Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus Article Swipe
Guillermo Ontanilla Clavijo
,
Julia Praena Segovia
,
Álvaro Giráldez Gallego
,
Elisa Cordero
,
José Manuel Sousa Martı́n
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.17235/reed.2017.4072/2015
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.17235/reed.2017.4072/2015
Epstein-Barr virus, a member of the Herpesviridae family, is responsible for the infectious mononucleosis clinical syndrome, which mainly includes the pharyngitis, fever, and lymphadenopathy triad after incubation for 30-50 days. The liver is involved in 80-90% of patients in a self-limiting transient manner, with jaundice being much more uncommon (5%). From a hematological standpoint it may manifest aplastic anemia, neutropenia, and thrombocytopenia. We report a case of infectious mononucleosis that included severe acute hepatitis and was associated with severe hemolytic anemia secondary to cold agglutinins. After exclusion of other etiologies, and given the clinical suspicion of the above association, which was later confirmed by lab tests, empiric therapy was initiated with antiviral agents (aciclovir + valganciclovir) and corticoids, which resulted in a progressive clinical improvement until complete remission. Therefore, we believe that this case report will reinforce the clinical evidence in support of the above combined therapy for serious infectious mononucleosis as a step prior to liver transplantation.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.17235/reed.2017.4072/2015
- OA Status
- green
- Cited By
- 6
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3025956086
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3025956086Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.17235/reed.2017.4072/2015Digital Object Identifier
- Title
-
Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virusWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-01-01Full publication date if available
- Authors
-
Guillermo Ontanilla Clavijo, Julia Praena Segovia, Álvaro Giráldez Gallego, Elisa Cordero, José Manuel Sousa Martı́nList of authors in order
- Landing page
-
https://doi.org/10.17235/reed.2017.4072/2015Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://doaj.org/article/4b9ab3301745485d99654fb2b3de4e16Direct OA link when available
- Concepts
-
Medicine, Mononucleosis, Immunology, Cold Agglutinin, Jaundice, Aplastic anemia, Hepatitis, Autoimmune hemolytic anemia, Hepatitis A, Pharyngitis, Liver transplantation, Virus, Gastroenterology, Transplantation, Internal medicine, Bone marrow, AntibodyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2022: 2, 2020: 1, 2018: 1Per-year citation counts (last 5 years)
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3025956086 |
|---|---|
| doi | https://doi.org/10.17235/reed.2017.4072/2015 |
| ids.doi | https://doi.org/10.17235/reed.2017.4072/2015 |
| ids.mag | 3025956086 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/28376627 |
| ids.openalex | https://openalex.org/W3025956086 |
| fwci | 0.41171969 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000208 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Acute Disease |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D000293 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Adolescent |
| mesh[2].qualifier_ui | Q000175 |
| mesh[2].descriptor_ui | D000744 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | diagnosis |
| mesh[2].descriptor_name | Anemia, Hemolytic, Autoimmune |
| mesh[3].qualifier_ui | Q000821 |
| mesh[3].descriptor_ui | D000744 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | virology |
| mesh[3].descriptor_name | Anemia, Hemolytic, Autoimmune |
| mesh[4].qualifier_ui | Q000150 |
| mesh[4].descriptor_ui | D020031 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | complications |
| mesh[4].descriptor_name | Epstein-Barr Virus Infections |
| mesh[5].qualifier_ui | Q000175 |
| mesh[5].descriptor_ui | D020031 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | diagnosis |
| mesh[5].descriptor_name | Epstein-Barr Virus Infections |
| mesh[6].qualifier_ui | Q000276 |
| mesh[6].descriptor_ui | D020031 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | immunology |
| mesh[6].descriptor_name | Epstein-Barr Virus Infections |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D005260 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Female |
| mesh[8].qualifier_ui | Q000150 |
| mesh[8].descriptor_ui | D006525 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | complications |
| mesh[8].descriptor_name | Hepatitis, Viral, Human |
