Simple Esterification of [1-13C]-Alpha-Ketoglutarate Enhances Membrane Permeability and Allows for Noninvasive Tracing of Glutamate and Glutamine Production Article Swipe
Jenna E. AbuSalim
,
Kazutoshi Yamamoto
,
Natsuko Miura
,
Burchelle Blackman
,
Jeffrey Brender
,
Chandrasekhar Mushti
,
Tomohiro Seki
,
Kevin Camphausen
,
Rolf E. Swenson
,
Murali C. Krishna
,
Aparna H. Kesarwala
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1021/acschembio.1c00561
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1021/acschembio.1c00561
Alpha-ketoglutarate (α-KG) is a key metabolite and signaling molecule in cancer cells, but the low permeability of α-KG limits the study of α-KG mediated effects in vivo. Recently, cell-permeable monoester and diester α-KG derivatives have been synthesized for use in vivo, but many of these derivatives are not compatible for use in hyperpolarized carbon-13 nuclear magnetic resonance spectroscopy (HP-13C-MRS). HP-13C-MRS is a powerful technique that has been used to noninvasively trace labeled metabolites in real time. Here, we show that using diethyl-[1-13C]-α-KG as a probe in HP-13C-MRS allows for noninvasive tracing of α-KG metabolism in vivo.
Related Topics
Concepts
In vivo
Metabolite
Glutamine
Chemistry
Tracing
Nuclear magnetic resonance spectroscopy
Metabolism
Permeability (electromagnetism)
Alpha ketoglutarate
Glutamate receptor
Biochemistry
Biophysics
Membrane
Stereochemistry
Amino acid
Biology
Enzyme
Biotechnology
Receptor
Computer science
Operating system
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acschembio.1c00561
- OA Status
- green
- Cited By
- 15
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3200397647
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3200397647Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1021/acschembio.1c00561Digital Object Identifier
- Title
-
Simple Esterification of [1-13C]-Alpha-Ketoglutarate Enhances Membrane Permeability and Allows for Noninvasive Tracing of Glutamate and Glutamine ProductionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-09-23Full publication date if available
- Authors
-
Jenna E. AbuSalim, Kazutoshi Yamamoto, Natsuko Miura, Burchelle Blackman, Jeffrey Brender, Chandrasekhar Mushti, Tomohiro Seki, Kevin Camphausen, Rolf E. Swenson, Murali C. Krishna, Aparna H. KesarwalaList of authors in order
- Landing page
-
https://doi.org/10.1021/acschembio.1c00561Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/9107957Direct OA link when available
- Concepts
-
In vivo, Metabolite, Glutamine, Chemistry, Tracing, Nuclear magnetic resonance spectroscopy, Metabolism, Permeability (electromagnetism), Alpha ketoglutarate, Glutamate receptor, Biochemistry, Biophysics, Membrane, Stereochemistry, Amino acid, Biology, Enzyme, Biotechnology, Receptor, Computer science, Operating systemTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
15Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 4, 2023: 4, 2022: 2, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
42Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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