Silk Protein Gene Engineering and Its Applications: Recent Advances in Biomedicine Driven by Molecular Biotechnology Article Swipe
Xingxiang Ji
,
Yanyan Li
,
Jingsheng Wang
,
Gang Wang
,
Bin Ma
,
Jingfei Shi
,
Chao Cui
,
Ruiming Wang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.2147/dddt.s504783
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.2147/dddt.s504783
Silk protein, as a natural polymer material with unique structures and properties, exhibits tremendous potential in the biomedical field. Given the limited production and restricted properties of natural silk proteins, molecular biotechnology has been extensively applied in silk protein genetic engineering to produce novel silk proteins with specific properties. This review outlines the roles of major model organisms, such as silkworms and spiders, in silk protein production, and provides a detailed introduction to the applications of gene editing technologies (eg, CRISPR-Cas9), transgenic expression technologies, and synthetic biology techniques in silk protein genetic engineering. By analyzing the genetic factors influencing silk protein expression, this review further elaborates on the innovative applications of silk proteins in drug delivery systems, tissue engineering and regenerative medicine (eg, skin, bone, cartilage, and vascular repair), as well as antibacterial immune strategies. Notably, modified silk proteins expressed by transgenic silkworms demonstrate significant advantages in enhancing drug bioavailability and promoting cell proliferation and differentiation. In conclusion, silk protein gene engineering, through continuous innovations in molecular biotechnology, has provided an effective pathway for the production of high-performance silk protein materials. The extensive applications of these modified silk proteins in the biomedical field have not only expanded the functionality of silk proteins but also offered new approaches to address medical challenges. In the future, the development of silk protein gene engineering will further rely on interdisciplinary integration to promote in-depth research and the expansion of industrial applications of silk proteins.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.2147/dddt.s504783
- OA Status
- gold
- Cited By
- 5
- References
- 173
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4406824394
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4406824394Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.2147/dddt.s504783Digital Object Identifier
- Title
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Silk Protein Gene Engineering and Its Applications: Recent Advances in Biomedicine Driven by Molecular BiotechnologyWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-01-01Full publication date if available
- Authors
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Xingxiang Ji, Yanyan Li, Jingsheng Wang, Gang Wang, Bin Ma, Jingfei Shi, Chao Cui, Ruiming WangList of authors in order
- Landing page
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https://doi.org/10.2147/dddt.s504783Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.2147/dddt.s504783Direct OA link when available
- Concepts
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Biomedicine, SILK, Computational biology, Biotechnology, Protein engineering, Biology, Nanotechnology, Engineering, Bioinformatics, Materials science, Biochemistry, Telecommunications, EnzymeTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
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2025: 5Per-year citation counts (last 5 years)
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173Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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