Significant Efficacy of a Single Low Dose of Primaquine Compared to Stand-Alone Artemisinin Combination Therapy in Reducing Gametocyte Carriage in Cambodian Patients with Uncomplicated Multidrug-Resistant Plasmodium falciparum Malaria Article Swipe
Amélie Vantaux
,
Saorin Kim
,
Eakpor Piv
,
Sophy Chy
,
Laura Berne
,
Nimol Khim
,
Dysoley Lek
,
Siv Sovannaroth
,
Mavuto Mukaka
,
Walter Taylor
,
Didier Ménard
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1128/aac.02108-19
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1128/aac.02108-19
Since 2012, a single low dose of primaquine (SLDPQ; 0.25 mg/kg of body weight) with artemisinin-based combination therapies has been recommended as the first-line treatment of acute uncomplicated Plasmodium falciparum malaria to interrupt its transmission, especially in low-transmission settings of multidrug resistance, including artemisinin resistance. Policy makers in Cambodia have been reluctant to implement this recommendation due to primaquine safety concerns and a lack of data on its efficacy.
Related Topics
Concepts
Primaquine
Artemisinin
Gametocyte
Malaria
Medicine
Plasmodium falciparum
Multiple drug resistance
Drug resistance
Combination therapy
Piperaquine
Carriage
Virology
Pharmacology
Chloroquine
Biology
Immunology
Microbiology
Pathology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1128/aac.02108-19
- OA Status
- hybrid
- Cited By
- 14
- References
- 44
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3011312638
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3011312638Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1128/aac.02108-19Digital Object Identifier
- Title
-
Significant Efficacy of a Single Low Dose of Primaquine Compared to Stand-Alone Artemisinin Combination Therapy in Reducing Gametocyte Carriage in Cambodian Patients with Uncomplicated Multidrug-Resistant Plasmodium falciparum MalariaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
-
2020-03-13Full publication date if available
- Authors
-
Amélie Vantaux, Saorin Kim, Eakpor Piv, Sophy Chy, Laura Berne, Nimol Khim, Dysoley Lek, Siv Sovannaroth, Mavuto Mukaka, Walter Taylor, Didier MénardList of authors in order
- Landing page
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https://doi.org/10.1128/aac.02108-19Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
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https://doi.org/10.1128/aac.02108-19Direct OA link when available
- Concepts
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Primaquine, Artemisinin, Gametocyte, Malaria, Medicine, Plasmodium falciparum, Multiple drug resistance, Drug resistance, Combination therapy, Piperaquine, Carriage, Virology, Pharmacology, Chloroquine, Biology, Immunology, Microbiology, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
14Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 3, 2023: 3, 2022: 5, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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44Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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