bioRxiv (Cold Spring Harbor Laboratory)
Sex differences in deep brain shape and asymmetry persist across schizophrenia and healthy individuals: A meta-analysis from the ENIGMA-Schizophrenia Working Group
October 2024 • Daniel G. Cimmino, Brinley N. Zabriskie, Steven G. Luke, Boris A. Gutman, Dmitry Isaev, Kathryn Alpert, David C. Glahn, Amanda Rodrigue, Sinead Kelly…
Abstract Background Schizophrenia (SCZ) is characterized by a disconnect from reality that manifests as various clinical and cognitive symptoms, and persistent neurobiological abnormalities. Sex-related differences in clinical presentation imply separate brain substrates. The present study characterized deep brain morphology using shape features to understand the independent effects of diagnosis and sex on the brain, and to determine whether the neurobiology of schizophrenia varies as a function of sex. Methods Th…