| mesh[9].qualifier_ui | Q000175 |
| mesh[9].descriptor_ui | D006525 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | diagnosis |
| mesh[9].descriptor_name | Hepatitis, Viral, Human |
| mesh[10].qualifier_ui | Q000276 |
| mesh[10].descriptor_ui | D006525 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | immunology |
| mesh[10].descriptor_name | Hepatitis, Viral, Human |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D006801 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Humans |
| mesh[12].qualifier_ui | Q000150 |
| mesh[12].descriptor_ui | D007244 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | complications |
| mesh[12].descriptor_name | Infectious Mononucleosis |
| mesh[13].qualifier_ui | Q000175 |
| mesh[13].descriptor_ui | D007244 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | diagnosis |
| mesh[13].descriptor_name | Infectious Mononucleosis |
| mesh[14].qualifier_ui | Q000276 |
| mesh[14].descriptor_ui | D007244 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | immunology |
| mesh[14].descriptor_name | Infectious Mononucleosis |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D012720 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Severity of Illness Index |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D000208 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Acute Disease |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D000293 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Adolescent |
| mesh[18].qualifier_ui | Q000175 |
| mesh[18].descriptor_ui | D000744 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | diagnosis |
| mesh[18].descriptor_name | Anemia, Hemolytic, Autoimmune |
| mesh[19].qualifier_ui | Q000821 |
| mesh[19].descriptor_ui | D000744 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | virology |
| mesh[19].descriptor_name | Anemia, Hemolytic, Autoimmune |
| mesh[20].qualifier_ui | Q000150 |
| mesh[20].descriptor_ui | D020031 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | complications |
| mesh[20].descriptor_name | Epstein-Barr Virus Infections |
| mesh[21].qualifier_ui | Q000175 |
| mesh[21].descriptor_ui | D020031 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | diagnosis |
| mesh[21].descriptor_name | Epstein-Barr Virus Infections |
| mesh[22].qualifier_ui | Q000276 |
| mesh[22].descriptor_ui | D020031 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | immunology |
| mesh[22].descriptor_name | Epstein-Barr Virus Infections |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D005260 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Female |
| mesh[24].qualifier_ui | Q000150 |
| mesh[24].descriptor_ui | D006525 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | complications |
| mesh[24].descriptor_name | Hepatitis, Viral, Human |
| mesh[25].qualifier_ui | Q000175 |
| mesh[25].descriptor_ui | D006525 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | diagnosis |
| mesh[25].descriptor_name | Hepatitis, Viral, Human |
| mesh[26].qualifier_ui | Q000276 |
| mesh[26].descriptor_ui | D006525 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | immunology |
| mesh[26].descriptor_name | Hepatitis, Viral, Human |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D006801 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Humans |
| mesh[28].qualifier_ui | Q000150 |
| mesh[28].descriptor_ui | D007244 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | complications |
| mesh[28].descriptor_name | Infectious Mononucleosis |
| mesh[29].qualifier_ui | Q000175 |
| mesh[29].descriptor_ui | D007244 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | diagnosis |
| mesh[29].descriptor_name | Infectious Mononucleosis |
| mesh[30].qualifier_ui | Q000276 |
| mesh[30].descriptor_ui | D007244 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | immunology |
| mesh[30].descriptor_name | Infectious Mononucleosis |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D012720 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Severity of Illness Index |
| type | article |
| title | Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus |
| biblio.issue | 5 |
| biblio.volume | 109 |
| biblio.last_page | 390 |
| biblio.first_page | 388 |
| topics[0].id | https://openalex.org/T11660 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9995999932289124 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2720 |
| topics[0].subfield.display_name | Hematology |
| topics[0].display_name | Blood groups and transfusion |
