Severe COVID-19 and aging: are monocytes the key? Article Swipe
The ongoing pandemic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes a disproportionate number of severe cases and deaths in older adults. Severe SARS-CoV-2-associated disease (coronavirus disease 2019 (COVID-19)) was declared a pandemic by the World Health Organization in March 2020 and is characterized by cytokine storm, acute respiratory distress syndrome, and in some cases by systemic inflammation–related pathology. Currently, our knowledge of the determinants of severe COVID-19 is primarily observational. Here, I review emerging evidence to argue that monocytes, a circulating innate immune cell, are principal players in cytokine storm and associated pathologies in COVID-19. I also describe changes in monocyte function and phenotype that are characteristic of both aging and severe COVID-19, which suggests a potential mechanism underlying increased morbidity and mortality due to SARS-CoV-2 infection in older adults. The innate immune system is therefore a potentially important target for therapeutic treatment of COVID-19, but experimental studies are needed, and SARS-CoV-2 presents unique challenges for pre-clinical and mechanistic studies in vivo. The immediate establishment of colonies of SARS-CoV-2-susceptible animal models for aging studies, as well as strong collaborative efforts in the geroscience community, will be required in order to develop the therapies needed to combat severe COVID-19 in older adult populations.
Related Topics
Concepts
Coronavirus disease 2019 (COVID-19)
2019-20 coronavirus outbreak
Key (lock)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Betacoronavirus
Virology
Medicine
Computer science
Internal medicine
Disease
Infectious disease (medical specialty)
Outbreak
Computer security
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1007/s11357-020-00213-0
- https://link.springer.com/content/pdf/10.1007/s11357-020-00213-0.pdf
- OA Status
- hybrid
- Cited By
- 141
- References
- 111
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3036482760
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3036482760Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1007/s11357-020-00213-0Digital Object Identifier
- Title
-
Severe COVID-19 and aging: are monocytes the key?Work title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-06-15Full publication date if available
- Authors
-
Brandt D. PenceList of authors in order
- Landing page
-
https://doi.org/10.1007/s11357-020-00213-0Publisher landing page
- PDF URL
-
https://link.springer.com/content/pdf/10.1007/s11357-020-00213-0.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://link.springer.com/content/pdf/10.1007/s11357-020-00213-0.pdfDirect OA link when available
- Concepts
-
Coronavirus disease 2019 (COVID-19), 2019-20 coronavirus outbreak, Key (lock), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Betacoronavirus, Virology, Medicine, Computer science, Internal medicine, Disease, Infectious disease (medical specialty), Outbreak, Computer securityTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
141Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 11, 2023: 23, 2022: 25, 2021: 55Per-year citation counts (last 5 years)
- References (count)
-
111Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3036482760 |
|---|---|
| doi | https://doi.org/10.1007/s11357-020-00213-0 |
| ids.doi | https://doi.org/10.1007/s11357-020-00213-0 |
| ids.mag | 3036482760 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/32556942 |
| ids.openalex | https://openalex.org/W3036482760 |
| fwci | 14.38888392 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000367 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Age Factors |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D000073640 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Betacoronavirus |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D000086382 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | COVID-19 |
| mesh[3].qualifier_ui | Q000150 |
| mesh[3].descriptor_ui | D018352 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | complications |
| mesh[3].descriptor_name | Coronavirus Infections |
| mesh[4].qualifier_ui | Q000276 |
| mesh[4].descriptor_ui | D018352 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | immunology |
| mesh[4].descriptor_name | Coronavirus Infections |
| mesh[5].qualifier_ui | Q000473 |
| mesh[5].descriptor_ui | D018352 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | pathology |
| mesh[5].descriptor_name | Coronavirus Infections |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D006801 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Humans |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D007111 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Immunity, Cellular |
| mesh[8].qualifier_ui | Q000502 |
| mesh[8].descriptor_ui | D009000 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | physiology |
| mesh[8].descriptor_name | Monocytes |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D058873 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Pandemics |
| mesh[10].qualifier_ui | Q000150 |
| mesh[10].descriptor_ui | D011024 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | complications |
| mesh[10].descriptor_name | Pneumonia, Viral |
| mesh[11].qualifier_ui | Q000276 |
| mesh[11].descriptor_ui | D011024 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | immunology |
| mesh[11].descriptor_name | Pneumonia, Viral |
| mesh[12].qualifier_ui | Q000473 |
| mesh[12].descriptor_ui | D011024 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | pathology |
| mesh[12].descriptor_name | Pneumonia, Viral |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D012307 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Risk Factors |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D000086402 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | SARS-CoV-2 |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D000367 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Age Factors |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D000073640 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Betacoronavirus |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D000086382 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | COVID-19 |
| mesh[18].qualifier_ui | Q000150 |
| mesh[18].descriptor_ui | D018352 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | complications |
| mesh[18].descriptor_name | Coronavirus Infections |
| mesh[19].qualifier_ui | Q000276 |
| mesh[19].descriptor_ui | D018352 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | immunology |
| mesh[19].descriptor_name | Coronavirus Infections |
| mesh[20].qualifier_ui | Q000473 |
| mesh[20].descriptor_ui | D018352 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | pathology |
| mesh[20].descriptor_name | Coronavirus Infections |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D006801 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Humans |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D007111 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Immunity, Cellular |
| mesh[23].qualifier_ui | Q000502 |
| mesh[23].descriptor_ui | D009000 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | physiology |
| mesh[23].descriptor_name | Monocytes |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D058873 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Pandemics |
| mesh[25].qualifier_ui | Q000150 |
| mesh[25].descriptor_ui | D011024 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | complications |
| mesh[25].descriptor_name | Pneumonia, Viral |
| mesh[26].qualifier_ui | Q000276 |
| mesh[26].descriptor_ui | D011024 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | immunology |
| mesh[26].descriptor_name | Pneumonia, Viral |
| mesh[27].qualifier_ui | Q000473 |
| mesh[27].descriptor_ui | D011024 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | pathology |
| mesh[27].descriptor_name | Pneumonia, Viral |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D012307 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Risk Factors |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D000086402 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | SARS-CoV-2 |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D000367 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Age Factors |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D000073640 |
| mesh[31].is_major_topic | True |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Betacoronavirus |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D000086382 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | COVID-19 |
| mesh[33].qualifier_ui | Q000150 |
| mesh[33].descriptor_ui | D018352 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | complications |
| mesh[33].descriptor_name | Coronavirus Infections |
| mesh[34].qualifier_ui | Q000276 |
| mesh[34].descriptor_ui | D018352 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | immunology |
| mesh[34].descriptor_name | Coronavirus Infections |
| mesh[35].qualifier_ui | Q000473 |
| mesh[35].descriptor_ui | D018352 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | pathology |
