Shear type and magnitude affect aortic valve endothelial cell morphology, orientation, and differentiation Article Swipe
Nandini Deb
,
Mir Ali
,
Ashley Mathews
,
Ya‐Wen Chang
,
Carla M. R. Lacerda
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1177/15353702211023359
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1177/15353702211023359
Valvular endothelial cells line the outer layer of heart valves and can withstand shear forces caused by blood flow. In contrast to vascular endothelial cells, there is limited amount of research over valvular endothelial cells. For this reason, the exact physiologic behavior of valvular endothelial cells is unclear. Prior studies have concluded that valvular endothelial cells align perpendicularly to the direction of blood flow, while vascular endothelial cells align parallel to blood flow. Other studies have suggested that different ranges of shear stress uniquely impact the behavior of valvular endothelial cells. The goal of this study was to characterize the response of valvular endothelial cell under different types, magnitudes, and durations of shear stress. In this work, the results demonstrated that with increased shear rate and duration of exposure, valvular endothelial cells no longer possessed the traditional cuboidal morphology. Instead through the change in cell circularity and aspect ratio, valvular endothelial cells aligned in an organized manner. In addition, different forms of shear exposure caused the area and circularity of valvular endothelial cells to decrease while inducing mesenchymal transformation validated through αSMA and TGFβ 1 expression. This is the first investigation showing that valvular endothelial cells alignment is not as straightforward as once thought (perpendicular to flow). Different types and magnitudes of shear induce different local behaviors. This is also the first demonstration of valvular endothelial cells undergoing EndMT without chemical inducers on a soft surface in vitro. Findings from this study provide insights to understanding the pathophysiology of valvular endothelial cells which can potentially propel future artificial engineered heart valves.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/15353702211023359
- OA Status
- green
- Cited By
- 13
- References
- 49
- Related Works
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- OpenAlex ID
- https://openalex.org/W3179963141
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3179963141Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1177/15353702211023359Digital Object Identifier
- Title
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Shear type and magnitude affect aortic valve endothelial cell morphology, orientation, and differentiationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-07-14Full publication date if available
- Authors
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Nandini Deb, Mir Ali, Ashley Mathews, Ya‐Wen Chang, Carla M. R. LacerdaList of authors in order
- Landing page
-
https://doi.org/10.1177/15353702211023359Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/8581827Direct OA link when available
- Concepts
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Endothelial stem cell, Shear stress, Aortic valve, Endothelium, Internal medicine, Heart valve, Cell biology, Cardiology, Materials science, Chemistry, In vitro, Medicine, Biology, Biochemistry, Composite materialTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
13Total citation count in OpenAlex
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2025: 1, 2024: 4, 2023: 5, 2022: 1, 2021: 2Per-year citation counts (last 5 years)
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49Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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