| topics[1].id | https://openalex.org/T12849 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9993000030517578 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2725 |
| topics[1].subfield.display_name | Infectious Diseases |
| topics[1].display_name | Parvovirus B19 Infection Studies |
| topics[2].id | https://openalex.org/T10981 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9975000023841858 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2713 |
| topics[2].subfield.display_name | Epidemiology |
| topics[2].display_name | Cytomegalovirus and herpesvirus research |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.9126957654953003 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C2776129502 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7901687622070312 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q207367 |
| concepts[1].display_name | Mononucleosis |
| concepts[2].id | https://openalex.org/C203014093 |
| concepts[2].level | 1 |
| concepts[2].score | 0.5865723490715027 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[2].display_name | Immunology |
| concepts[3].id | https://openalex.org/C2910849039 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5401958227157593 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q3606543 |
| concepts[3].display_name | Cold Agglutinin |
| concepts[4].id | https://openalex.org/C2778456037 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5189061760902405 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q133244 |
| concepts[4].display_name | Jaundice |
| concepts[5].id | https://openalex.org/C2781440808 |
| concepts[5].level | 3 |
| concepts[5].score | 0.5177661180496216 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q846316 |
| concepts[5].display_name | Aplastic anemia |
| concepts[6].id | https://openalex.org/C2776029263 |
| concepts[6].level | 2 |
| concepts[6].score | 0.5074688792228699 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q131742 |
| concepts[6].display_name | Hepatitis |
| concepts[7].id | https://openalex.org/C2777385706 |
| concepts[7].level | 3 |
| concepts[7].score | 0.4870605766773224 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q28814 |
| concepts[7].display_name | Autoimmune hemolytic anemia |
| concepts[8].id | https://openalex.org/C2775876817 |
| concepts[8].level | 3 |
| concepts[8].score | 0.4825586676597595 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q157661 |
| concepts[8].display_name | Hepatitis A |
| concepts[9].id | https://openalex.org/C2779279270 |
| concepts[9].level | 2 |
| concepts[9].score | 0.4199501574039459 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q2085267 |
| concepts[9].display_name | Pharyngitis |
| concepts[10].id | https://openalex.org/C2779609443 |
| concepts[10].level | 3 |
| concepts[10].score | 0.4132785201072693 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q1368191 |
| concepts[10].display_name | Liver transplantation |
| concepts[11].id | https://openalex.org/C2522874641 |
| concepts[11].level | 2 |
| concepts[11].score | 0.30800625681877136 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q808 |
| concepts[11].display_name | Virus |
| concepts[12].id | https://openalex.org/C90924648 |
| concepts[12].level | 1 |
| concepts[12].score | 0.2776254117488861 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q120569 |
| concepts[12].display_name | Gastroenterology |
| concepts[13].id | https://openalex.org/C2911091166 |
| concepts[13].level | 2 |
| concepts[13].score | 0.2606777548789978 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q106419912 |
| concepts[13].display_name | Transplantation |
| concepts[14].id | https://openalex.org/C126322002 |
| concepts[14].level | 1 |
| concepts[14].score | 0.25752484798431396 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[14].display_name | Internal medicine |
| concepts[15].id | https://openalex.org/C2780007613 |
| concepts[15].level | 2 |
| concepts[15].score | 0.1449832022190094 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q546523 |
| concepts[15].display_name | Bone marrow |
| concepts[16].id | https://openalex.org/C159654299 |
| concepts[16].level | 2 |
| concepts[16].score | 0.12049543857574463 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q79460 |
| concepts[16].display_name | Antibody |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.9126957654953003 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/mononucleosis |
| keywords[1].score | 0.7901687622070312 |
| keywords[1].display_name | Mononucleosis |
| keywords[2].id | https://openalex.org/keywords/immunology |
| keywords[2].score | 0.5865723490715027 |