| mesh[35].descriptor_name | Coronavirus Infections |
| mesh[36].qualifier_ui | |
| mesh[36].descriptor_ui | D006801 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | |
| mesh[36].descriptor_name | Humans |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D007111 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | Immunity, Cellular |
| mesh[38].qualifier_ui | Q000502 |
| mesh[38].descriptor_ui | D009000 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | physiology |
| mesh[38].descriptor_name | Monocytes |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D058873 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Pandemics |
| mesh[40].qualifier_ui | Q000150 |
| mesh[40].descriptor_ui | D011024 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | complications |
| mesh[40].descriptor_name | Pneumonia, Viral |
| mesh[41].qualifier_ui | Q000276 |
| mesh[41].descriptor_ui | D011024 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | immunology |
| mesh[41].descriptor_name | Pneumonia, Viral |
| mesh[42].qualifier_ui | Q000473 |
| mesh[42].descriptor_ui | D011024 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | pathology |
| mesh[42].descriptor_name | Pneumonia, Viral |
| mesh[43].qualifier_ui | |
| mesh[43].descriptor_ui | D012307 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | |
| mesh[43].descriptor_name | Risk Factors |
| mesh[44].qualifier_ui | |
| mesh[44].descriptor_ui | D000086402 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | |
| mesh[44].descriptor_name | SARS-CoV-2 |
| type | review |
| title | Severe COVID-19 and aging: are monocytes the key? |
| biblio.issue | 4 |
| biblio.volume | 42 |
| biblio.last_page | 1061 |
| biblio.first_page | 1051 |
| topics[0].id | https://openalex.org/T11368 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9990000128746033 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2728 |
| topics[0].subfield.display_name | Neurology |
| topics[0].display_name | Long-Term Effects of COVID-19 |
| topics[1].id | https://openalex.org/T10041 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9988999962806702 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2725 |
| topics[1].subfield.display_name | Infectious Diseases |
| topics[1].display_name | COVID-19 Clinical Research Studies |
| topics[2].id | https://openalex.org/T11861 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.98089998960495 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2706 |
| topics[2].subfield.display_name | Critical Care and Intensive Care Medicine |
| topics[2].display_name | Thermal Regulation in Medicine |
| is_xpac | False |
| apc_list.value | 3090 |
| apc_list.currency | EUR |
| apc_list.value_usd | 3990 |
| apc_paid.value | 3090 |
| apc_paid.currency | EUR |
| apc_paid.value_usd | 3990 |
| concepts[0].id | https://openalex.org/C3008058167 |
| concepts[0].level | 4 |
| concepts[0].score | 0.834011971950531 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q84263196 |
| concepts[0].display_name | Coronavirus disease 2019 (COVID-19) |
| concepts[1].id | https://openalex.org/C3006700255 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6155000329017639 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q81068910 |
| concepts[1].display_name | 2019-20 coronavirus outbreak |
| concepts[2].id | https://openalex.org/C26517878 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5665825605392456 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q228039 |
| concepts[2].display_name | Key (lock) |
| concepts[3].id | https://openalex.org/C3007834351 |
| concepts[3].level | 5 |
| concepts[3].score | 0.5595260262489319 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q82069695 |
| concepts[3].display_name | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
| concepts[4].id | https://openalex.org/C2778137277 |
| concepts[4].level | 5 |
| concepts[4].score | 0.41289791464805603 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q16532287 |
| concepts[4].display_name | Betacoronavirus |
| concepts[5].id | https://openalex.org/C159047783 |
| concepts[5].level | 1 |
| concepts[5].score | 0.40576809644699097 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7215 |
| concepts[5].display_name | Virology |
| concepts[6].id | https://openalex.org/C71924100 |
| concepts[6].level | 0 |
| concepts[6].score | 0.37707284092903137 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[6].display_name | Medicine |
| concepts[7].id | https://openalex.org/C41008148 |
| concepts[7].level | 0 |
| concepts[7].score | 0.1981503665447235 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q21198 |
