Significant prognostic difference between Grade Group 4 and 5 in the 2014 International Society of Urological Pathology Grading System for High Grade Prostate Cancer with Bone Metastasis Article Swipe
Yasutaka Yamada
,
Shinichi Sakamoto
,
Jun Shimazaki
,
Masahiro Sugiura
,
Yoshiyasu Amiya
,
Makoto Sasaki
,
Takayuki Shima
,
Akira Komiya
,
Noriyuki Suzuki
,
Koichiro Akakura
,
Tomohiko Ichikawa
,
Hiroomi Nakatsu
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1016/j.prnil.2017.03.001
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1016/j.prnil.2017.03.001
Background: To investigate prognostic difference between Gleason Score (GS) 8 and 9–10, as the 2014 International Society of Urological Pathology Gleason Grading Systems proposed, in patients with prostate cancer (PCa) with bone metastasis. Materials and methods: We retrospectively reviewed data on 106 patients with GS 8–10 between 2006 and 2016. All patients received androgen deprivation therapy immediately. We validated biochemical recurrence, PCa-specific survival, and overall survival, and analyzed the predictive value for overall survival. Results: Patients with GS 9–10 had significantly lower PCa-specific survival (50.5% vs. 83.4%, P=0.01) and overall survival (38.8% vs. 66.3%, P=0.04) at 5 years than those with GS 8, while biochemical recurrence rate was not significantly different (P=0.26). Furthermore, these significant differences between GS 8 and 9–10 were also observed among high-risk groups proposed in Japan Cancer of the Prostate Risk Assessment Stratification (prostate cancer-specific survival: P=0.03, overall survival: P=0.04, respectively). Pathological GS 9–10 was an independent prognostic factor for overall survival (hazard ratio=1.97, P=0.04) in multivariable cox proportional hazard regression analysis. Among patients with GS 9–10, albumin level was an only prognostic factor for overall survival (hazard ratio=0.33, P<0.01). Conclusion: Pathological GS 9–10 predicts significantly worse outcomes than GS 8 in Japanese PCa patients with bone metastasis. Our data indicated clinical significance of discriminating the 2014 International Society of Urological Pathology Gleason Grading Group 4 and 5 among high-risk PCa patients with bone metastasis.
Related Topics
Concepts
Medicine
Prostate cancer
Hazard ratio
Proportional hazards model
Grading (engineering)
Internal medicine
Bone metastasis
Biochemical recurrence
Pathological
Oncology
Metastasis
Prostate
Prostatectomy
Urology
Cancer
Confidence interval
Engineering
Civil engineering
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.prnil.2017.03.001
- OA Status
- gold
- Cited By
- 6
- References
- 29
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2595043001
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2595043001Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.prnil.2017.03.001Digital Object Identifier
- Title
-
Significant prognostic difference between Grade Group 4 and 5 in the 2014 International Society of Urological Pathology Grading System for High Grade Prostate Cancer with Bone MetastasisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-03-16Full publication date if available
- Authors
-
Yasutaka Yamada, Shinichi Sakamoto, Jun Shimazaki, Masahiro Sugiura, Yoshiyasu Amiya, Makoto Sasaki, Takayuki Shima, Akira Komiya, Noriyuki Suzuki, Koichiro Akakura, Tomohiko Ichikawa, Hiroomi NakatsuList of authors in order
- Landing page
-
https://doi.org/10.1016/j.prnil.2017.03.001Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1016/j.prnil.2017.03.001Direct OA link when available
- Concepts
-
Medicine, Prostate cancer, Hazard ratio, Proportional hazards model, Grading (engineering), Internal medicine, Bone metastasis, Biochemical recurrence, Pathological, Oncology, Metastasis, Prostate, Prostatectomy, Urology, Cancer, Confidence interval, Engineering, Civil engineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2021: 2, 2020: 3, 2019: 1Per-year citation counts (last 5 years)
- References (count)
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29Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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