| keywords[2].display_name | Immunology |
| keywords[3].id | https://openalex.org/keywords/cold-agglutinin |
| keywords[3].score | 0.5401958227157593 |
| keywords[3].display_name | Cold Agglutinin |
| keywords[4].id | https://openalex.org/keywords/jaundice |
| keywords[4].score | 0.5189061760902405 |
| keywords[4].display_name | Jaundice |
| keywords[5].id | https://openalex.org/keywords/aplastic-anemia |
| keywords[5].score | 0.5177661180496216 |
| keywords[5].display_name | Aplastic anemia |
| keywords[6].id | https://openalex.org/keywords/hepatitis |
| keywords[6].score | 0.5074688792228699 |
| keywords[6].display_name | Hepatitis |
| keywords[7].id | https://openalex.org/keywords/autoimmune-hemolytic-anemia |
| keywords[7].score | 0.4870605766773224 |
| keywords[7].display_name | Autoimmune hemolytic anemia |
| keywords[8].id | https://openalex.org/keywords/hepatitis-a |
| keywords[8].score | 0.4825586676597595 |
| keywords[8].display_name | Hepatitis A |
| keywords[9].id | https://openalex.org/keywords/pharyngitis |
| keywords[9].score | 0.4199501574039459 |
| keywords[9].display_name | Pharyngitis |
| keywords[10].id | https://openalex.org/keywords/liver-transplantation |
| keywords[10].score | 0.4132785201072693 |
| keywords[10].display_name | Liver transplantation |
| keywords[11].id | https://openalex.org/keywords/virus |
| keywords[11].score | 0.30800625681877136 |
| keywords[11].display_name | Virus |
| keywords[12].id | https://openalex.org/keywords/gastroenterology |
| keywords[12].score | 0.2776254117488861 |
| keywords[12].display_name | Gastroenterology |
| keywords[13].id | https://openalex.org/keywords/transplantation |
| keywords[13].score | 0.2606777548789978 |
| keywords[13].display_name | Transplantation |
| keywords[14].id | https://openalex.org/keywords/internal-medicine |
| keywords[14].score | 0.25752484798431396 |
| keywords[14].display_name | Internal medicine |
| keywords[15].id | https://openalex.org/keywords/bone-marrow |
| keywords[15].score | 0.1449832022190094 |
| keywords[15].display_name | Bone marrow |
| keywords[16].id | https://openalex.org/keywords/antibody |
| keywords[16].score | 0.12049543857574463 |
| keywords[16].display_name | Antibody |
| language | en |
| locations[0].id | doi:10.17235/reed.2017.4072/2015 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S33840552 |
| locations[0].source.issn | 1130-0108, 2340-4167 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 1130-0108 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Revista Española de Enfermedades Digestivas |
| locations[0].source.host_organization | https://openalex.org/P4310322006 |
| locations[0].source.host_organization_name | Arán Ediciones |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310322006 |
| locations[0].source.host_organization_lineage_names | Arán Ediciones |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Revista Española de Enfermedades Digestivas |
| locations[0].landing_page_url | https://doi.org/10.17235/reed.2017.4072/2015 |
| locations[1].id | pmid:28376627 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Revista espanola de enfermedades digestivas |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/28376627 |
| locations[2].id | pmh:oai:doaj.org/article:4b9ab3301745485d99654fb2b3de4e16 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | cc-by-sa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Revista Espanola de Enfermedades Digestivas, Vol 109, Iss 5, Pp 388-390 |
| locations[2].landing_page_url | https://doaj.org/article/4b9ab3301745485d99654fb2b3de4e16 |
| locations[3].id | pmh:oai:idus.us.es:11441/158771 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400333 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | idUS (Universidad de Sevilla) |
| locations[3].source.host_organization | https://openalex.org/I79238269 |
| locations[3].source.host_organization_name | Universidad de Sevilla |
| locations[3].source.host_organization_lineage | https://openalex.org/I79238269 |
| locations[3].license | cc-by-nc-nd |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | info:eu-repo/semantics/article |
| locations[3].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | https://idus.us.es/handle//11441/158771 |
| locations[4].id | pmh:oai:scielo:S1130-01082017000500023 |
| locations[4].is_oa | False |
| locations[4].source.id | https://openalex.org/S4306400305 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | Sociedad (University of Buenos Aires) |
| locations[4].source.host_organization | https://openalex.org/I24354313 |
| locations[4].source.host_organization_name | University of Buenos Aires |