| concepts[7].display_name | Computer science |
| concepts[8].id | https://openalex.org/C126322002 |
| concepts[8].level | 1 |
| concepts[8].score | 0.11289015412330627 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[8].display_name | Internal medicine |
| concepts[9].id | https://openalex.org/C2779134260 |
| concepts[9].level | 2 |
| concepts[9].score | 0.09249445796012878 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[9].display_name | Disease |
| concepts[10].id | https://openalex.org/C524204448 |
| concepts[10].level | 3 |
| concepts[10].score | 0.08595910668373108 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q788926 |
| concepts[10].display_name | Infectious disease (medical specialty) |
| concepts[11].id | https://openalex.org/C116675565 |
| concepts[11].level | 2 |
| concepts[11].score | 0.08109539747238159 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q3241045 |
| concepts[11].display_name | Outbreak |
| concepts[12].id | https://openalex.org/C38652104 |
| concepts[12].level | 1 |
| concepts[12].score | 0.0784861147403717 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q3510521 |
| concepts[12].display_name | Computer security |
| keywords[0].id | https://openalex.org/keywords/coronavirus-disease-2019 |
| keywords[0].score | 0.834011971950531 |
| keywords[0].display_name | Coronavirus disease 2019 (COVID-19) |
| keywords[1].id | https://openalex.org/keywords/2019-20-coronavirus-outbreak |
| keywords[1].score | 0.6155000329017639 |
| keywords[1].display_name | 2019-20 coronavirus outbreak |
| keywords[2].id | https://openalex.org/keywords/key |
| keywords[2].score | 0.5665825605392456 |
| keywords[2].display_name | Key (lock) |
| keywords[3].id | https://openalex.org/keywords/severe-acute-respiratory-syndrome-coronavirus-2 |
| keywords[3].score | 0.5595260262489319 |
| keywords[3].display_name | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
| keywords[4].id | https://openalex.org/keywords/betacoronavirus |
| keywords[4].score | 0.41289791464805603 |
| keywords[4].display_name | Betacoronavirus |
| keywords[5].id | https://openalex.org/keywords/virology |
| keywords[5].score | 0.40576809644699097 |
| keywords[5].display_name | Virology |
| keywords[6].id | https://openalex.org/keywords/medicine |
| keywords[6].score | 0.37707284092903137 |
| keywords[6].display_name | Medicine |
| keywords[7].id | https://openalex.org/keywords/computer-science |
| keywords[7].score | 0.1981503665447235 |
| keywords[7].display_name | Computer science |
| keywords[8].id | https://openalex.org/keywords/internal-medicine |
| keywords[8].score | 0.11289015412330627 |
| keywords[8].display_name | Internal medicine |
| keywords[9].id | https://openalex.org/keywords/disease |
| keywords[9].score | 0.09249445796012878 |
| keywords[9].display_name | Disease |
| keywords[10].id | https://openalex.org/keywords/infectious-disease |
| keywords[10].score | 0.08595910668373108 |
| keywords[10].display_name | Infectious disease (medical specialty) |
| keywords[11].id | https://openalex.org/keywords/outbreak |
| keywords[11].score | 0.08109539747238159 |
| keywords[11].display_name | Outbreak |
| keywords[12].id | https://openalex.org/keywords/computer-security |
| keywords[12].score | 0.0784861147403717 |
| keywords[12].display_name | Computer security |
| language | en |
| locations[0].id | doi:10.1007/s11357-020-00213-0 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210237251 |
| locations[0].source.issn | 2509-2715, 2509-2723 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 2509-2715 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | GeroScience |
| locations[0].source.host_organization | https://openalex.org/P4310319972 |
| locations[0].source.host_organization_name | Springer International Publishing |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319972 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://link.springer.com/content/pdf/10.1007/s11357-020-00213-0.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | GeroScience |
| locations[0].landing_page_url | https://doi.org/10.1007/s11357-020-00213-0 |
| locations[1].id | pmid:32556942 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | GeroScience |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/32556942 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:7299454 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | GeroScience |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/7299454 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5008190677 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-4059-9092 |
