaly
,
Heba Murad
,
Mohamed A. Dawoud
,
Kamal Okasha
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.htct.2022.09.1240
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.htct.2022.09.1240
Objective: Hemodialysis (HD) vascular access (VA) failure is the dominant cause of morbidity and the major cost of care for ESRD patients. The aim of the present work is to assess the serum level of vascular cell adhesion molecule and P- selectin in HD patients as markers for early thrombotic VA event. Methodology: 90 CKD patients divided into three groups: group I: 10 subjects apparently health, group II: 10 Patients with CKD stage IV-V on medical treatment and group III: 70 Patients with CKD stage V on HD with recent VA insertion divided into 2 subgroups: Subgroup III a: 57 patients with AV shunt and subgroup III b: 13 patients with permanent catheter. Laboratory investigations done (blood urea, serum creatinine, eGFR, CBC, PT, and INR), imaging and serum VCAM 1, P selectin before and 6 months after HD Results: There was positive connection between VCAM and P selectin and dialysis with statistics in form of p value (<0.001). Markers level pre dialysis and after 6 months of dialysis revealed that range of p selectin and VCAM1 level after 6 months are higher than pre dialysis level. Conclusion: Detection of elevated serum level of circulating sVCAM-1 and s P-selectin could be useful in the prediction of native AVF and permanent catheter thrombosis in chronic HD patients. The association between sVCAM-1 and s P-selectin and thrombosis in HD patients increases the evidence of the role of adhesion molecules in VA thrombosis
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- OA Status
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All OpenAlex metadata
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https://doi.org/10.1016/j.htct.2022.09.1240Digital Object Identifier
- Title
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SERUM LEVEL OF VASCULAR CELL ADHESION MOLECULE AND P SELECTIN AS THROMBOPHILIC RISK FACTOR FOR EARLY VASCULAR ACCESS THROMBOTIC OCCLUSION IN HEMODIALYSIS PATIENTSWork title
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articleOpenAlex work type
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enPrimary language
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2022Year of publication
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2022-10-01Full publication date if available
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Mohamed Fouad Sherif, Amr Gawaly, Heba Murad, Mohamed A. Dawoud, Kamal OkashaList of authors in order
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https://doi.org/10.1016/j.htct.2022.09.1240Publisher landing page
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://doi.org/10.1016/j.htct.2022.09.1240Direct OA link when available
- Concepts
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Medicine, Hemodialysis, Thrombosis, Creatinine, Internal medicine, Dialysis, Kidney disease, GastroenterologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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