| locations[4].source.host_organization_lineage | https://openalex.org/I24354313 |
| locations[4].license | |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | journal article |
| locations[4].license_id | |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Revista Española de Enfermedades Digestivas v.109 n.5 2017 |
| locations[4].landing_page_url | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082017000500023 |
| locations[5].id | pmh:oai:www.repositoriosalud.es:10668/11053 |
| locations[5].is_oa | True |
| locations[5].source.id | https://openalex.org/S4377196114 |
| locations[5].source.issn | |
| locations[5].source.type | repository |
| locations[5].source.is_oa | False |
| locations[5].source.issn_l | |
| locations[5].source.is_core | False |
| locations[5].source.is_in_doaj | False |
| locations[5].source.display_name | RISalud Institutional Health Repository of Andalucía |
| locations[5].source.host_organization | |
| locations[5].source.host_organization_name | |
| locations[5].license | other-oa |
| locations[5].pdf_url | |
| locations[5].version | submittedVersion |
| locations[5].raw_type | research article |
| locations[5].license_id | https://openalex.org/licenses/other-oa |
| locations[5].is_accepted | False |
| locations[5].is_published | False |
| locations[5].raw_source_name | |
| locations[5].landing_page_url | http://hdl.handle.net/10668/11053 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5003891283 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Guillermo Ontanilla Clavijo |
| authorships[0].countries | ES |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210153139 |
| authorships[0].affiliations[0].raw_affiliation_string | Aparato Digestivo, Hospital Universitario Virgen del Rocío, España. |
| authorships[0].institutions[0].id | https://openalex.org/I4210153139 |
| authorships[0].institutions[0].ror | https://ror.org/04vfhnm78 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210153139 |
| authorships[0].institutions[0].country_code | ES |
| authorships[0].institutions[0].display_name | Hospital Universitario Virgen del Rocío |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Guillermo Ontanilla Clavijo |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Aparato Digestivo, Hospital Universitario Virgen del Rocío, España. |
| authorships[1].author.id | https://openalex.org/A5065495124 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Julia Praena Segovia |
| authorships[1].countries | ES |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210153139 |
| authorships[1].affiliations[0].raw_affiliation_string | Enfermedades Infecciosas, Hospital Universitario Virgen del Rocío, España. |
| authorships[1].institutions[0].id | https://openalex.org/I4210153139 |
| authorships[1].institutions[0].ror | https://ror.org/04vfhnm78 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210153139 |
| authorships[1].institutions[0].country_code | ES |
| authorships[1].institutions[0].display_name | Hospital Universitario Virgen del Rocío |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Julia Praena Segovia |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Enfermedades Infecciosas, Hospital Universitario Virgen del Rocío, España. |
| authorships[2].author.id | https://openalex.org/A5082257255 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-6849-9272 |
| authorships[2].author.display_name | Álvaro Giráldez Gallego |
| authorships[2].countries | ES |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210153139 |
| authorships[2].affiliations[0].raw_affiliation_string | UGC Enfermedades Digestivas, Hospital Universitario Virgen del Rocío, España. |
| authorships[2].institutions[0].id | https://openalex.org/I4210153139 |
| authorships[2].institutions[0].ror | https://ror.org/04vfhnm78 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210153139 |
| authorships[2].institutions[0].country_code | ES |
| authorships[2].institutions[0].display_name | Hospital Universitario Virgen del Rocío |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Álvaro Giráldez Gallego |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | UGC Enfermedades Digestivas, Hospital Universitario Virgen del Rocío, España. |
| authorships[3].author.id | https://openalex.org/A5021918368 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-7766-7266 |
| authorships[3].author.display_name | Elisa Cordero |
| authorships[3].countries | ES |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210153139 |
| authorships[3].affiliations[0].raw_affiliation_string | Enfermedades Infecciosas, Hospital Universitario Virgen del Rocío, España. |
| authorships[3].institutions[0].id | https://openalex.org/I4210153139 |
| authorships[3].institutions[0].ror | https://ror.org/04vfhnm78 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210153139 |
| authorships[3].institutions[0].country_code | ES |
| authorships[3].institutions[0].display_name | Hospital Universitario Virgen del Rocío |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | María Elisa Cordero Matía |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Enfermedades Infecciosas, Hospital Universitario Virgen del Rocío, España. |
| authorships[4].author.id | https://openalex.org/A5113845704 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-8158-273X |
| authorships[4].author.display_name | José Manuel Sousa Martı́n |
| authorships[4].countries | ES |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210153139 |
| authorships[4].affiliations[0].raw_affiliation_string | UGC Enfermedades Digestivas, Hospital Universitario Virgen del Rocío, España. |
| authorships[4].institutions[0].id | https://openalex.org/I4210153139 |
| authorships[4].institutions[0].ror | https://ror.org/04vfhnm78 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210153139 |
| authorships[4].institutions[0].country_code | ES |
| authorships[4].institutions[0].display_name | Hospital Universitario Virgen del Rocío |
| authorships[4].author_position | last |
| authorships[4].raw_author_name | José Manuel Sousa Martín |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | UGC Enfermedades Digestivas, Hospital Universitario Virgen del Rocío, España. |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doaj.org/article/4b9ab3301745485d99654fb2b3de4e16 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11660 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9995999932289124 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2720 |
| primary_topic.subfield.display_name | Hematology |
| primary_topic.display_name | Blood groups and transfusion |
| related_works | https://openalex.org/W2334527718, https://openalex.org/W2145031594, https://openalex.org/W2412731677, https://openalex.org/W2418417809, https://openalex.org/W2983268759, https://openalex.org/W1618438483, https://openalex.org/W1966020787, https://openalex.org/W133341763, https://openalex.org/W2023273525, https://openalex.org/W3025956086 |
| cited_by_count | 6 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2022 |
| counts_by_year[1].cited_by_count | 2 |
| counts_by_year[2].year | 2020 |
| counts_by_year[2].cited_by_count | 1 |
| counts_by_year[3].year | 2018 |
| counts_by_year[3].cited_by_count | 1 |
| locations_count | 6 |
| best_oa_location.id | pmh:oai:doaj.org/article:4b9ab3301745485d99654fb2b3de4e16 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306401280 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| best_oa_location.source.host_organization | |
| best_oa_location.source.host_organization_name | |
| best_oa_location.license | cc-by-sa |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-sa |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | Revista Espanola de Enfermedades Digestivas, Vol 109, Iss 5, Pp 388-390 |
| best_oa_location.landing_page_url | https://doaj.org/article/4b9ab3301745485d99654fb2b3de4e16 |
| primary_location.id | doi:10.17235/reed.2017.4072/2015 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S33840552 |
| primary_location.source.issn | 1130-0108, 2340-4167 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 1130-0108 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Revista Española de Enfermedades Digestivas |
| primary_location.source.host_organization | https://openalex.org/P4310322006 |
| primary_location.source.host_organization_name | Arán Ediciones |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310322006 |
| primary_location.source.host_organization_lineage_names | Arán Ediciones |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Revista Española de Enfermedades Digestivas |
| primary_location.landing_page_url | https://doi.org/10.17235/reed.2017.4072/2015 |
| publication_date | 2017-01-01 |
| publication_year | 2017 |
| referenced_works_count | 0 |
| abstract_inverted_index.+ | 114 |
| abstract_inverted_index.a | 2, 39, 51, 64, 121, 152 |
| abstract_inverted_index.We | 62 |
| abstract_inverted_index.as | 151 |
| abstract_inverted_index.by | 103 |
| abstract_inverted_index.in | 34, 38, 120, 140 |
| abstract_inverted_index.is | 8, 32 |
| abstract_inverted_index.it | 54 |
| abstract_inverted_index.of | 4, 36, 66, 87, 95, 142 |
