Significance of MALAT1 Long Non-coding RNA and miR-20a-5p in regulating epithelial mesenchymal transition in luminal breast cancer patients Article Swipe
Gehad Tarek
,
Manar S. Fouda
,
Mohamed M. Omran
,
Gehan Safwat
,
Mahmoud M. Kamel
,
Abdel Hady A. Abdel Wahab
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-6277445/v1
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-6277445/v1
Breast cancer is a serious health concern and the most common cancer affecting women worldwide. Non-coding RNAs, especially long non-coding RNAs and microRNAs are crucial in regulating biological processes that contribute to breast cancer development. MALAT1, a long non-coding RNA, is pivotal in the progression of breast cancer. Epithelial-mesenchymal transition (EMT) is critical for cell movement during embryonic development. Clarifying this role could pave various avenues for developing innovative strategies for combating this type of malignancy. The present study aimed to determine the associations between MALAT1 levels, relevant miRNAs (miR-17-5p, miR-20a-5p, miR93-5p, and miR-146a-5p) and EMT markers (E-cadherin, N-cadherin, Vimentin, Fibronectin, Twist, SNAI1, Slug, ZEB1, and ZEB2) in luminal breast cancer patients. Fresh tissues were collected from fifty patients and twenty noncancerous controls. Differential expression of the markers was evaluated using qRT-PCR assay. Spearman Rho test assessed the relationship between the expression levels. Linear regression test evaluated the correlation between the parameters and various clinico-pathological features. MALAT1 was highly expressed in breast cancer tissues. Overexpression of miR-20a-5p, and ZEB2 was reported, whereas miR146a-5p, ZEB1 and Vimentin levels were suppressed. miR-20a-5p expression was positively correlated with those of SNAI1, E-cadherin, N-cadherin and Slug and was significantly associated with family history and tumor site. In conclusion, MALAT1 and miR-20a-5p play crucial roles in luminal breast cancer development and progression. Furthermore, miR-20a-5p plays an oncogenic role by enhancing the EMT process. Finally, MALAT1 and miR-20a-5p might serve as potential therapeutic targets in luminal breast cancer.
Related Topics
Concepts
MALAT1
Epithelial–mesenchymal transition
Breast cancer
Long non-coding RNA
RNA
Coding (social sciences)
Cancer research
Competing endogenous RNA
Transition (genetics)
Cancer
Oncology
Biology
Internal medicine
Gene
Medicine
Genetics
Mathematics
Statistics
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-6277445/v1
- https://www.researchsquare.com/article/rs-6277445/latest.pdf
- OA Status
- gold
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410206798
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4410206798Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-6277445/v1Digital Object Identifier
- Title
-
Significance of MALAT1 Long Non-coding RNA and miR-20a-5p in regulating epithelial mesenchymal transition in luminal breast cancer patientsWork title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-05-08Full publication date if available
- Authors
-
Gehad Tarek, Manar S. Fouda, Mohamed M. Omran, Gehan Safwat, Mahmoud M. Kamel, Abdel Hady A. Abdel WahabList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-6277445/v1Publisher landing page
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https://www.researchsquare.com/article/rs-6277445/latest.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.researchsquare.com/article/rs-6277445/latest.pdfDirect OA link when available
- Concepts
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MALAT1, Epithelial–mesenchymal transition, Breast cancer, Long non-coding RNA, RNA, Coding (social sciences), Cancer research, Competing endogenous RNA, Transition (genetics), Cancer, Oncology, Biology, Internal medicine, Gene, Medicine, Genetics, Mathematics, StatisticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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40Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| primary_location.id | doi:10.21203/rs.3.rs-6277445/v1 |
| primary_location.is_oa | True |
| primary_location.source | |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.researchsquare.com/article/rs-6277445/latest.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
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| primary_location.landing_page_url | https://doi.org/10.21203/rs.3.rs-6277445/v1 |
| publication_date | 2025-05-08 |
| publication_year | 2025 |
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