Shaping the risk for late-life neurodegenerative disease: A systematic review on prenatal risk factors for Alzheimer’s disease-related volumetric brain biomarkers Article Swipe
Amber Boots
,
Aline Marileen Wiegersma
,
Yasaman Vali
,
Malon Van den Hof
,
Miranda Langendam
,
Jacqueline Limpens
,
Ellen V. Backhouse
,
Susan D. Shenkin
,
Joanna M. Wardlaw
,
Tessa J. Roseboom
,
Susanne R. de Rooij
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.neubiorev.2022.105019
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.neubiorev.2022.105019
Environmental exposures including toxins and nutrition may hamper the developing brain in utero, limiting the brain's reserve capacity and increasing the risk for Alzheimer's disease (AD). The purpose of this systematic review is to summarize all currently available evidence for the association between prenatal exposures and AD-related volumetric brain biomarkers. We systematically searched MEDLINE and Embase for studies in humans reporting on associations between prenatal exposure(s) and AD-related volumetric brain biomarkers, including whole brain volume (WBV), hippocampal volume (HV) and/or temporal lobe volume (TLV) measured with structural magnetic resonance imaging (PROSPERO; CRD42020169317). Risk of bias was assessed using the Newcastle Ottawa Scale. We identified 79 eligible studies (search date: August 30th, 2020; Ntotal=24,784; median age 10.7 years) reporting on WBV (N = 38), HV (N = 63) and/or TLV (N = 5) in exposure categories alcohol (N = 30), smoking (N = 7), illicit drugs (N = 14), mental health problems (N = 7), diet (N = 8), disease, treatment and physiology (N = 10), infections (N = 6) and environmental exposures (N = 3). Overall risk of bias was low. Prenatal exposure to alcohol, opioids, cocaine, nutrient shortage, placental dysfunction and maternal anemia was associated with smaller brain volumes. We conclude that the prenatal environment is important in shaping the risk for late-life neurodegenerative disease.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.neubiorev.2022.105019
- OA Status
- hybrid
- Cited By
- 16
- References
- 126
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4313529321
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4313529321Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.neubiorev.2022.105019Digital Object Identifier
- Title
-
Shaping the risk for late-life neurodegenerative disease: A systematic review on prenatal risk factors for Alzheimer’s disease-related volumetric brain biomarkersWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-01-03Full publication date if available
- Authors
-
Amber Boots, Aline Marileen Wiegersma, Yasaman Vali, Malon Van den Hof, Miranda Langendam, Jacqueline Limpens, Ellen V. Backhouse, Susan D. Shenkin, Joanna M. Wardlaw, Tessa J. Roseboom, Susanne R. de RooijList of authors in order
- Landing page
-
https://doi.org/10.1016/j.neubiorev.2022.105019Publisher landing page
- Open access
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YesWhether a free full text is available
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-
hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.neubiorev.2022.105019Direct OA link when available
- Concepts
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Medicine, Brain size, Disease, Alzheimer's disease, Physiology, Internal medicine, Magnetic resonance imaging, RadiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
16Total citation count in OpenAlex
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2025: 6, 2024: 5, 2023: 5Per-year citation counts (last 5 years)
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126Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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