| abstract_inverted_index.to | 82, 155 |
| abstract_inverted_index.we | 129 |
| abstract_inverted_index.The | 30 |
| abstract_inverted_index.and | 22, 60, 74, 90, 116 |
| abstract_inverted_index.for | 10, 27, 147 |
| abstract_inverted_index.lab | 104 |
| abstract_inverted_index.may | 55 |
| abstract_inverted_index.the | 5, 11, 19, 92, 96, 137, 143 |
| abstract_inverted_index.was | 75, 100, 108 |
| abstract_inverted_index.From | 50 |
| abstract_inverted_index.case | 65, 133 |
| abstract_inverted_index.cold | 83 |
| abstract_inverted_index.more | 47 |
| abstract_inverted_index.much | 46 |
| abstract_inverted_index.step | 153 |
| abstract_inverted_index.that | 69, 131 |
| abstract_inverted_index.this | 132 |
| abstract_inverted_index.will | 135 |
| abstract_inverted_index.with | 43, 77, 110 |
| abstract_inverted_index.(5%). | 49 |
| abstract_inverted_index.30-50 | 28 |
| abstract_inverted_index.After | 85 |
| abstract_inverted_index.above | 97, 144 |
| abstract_inverted_index.acute | 72 |
| abstract_inverted_index.after | 25 |
| abstract_inverted_index.being | 45 |
| abstract_inverted_index.days. | 29 |
| abstract_inverted_index.given | 91 |
| abstract_inverted_index.later | 101 |
| abstract_inverted_index.liver | 31, 156 |
| abstract_inverted_index.other | 88 |
| abstract_inverted_index.prior | 154 |
| abstract_inverted_index.triad | 24 |
| abstract_inverted_index.until | 125 |
| abstract_inverted_index.which | 16, 99, 118 |
| abstract_inverted_index.80-90% | 35 |
| abstract_inverted_index.agents | 112 |
| abstract_inverted_index.anemia | 80 |
| abstract_inverted_index.fever, | 21 |
| abstract_inverted_index.mainly | 17 |
| abstract_inverted_index.member | 3 |
| abstract_inverted_index.report | 63, 134 |
| abstract_inverted_index.severe | 71, 78 |
| abstract_inverted_index.tests, | 105 |
| abstract_inverted_index.virus, | 1 |
| abstract_inverted_index.anemia, | 58 |
| abstract_inverted_index.believe | 130 |
| abstract_inverted_index.empiric | 106 |
| abstract_inverted_index.family, | 7 |
| abstract_inverted_index.manner, | 42 |
| abstract_inverted_index.serious | 148 |
| abstract_inverted_index.support | 141 |
| abstract_inverted_index.therapy | 107, 146 |
| abstract_inverted_index.aplastic | 57 |
| abstract_inverted_index.clinical | 14, 93, 123, 138 |
| abstract_inverted_index.combined | 145 |
| abstract_inverted_index.complete | 126 |
| abstract_inverted_index.evidence | 139 |
| abstract_inverted_index.included | 70 |
| abstract_inverted_index.includes | 18 |
| abstract_inverted_index.involved | 33 |
| abstract_inverted_index.jaundice | 44 |
| abstract_inverted_index.manifest | 56 |
| abstract_inverted_index.patients | 37 |
| abstract_inverted_index.resulted | 119 |
| abstract_inverted_index.uncommon | 48 |
| abstract_inverted_index.antiviral | 111 |
| abstract_inverted_index.confirmed | 102 |
| abstract_inverted_index.exclusion | 86 |
| abstract_inverted_index.hemolytic | 79 |
| abstract_inverted_index.hepatitis | 73 |
| abstract_inverted_index.initiated | 109 |
| abstract_inverted_index.reinforce | 136 |
| abstract_inverted_index.secondary | 81 |
| abstract_inverted_index.suspicion | 94 |
| abstract_inverted_index.syndrome, | 15 |
| abstract_inverted_index.transient | 41 |
| abstract_inverted_index.(aciclovir | 113 |
| abstract_inverted_index.Therefore, | 128 |
| abstract_inverted_index.associated | 76 |
| abstract_inverted_index.incubation | 26 |
| abstract_inverted_index.infectious | 12, 67, 149 |
| abstract_inverted_index.remission. | 127 |
| abstract_inverted_index.standpoint | 53 |
| abstract_inverted_index.corticoids, | 117 |
| abstract_inverted_index.etiologies, | 89 |
| abstract_inverted_index.improvement | 124 |
| abstract_inverted_index.progressive | 122 |
| abstract_inverted_index.responsible | 9 |
| abstract_inverted_index.Epstein-Barr | 0 |
| abstract_inverted_index.agglutinins. | 84 |
| abstract_inverted_index.association, | 98 |
| abstract_inverted_index.neutropenia, | 59 |
| abstract_inverted_index.pharyngitis, | 20 |
| abstract_inverted_index.Herpesviridae | 6 |
| abstract_inverted_index.hematological | 52 |
| abstract_inverted_index.mononucleosis | 13, 68, 150 |
| abstract_inverted_index.self-limiting | 40 |
| abstract_inverted_index.lymphadenopathy | 23 |
| abstract_inverted_index.valganciclovir) | 115 |
| abstract_inverted_index.transplantation. | 157 |
| abstract_inverted_index.thrombocytopenia. | 61 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8500000238418579 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.65812643 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |