Silk Composite‐Based Multifunctional Pellets for Controlled Release Article Swipe
Sushma Indrakumar
,
Sriram Bharath Gugulothu
,
Akshat Joshi
,
Tapan Kumar Dash
,
Vivek Mishra
,
Bharat Tandon
,
Kaushik Chatterjee
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/mabi.202400410
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/mabi.202400410
Chronic wounds present significant clinical challenges due to the high risk of infections and persistent inflammation. While personalized treatments in point‐of‐care settings are crucial, they are limited by the complex fabrication techniques of the existing products. The calcium sulfate hemihydrate (CSH)‐based drug delivery platform enables rapid fabrication but lacks antioxidant and antibacterial properties, essential to promote healing. To develop a multifunctional platform, a tannic acid (TA)‐silk fibroin (SF) complex is engineered and incorporated as an additive in CSH cement. This cement is then cast into pellets to create silk/bioceramic‐based composite drug delivery systems, designed for point‐of‐care use. Compared to neat CSH pellets, the composite pellets exhibit a 7.5‐fold increase in antioxidant activity and prolonged antibacterial efficacy (up to 13 d). Moreover, the subcutaneous implantation of the pellets shows no hallmarks of local or systemic toxicity in a rodent model. The pellets are optimized in composition and fabrication to ease market translation. Clinically, the pellets have the potential to be further developed into products to place on wound beds or fill into bone cavities that are designed to deliver the intended therapeutic effect. The developed multifunctional system proves to be a promising solution for personalized treatment in point‐of‐care settings.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/mabi.202400410
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mabi.202400410
- OA Status
- bronze
- Cited By
- 1
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4403578458
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4403578458Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/mabi.202400410Digital Object Identifier
- Title
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Silk Composite‐Based Multifunctional Pellets for Controlled ReleaseWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
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2024-10-20Full publication date if available
- Authors
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Sushma Indrakumar, Sriram Bharath Gugulothu, Akshat Joshi, Tapan Kumar Dash, Vivek Mishra, Bharat Tandon, Kaushik ChatterjeeList of authors in order
- Landing page
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https://doi.org/10.1002/mabi.202400410Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mabi.202400410Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mabi.202400410Direct OA link when available
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Pellets, Drug delivery, Fabrication, Materials science, Fibroin, Composite number, Nanotechnology, Chemical engineering, SILK, Biomedical engineering, Medicine, Composite material, Engineering, Pathology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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46Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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