| authorships[0].author.display_name | Brandt D. Pence |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I94658018 |
| authorships[0].affiliations[0].raw_affiliation_string | School of Health Studies, University of Memphis, Memphis, TN, 38152, USA |
| authorships[0].institutions[0].id | https://openalex.org/I94658018 |
| authorships[0].institutions[0].ror | https://ror.org/01cq23130 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I94658018 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | University of Memphis |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Brandt D. Pence |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | School of Health Studies, University of Memphis, Memphis, TN, 38152, USA |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://link.springer.com/content/pdf/10.1007/s11357-020-00213-0.pdf |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Severe COVID-19 and aging: are monocytes the key? |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11368 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9990000128746033 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2728 |
| primary_topic.subfield.display_name | Neurology |
| primary_topic.display_name | Long-Term Effects of COVID-19 |
| related_works | https://openalex.org/W4382894326, https://openalex.org/W3198183218, https://openalex.org/W3009669391, https://openalex.org/W3036314732, https://openalex.org/W4280491013, https://openalex.org/W3031607536, https://openalex.org/W3171943759, https://openalex.org/W3125428285, https://openalex.org/W4317567423, https://openalex.org/W4308304321 |
| cited_by_count | 141 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 11 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 23 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 25 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 55 |
| counts_by_year[5].year | 2020 |
| counts_by_year[5].cited_by_count | 25 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1007/s11357-020-00213-0 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210237251 |
| best_oa_location.source.issn | 2509-2715, 2509-2723 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 2509-2715 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | GeroScience |
| best_oa_location.source.host_organization | https://openalex.org/P4310319972 |
| best_oa_location.source.host_organization_name | Springer International Publishing |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319972 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://link.springer.com/content/pdf/10.1007/s11357-020-00213-0.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | GeroScience |
| best_oa_location.landing_page_url | https://doi.org/10.1007/s11357-020-00213-0 |
| primary_location.id | doi:10.1007/s11357-020-00213-0 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210237251 |
| primary_location.source.issn | 2509-2715, 2509-2723 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 2509-2715 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | GeroScience |
| primary_location.source.host_organization | https://openalex.org/P4310319972 |
| primary_location.source.host_organization_name | Springer International Publishing |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319972 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://link.springer.com/content/pdf/10.1007/s11357-020-00213-0.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | GeroScience |
| primary_location.landing_page_url | https://doi.org/10.1007/s11357-020-00213-0 |
| publication_date | 2020-06-15 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W2482757689, https://openalex.org/W2811473116, https://openalex.org/W3011147220, https://openalex.org/W3021880084, https://openalex.org/W2906988593, https://openalex.org/W3012831148, https://openalex.org/W3002539152, https://openalex.org/W3014003872, https://openalex.org/W3002108456, https://openalex.org/W3014799733, https://openalex.org/W2134266729, https://openalex.org/W2617620062, https://openalex.org/W2026178330, https://openalex.org/W3023570319, https://openalex.org/W2903322118, https://openalex.org/W3011622189, https://openalex.org/W3023991776, https://openalex.org/W3022476456, https://openalex.org/W3012099172, https://openalex.org/W3025911508, https://openalex.org/W3014748555, https://openalex.org/W2884081989, https://openalex.org/W2402075445, https://openalex.org/W3016288338, https://openalex.org/W3009906937, https://openalex.org/W2602237780, https://openalex.org/W3025320502, https://openalex.org/W3016042519, https://openalex.org/W3011176674, https