Shotgun metagenomics detects the human pegivirus complete genome in a pediatric patient with acute hepatitis of unknown etiology: a case report Article Swipe
Roberta Vazzana
,
Alessandra Mularoni
,
Claudia Vaiana
,
Andrea Cona
,
Giovanni Mulè
,
Concetta Amato
,
Giusy Ranucci
,
Pier Giulio Conaldi
,
Valentina Agnese
,
Nicola Cuscino
,
Alessia Gallo
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fgene.2025.1653082
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fgene.2025.1653082
Human pegivirus (HPgV) is a positive-sense, single-strand RNA virus belonging to the Flaviviridae family. Although not conclusively linked to a specific disease, an increasing number of studies have recently reported an association between this virus and different human pathologies. In this study, we present a 6-month-old female infant admitted to the hospital for severe acute hepatitis. Her clinical history started with a one week of fever and diarrhea treated with paracetamol and amoxicillin–clavulanate for a total of 4 days. The persistence of the symptoms, high levels of transaminases, coagulopathy, increased lymphocytosis, and C-reactive protein (CRP) in the blood suggested an acute hepatitis episode. Serological and molecular biology tests for hepatotropic and non-hepatotropic viruses, including hepatitis B virus (HBV), hepatitis A virus (HAV), hepatitis C virus (HCV), hepatitis E virus (HEV), Epstein–Barr virus (EBV), cytomegalovirus (CMV), herpes simplex virus (HSV), enterovirus, and adenovirus, were negative. Metabolic and genetic alterations, deficiency of alpha-1 antitrypsin, and Wilson’s disease were ruled out following negative results. The child was thus treated with supportive therapy. Metagenomic next-generation sequencing (mNGS) performed to identify other possible infective agents undetected with the classical tests, showed the presence of the complete genome of human HPgV-1. This case provides further evidence supporting the hypothesis of the pathogenic role of HPgV-1 and warrants particular attention, especially in the pediatric population. Moreover, here we confirmed the diagnostic power of metagenomic-NGS in the detection of unusual pathogens.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fgene.2025.1653082
- https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1653082/pdf
- OA Status
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- 1
- References
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- OpenAlex ID
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All OpenAlex metadata
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Shotgun metagenomics detects the human pegivirus complete genome in a pediatric patient with acute hepatitis of unknown etiology: a case reportWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
- Publication date
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2025-09-11Full publication date if available
- Authors
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Roberta Vazzana, Alessandra Mularoni, Claudia Vaiana, Andrea Cona, Giovanni Mulè, Concetta Amato, Giusy Ranucci, Pier Giulio Conaldi, Valentina Agnese, Nicola Cuscino, Alessia GalloList of authors in order
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https://doi.org/10.3389/fgene.2025.1653082Publisher landing page
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https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1653082/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1653082/pdfDirect OA link when available
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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