Sheathless Focusing and Separation of Diverse Nanoparticles in Viscoelastic Solutions with Minimized Shear Thinning Article Swipe
Chao Liu
,
Baoquan Ding
,
Chun‐Dong Xue
,
Yu Tian
,
Guoqing Hu
,
Jiashu Sun
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1021/acs.analchem.6b04564
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1021/acs.analchem.6b04564
Viscoelastic microfluidics becomes an efficient and label-free hydrodynamic technology to enrich and separate micrometer-scale particles, including blood cells, circulating tumor cells, and bacteria. However, the manipulation of nanoscale particles by viscoelastic microfluidics remains a major challenge, because the viscoelastic force acting on the smaller particle decreases dramatically. In contrast to the commonly used polymer solutions of high molecular weight, herein we utilize the aqueous solutions of poly(ethylene oxide) (PEO) of low molecular weight with minimized shear thinning but sufficient elastic force for high-quality focusing and separation of various nanoparticles. The focusing efficiencies of 100 nm polystyrene (PS) nanoparticles and λ-DNA molecules are 84% and 85%, respectively, in a double spiral microchannel, without the aid of sheath flows. Furthermore, we demonstrate the size-based viscoelastic separation of two sets of binary mixtures-100/2000 nm PS particles and λ-DNA molecules/blood platelets-all achieving separation efficiencies of >95% in the same device. Our proposal technique would be a promising approach for enrichment/separation of the nanoparticles encountered in applications of analytical chemistry and nanotechnology.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acs.analchem.6b04564
- OA Status
- green
- Cited By
- 93
- References
- 38
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2554100694
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2554100694Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1021/acs.analchem.6b04564Digital Object Identifier
- Title
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Sheathless Focusing and Separation of Diverse Nanoparticles in Viscoelastic Solutions with Minimized Shear ThinningWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-11-25Full publication date if available
- Authors
-
Chao Liu, Baoquan Ding, Chun‐Dong Xue, Yu Tian, Guoqing Hu, Jiashu SunList of authors in order
- Landing page
-
https://doi.org/10.1021/acs.analchem.6b04564Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://dspace.imech.ac.cn/handle/311007/59974Direct OA link when available
- Concepts
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Chemistry, Viscoelasticity, Shear thinning, Nanoparticle, Shear (geology), Thinning, Chromatography, Nanotechnology, Polymer science, Chemical engineering, Composite material, Rheology, Materials science, Biology, Ecology, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
93Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 15, 2024: 6, 2023: 6, 2022: 6, 2021: 14Per-year citation counts (last 5 years)
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38Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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