://openalex.org/W2900653572, https://openalex.org/W3015571324, https://openalex.org/W1482873758, https://openalex.org/W3009912996, https://openalex.org/W2594075087, https://openalex.org/W2607819139, https://openalex.org/W2967035454, https://openalex.org/W1985634053, https://openalex.org/W2091671824, https://openalex.org/W1966238900, https://openalex.org/W3024643080, https://openalex.org/W2915839491, https://openalex.org/W3012658614, https://openalex.org/W1969015124, https://openalex.org/W1845012539, https://openalex.org/W2941620462, https://openalex.org/W2775503072, https://openalex.org/W3015835940, https://openalex.org/W2015163231, https://openalex.org/W2468925656, https://openalex.org/W3012925204, https://openalex.org/W2793282252, https://openalex.org/W2798053566, https://openalex.org/W2913983329, https://openalex.org/W3003951199, https://openalex.org/W2518307266, https://openalex.org/W3024126428, https://openalex.org/W3016710356, https://openalex.org/W3009859788, https://openalex.org/W2129655352, https://openalex.org/W1963580683, https://openalex.org/W3015226680, https://openalex.org/W3009314935, https://openalex.org/W2130083996, https://openalex.org/W3006785559, https://openalex.org/W3025206324, https://openalex.org/W3016502272, https://openalex.org/W2058743791, https://openalex.org/W3015090018, https://openalex.org/W3014233146, https://openalex.org/W3025871232, https://openalex.org/W2732557031, https://openalex.org/W2175952151, https://openalex.org/W3017331996, https://openalex.org/W2605810679, https://openalex.org/W3115033508, https://openalex.org/W3005079553, https://openalex.org/W3003790823, https://openalex.org/W2959092261, https://openalex.org/W3013893137, https://openalex.org/W3011534780, https://openalex.org/W3024096493, https://openalex.org/W3022970339, https://openalex.org/W2971409067, https://openalex.org/W6959396634, https://openalex.org/W1966929320, https://openalex.org/W2124259324, https://openalex.org/W3010338568, https://openalex.org/W2900546567, https://openalex.org/W3013070728, https://openalex.org/W3010637630, https://openalex.org/W3013862778, https://openalex.org/W3010126769, https://openalex.org/W3012655019, https://openalex.org/W3003154936, https://openalex.org/W3009976289, https://openalex.org/W2123669249, https://openalex.org/W3009885589, https://openalex.org/W3004280078, https://openalex.org/W3011230498, https://openalex.org/W3020655115, https://openalex.org/W1984378291, https://openalex.org/W3043002108, https://openalex.org/W3114705283, https://openalex.org/W3006846061, https://openalex.org/W2022043783, https://openalex.org/W3047753928, https://openalex.org/W3165656738, https://openalex.org/W3102142150, https://openalex.org/W3100462427, https://openalex.org/W3015280639, https://openalex.org/W3001118548 |
| referenced_works_count | 111 |
| abstract_inverted_index.I | 72, 96 |
| abstract_inverted_index.a | 11, 31, 80, 116, 137 |
| abstract_inverted_index.as | 175, 177 |
| abstract_inverted_index.be | 186 |
| abstract_inverted_index.by | 33, 44, 55 |
| abstract_inverted_index.in | 19, 38, 52, 88, 94, 100, 128, 161, 181, 188, 199 |
| abstract_inverted_index.is | 42, 68, 135 |
| abstract_inverted_index.of | 14, 62, 65, 108, 144, 166, 168 |
| abstract_inverted_index.to | 76, 125, 190, 195 |
| abstract_inverted_index.The | 1, 131, 163 |
| abstract_inverted_index.and | 17, 41, 51, 91, 103, 111, 122, 151, 158 |
| abstract_inverted_index.are | 85, 106, 149 |
| abstract_inverted_index.but | 146 |
| abstract_inverted_index.due | 124 |
| abstract_inverted_index.for | 141, 156, 172 |
| abstract_inverted_index.our | 60 |
| abstract_inverted_index.the | 34, 63, 182, 192 |
| abstract_inverted_index.was | 29 |
| abstract_inverted_index.2019 | 27 |
| abstract_inverted_index.2020 | 40 |
| abstract_inverted_index.also | 97 |
| abstract_inverted_index.both | 109 |
| abstract_inverted_index.some | 53 |
| abstract_inverted_index.that | 78, 105 |
| abstract_inverted_index.well | 176 |
| abstract_inverted_index.will | 185 |
| abstract_inverted_index.Here, | 71 |
| abstract_inverted_index.March | 39 |
| abstract_inverted_index.World | 35 |
| abstract_inverted_index.acute | 5, 47 |
| abstract_inverted_index.adult | 201 |
| abstract_inverted_index.aging | 110, 173 |
| abstract_inverted_index.argue | 77 |
| abstract_inverted_index.cases | 16, 54 |
| abstract_inverted_index.cell, | 84 |
| abstract_inverted_index.older | 20, 129, 200 |
| abstract_inverted_index.order | 189 |
| abstract_inverted_index.storm | 90 |
| abstract_inverted_index.vivo. | 162 |
| abstract_inverted_index.which | 114 |
| abstract_inverted_index.Health | 36 |
