Short‐term dietary methionine restriction with high fat diet counteracts metabolic dysfunction in male mice Article Swipe
Marissa McGilvrey
,
Bethany Fortier
,
Diana Cooke
,
Mohamed Mahdi
,
Benjamin Tero
,
Christian M. Potts
,
Abigail Kaija
,
Larisa Ryzhova
,
Carolina Cora
,
Adam Richardson
,
Douglas V. Guzior
,
Ilka Pinz
,
Calvin Vary
,
Robert A. Koza
,
Gene P. Ables
,
Lucy Liaw
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.14814/phy2.70405
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.14814/phy2.70405
Dietary methionine restriction (MetR) promotes metabolic health, and we tested the impact of short durations of MetR on high fat diet (HFD)‐induced metabolic dysfunction with the maintenance of HFD. Male C57BL/6J mice were fed HFD from 10 to 25 weeks of age, then maintained on HFD or fed HFD with 80% reduced methionine (HFD‐MetR) for 3, 5, or 10 days. Blood, liver, adipose tissue, and aortae underwent phenotypic assessment, proteomics, and metabolomics. HFD‐MetR induced rapid weight loss and robust metabolic improvement within 10 days. Significant reductions in body weight, circulating triglycerides, glucose, insulin, adipokines and hepatokines reflected metabolic health. Proteomics revealed enriched metabolic signatures in perivascular adipose tissue (PVAT) and structural remodeling signatures in aorta. Metabolomics identified a cardioprotective signature in blood plasma, and activated mitochondrial activity and energy production in liver and brown adipose tissue. HFD‐MetR reversed metabolic dysfunction, and novel proteomic and metabolomic signatures were identified. Multi‐organ molecular changes in lipid metabolism, mitochondrial function, and bioenergetics are predicted to impact adipose tissue and liver function and cardiovascular health. Our identification of rapid changes in protein and metabolite signatures with accelerated restoration of metabolic health can be leveraged to evaluate biomarkers of metabolic health and disease in a translational context.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.14814/phy2.70405
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.14814/phy2.70405
- OA Status
- gold
- References
- 72
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411370943
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411370943Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.14814/phy2.70405Digital Object Identifier
- Title
-
Short‐term dietary methionine restriction with high fat diet counteracts metabolic dysfunction in male miceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-06-01Full publication date if available
- Authors
-
Marissa McGilvrey, Bethany Fortier, Diana Cooke, Mohamed Mahdi, Benjamin Tero, Christian M. Potts, Abigail Kaija, Larisa Ryzhova, Carolina Cora, Adam Richardson, Douglas V. Guzior, Ilka Pinz, Calvin Vary, Robert A. Koza, Gene P. Ables, Lucy LiawList of authors in order
- Landing page
-
https://doi.org/10.14814/phy2.70405Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.14814/phy2.70405Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.14814/phy2.70405Direct OA link when available
- Concepts
-
Adipose tissue, Endocrinology, Internal medicine, Metabolomics, Metabolic syndrome, Biology, Context (archaeology), Adipokine, FGF21, Methionine, Insulin resistance, Medicine, Diabetes mellitus, Bioinformatics, Biochemistry, Paleontology, Receptor, Fibroblast growth factor, Amino acidTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
72Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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