Single-cell multiomics identifies both shared and unique features of immune dysfunction in Parkinson’s disease and inflammatory bowel disease colon, plasma and stool Article Swipe
MacKenzie L. Bolen
,
Marie‐Annick Buendia
,
Ji Shi
,
Hannah A. Staley
,
Jennifer M. Kachergus
,
Philip A. Efron
,
Gwoncheol Park
,
Ravinder Nagpal
,
Stephan D. Alvarez
,
Qing‐Shan Xue
,
Nikolaus R. McFarland
,
Ellen M. Zimmermann
,
Christopher E. Forsmark
,
Kelly B. Menees
,
Azucena Salas
,
E. Aubrey Thompson
,
Malú G. Tansey
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.04.29.651228
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.04.29.651228
Parkinson’s disease (PD) is the fastest growing neurodegenerative disease in the world 1 . Gastrointestinal (GI) dysfunction can occur decades before motor impairments and in up to 80% of individuals living with PD 2,3,4 . We investigated peripheral relationships that may underlie mechanisms along the gut-blood axis that contribute to PD pathogenesis. Single-cell multiomic spatial molecular imaging (SMI) of colonic tissue localized inflammatory injury within epithelial cells that appear to be associated with iron mishandling in both inflammatory bowel disease (IBD) and PD biosamples. We found that both the single-cell SMI of RNA and protein revealed parallel cross-modal dysregulation in the gut epithelium, in both IBD and PD biosamples. These data are accompanied by plasma (PD) and stool (IBD) protein depletion of CCL22. Our findings suggest iron mishandling along the gut barrier likely contributes to systemic inflammation, which may be the catalyst that primes circulating immune cells to body-first PD pathogenesis.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.04.29.651228
- https://www.biorxiv.org/content/biorxiv/early/2025/05/02/2025.04.29.651228.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 70
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410027322
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4410027322Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2025.04.29.651228Digital Object Identifier
- Title
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Single-cell multiomics identifies both shared and unique features of immune dysfunction in Parkinson’s disease and inflammatory bowel disease colon, plasma and stoolWork title
- Type
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preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-05-02Full publication date if available
- Authors
-
MacKenzie L. Bolen, Marie‐Annick Buendia, Ji Shi, Hannah A. Staley, Jennifer M. Kachergus, Philip A. Efron, Gwoncheol Park, Ravinder Nagpal, Stephan D. Alvarez, Qing‐Shan Xue, Nikolaus R. McFarland, Ellen M. Zimmermann, Christopher E. Forsmark, Kelly B. Menees, Azucena Salas, E. Aubrey Thompson, Malú G. TanseyList of authors in order
- Landing page
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https://doi.org/10.1101/2025.04.29.651228Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2025/05/02/2025.04.29.651228.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
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-
https://www.biorxiv.org/content/biorxiv/early/2025/05/02/2025.04.29.651228.full.pdfDirect OA link when available
- Concepts
-
Disease, Inflammatory bowel disease, Immune system, Medicine, Immunology, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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70Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.80% | 28 |
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| abstract_inverted_index.Our | 124 |
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| abstract_inverted_index.that | 40, 48, 68, 87, 143 |
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| abstract_inverted_index.spatial | 55 |
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| citation_normalized_percentile.is_in_top_10_percent | True |