| abstract_inverted_index.Severe | 22 |
| abstract_inverted_index.animal | 170 |
| abstract_inverted_index.causes | 10 |
| abstract_inverted_index.combat | 196 |
| abstract_inverted_index.deaths | 18 |
| abstract_inverted_index.immune | 83, 133 |
| abstract_inverted_index.innate | 82, 132 |
| abstract_inverted_index.models | 171 |
| abstract_inverted_index.needed | 194 |
| abstract_inverted_index.number | 13 |
| abstract_inverted_index.review | 73 |
| abstract_inverted_index.severe | 4, 15, 66, 112, 197 |
| abstract_inverted_index.storm, | 46 |
| abstract_inverted_index.strong | 178 |
| abstract_inverted_index.system | 134 |
| abstract_inverted_index.target | 140 |
| abstract_inverted_index.unique | 154 |
| abstract_inverted_index.adults. | 21, 130 |
| abstract_inverted_index.changes | 99 |
| abstract_inverted_index.develop | 191 |
| abstract_inverted_index.disease | 24, 26 |
| abstract_inverted_index.efforts | 180 |
| abstract_inverted_index.needed, | 150 |
| abstract_inverted_index.ongoing | 2 |
| abstract_inverted_index.players | 87 |
| abstract_inverted_index.studies | 148, 160 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.COVID-19 | 67, 198 |
| abstract_inverted_index.colonies | 167 |
| abstract_inverted_index.cytokine | 45, 89 |
| abstract_inverted_index.declared | 30 |
| abstract_inverted_index.describe | 98 |
| abstract_inverted_index.distress | 49 |
| abstract_inverted_index.emerging | 74 |
| abstract_inverted_index.evidence | 75 |
| abstract_inverted_index.function | 102 |
| abstract_inverted_index.monocyte | 101 |
| abstract_inverted_index.pandemic | 3, 32 |
| abstract_inverted_index.presents | 153 |
| abstract_inverted_index.required | 187 |
| abstract_inverted_index.studies, | 174 |
| abstract_inverted_index.suggests | 115 |
| abstract_inverted_index.syndrome | 7 |
| abstract_inverted_index.systemic | 56 |
| abstract_inverted_index.COVID-19, | 113, 145 |
| abstract_inverted_index.COVID-19. | 95 |
| abstract_inverted_index.immediate | 164 |
| abstract_inverted_index.important | 139 |
| abstract_inverted_index.increased | 120 |
| abstract_inverted_index.infection | 127 |
| abstract_inverted_index.knowledge | 61 |
| abstract_inverted_index.mechanism | 118 |
| abstract_inverted_index.morbidity | 121 |
| abstract_inverted_index.mortality | 123 |
| abstract_inverted_index.phenotype | 104 |
| abstract_inverted_index.potential | 117 |
| abstract_inverted_index.primarily | 69 |
| abstract_inverted_index.principal | 86 |
| abstract_inverted_index.syndrome, | 50 |
| abstract_inverted_index.therapies | 193 |
| abstract_inverted_index.therefore | 136 |
| abstract_inverted_index.treatment | 143 |
| abstract_inverted_index.Currently, | 59 |
| abstract_inverted_index.SARS-CoV-2 | 126, 152 |
| abstract_inverted_index.associated | 92 |
| abstract_inverted_index.challenges | 155 |
| abstract_inverted_index.community, | 184 |
| abstract_inverted_index.monocytes, | 79 |
| abstract_inverted_index.pathology. | 58 |
| abstract_inverted_index.underlying | 119 |
| abstract_inverted_index.(COVID-19)) | 28 |
| abstract_inverted_index.circulating | 81 |
| abstract_inverted_index.geroscience | 183 |
| abstract_inverted_index.mechanistic | 159 |
| abstract_inverted_index.pathologies | 93 |
| abstract_inverted_index.potentially | 138 |
| abstract_inverted_index.respiratory | 6, 48 |
| abstract_inverted_index.therapeutic | 142 |
| abstract_inverted_index.(SARS-CoV-2) | 9 |
| abstract_inverted_index.(coronavirus | 25 |
| abstract_inverted_index.Organization | 37 |
| abstract_inverted_index.determinants | 64 |
| abstract_inverted_index.experimental | 147 |
| abstract_inverted_index.populations. | 202 |
| abstract_inverted_index.pre-clinical | 157 |
| abstract_inverted_index.characterized | 43 |
| abstract_inverted_index.collaborative | 179 |
| abstract_inverted_index.coronavirus-2 | 8 |
| abstract_inverted_index.establishment | 165 |
| abstract_inverted_index.characteristic | 107 |
| abstract_inverted_index.observational. | 70 |
| abstract_inverted_index.disproportionate | 12 |
| abstract_inverted_index.SARS-CoV-2-associated | 23 |
| abstract_inverted_index.SARS-CoV-2-susceptible | 169 |
| abstract_inverted_index.inflammation–related | 57 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 95 |
| corresponding_author_ids | https://openalex.org/A5008190677 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 1 |
| corresponding_institution_ids | https://openalex.org/I94658018 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8899999856948853 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.98840908 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |