Sex-Specific Patterns and Predictors of Reverse Left Ventricular Remodeling and Outcomes in STEMI Patients with LVEF ≤ 50% After Successful Primary Angioplasty Article Swipe
Bogdan Buz
,
Sergiu-Florin Arnăutu
,
Mirela Tomescu
,
Minodora Andor
,
Simina Crişan
,
Dan Gaiță
,
Cristina Văcărescu
,
Constantin-Tudor Luca
,
Cristian Mornoş
,
Dragoș Cozma
,
Diana-Aurora Arnăutu
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines13071782
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines13071782
Background: Sex-related differences in left ventricular (LV) reverse remodeling following ST-segment elevation myocardial infarction (STEMI) remain underexplored. We aimed to investigate predictors of reverse remodeling and its association with clinical outcomes, with a focus on sex-specific differences. Methods: We enrolled 253 STEMI patients (91 women, 28%) and assessed echocardiographic parameters at baseline and six months. LV reverse remodeling was defined as a ≥15% reduction in LV end-diastolic volume (LVEDV). Multivariate logistic regression identified independent predictors of remodeling. Clinical outcomes were evaluated over a median follow-up of 17 months (IQR 14–22 months), including major adverse cardiac events (MACEs). Kaplan–Meier and Cox regression analyses were performed. Results: Reverse remodeling occurred in 43% of patients and was more frequent in men than women (47% vs. 37%, p = 0.04). Male sex (OR 0.30; 95% CI: 0.14–0.65; p < 0.0001) and baseline global work efficiency (GWE) (OR 1.64; 95% CI: 1.45–1.85; p < 0.0001) were independent predictors. Men exhibited greater reductions in LVEDV, greater improvements in LV ejection fraction, and superior myocardial work indices. Over the follow-up, patients with reverse remodeling had significantly lower MACE rates compared to those without (10% vs. 24%, p < 0.01). Cox regression demonstrated that reverse remodeling was associated with a reduced risk of MACEs (HR 0.318; 95% CI: 0.181–0.557; p < 0.0001). Conclusions: LV reverse remodeling after STEMI is associated with improved clinical outcomes and is influenced by sex-specific differences. Baseline myocardial work indices, particularly GWE, are strong predictors of reverse remodeling. Men demonstrated a more favorable remodeling profile and myocardial recovery compared to women.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/biomedicines13071782
- https://www.mdpi.com/2227-9059/13/7/1782/pdf?version=1753096271
- OA Status
- gold
- References
- 34
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412519920
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4412519920Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/biomedicines13071782Digital Object Identifier
- Title
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Sex-Specific Patterns and Predictors of Reverse Left Ventricular Remodeling and Outcomes in STEMI Patients with LVEF ≤ 50% After Successful Primary AngioplastyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-07-21Full publication date if available
- Authors
-
Bogdan Buz, Sergiu-Florin Arnăutu, Mirela Tomescu, Minodora Andor, Simina Crişan, Dan Gaiță, Cristina Văcărescu, Constantin-Tudor Luca, Cristian Mornoş, Dragoș Cozma, Diana-Aurora ArnăutuList of authors in order
- Landing page
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https://doi.org/10.3390/biomedicines13071782Publisher landing page
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https://www.mdpi.com/2227-9059/13/7/1782/pdf?version=1753096271Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2227-9059/13/7/1782/pdf?version=1753096271Direct OA link when available
- Concepts
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Ejection fraction, Cardiology, Angioplasty, Internal medicine, Medicine, Ventricular remodeling, Primary angioplasty, Heart failure, Myocardial infarction, Percutaneous coronary interventionTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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34Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| corresponding_institution_ids | https://openalex.org/I4210088791 |
| citation_normalized_percentile.value | 0.4412272 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |